Article
Immunology
Caroline Charlier, Julia Dina, Francois Freymuth, Astrid Vabret, Olivier Lortholary, Denise Antona, Marc Lecuit
Summary: Research shows that measles virus can be detected in the saliva and blood of pregnant women, leading to transmission to the fetus during pregnancy, resulting in asymptomatic infection at birth. Despite severe peripartum congenital measles, asymptomatic vertical transmission of the measles virus can occur in early pregnancy.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Aleksandra Stupak, Tomasz Geca, Anna Kwasniewska, Radoslaw Mlak, Pawel Piwowarczyk, Robert Nawrot, Anna Gozdzicka-Jozefiak, Wojciech Kwasniewski
Summary: A comparative analysis was conducted to assess the impact of bacteria on placental development and function in pregnancies with late fetal growth restriction (FGR). The presence of microorganisms in various components of the pregnancy disproves the theory of the sterile uterus. Bacterial infections have been linked to maternal overproduction of pro-inflammatory cytokines and can cause both short- and long-term problems.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Meng Li, Zhenyu Huang, Zhi Tao, Yiting Meng, Jia Wen, Qiongqiong Zhang, Ying Liu, Mengyuan Shang, Ying Wang, Yufeng Wang, Rui Chen, Xiaoqian Wang, Yang Cao, Lei Zhang, Qinping Liao
Summary: This study compared the dynamics of lower and upper genital tract microbiota in normal term pregnancy, histological chorioamnionitis (HCA), and clinical chorioamnionitis (CCA) patients. The results showed that there was no significant difference in the vaginal and cervical microbiota composition among these three groups. Furthermore, some normal-term pregnant women can harbor non-pathogenic microbiota in the uterine cavity. Sterile inflammation is more frequent than microbial-associated inflammation in term HCA and CCA patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biology
Suhas Sureshchandra, Brianna M. Doratt, Norma Mendza, Oleg Varlamov, Monica Rincon, Nicole E. Marshall, Ilhem Messaoudi
Summary: Maternal pre-pregnancy obesity is linked to unfavorable outcomes in both mother and offspring, including increased susceptibility and severity of neonatal infections. This study reveals that pregravid obesity disrupts umbilical cord blood monocyte responses to bacterial and viral pathogens. It demonstrates that interferon-stimulated gene expression and inflammatory responses to respiratory syncytial virus and E. coli are significantly dampened. Additionally, it suggests that maternal obesity alters metabolic, signaling, and epigenetic profiles of fetal monocytes, leading to immune paralysis during late gestation and at birth.
Article
Immunology
Adrienne M. Antonson, Adam D. Kenney, Helen J. Chen, Kara N. Corps, Jacob S. Yount, Tamar L. Gur
Summary: Research found that mild or moderately pathogenic IAV infection during pregnancy does not induce inflammation in the developing fetal brain, and did not observe the hallmarks of mimetic-induced MIA, highlighting the importance of using live pathogen infection models for MIA study.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Obstetrics & Gynecology
John M. D. Thompson, Alexander E. P. Heazell, Robin S. Cronin, Jessica Wilson, Minglan Li, Adrienne Gordon, Lisa M. Askie, Louise M. O'Brien, Camille Raynes-Greenow, Tomasina Stacey, Edwin A. Mitchell, Lesley M. E. McCowan, Billie F. Bradford
Summary: Maternal perception of fetal movements during pregnancy is important, and a reduction in movements is associated with increased odds of late stillbirth. The study aimed to assess the pattern of maternal perception of fetal movement by gestation and birthweight quartile, and to analyze the association of stillbirth with perception of fetal movements.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Biochemistry & Molecular Biology
Gina Marie Uehre, Svetlana Tchaikovski, Atanas Ignatov, Ana Claudia Zenclussen, Mandy Busse
Summary: The signaling of B cells is crucial in the pathogenesis of preterm birth. Deficiency or loss of specific signaling molecules in B cells can lead to a shift from immune regulation to inflammation, resulting in preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Mandy Busse, Susanne Plenagl, Norina Kim Jutta Campe, Andreas J. Mueller, Kerry Tedford, Anne Schumacher, Ana Claudia Zenclussen
Summary: The loss of MyD88 signaling in maternal B cells may lead to intrauterine fetal death during pregnancy, while the activation of this signal could protect the mother from infection but potentially harm the fetus.
Article
Nutrition & Dietetics
Nicole U. Stoffel, Michael B. Zimmermann, Ana C. Cepeda-Lopez, Karla Cervantes-Gracia, Daniel Llanas-Cornejo, Christophe Zeder, Siriporn Tuntipopipat, Sakita Moungmaithong, Narumon Densupsoontorn, Katharina Quack Loetscher, Sueppong Gowachirapant, Isabelle Herter-Aeberli
Summary: Overweight/obese pregnant women fail to upregulate iron absorption in late pregnancy, resulting in reduced iron transfer to the fetus and lower body iron stores in infants.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cell Biology
Amber R. Moore, Nora Vivanco Gonzalez, Katherine A. Plummer, Olivia R. Mitchel, Harleen Kaur, Moises Rivera, Brian Collica, Mako Goldston, Ferda Filiz, Michael Angelo, Theo D. Palmer, Sean C. Bendall
Summary: The immune system and placenta have a dynamic relationship during gestation, playing an important role in fetal growth and development. By immunophenotyping the maternal-fetal interface, distinct immune profiles can be identified, and the significant role of the innate immune system in placental development is revealed.
Article
Reproductive Biology
Xiuxiu Xu, Yonggang Zhou, Binqing Fu, Haiming Wei
Summary: During pregnancy, the interaction between maternal decidual tissue and fetal trophoblasts at the maternal-fetal interface is responsible for supplying nutrition to the fetus. Uterine natural killer (uNK) cells, the most abundant immune cells at the interface, play critical roles throughout pregnancy.
BIOLOGY OF REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Lauren A. Soc Maternal Fetal Med SMFM, Andrea D. Shields, Lauren A. Plante, Judette M. Louis, SMFM Publicat Comm
Summary: Maternal sepsis is a leading cause of maternal morbidity and mortality, with potential for prevention. This article summarizes the current knowledge and provides guidance for the management of sepsis during pregnancy and the postpartum period. The importance of early recognition, prompt treatment, and ongoing support for sepsis survivors and their families is emphasized.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cell Biology
Ryan C. V. Lintao, Ananth Kumar Kammala, Enkhtuya Radnaa, Mohamed Bettayeb, Kathleen L. Vincent, Igor Patrikeev, Jerome Yaklic, Elizabeth A. Bonney, Ramkumar Menon
Summary: This study aimed to characterize fetal microchimeric immune cells in the maternal heart during pregnancy and postpartum, and to identify differences in these fetal microchimeric subpopulations between normal and pregnancies complicated by spontaneous preterm induced by ascending infection.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Ana Paula Brioschi dos Santos, Creuza Rachel Vicente, Joao Paulo Cola, Luana Fiengo Tanaka, Juliana Rodrigues Tovar Garbin, Larissa Soares Dell'Antonio, Cristiano Soares da Silva Dell'Antonio, Angelica Espinosa Miranda
Summary: This study aimed to evaluate the risk of maternal death and fetal death among pregnant women infected with SARS-CoV-2. The results showed that pregnant women with COVID-19 had a higher risk of maternal death, fetal death/stillbirth, preterm birth, cesarean delivery, and cesarean section occurring before the onset of labor.
Review
Nutrition & Dietetics
Veena Sangkhae, Allison L. Fisher, Tomas Ganz, Elizabeta Nemeth
Summary: During pregnancy, iron requirements increase significantly to support maternal and fetal development. While iron supplementation is common, excessive intake can also lead to adverse outcomes, especially in high-income countries where iron fortification and red meat consumption are prevalent.
ANNUAL REVIEW OF NUTRITION
(2023)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)