期刊
JOURNAL OF GERIATRIC CARDIOLOGY
卷 8, 期 3, 页码 159-167出版社
SCIENCE PRESS
DOI: 10.3724/SP.J.1263.2011.00159
关键词
aging; heart; mitochondria; heart diseases; reactive oxygen species
资金
- Alberta Innovates Health Solutions
- Heart and Stroke Foundation of Canada
- Alberta Heritage Foundation for Medical Research (AHFMR)
The average human life span has markedly increased in modern society largely attributed to advances in medical and therapeutic sciences that have successfully reduced important health risks. However, advanced age results in numerous alterations to cellular and subcellular components that can impact the overall health and function of an individual. Not surprisingly, advanced age is a major risk factor for the development of heart disease in which elderly populations observe increased morbidity and mortality. Even healthy individuals that appear to have normal heart function under resting conditions, actually have an increased susceptibility and vulnerability to stress. This is confounded by the impact that stress and disease can have over time to both the heart and vessels. Although, there is a rapidly growing body of literature investigating the effects of aging on the heart and how age-related alterations affect cardiac function, the biology of aging and underlying mechanisms remain unclear. In this review, we summarize effects of aging on the heart and discuss potential theories of cellular aging with special emphasis on mitochondrial dysfunction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据