Article
Multidisciplinary Sciences
Amanda Takats, Gergo Berke, Noemi Gede, Balazs Csaba Nemeth, Heiko Witt, Stanislaw Gluszek, Agnieszka Magdalena Rygiel, Peter Hegyi, Miklos Sahin-Toth, Eszter Hegyi
Summary: This meta-analysis confirms the clinical significance of CTRC variants in chronic pancreatitis (CP) and provides further justification for genetic screening of CP patients. Heterozygous loss-of-function CTRC variants increase the risk for CP approximately 3-7-fold.
Letter
Immunology
Daniel J. Becker, Allison Byrd, Tara M. Smiley, Mariana Fernandes Marques, Julissa Villegas Nunez, Katherine M. Talbott, Jonathan W. Atwell, Dmitriy V. Volokhov, Ellen D. Ketterson, Alex E. Jahn, Kerry L. Clark
Summary: American robins and dark-eyed juncos have been found to be competent hosts for arthropod-borne diseases, and this study identified two novel Rickettsia species in these bird species. The results suggest that the spring migration of these birds could disperse the novel rickettsiae to their breeding grounds.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Ecology
Shilu Zheng, Juntao Hu, Zhijun Ma, David Lindenmayer, Jiajia Liu
Summary: The authors used body size data from mammal and bird museum collections in North America to show that intraspecific variation in body size has increased over time, while mean body size has not changed. Previous studies have mainly focused on the declining average body size of animals, and less is known about long-term changes in intraspecific trait variation, which is crucial for understanding species' ability to cope with environmental challenges.
NATURE ECOLOGY & EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Kirsten Ann Pearsons, Sarah E. Lower, John F. Tooker
Summary: Research shows that firefly larvae are sensitive to clothianidin insecticide, exhibiting long-term intoxication and mortality when exposed to concentrations above 1,000 ng g-1 soil. Even under sub-lethal exposure, firefly larvae displayed behavioral changes that could decrease their survival in the wild, highlighting the need for further work to assess the impact in natural populations.
Article
Gastroenterology & Hepatology
Gergo Berke, Sebastian Beer, Noemi Gede, Amanda Takats, Andrea Szentesi, Peter Hegyi, Jonas Rosendahl, Miklos Sahin-Toth, Balazs Csaba Nemeth, Eszter Hegyi
Summary: Chymotrypsin C (CTRC) is a digestive enzyme produced by the pancreas that regulates trypsin activity and protects against chronic pancreatitis (CP). Variants of CTRC, including c.180C>T, increase the risk of CP. Meta-analysis showed that the c.180C>T variant has a higher frequency in CP patients compared to controls, and homozygous carriers have a stronger CP risk. Additionally, this variant is associated with reduced CTRC mRNA levels in the pancreas. These findings suggest that the CTRC variant c.180C>T is a clinically relevant risk factor for CP.
Article
Ecology
Susan J. Prichard, Paul F. Hessburg, R. Keala Hagmann, Nicholas A. Povak, Solomon Z. Dobrowski, Matthew D. Hurteau, Van R. Kane, Robert E. Keane, Leda N. Kobziar, Crystal A. Kolden, Malcolm North, Sean A. Parks, Hugh D. Safford, Jens T. Stevens, Larissa L. Yocom, Derek J. Churchill, Robert W. Gray, David W. Huffman, Frank K. Lake, Pratima Khatri-Chhetri
Summary: It is necessary to take a range of proactive management actions to adapt to changing climatic and wildfire regimes, including restoring active fire regimes, prescribed burning, and thinning in western North American forests. These actions should be consistent with land management allocations and forest conditions to help maintain the ecological balance of the forests.
ECOLOGICAL APPLICATIONS
(2021)
Article
Meteorology & Atmospheric Sciences
David. W. Pierce, Daniel. R. Cayan, Daniel. R. Feldman, Mark. D. Risser
Summary: A new set of CMIP6 data downscaled using the LOCA statistical method has been produced, which covers central Mexico through southern Canada at a resolution of 6 km. The improvements in daily precipitation extremes compared to CMIP5 downscaled data have important societal and economic implications. These improvements are achieved by using a better precipitation training dataset and implementing an ensemble bias correction.
JOURNAL OF HYDROMETEOROLOGY
(2023)
Article
Gastroenterology & Hepatology
Marcin Krawczyk, Olga Niewiadomska, Irena Jankowska, Krzysztof Jankowski, Sebastian Wieckowski, Dariusz Lebensztejn, Sabina Wiecek, Jolanta Gozdowska, Zbigniew Kulaga, Susanne N. Weber, Dieter Lutjohann, Frank Lammert, Piotr Socha
Summary: This study found that the ABCG8 p.D19H and NPC1L1 rs217434 variants increase the risk of early-onset gallstone formation in children. These results suggest a common lithogenic pathway between children and adults.
LIVER INTERNATIONAL
(2022)
Article
Biodiversity Conservation
Daniel A. Nesbit, Madeline C. Cowen, Gregory F. Grether, Jonathan P. Drury
Summary: As species' ranges shift due to human-induced global changes, species interactions are expected to have a significant impact on range dynamics and the composition of modified species assemblages. While most research focuses on the effects of trophic interactions and exploitative competition, this study found that interspecific competition for territories has had a stabilizing influence on species coexistence over the past two decades.
Article
Hematology
Justin P. McWilliams, Shamaita Majumdar, Grace H. Kim, Jihey Lee, Kevin Seals, Samantha Tangchaiburana, Stephanie Gilbert, Gary R. Duckwiler
Summary: This study evaluated the efficacy of doxycycline on epistaxis in HHT patients and found that doxycycline treatment did not reduce the severity and frequency of nosebleeds. However, post hoc analysis suggested possible benefits of doxycycline in reducing gushing episodes and duration of epistaxis over time. Further research with a larger sample size and longer treatment duration is needed.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Genetics & Heredity
Martje G. Pauly, G. Christoph Korenke, Sokhna Haissatou Diaw, Anne Groezinger, Ana Cazurro-Gutierrez, Belen Perez-Duenas, Victoria Gonzalez, Alfons Macaya, Ana Teresa Serrano Anton, Borut Peterlin, Ivana Babic Bozovic, Ales Maver, Alexander Muenchau, Katja Lohmann
Summary: This article describes four new patients who presented with a tremor-parkinsonism syndrome at a young age and responded well to levodopa. All patients carry the same recurrent missense variant and may also have other variants. Investigation of mitochondrial function revealed abnormalities, and a literature review summarized the phenotypical spectrum of WARS2-related disorders. Diagnosis of WARS2-related disorders is challenging due to the broad range of symptoms and the occurrence of a common missense change in the general population.
Article
Entomology
Allison Brackley, John Lill, Martha Weiss
Summary: Pupal mortality of the silver-spotted skipper varies between summer and winter generations, with higher predation rates in the summer despite a longer pupal duration in the winter. The presence of a shelter increases survival in the summer, but not in the winter.
ENVIRONMENTAL ENTOMOLOGY
(2022)
Article
Forestry
Neil F. J. Ott, Shaun A. Watmough
Summary: The study found that different tree species can influence the nutrient and metal content in litterfall and soil, particularly in terms of carbon and basic nutrient inputs. Differences in litterfall and soil chemistry were primarily influenced by forest composition, highlighting the importance of considering tree species composition when assessing nutrient cycling in forests.
Article
Biochemistry & Molecular Biology
Caroline Cazin, Yasmine Boumerdassi, Guillaume Martinez, Selima Fourati Ben Mustapha, Marjorie Whitfield, Charles Coutton, Nicolas Thierry-Mieg, Pierre Di Pizio, Nathalie Rives, Christophe Arnoult, Aminata Toure, Pierre F. Ray, Raoudha Zouari, Christophe Sifer, Zine-Eddine Kherraf
Summary: Acephalic spermatozoa syndrome (ASS) is a rare and severe type of teratozoospermia caused by genetic variants in the SUN5 gene, particularly prevalent in the North African population. A specific SUN5 variant, identified in the study, may serve as a useful genetic marker for selecting appropriate treatment options like intra-cytoplasmic sperm injection (ICSI) for affected individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Jorge Andres Ramirez, Valentina Vitali, Jordi Martinez-Vilalta, I. Tanya Handa, Christian Messier
Summary: Trees in urban areas face various stresses that can damage their tissues and lead to complex growth and physiological responses. Tissue damage may affect tree growth more than non-structural carbohydrate concentrations, and trees can adjust their carbohydrate reserves to meet metabolic demands under stressful conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemical Research Methods
Soyeon Kim, YuLong Bai, Zhenjiang Fan, Brenda Diergaarde, George C. Tseng, Hyun Jung Park
Summary: The study utilizes the PRIMATA-APA method to analyze TCGA breast cancer data, revealing that global APA events can alter the number of target sites for specific miRNAs enriched in cancer development and treatment. The knockdown of NUDT21 in HeLa cells shows that APA events can change the target sites of common tamoMiRNAs. The findings suggest that APA-induced tumorigenesis is attributed to changes in miRNA target sites rather than the APA events themselves.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Gastroenterology & Hepatology
Jeroen R. Huyghe, Tabitha A. Harrison, Stephanie A. Bien, Heather Hampel, Jane C. Figueiredo, Stephanie L. Schmit, David Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A. Baron, Amanda J. Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M. Levine, Vittorio Perduca, Aurora Perez-Cornago, Lori C. Sakoda, Fredrick R. Schumacher, Martha L. Slattery, Amanda E. Toland, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Antonio Agudo, Demetrius Albanes, M. Henar Alonso, Kristin Anderson, Coral Arnau-Collell, Volker Arndt, Barbara L. Banbury, Michael C. Bassik, Sonja Berndt, Stephane Bezieau, D. Timothy Bishop, Juergen Boehm, Heiner Boeing, Marie-Christine Boutron-Ruault, Hermann Brenner, Stefanie Brezina, Stephan Buch, Daniel D. Buchanan, Andrea Burnett-Hartman, Bette J. Caan, Peter T. Campbell, Prudence R. Carr, Antoni Castells, Sergi Castellvi-Bel, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Keith R. Curtis, Albert de la Chapelle, Douglas F. Easton, Dallas R. English, Edith J. M. Feskens, Manish Gala, Steven J. Gallinger, W. James Gauderman, Graham G. Giles, Phyllis J. Goodman, William M. Grady, John S. Grove, Andrea Gsur, Marc J. Gunter, Robert W. Haile, Jochen Hampe, Michael Hoffmeister, John L. Hopper, Wan-Ling Hsu, Wen-Yi Huang, Thomas J. Hudson, Mazda Jenab, Mark A. Jenkins, Amit D. Joshi, Temitope O. Keku, Charles Kooperberg, Tilman Kuhn, Sebastien Kury, Loic Le Marchand, Flavio Lejbkowicz, Christopher Li, Li Li, Wolfgang Lieb, Annika Lindblom, Noralane M. Lindor, Satu Mannisto, Sanford D. Markowitz, Roger L. Milne, Lorena Moreno, Neil Murphy, Rami Nassir, Kenneth Offit, Shuji Ogino, Salvatore Panico, Patrick S. Parfrey, Rachel Pearlman, Paul D. P. Pharoah, Amanda Phipps, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Lihong Qi, Leon Raskin, Gad Rennert, Hedy S. Rennert, Elio Riboli, Clemens Schafmayer, Robert E. Schoen, Daniela Seminara, Mingyang Song, Yu-Ru Su, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Antonia Trichopoulou, Cornelia M. Ulrich, Kala Visvanathan, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Korbinian Weigl, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Goncalo R. Abecasis, Deborah A. Nickerson, Peter C. Scacheri, Anshul Kundaje, Graham Casey, Stephen B. Gruber, Li Hsu, Victor Moreno, Richard B. Hayes, Polly A. Newcomb, Ulrike Peters
Summary: Understanding the etiologic heterogeneity of colorectal cancer is crucial for precision prevention efforts. By performing GWAS meta-analyses, we identified 13 loci that reached genome-wide significance for specific colorectal cancer subsites, with evidence of heterogeneity between anatomical subsites. This suggests that the genetic architectures of proximal and distal CRC are partly distinct, highlighting the importance of considering tumour subsite in studies of risk factors and prevention strategies.
Article
Genetics & Heredity
Corina Lesseur, Aida Ferreiro-Iglesias, James D. McKay, Yohan Bosse, Mattias Johansson, Valerie Gaborieau, Maria Teresa Landi, David C. Christiani, Neil C. Caporaso, Stig E. Bojesen, Christopher I. Amos, Sanjay Shete, Geoffrey Liu, Gadi Rennert, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Chu Chen, Liloglou Triantafillos, John K. Field, Marion Dawn Teare, Lambertus A. Kiemeney, Brenda Diergaarde, Robert L. Ferris, Shanbeh Zienolddiny, Stephen Lam, Andrew F. Olshan, Mark C. Weissler, Martin Lacko, Angela Risch, Heike Bickeboller, Andy R. Ness, Steve Thomas, Loic Le Marchand, Matthew B. Schabath, Victor Wunsch-Filho, Eloiza H. Tajara, Angeline S. Andrew, Gary M. Clifford, Philip Lazarus, Kjell Grankvist, Mikael Johansson, Susanne Arnold, Olle Melander, Hans Brunnstrom, Stefania Boccia, Gabriella Cadoni, Wim Timens, Ma'en Obeidat, Xiangjun Xiao, Richard S. Houlston, Rayjean J. Hung, Paul Brennan
Summary: Squamous cell carcinomas (SqCC) of the aerodigestive tract share common etiological risk factors and genetic susceptibility. A meta-analysis of GWAS data identified novel and pleiotropic risk variants, highlighting the importance of cross-cancer analyses. Gene-based association and gene set enrichment revealed SqCC-related genes involved in DNA damage and epigenetic regulation pathways. The study suggests overlap in genetic factors influencing aerodigestive SqCC risk in European populations.
Article
Medicine, General & Internal
Mark Gormley, Tom Dudding, Linda Kachuri, Kimberley Burrows, Amanda H. W. Chong, Richard M. Martin, Steven J. Thomas, Jessica Tyrrell, Andrew R. Ness, Paul Brennan, Marcus R. Munafo, Miranda Pring, Stefania Boccia, Andrew F. Olshan, Brenda Diergaarde, Rayjean J. Hung, Geoffrey Liu, Eloiza H. Tajara, Patricia Severino, Tatiana N. Toporcov, Martin Lacko, Tim Waterboer, Nicole Brenner, George Davey Smith, Emma E. Vincent, Rebecca C. Richmond
Summary: Evidence from the study suggests that genetic variants related to sexual behavior traits may have correlated pleiotropy, highlighting the importance of multivariable approaches and evidence triangulation in Mendelian randomization studies of complex behavioral traits.
Article
Oncology
Line M. H. Schack, Elnaz Naderi, Laura Fachal, Leila Dorling, Craig Luccarini, Alison M. Dunning, Enya H. W. Ong, Melvin L. K. Chua, Johannes A. Langendijk, Behrooz Z. Alizadeh, Jens Overgaard, Jesper Grau Eriksen, Christian Nicolaj Andreassen, Jan Alsner
Summary: This study conducted a two-stage genome-wide association study on head and neck cancer patients, identifying and replicating a genetic locus associated with mucositis.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Yuhan Huang, Xinwei Hua, Julia D. Labadie, Tabitha A. Harrison, James Y. Dai, Sara Lindstrom, Yi Lin, Sonja Berndt, Daniel D. Buchanan, Peter T. Campbell, Graham Casey, Steven J. Gallinger, Marc J. Gunter, Michael Hoffmeister, Mark A. Jenkins, Lori C. Sakoda, Robert E. Schoen, Brenda Diergaarde, Martha L. Slattery, Emily White, Graham Giles, Hermann Brenner, Jenny Chang-Claude, Amit Joshi, Wenjie Ma, Rish K. Pai, Andrew T. Chan, Ulrike Peters, Polly A. Newcomb
Summary: Elevated levels of C-reactive protein (CRP) in the blood have been associated with colorectal cancer (CRC) survival. This study examined the genetic variants associated with CRP levels and their interactions with sex and lifestyle factors in relation to CRC-specific mortality. The results showed a significant interaction between a genetic variant and sex in determining CRC-specific mortality.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Julia Manzo, Shannon Puhalla, Shalu Pahuja, Fei Ding, Yan Lin, Leonard Appleman, Hussein Tawbi, Ronald Stoller, James J. Lee, Brenda Diergaarde, Brian F. Kiesel, Jing Yu, Antoinette R. Tan, Chandra P. Belani, Helen Chew, Agustin A. Garcia, Robert J. Morgan, Andrea E. Wahner Hendrickson, Daniel W. Visscher, Rachel M. Hurley, Scott H. Kaufmann, Elizabeth M. Swisher, Steffi Oesterreich, Tiffany Katz, Jiuping Ji, Yiping Zhang, Ralph E. Parchment, Alice Chen, Wenrui Duan, Vincent Giranda, Stacie P. Shepherd, S. Percy Ivy, Edward Chu, Jan H. Beumer
Summary: This study determined the recommended dose and preliminary efficacy of PARP inhibitor veliparib in patients with BRCA mutated and BRCA wildtype cancers. The results showed that veliparib exhibited clinical activity in patients with BRCA mutated and BRCA wildtype cancers.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Ting Zhai, Brenda Diergaarde, David O. Wilson, Huining Kang, Akshay Sood, Samuel H. Bayliss, Jian-Min Yuan, Maria A. Picchi, Qing Lan, Steven A. Belinsky, Jill M. Siegfried, Linda S. Cook, Shuguang Leng
Summary: This study examines the associations between early menopause and lung health, lung cancer risk, and mortality in middle-aged and older female smokers. The results show that early natural menopause is a risk factor for lung diseases and mortality in this population.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Hilary A. Robbins, Karine Alcala, Elham Khodayari Moez, Florence Guida, Sera Thomas, Hana Zahed, Matthew T. Warkentin, Karl Smith-Byrne, Yonathan Brhane, David Muller, Xiaoshuang Feng, Demetrius Albanes, Melinda C. Aldrich, Alan A. Arslan, Julie Bassett, Christine D. Berg, Qiuyin Cai, Chu Chen, Michael P. A. Davies, Brenda Diergaarde, John K. Field, Neal D. Freedman, Wen-Yi Huang, Mikael Johansson, Michael Jones, Woon-Puay Koh, Stephen Lam, Qing Lan, Arnulf Langhammer, Linda M. Liao, Geoffrey Liu, Reza Malekzadeh, Roger L. Milne, Luis M. Montuenga, Thomas Rohan, Howard D. Sesso, Gianluca Severi, Mahdi Sheikh, Rashmi Sinha, Xiao-Ou Shu, Victoria L. Stevens, Martin C. Tammemaegi, Lesley F. Tinker, Kala Visvanathan, Ying Wang, Renwei Wang, Stephanie J. Weinstein, Emily White, David Wilson, Jian-Min Yuan, Xuehong Zhang, Wei Zheng, Christopher I. Amos, Paul Brennan, Mattias Johansson, Rayjean J. Hung
Summary: The INTEGRAL program aims to develop tools for optimizing LDCT lung cancer screening. It includes the Risk Biomarker and Nodule Malignancy projects, which investigate circulating protein markers for identifying individuals likely to benefit from screening and distinguishing benign versus malignant nodules. A total of 1161 and 1078 proteins were measured, and 21 proteins were selected for performance evaluation in the Risk Biomarker and Nodule Malignancy projects.
ANNALS OF EPIDEMIOLOGY
(2023)
Article
Oncology
Sanjeev Budhathoki, Brenda Diergaarde, Geoffrey Liu, Andrew Olshan, Andrew Ness, Tim Waterboer, Shama Virani, Patricia Basta, Noemi Bender, Nicole Brenner, Tom Dudding, Neil Hayes, Andrew Hope, Shao Hui Huang, Katrina Hueniken, Beatriz Kanterewicz, James D. McKay, Miranda Pring, Steve Thomas, Kathy Wisniewski, Sera Thomas, Yonathan Brhane, Antonio Agudo, Laia Alemany, Areti Lagiou, Luigi Barzan, Cristina Canova, David I. Conway, Claire M. Healy, Ivana Holcatova, Pagona Lagiou, Gary J. Macfarlane, Tatiana V. Macfarlane, Jerry Polesel, Lorenzo Richiardi, Max Robinson, Ariana Znaor, Paul Brennan, Rayjean J. Hung
Summary: To aid early detection of head and neck cancer, a risk prediction model based on demographic and lifestyle factors, HPV serological markers, and genetic markers has been developed. The risk models showed reasonable predictive accuracy for overall head and neck cancer, and substantially improved accuracy for oropharyngeal cancer when including HPV serology. These models may be helpful for identifying high-risk individuals.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Sonja Berndt, Daniel D. Buchanan, Amanda J. Cross, Brenda Diergaarde, Steven J. Gallinger, Marc J. Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A. Jenkins, Yi Lin, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Syed H. Zaidi, John D. Potter, Jeffrey A. Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Ulrike Peters, Amanda Phipps, Shuji Ogino
Summary: This study analyzed 13,101 colorectal cancer cases and found a significant association between tumor location and molecular features. The detailed colonic location and tumor molecular features play an important role in the prognostication and precision medicine of colon cancer.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Claire E. E. Thomas, Jennifer J. J. Adibi, Allison L. L. Kuipers, Brenda Diergaarde, Hung N. N. Luu, Aizhen Jin, Woon-Puay Koh, Yu-Tang Gao, Jennifer Adams-Haduch, Renwei Wang, Anna Lokshin, Jaideep Behari, Jian-Min Yuan
Summary: CD137 is associated with increased risk of hepatocellular carcinoma (HCC) and may serve as a long-term risk marker for HCC development.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Kathryn Demanelis, Margaret Rosenzweig, Linda B. Robertson, Carissa A. Low, Shayla Daniels, Hiba Abujaradeh, Beth Simon, Dana H. Bovbjerg, Brenda Diergaarde
Summary: This study examines the disparities in concerns related to the COVID-19 pandemic and cancer care between rural and urban cancer patients in western Pennsylvania. The findings suggest that rural patients are more concerned about the health threat of COVID-19 and vaccine hesitancy. This highlights the need for further investigation into how these concerns exacerbate rural-urban disparities in cancer care and prognosis.
CANCER CAUSES & CONTROL
(2023)
Editorial Material
Obstetrics & Gynecology
Ting Zhai, Brenda Diergaarde, David O. Wilson, Huining Kang, Akshay Sood, Samuel H. Bayliss, Jian-Min Yuan, Maria A. Picchi, Qing Lan, Steven A. Belinsky, Jill M. Siegfried, Linda S. Cook, Shuguang Leng
Summary: Menopause is driven by ovarian aging and the decline of estrogen levels, which can affect lung function and increase the risk of respiratory diseases in postmenopausal women. Cigarette smoking and early menopause have a synergistic effect on lung function decline. This study aims to investigate the associations between early menopause and lung biomarkers, lung cancer risk, and cause-specific mortality, and the findings suggest that early menopause is associated with worse lung health and increased risk of respiratory diseases and lung cancer-specific mortality in middle-aged and older smokers.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2023)
Article
Gastroenterology & Hepatology
Claire E. Thomas, Brenda Diergaarde, Allison L. Kuipers, Jennifer J. Adibi, Hung N. Luu, Xuling Chang, Rajkumar Dorajoo, Chew-Kiat Heng, Chiea-Chuen Khor, Renwei Wang, Aizhen Jin, Woon-Puay Koh, Jian-Min Yuan
Summary: Using data from the Singapore Chinese Health Study (SCHS), researchers found a strong correlation between a polygenic risk score (PRS) for hepatic fat (HFC-PRS) and nonalcoholic fatty liver disease (NAFLD), as well as an increased risk of hepatocellular carcinoma (HCC).
HEPATOLOGY COMMUNICATIONS
(2022)