期刊
CURRENT OPINION IN INSECT SCIENCE
卷 10, 期 -, 页码 110-117出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cois.2015.05.003
关键词
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资金
- National Institutes of Health [R21AI094289, R21AI099528, R21AI101345, R21AI088035]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI099528, R21AI088035, R21AI101345, R21AI094289] Funding Source: NIH RePORTER
Interactions between a pathogen and a vector are plastic and dynamic. Such interactions can be more rapidly accommodated by epigenetic changes than by genetic mutations. Gene expression can be affected by the proximity to the heterochromatin, by local histone modifications, and by the three-dimensional position within the nucleus. Recent studies of disease vectors indicate that gene regulation by these factors can be important for susceptibility to pathogens, reproduction, immunity, development, and longevity. Knowledge about heterochromatin, histone modifications, and nuclear architecture will help our understanding of epigenetic mechanisms that control gene function at traits related to vectorial capacity.
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