Article
Endocrinology & Metabolism
Sriram Gubbi, Ranganath Muniyappa, Susmeeta T. Sharma, Shivraj Grewal, Raven McGlotten, Lynnette K. Nieman
Summary: Short-term administration of mifepristone improved adipose and hepatic insulin sensitivity in obese individuals with hyperglycemia but without hypercortisolism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Rehabilitation
Gary J. Farkas, Ann M. Swartz, Ashraf S. Gorgey, Arthur S. Berg, David R. Gater
Summary: A single bout of arm crank ergometry exercise at 75% VO2Peak acutely improved glucose metabolism in individuals with paraplegia, but the effect was not sustained after 24 hours.
DISABILITY AND REHABILITATION
(2022)
Article
Medicine, Research & Experimental
Rodrigo Martins Pereira, Kellen Cristina da Cruz Rodrigues, Marcella Ramos Sant'Ana, Guilherme Francisco Peruca, Chadi Pellegrini Anaruma, Thais Dantis Pereira de Campos, Raphael dos Santos Canciglieri, Diego Gomes de Melo, Fernando Moreira Simabuco, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Eduardo Rochete Ropelle, Jose Rodrigo Pauli, Leandro Pereira de Moura
Summary: The study showed that short-term combined training can reduce glucose levels and fatty liver, improve hepatic insulin sensitivity, and reduce complications caused by fatty liver.
Article
Biochemistry & Molecular Biology
Carlos Henriquez-Olguin, Roberto Meneses-Valdes, Steffen H. Raun, Samantha Gallero, Jonas R. Knudsen, Zhencheng Li, Jingwen Li, Lykke Sylow, Enrique Jaimovich, Thomas E. Jensen
Summary: The study investigates the role of NOX2 in the interaction between diet-induced insulin resistance and exercise training in skeletal muscle. The results suggest that NOX2 deficiency worsens the effects of a high-fat diet on body weight, body composition, and glucose intolerance. Additionally, the lack of NOX2 activity during exercise training reduces several metabolic adaptations in skeletal muscle.
Article
Biochemistry & Molecular Biology
Lea Sani, Nicolas Cardinault, Julien Astier, Patrice Darmon, Jean Francois Landrier
Summary: This study aimed to evaluate the effect of supplementation with standardized poplar propolis extract powder (PPEP) on insulin homeostasis in non-diabetic insulin-resistant volunteers with obesity. The results showed that PPEP supplementation improved insulin sensitivity by reducing the number of insulin-resistant subjects and decreasing the insulin sensitivity Matsuda index (ISI-M).
Article
Biology
Jiexiu Zhao, Yiwei Feng, Zhijian Rao, Han Li, Jincheng Xu, Shuqiang Cui, Lili Lai
Summary: This study investigated the effects of exercise combined with heat treatment on insulin sensitivity in skeletal muscle of obese rats. The results showed that this combination approach effectively improved insulin resistance by regulating HSF1/HSP27 and JAK2/STAT3 pathways in the slow-twitch muscle. Importantly, exercise combined with heat treatment was more effective than either intervention alone in improving insulin resistance.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Ilhame Diboun, Layla Al-Mansoori, Hend Al-Jaber, Omar Albagha, Mohamed A. Elrayess
Summary: This study compared the metabolic profiles of individuals with insulin resistance (IR) and insulin sensitivity (IS), finding that IR participants had increased androgenic steroids and microbiota byproducts, while IS participants had elevated levels of long-chain fatty acids. ROC analysis suggested that using metabolites selected by GLMNET provided better discriminatory performance for IR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Stefany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Nilmara Cunha da Silva, Lyandra Dias da Silva, Kyria Jayanne Climaco Cruz, Dilina do Nascimento Marreiro
Summary: Magnesium plays a crucial role in insulin secretion and action by regulating protein kinase activity and reducing oxidative stress and chronic inflammation that affect insulin sensitivity. Magnesium deficiency is associated with glucose intolerance, while magnesium supplementation can stimulate insulin secretion and improve insulin sensitivity in peripheral tissues.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Multidisciplinary Sciences
Hui Zhang, Laura K. Simpson, Nicholas P. Carbone, Michael F. Hirshman, Pasquale Nigro, Maria Vamvini, Laurie J. Goodyear, Roeland J. W. Middelbeek
Summary: Exercise training can improve glycemic control and insulin secretion in adults with type 2 diabetes, possibly through improved processing of insulin and increased beta-cell function. A 10-week moderate-intensity exercise program was found to enhance glycemic control, insulin sensitivity, and late-phase insulin secretion in individuals with type 2 diabetes. These improvements were associated with changes in VO2peak and correlated with changes in concentrations of Ras-Responsive Element Binding Protein 1 (RREB1), suggesting a potential inhibitory role of RREB1 on insulin secretion.
Article
Cell Biology
Penghua Fang, Ran Ge, Yuqing She, Juan Zhao, Jing Yan, Xizhong Yu, Yu Jin, Wenbin Shang, Zhenwen Zhang
Summary: Obesity is associated with insulin resistance and T2DM, while physical exercise can improve this condition by increasing the expression of spexin in adipose tissue. Combining spexin with exercise training is an effective therapeutic strategy for age-associated diseases.
AGEING RESEARCH REVIEWS
(2022)
Article
Oncology
Theodora A. Constantin, Anabel Varela-Carver, Kyle K. Greenland, Gilberto Serrano de Almeida, Ellen Olden, Lucy Penfold, Simon Ang, Alice Ormrod, Damien A. Leach, Chun-Fui Lai, Edward K. Ainscow, Ash K. Bahl, David Carling, Matthew J. Fuchter, Simak Ali, Charlotte L. Bevan
Summary: This study demonstrates that the CDK7 inhibitor CT7001 selectively inhibits proliferation and cell cycle in prostate cancer cells, and exerts antitumor effects by activating p53, inducing apoptosis, and suppressing transcription mediated by full-length and constitutively active AR splice variants. Oral administration of CT7001 suppresses the growth of CRPC xenografts, and significantly enhances the growth inhibition achieved by enzalutamide. Transcriptome analyses indicate that the mode of action of CT7001 in vivo is through inhibition of the cell cycle and AR function.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Yong Zhang, Tingting Ye, Puqing Zhou, Runjing Li, Zuofeng Liu, Jianyuan Xie, Tianmiao Hua, Qingyan Sun
Summary: Recent research shows that swimming exercise can effectively improve insulin resistance, promote glucose metabolism, reduce body weight and fat accumulation, lower serum FFA levels, and hepatic triglyceride content. Exercise also decreases ASK1 phosphorylation, improves JNK1-IRS1-Akt signaling, and enhances insulin sensitivity.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gabriela Alves Bronczek, Gabriela Moreira Soares, Carine Marmentini, Antonio Carlos Boschero, Jose Maria Costa-Junior
Summary: Resistance training increases insulin secretion and beta cell function, enhancing beta cell glucose sensing and survival. In vitro experiments using a pancreatic beta cell line showed increased insulin secretion and expression of glucose transporter 2 (GLUT2) and glucokinase (GCK) when incubated with serum from trained mice. Trained serum also protected cells from cytokine-induced apoptosis. In vivo experiments using diabetic mice showed that resistance training improved muscle mass, reduced blood glucose levels, and enhanced glucose tolerance, potentially through increased insulin levels and beta cell mass.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Fangluo Chen, Dylan C. Sarver, Muzna Saqib, Mingqi Zhou, Susan Aja, Marcus M. Seldin, G. William Wong
Summary: The protein CTRPl3 is found to play a role in regulating insulin secretion and metabolism. It has been shown to improve glucose metabolism and triglyceride clearance, reduce obesity and inflammation when deficient. Genetic variation of CTRP13 expression in humans may be associated with metabolic syndrome.
MOLECULAR METABOLISM
(2023)
Article
Geriatrics & Gerontology
Andrea M. Brennan, Robert A. Standley, Steven J. Anthony, Kory E. Grench, Nicole L. Helbling, James P. DeLany, Heather H. Cornnell, Fanchao Yi, Maja Stefanovic-Racic, Frederico G. S. Toledo, Paul M. Coen, Elvis A. Carnero, Bret H. Goodpaster
Summary: Exercise with weight loss improves insulin sensitivity, aerobic capacity, and body composition in older obese adults. It also reduces ectopic fat and preserves lean mass and strength. However, weight loss alone may lead to decreased lean mass and strength. Therefore, regular exercise is important for older adults aiming to lose weight in order to achieve cardiometabolic and functional benefits that may not occur with calorie restriction-induced weight loss alone.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Meeting Abstract
Endocrinology & Metabolism
Phoebe F. Chang, Daniel Acevedo, Sara M. Reyna
Article
Endocrinology & Metabolism
Sara M. Reyna, Sangeeta Ghosh, Puntip Tantiwong, C. S. Reddy Meka, Phyllis Eagan, Christopher P. Jenkinson, Eugenio Cersosimo, Ralph A. DeFronzo, Dawn K. Coletta, Apiradee Sriwijitkamol, Nicolas Musi
Article
Endocrinology & Metabolism
Giovanna Muscogiuri, Adam B. Salmon, Cristina Aguayo-Mazzucato, Mengyao Li, Bogdan Balas, Rodolfo Guardado-Mendoza, Andrea Giaccari, Robert L. Reddick, Sara M. Reyna, Gordon Weir, Ralph A. DeFronzo, Holly Van Remmen, Nicolas Musi
Article
Endocrinology & Metabolism
J. Joya-Galeana, M. Fernandez, A. Cervera, S. Reyna, S. Ghosh, C. Triplitt, N. Musi, R. A. DeFronzo, E. Cersosimo
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2011)
Article
Endocrinology & Metabolism
A. Monroy, S. Kamath, A. O. Chavez, V. E. Centonze, M. Veerasamy, A. Barrentine, J. J. Wewer, D. K. Coletta, C. Jenkinson, R. M. Jhingan, D. Smokler, S. Reyna, N. Musi, R. Khokka, M. Federici, D. Tripathy, R. A. DeFronzo, F. Folli
Review
Biochemistry & Molecular Biology
Bruno Guigas, Kei Sakamoto, Nellie Taleux, Sara M. Reyna, Nicolas Musi, Benoit Viollet, Louis Hue
Article
Biochemistry & Molecular Biology
Fang-Mei Chang, Sara M. Reyna, Jose C. Granados, Sung-Jen Wei, Wendy Innis-Whitehouse, Shivani K. Maffi, Edward Rodriguez, Thomas J. Slaga, John D. Short
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Meeting Abstract
Endocrinology & Metabolism
Phoebe F. Chang, Sara M. Reyna
Article
Biochemistry & Molecular Biology
Lixin Wang, Bogdan Balas, Christine Y. Christ-Roberts, Ryang Yeo Kim, Fresnida J. Ramos, Chintan K. Kikani, Cuiling Li, Chuxia Deng, Sara Reyna, Nicolas Musi, Lily Q. Dong, Ralph A. DeFronzo, Feng Liu
MOLECULAR AND CELLULAR BIOLOGY
(2007)
Article
Physiology
Oscar Ochoa, Dongxu Sun, Sara M. Reyes-Reyna, Lindsay L. Waite, Joel E. Michalek, Linda M. McManus, Paula K. Shiremn
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2007)
Article
Endocrinology & Metabolism
Apiradee Sriwijitkamol, Dawn K. Coletta, Estela Wajcberg, Gabriela B. Balbontin, Sara M. Reyna, John Barrientes, Phyllis A. Eagan, Christopher P. Jenkinson, Eugenio Cersosimo, Ralph A. DeFronzo, Kei Sakamoto, Nicolas Musi
Article
Cell Biology
Veronica Contreras-Shannon, Oscar Ochoa, Sara M. Reyes-Reyna, Dongxu Sun, Joel E. Michalek, William A. Kuziel, Linda M. McManus, Paula K. Shireman
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2007)
Article
Surgery
Paula K. Shireman, Veronica Contreras-Shannon, Sara M. Reyes-Reyna, Susan C. Robinson, Linda M. McManus
JOURNAL OF SURGICAL RESEARCH
(2006)
Article
Biochemical Research Methods
ZP Yi, ML Luo, LJ Mandarino, SM Reyna, CA Carroll, ST Weintraub
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2006)