Review
Gastroenterology & Hepatology
Bashar J. Qumseya, Yazan Qumsiyeh, Sandeep A. Ponniah, David Estores, Dennis Yang, Crystal N. Johnson-Mann, Jeffrey Friedman, Alexander Ayzengart, Peter V. Draganov
Summary: After analyzing 10 studies, it was found that the prevalence of BE is high in patients undergoing EGD after SG, with no significant correlation with postoperative GERD symptoms. Most cases of BE were observed after 3 years.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Medicine, General & Internal
Kazumi Inokuchi, Takahiro Ochiya, Juntaro Matsuzaki
Summary: Esophageal adenocarcinoma (EAC) is the major histologic type of esophageal cancer in Western countries with a poor prognosis primarily due to late stage diagnosis. Barrett's esophagus (BE) is a precursor lesion of EAC. Extracellular microRNAs (miRNAs) may serve as non-invasive markers for the management of EAC in the future, with potential utility for diagnosis and treatment responses. Multiple studies have reported dysregulation of certain miRNAs in both EAC and BE, suggesting their potential as valuable biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Nour Hamade, Amrit K. Kamboj, Rajesh Krishnamoorthi, Siddharth Singh, Leslie C. Hassett, David A. Katzka, Charles J. Kahi, Hala Fatima, Prasad G. Iyer
Summary: Through analysis of multiple studies, a statistically significant inverse correlation was found between neoplasia detection rate and post-endoscopy Barrett's neoplasia, indicating that with an increase in neoplasia detection rate, post-endoscopy Barrett's neoplasia decreases. Further studies are needed to validate this correlation.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Tarek Sawas, Abdul Mounaem Majzoub, James Haddad, Thomas Tielleman, Tarek Nayfeh, Rena Yadlapati, Siddharth Singh, Jennifer Kolb, Ravy K. Vajravelu, David A. Katzka, Sachin Wani
Summary: This study aimed to estimate the proportion of postendoscopy esophageal adenocarcinoma (PEEC) within the first year after Barrett's esophagus (BE) diagnosis. The results showed a high proportion of PEEC among patients with EAC and EAC-F HGD, and the proportion was inversely related to incident EAC. It is necessary to use the best endoscopic techniques and implement quality measures and educational tools to improve neoplasia detection and reduce PEEC.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marcel Gehrung, Mireia Crispin-Ortuzar, Adam G. Berman, Maria O'Donovan, Rebecca C. Fitzgerald, Florian Markowetz
Summary: Deep learning methods have been successfully integrated with expert knowledge and clinical decision pathways to automate the analysis of Cytosponge-TFF3 test samples for the early detection of Barrett's esophagus. By defining triage classes based on pathologists' decision patterns, the workload of pathologists can be reduced by 57% without compromising diagnostic performance. The clinician-in-the-loop deep learning system streamlines the workflow for Barrett's esophagus detection while maintaining the accuracy of manual review.
Review
Gastroenterology & Hepatology
Leonardo H. Eusebi, Andrea Telese, Giovanna G. Cirota, Rehan Haidry, R. Maurizio Zagari, Franco Bazzoli, Alexander C. Ford
Summary: Gastro-esophageal reflux (GER) symptoms are associated with an increased odds of Barrett's esophagus (BE), especially when the symptoms occur weekly. However, GER symptoms have low sensitivity and specificity for predicting BE, except for a strong association with long segment BE. Screening individuals with weekly GER symptoms may be beneficial to rule out long segment BE.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Review
Gastroenterology & Hepatology
D. Chamil Codipilly, Apoorva Krishna Chandar, Kenneth K. Wang, David A. Katzka, John R. Goldblum, Prashanthi N. Thota, Gary W. Falk, Amitabh Chak, Prasad G. Iyer
Summary: WATS3D has shown an incremental yield in dysplasia detection in Barrett's esophagus, but the clinical significance of this increased detection remains uncertain. Further endoscopic follow-up data are needed to determine the optimal clinical application and significance of WATS3D in dysplasia detection.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Pediatrics
Paul T. Jensen, Keumseok Koh, Rebecca E. Cash, Stacy P. Ardoin, Ayaz Hyder
PEDIATRIC RHEUMATOLOGY
(2020)
Article
Public, Environmental & Occupational Health
A. Hyder
Article
Environmental Sciences
Ayaz Hyder, Andrew A. May
ENVIRONMENTAL HEALTH
(2020)
Review
Economics
Elizabeth Beaulieu, Catherine DiGennaro, Erin Stringfellow, Ava Connolly, Ava Hamilton, Ayaz Hyder, Magdalena Cerda, Katherine M. Keyes, Mohammad S. Jalali
Summary: The systematic review identified 23 simulation-based economic evaluation studies, with naloxone distribution and methadone maintenance treatment consistently found to be cost-effective strategies. However, there are still areas that have not been covered by research, providing important directions for future studies.
Article
Multidisciplinary Sciences
Ayaz Hyder, Jinhyung Lee, Ashley Dundon, Lauren T. Southerland, David All, Gretchen Hammond, Harvey J. Miller
Summary: This study explored the concept of Opioid Treatment Deserts and found disparities in access to opioid treatment in Columbus, Ohio, particularly among different racial groups. Quantifying and visualizing these disparities using local public safety data can help stakeholders better plan and allocate resources for more equitable access to MAT for OUD.
Article
Public, Environmental & Occupational Health
Ayaz Hyder, Anne Trinh, Pranav Padmanabhan, John Marschhausen, Alexander Wu, Alexander Evans, Radhika Iyer, Alexandria Jones
Summary: Data-informed decision making is important in school districts, but local health departments face challenges in providing data, especially during a pandemic. A school-based COVID-19 surveillance system was rapidly planned and deployed in a metropolitan US county, utilizing various data sources and indicators to track the spread of the virus. The system, known as CATS, included web-based applications, automated alerts, and weekly reports for stakeholders, enabling data-informed decision making for school administrators, school boards, and local health departments.
PUBLIC HEALTH REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Yuchen Li, Harvey J. Miller, Elisabeth D. Root, Ayaz Hyder, Desheng Liu
Summary: Opioid use disorder is a serious public health crisis in the United States, and social and economic conditions are major factors contributing to the variations in opioid overdose events (OOEs). This study explores the use of non-traditional geospatial data, such as Google Street View images and non-emergency service requests, as indicators of social and physical conditions in community neighborhoods. The findings reveal positive associations between community disorder indicators and OOEs, while perceived safety, wealth, and liveliness measures from street view imagery are negatively associated with the risk of OOEs. The results suggest that social inequality and distress contribute to the opioid epidemic crisis.
Article
Green & Sustainable Science & Technology
Ayaz Hyder, Angela Blatt, Allan D. Hollander, Casey Hoy, Patrick R. Huber, Matthew C. Lange, James F. Quinn, Courtney M. Riggle, Ruth Sloan, Thomas P. Tomich
Summary: Current studies on data sharing in the food system have focused on infrastructure development, neglecting the role of power dynamics among stakeholders. This study used a workshop to explore power dynamics in relation to data sharing and health outcomes. The findings reveal imbalances in power relationships among stakeholders and emphasize the need for initiatives to increase power across stakeholder groups.
Letter
Substance Abuse
Bridget Freisthler, Ayaz Hyder, Kathryn E. Lancaster, Elaine M. Louden, Abigail Marie Rinderle
INTERNATIONAL JOURNAL OF DRUG POLICY
(2023)
Review
Environmental Sciences
Keumseok Koh, Ayaz Hyder, Yogita Karale, Maged N. Kamel Boulos
Summary: This study conducted a systematic narrative review to understand the usage of big geospatial sensing data, ancillary data, and spatial data infrastructures in public health studies. The study found that geospatial big data has been inconsistently used in existing studies, with a focus on the public health field. The research also highlighted the importance of interdisciplinary collaboration to fully utilize geospatial big data in future public health studies.
Book Review
Urban Studies
Ayaz Hyder
JOURNAL OF URBAN AFFAIRS
(2023)
Review
Green & Sustainable Science & Technology
Thomas P. Tomich, Casey Hoy, Michael R. Dimock, Allan D. Hollander, Patrick R. Huber, Ayaz Hyder, Matthew C. Lange, Courtney M. Riggle, Michael T. Roberts, James F. Quinn
Summary: Public interest in the origin and production of food has grown, especially during the COVID-19 pandemic, revealing weaknesses in food systems' ability to support livelihoods and the environment. Addressing these issues requires collaborative research, innovation, and measurable benchmarks to increase inclusivity, sustainability, and resilience within food systems. Food systems informatics can enhance these aspects through user-driven interaction and experimentation, creating verifiable sustainability claims and improving health outcomes.
Article
Public, Environmental & Occupational Health
Yuchen Li, Harvey J. Miller, Ayaz Hyder, Peng Jia
Summary: This paper proposes a novel regionalized sequential alignment analysis using opioid overdose events data to assess the spatiotemporal similarity of opioid overdose evolutionary trajectories within regions that share similar socioeconomic status. By adopting this methodology, we can better understand the spatiotemporal evolution of opioid overdose events and identify regions with similar patterns of evolution, enabling policymakers and health researchers to develop effective interventions and policies to address the opioid crisis at the local level.
SOCIAL SCIENCE & MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Magdalena Cerda, Mohammad S. Jalali, Ava D. Hamilton, Catherine DiGennaro, Ayaz Hyder, Julian Santaella-Tenorio, Navdep Kaur, Christina Wang, Katherine M. Keyes
Summary: The opioid overdose crisis is complex and driven by various social, structural, and economic factors. Simulation models have been used to study and address this issue, with different types of models and a focus on intervention cost-effectiveness and services for people with opioid use disorder (OUD). Researchers are discussing model calibration, validation, and potential biases in parameter inputs to improve transparency and reproducibility.
EPIDEMIOLOGIC REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Ayaz Hyder, Kierra S. Barnett
Summary: The study estimated the prevalence of low birth weight and preterm birth among Arab American women in Ohio, finding that low birth weight is influenced by ethnicity while preterm birth is influenced by nativity among this population.
MATERNAL AND CHILD HEALTH JOURNAL
(2021)