4.3 Article

Macroporous Composite Cryogels with Embedded Polystyrene Divinylbenzene Microparticles for the Adsorption of Toxic Metabolites from Blood

期刊

JOURNAL OF CHEMISTRY
卷 2013, 期 -, 页码 -

出版社

HINDAWI LTD
DOI: 10.1155/2013/348412

关键词

-

资金

  1. European commission within the MONACO-EXTRA project Monolithic Adsorbent Columns for Extracorporeal Medical Devices and Bioseparations [FP7-PEOPLE-2007-3-1-IAPP]

向作者/读者索取更多资源

Composite monolithic adsorbents were prepared by the incorporation of neutral polystyrene divinylbenzene (PS-DVB) microparticles into macroporous polymer structures produced by cryogelation of agarose or poly(vinyl alcohol). The composite materials exhibited excellent flow-through properties. Scanning electron microscopy of the composite cryogels revealed that the microparticles were covered by thin films of poly(vinyl alcohol) or agarose and thus were withheld in the monolith structure. Plain PS-DVB microparticles showed efficient adsorption of albumin-bound toxins related to liver failure (bilirubin and cholic acid) and of cytokines (tumor necrosis factor-alpha and interleukin-6). The rates of adsorption and the amount of adsorbed factors were lower for the embedded microparticles as compared to the parent PS-DVB microparticles, indicating the importance of the accessibility of the adsorbent pores. Still, the macroporous composite materials showed efficient adsorption of albumin-bound toxins related to liver failure as well as efficient binding of cytokines, combined with good blood compatibility. Thus, the incorporation of microparticles into macroporous polymer structures may provide an option for the development of adsorption modules for extracorporeal blood purification.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Biochemistry & Molecular Biology

Comparative Analysis of Platelet-Derived Extracellular Vesicles Using Flow Cytometry and Nanoparticle Tracking Analysis

Sobha Karuthedom George, Lucia Laukova, Rene Weiss, Vladislav Semak, Birgit Fendl, Victor U. Weiss, Stephanie Steinberger, Guenter Allmaier, Carla Tripisciano, Viktoria Weber

Summary: This study demonstrates the differences in counting and characterizing platelet-derived EVs using different instruments and techniques. Flow cytometry and nanoparticle tracking analysis can accurately quantify the number of EVs, and reveal potential discrepancies in counts between different instruments.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Cell Biology

Analysis of Inflammatory Mediator Profiles in Sepsis Patients Reveals That Extracellular Histones Are Strongly Elevated in Nonsurvivors

Tanja Eichhorn, Ingrid Linsberger, Lucia Laukova, Carla Tripisciano, Birgit Fendl, Rene Weiss, Franz Koenig, Gerhard Valicek, Georg Miestinger, Christoph Hoermann, Viktoria Weber

Summary: The study found that there is a wide range of mediator concentrations among sepsis patients, indicating their heterogeneity. Elevated levels and correlations of damage-associated molecular patterns and markers of endothelial activation suggest severe tissue damage, with extracellular histones being significantly higher in nonsurvivors, indicating diagnostic and prognostic potential.

MEDIATORS OF INFLAMMATION (2021)

Article Multidisciplinary Sciences

Extracellular vesicles are associated with C-reactive protein in sepsis

Birgit Fendl, Rene Weiss, Tanja Eichhorn, Ingrid Linsberger, Taras Afonyushkin, Florian Puhm, Christoph J. Binder, Michael B. Fischer, Viktoria Weber

Summary: There is increasing evidence that C-reactive protein (CRP) can mediate inflammatory reactions by binding with extracellular vesicles (EVs), and an adsorbent can effectively remove free CRP and CRP+ EVs to reduce inflammation.

SCIENTIFIC REPORTS (2021)

Article Microbiology

Genomic and Phenotypic Analysis of Linezolid-Resistant Staphylococcus epidermidis in a Tertiary Hospital in Innsbruck, Austria

Silke Huber, Miriam A. Knoll, Michael Berktold, Reinhard Wuerzner, Anita Brindlmayer, Viktoria Weber, Andreas E. Posch, Katharina Mrazek, Sarah Lepuschitz, Michael Ante, Stephan Beisken, Dorothea Orth-Hoeller, Johannes Weinberger

Summary: Whole genome sequencing is a useful tool for monitoring resistance mechanisms in bacteria. This retrospective study found that the major resistance mechanisms in linezolid-resistant Staphylococcus epidermidis (LRSE) were mutations in 23S rRNA and the presence of the cfr gene, with most LRSE isolates showing high resistance levels to linezolid. Linezolid usage was identified as the main factor contributing to the development of resistance, and monitoring of the cfr gene in LRSE and restriction of linezolid usage are potential key steps to reduce resistance and transmission.

MICROORGANISMS (2021)

Article Biochemistry & Molecular Biology

Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones

Marie Ebeyer-Masotta, Tanja Eichhorn, Rene Weiss, Vladislav Semak, Lucia Laukova, Michael B. Fischer, Viktoria Weber

Summary: Inflammation and thrombosis are closely related in various diseases, including ischemic events, sepsis, and COVID-19. Activated neutrophils, platelets, and other factors drive immunothrombosis. Research has shown that the use of heparin-functionalized adsorbents can effectively remove central effectors of immunothrombosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Letter Infectious Diseases

Performance of lateral flow assays for SARS-CoV-2 compared to RT-qPCR

Matthias Pilecky, Stephan Harm, Christoph Bauer, Jennifer Zottl, Robert Emprechtinger, Tanja Eichhorn, Claudia Schildboeck, Michael Ecker, Martin Willheim, Viktoria Weber, Jens Hartmann

JOURNAL OF INFECTION (2022)

Article Chemistry, Multidisciplinary

ENTEROSORPTION IN THE TREATMENT OF HEAVY METAL POISONING

Sergey Mikhalovsky, Oleksandr Voytko, Violetta Demchenko, Pavlo Demchenko

Summary: Heavy metals and their compounds are classified as one of the most toxic substances to human health, commonly entering the human body through air, water, and food. While some are naturally present in the environment, more often they pollute it due to anthropogenic activities. Limited medical agents are available for the treatment of acute heavy metal poisoning, and there is currently no specific treatment for chronically exposed individuals.

CHEMISTRY JOURNAL OF MOLDOVA (2021)

Review Chemistry, Analytical

State of the Art of Chemosensors in a Biomedical Context

Erich Kny, Ciril Reiner-Rozman, Jakub Dostalek, Achim-Walter Hassel, Christa Noehammer, Florian Pfaffeneder-Mantai, Sabine Szunerits, Viktoria Weber, Wolfgang Knoll, Christoph Kleber

Summary: Healthcare is undergoing major transformations, necessitating the use of new technologies to support personalized medicine and disease prevention. Biomarkers in bodily fluids such as blood, urine, sweat, or saliva can be used for early diagnosis, disease monitoring, and predicting response to treatment. The development of non-invasive analysis methods has been driven by the need for patients to use and apply diagnostic approaches themselves. This review focuses on novel sensing systems for detecting various endogenous biomarkers associated with human diseases in bodily fluids and exhaled breath.

CHEMOSENSORS (2022)

Review Cell Biology

Activated Platelets and Platelet-Derived Extracellular Vesicles Mediate COVID-19-Associated Immunothrombosis

Marie Ebeyer-Masotta, Tanja Eichhorn, Rene Weiss, Lucia Laukova, Viktoria Weber

Summary: Activated platelets and platelet-derived extracellular vesicles play central roles in thromboembolic complications associated with severe COVID-19, but dysregulated platelet activation can lead to immunothrombosis. Activated platelets stimulate neutrophil activation through the release of mediators, resulting in abnormal activation of inflammation and coagulation processes.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

Article Biochemistry & Molecular Biology

Targeting the Structural Integrity of Extracellular Vesicles via Nano Electrospray Gas-Phase Electrophoretic Mobility Molecular Analysis (nES GEMMA)

Stephanie Steinberger, Sobha Karuthedom George, Lucia Laukova, Rene Weiss, Carla Tripisciano, Martina Marchetti-Deschmann, Viktoria Weber, Gunter Allmaier, Victor U. Weiss

Summary: Extracellular vesicles (EVs) have potential applications in the medical field, and their stability during isolation and purification is crucial. This study investigated EV stability and particle numbers using nES GEMMA and NTA techniques, and found that nES GEMMA can provide important information on EV stability.

MEMBRANES (2022)

Article Engineering, Biomedical

Polyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis

Vladislav Semak, Tanja Eichhorn, Rene Weiss, Viktoria Weber

Summary: In this study, blood-compatible matrices were developed by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. The coating enhanced the blood compatibility of hydrophobic adsorbents, while had little effect on hydrophilic adsorbents. The coating maintained the adsorption capacity and reduced the activation of blood cells.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

Article Medicine, General & Internal

Infection with SARS-CoV-2 Is Associated with Elevated Levels of IP-10, MCP-1, and IL-13 in Sepsis Patients

Tanja Eichhorn, Silke Huber, Rene Weiss, Marie Ebeyer-Masotta, Lucia Laukova, Robert Emprechtinger, Rosa Bellmann-Weiler, Ingo Lorenz, Judith Martini, Markus Pirklbauer, Dorothea Orth-Hoeller, Reinhard Wuerzner, Viktoria Weber

Summary: Immunothrombosis is a central pathomechanism in sepsis and COVID-19, characterized by excessive inflammatory response and overactivation of the coagulation system, leading to multiple organ failure and death.

DIAGNOSTICS (2023)

暂无数据