Article
Multidisciplinary Sciences
Kenichiro Suzuki, Yasunori Inoue, Kazuo Ogawa, Tomohisa Nagoshi, Kosuke Minai, Takayuki Ogawa, Makoto Kawai, Michihiro Yoshimura
Summary: This study investigated the effects of coronary risk factors on left ventricular size and cardiac function using structure equation modeling. It found that each risk factor directly affected the shape of the heart. Managing risk factors is crucial in reducing the heart failure pandemic, as vascular risk and heart failure risk are likely to evolve simultaneously.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Patrick M. Pilz, Jennifer E. Ward, Wei-Ting Chang, Attila Kiss, Edward Bateh, Alokkumar Jha, Sudeshna Fisch, Bruno K. Podesser, Ronglih Liao
Summary: This article outlines the strengths, limitations, and outcomes of small and large animal models of heart failure with reduced ejection fraction currently used in basic and translational research. Animal models play a critical role in understanding the molecular mechanisms of heart failure, although no model completely recapitulates the full human disease.
CIRCULATION RESEARCH
(2022)
Article
Biochemical Research Methods
Mona Malek Mohammadi, Aya Abouissa, Joerg Heineke
Summary: A neonatal mouse model of pressure overload by transverse aortic constriction (nTAC) was established, demonstrating different responses in mice at different postnatal stages, which could facilitate future research on therapeutic strategies.
Article
Chemistry, Multidisciplinary
Ajit Magadum, Neha Singh, Ann Anu Kurian, Mohammad Tofael Kabir Sharkar, Nishat Sultana, Elena Chepurko, Keerat Kaur, Magdalena M. Zak, Yoav Hadas, Djamel Lebeche, Susmita Sahoo, Roger Hajjar, Lior Zangi
Summary: Heart failure remains a major issue globally, with cardiac hypertrophy and fibrosis being key factors. The regulator Pip4k2c, associated with mTORC1, plays a role in these processes. Studies show that deleting Pip4k2c does not affect embryonic cardiac development, but leads to increased rates of CH, CF, and sudden death in adult mice. Upregulating Pip4k2c improves heart function, reverses CH and CF, and enhances survival through inhibiting TGF beta 1 via specific pathways. Loss-and-gain-of-function studies identify Pip4k2c as a potential therapeutic target for CF, CH, and HF, utilizing modRNA as an effective gene therapy approach.
Article
Cardiac & Cardiovascular Systems
Natalia Dmitrieva, Delong Liu, Colin O. Wu, Manfred Boehm
Summary: This study found that serum sodium levels above 142 mmol during middle age are associated with an increased risk of left ventricular hypertrophy (LVH) and heart failure (HF). Maintaining good hydration throughout life may help slow down the decline in cardiac function and reduce the prevalence of HF.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, Research & Experimental
Yizhou Feng, Yuan Yuan, Hongxia Xia, Zhaopeng Wang, Yan Che, Zhefu Hu, Jiangyang Deng, Fangfang Li, Qingqing Wu, Zhouyan Bian, Heng Zhou, Difei Shen, Qizhu Tang
Summary: OSMR deficiency exacerbates pressure overload-induced cardiac hypertrophy by modulating macrophages and OSM/LIFR/STAT3 signaling, suggesting that OSMR may be a potential target for treating pathological cardiac hypertrophy and heart failure.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jin-Ling Huo, Lemin Jiao, Qi An, Xiuying Chen, Yuruo Qi, Bingfei Wei, Yichao Zheng, Xiaojing Shi, Erhe Gao, Hong-Min Liu, Dong Chen, Cong Wang, Wen Zhao
Summary: This study evaluates the roles of myofibroblast- or cardiomyocyte-specific LSD1 deficiency in pressure overload-induced cardiac remodeling. The findings suggest that myofibroblast-specific LSD1 deletion attenuates transverse aortic constriction-induced cardiac remodeling and improves heart function, highlighting LSD1 as a potential therapeutic target for late-stage heart failure.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Xavier Revelo, Preethy Parthiban, Chen Chen, Fanta Barrow, Gavin Fredrickson, Haiguang Wang, Dogacan Yucel, Adam Herman, Jop H. van Berlo
Summary: This study assessed the role of cardiac immune cells in the early hypertrophy response to cardiac pressure overload and found that cardiac resident macrophages play a key role in stimulating angiogenesis and inhibiting fibrosis in response to cardiac pressure overload.
CIRCULATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jinxi Wang, Qian Shi, Yihui Wang, Logan W. Dawson, Grace Ciampa, Weiyang Zhao, Guangqin Zhang, Biyi Chen, Robert M. Weiss, Chad E. Grueter, Duane D. Hall, Long-Sheng Song
Summary: This study demonstrates the potential of JP2NT gene therapy in attenuating transcriptional remodeling and development of heart failure induced by cardiac stress. The findings suggest that JP2NT gene therapy may serve as a novel therapeutic approach for treating hypertrophy and heart failure.
CIRCULATION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
David Aluja, Sara Delgado-Tomas, Marisol Ruiz-Meana, Jose A. Barrabes, Javier Inserte
Summary: Despite advances in treatment, heart failure remains a major cause of illness and death. Preventing myocardial hypertrophy, which is an independent risk factor for heart failure, is a clinical objective. Recent studies suggest that calpains, a type of protein, play a role in the development of cardiac hypertrophy, and inhibiting calpains may be a potential pharmacological strategy. New compounds are being developed and tested in animal models to evaluate the effectiveness of calpain inhibition in treating pathological cardiac hypertrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Yuan, Shichen Bu, Meng Du, Yilong Wang, Chenhui Ju, Dandan Huang, Wenjing Xu, Xin Tan, Minglu Liang, Shan Deng, Liu Yang, Kai Huang
Summary: This study investigated the role of RNF207 in the development of pathological cardiac hypertrophy and dysfunction. The results showed that RNF207 exacerbated cardiac hypertrophy and fibrosis, while RNF207 knockdown alleviated these conditions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. Cohen, Eric Vittinghoff, Mark J. Pletcher, Norrina B. Allen, Sanjiv J. Shah, John T. Wilkins, Patricia P. Chang, Chiadi E. Ndumele, Anne B. Newman, Diane Ives, Mathew S. Maurer, Elizabeth C. Oelsner, Andrew E. Moran, Yiyi Zhang
Summary: This study highlights the independent associations between cardiovascular risk factor exposures during midlife and the development of heart failure (HF) in later life. High midlife systolic blood pressure and low midlife high-density lipoprotein cholesterol were associated with HF with reduced ejection fraction (HFrEF), while high midlife body mass index, systolic blood pressure, pulse pressure, and glucose were associated with HF with preserved ejection fraction (HFpEF).
JOURNAL OF CARDIAC FAILURE
(2021)
Article
Veterinary Sciences
Carlo Guglielmini, Carlotta Valente, Giovanni Romito, Chiara Mazzoldi, Marco Baron Toaldo, Marlos Goncalves Sousa, Marcela Wolf, Tamyris Beluque, Oriol Domenech, Valentina Patata, Francesco Porciello, Paolo Ferrari, Domenico Caivano, Barbara Contiero, Helen Poser
Summary: The aim of this study was to identify risk factors for the development of atrial fibrillation in dogs with an echocardiographic diagnosis of dilated cardiomyopathy (DCM). The results showed that increased left atrial diameter and presence of right atrial enlargement were significant predictors of atrial fibrillation development.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Sepiso K. Masenga, Annet Kirabo
Summary: This review summarizes the current understanding of hypertensive heart disease and discusses in detail the mechanisms associated with its development and complications, including left ventricular hypertrophy, atrial fibrillation, heart failure, and coronary artery disease. The review also briefly highlights the role of dietary salt, immunity, and genetic predisposition in the pathogenesis of hypertensive heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Hairuo Lin, Yingqi Zhu, Cankun Zheng, Donghong Hu, Siyuan Ma, Lin Chen, Qiancheng Wang, Zhenhuan Chen, Jiahe Xie, Yi Yan, Xiaobo Huang, Wangjun Liao, Masafumi Kitakaze, Jianping Bin, Yulin Liao
Summary: Exercise-induced myocardial hypertrophy preconditioning can increase myocardial resistance to pathological stress through an antihypertrophic effect mediated by the Mhrt779/Brg1/Hdac2/p-Akt/p-GSK3 beta signaling pathway.
Article
Nutrition & Dietetics
Mario Kratz, Leila R. Zelnick, Olgica Trenchevska, Joshua W. Jeffs, Chad R. Borges, Hsin-Hui Tseng, Sarah L. Booth, Bryan R. Kestenbaum, Kristina M. Utzschneider, Ian H. de Boer
Summary: In chronic kidney disease (CKD) patients, circulating osteocalcin concentrations are elevated, partly due to increased proportions of fragmented forms. However, osteocalcin carboxylation status does not significantly differ between individuals with and without CKD. The data also do not support the hypothesis that differences in osteocalcin carboxylation may explain reduced insulin sensitivity in individuals with CKD.
JOURNAL OF RENAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Christine P. Limonte, Leila R. Zelnick, John Ruzinski, Andrew N. Hoofnagle, Ravi Thadhani, Michal L. Melamed, I-Min Lee, Julie E. Buring, Howard D. Sesso, JoAnn E. Manson, Ian H. de Boer
Summary: This study found that supplementation with vitamin D-3 or n-3 fatty acids did not reduce inflammation levels over 5 years in adults with type 2 diabetes. While vitamin D-3 supplementation resulted in an increase in NT-proBNP, there was no significant difference compared to n-3 fatty acid supplementation.
Correction
Endocrinology & Metabolism
Christine P. Limonte, Leila R. Zelnick, John Ruzinski, Andrew N. Hoofnagle, Ravi Thadhani, Michal L. Melamed, I-Min Lee, Julie E. Buring, Howard D. Sesso, JoAnn E. Manson, Ian H. de Boer
Article
Urology & Nephrology
Yan Chen, Leila R. Zelnick, Andrew N. Hoofnagle, Catherine K. Yeung, Laura M. Shireman, Brian Phillips, Calder C. Brauchla, Ian de Boer, Linda Manahan, Susan R. Heckbert, Jonathan Himmelfarb, Bryan R. Kestenbaum
Summary: Secretory solute clearance measurements can predict kidney drug clearances, and there is tight linkage between GFR and proximal tubular secretory clearance in stable outpatients, indicating that eGFR is a useful surrogate for predicting secretory drug clearances in such patients.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Medicine, General & Internal
Leila R. Zelnick, Nicolae Leca, Bessie Young, Nisha Bansal
Summary: In a cohort study of 1658 self-identified Black adults with chronic kidney disease, commonly used estimates of kidney function did not correspond well with directly measured kidney function. Estimating kidney function not including a coefficient for race (vs including a race coefficient) was significantly associated with a shorter time to achieving an estimated glomerular filtration rate less than 20 mL/min/1.73 m(2), a key threshold of kidney function for referral and listing for kidney transplant. The findings suggest that biases in race-based glomerular filtration rate estimates may be associated with delays in potential kidney transplant eligibility.
Article
Urology & Nephrology
Leila R. Zelnick, Michael G. Shlipak, Elsayed Z. Soliman, Amanda Anderson, Robert Christenson, Mayank Kansal, Rajat Deo, Jiang He, Bernard G. Jaar, Matthew R. Weir, Panduranga Rao, Debbie L. Cohen, Jordana B. Cohen, Harold Feldman, Alan Go, Nisha Bansal
Summary: This study evaluated the prognostic value of cardiac biomarkers and echocardiographic variables in predicting heart failure (HF) in patients with chronic kidney disease (CKD). The results showed that NT-proBNP and hsTnT had better discrimination than the current HF prediction model. HF clinical prediction models tailored to CKD patients are needed.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Benjamin Lidgard, Leila R. Zelnick, Kevin D. O'Brien, Nisha Bansal
Summary: In a large ambulatory cohort of adults with CKD, symptoms of atherosclerotic cardiovascular disease were strongly associated with a higher risk for subsequent myocardial infarction, including chest pain and shortness of breath.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Simon Hsu, Leila R. Zelnick, Yvonne S. Lin, Cora M. Best, Bryan R. Kestenbaum, Kenneth E. Thummel, Andrew N. Hoofnagle, Ian H. de Boer
Summary: The study confirmed the correlation between 24,25-dihydroxyvitamin D (24,25(OH)(2)D) and the clearance rate of 25-hydroxyvitamin D (25(OH)D-3) as a marker for clearance. Participants with chronic kidney disease, kidney failure, Black participants, and those with lower serum albumin had lower VDMR.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Urology & Nephrology
Benjamin Lidgard, Nisha Bansal, Leila R. Zelnick, Andrew Hoofnagle, Jing Chen, Derek Colaizzo, Mirela Dobre, Katherine T. Mills, Anna C. Porter, Sylvia E. Rosas, Mark J. Sarnak, Stephen Seliger, James Sondheimer, Manjula Kurella Tamura, Kristine Yaffe, Bryan Kestenbaum
Summary: Lower kidney clearances of secreted solutes are associated with incident global cognitive decline in a prospective study of CKD, independent of eGFR. However, serum concentrations of the solutes were not associated with cognitive decline. Further research is needed to determine the specific domains of cognition affected by decreased secretory clearance and the underlying mechanisms of these associations.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Nutrition & Dietetics
Armin Ahmadi, M. Nazmul Huda, Brian J. Bennett, Jorge Gamboa, Leila R. Zelnick, Lucas R. Smith, Maria Chondronikola, Daniel Raftery, Ian H. de Boer, Baback Roshanravan
Summary: CKD is associated with decreased anabolic response to insulin, leading to protein-energy wasting. Targeted metabolic profiling of OGTT may help identify metabolic pathways contributing to disruptions to insulin response in CKD.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Urology & Nephrology
Nisha Bansal, Leila R. Zelnick, Jaejin An, Teresa N. Harrison, Ming -Sum Lee, Daniel E. Singer, Sue Hee Sung, Dongjie Fan, Alan S. Go
Summary: This study aimed to evaluate the risks of adverse effects in chronic kidney disease (CKD) patients after initiating atrial fibrillation (AF) therapies. The results showed a significant association between lower estimated glomerular filtration rate (eGFR) and higher risks of adverse effects after initiation of commonly used AF therapies. These findings can help guide therapeutic decisions for patients with CKD and AF.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nisha Bansal, Leila R. Zelnick, Jaejin An, Teresa N. Harrison, Ming-Sum Lee, Daniel E. Singer, Dongjie Fan, Alan S. Go
Summary: This study suggests that atrial fibrillation is associated with a increased risk of dementia, particularly in younger patients and those without chronic kidney disease, but does not vary significantly by sex, race, or ethnicity.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Hsu, Leila R. Zelnick, Nisha Bansal, Julia Brown, Michelle Denburg, Harold I. Feldman, Charles Ginsberg, Andrew N. Hoofnagle, Tamara Isakova, Mary B. Leonard, Benjamin Lidgard, Cassianne Robinson-Cohen, Myles Wolf, Dawei Xie, Bryan R. Kestenbaum, Ian H. de Boer, CRIC Study Investigators
Summary: The study investigated the associations of the vitamin D metabolite ratio (VDMR), 25-hydroxyvitamin D (25[OH]D), and 1,25-dihydroxyvitamin D (1,25[OH](2)D) with cardiovascular disease (CVD) in chronic kidney disease patients. The results showed that lower VDMR and 1,25(OH)(2)D were associated with incident CVD, while only 25(OH)D was associated with left ventricular mass index. However, none of these metabolites were found to be associated with incident CVD in chronic kidney disease after adjustment for relevant factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Urology & Nephrology
Christine P. Limonte, Leila R. Zelnick, Andrew N. Hoofnagle, Ravi Thadhani, Michal L. Melamed, Samia Mora, Nancy R. Cook, Heike Luttmann-Gibson, Howard D. Sesso, I-Min Lee, Julie E. Buring, JoAnn E. Manson, Ian H. de Boer
Summary: Based on the results of the Vitamin D and Omega-3 Trial (VITAL), there is no difference in the effects of vitamin D3 supplementation on cardiovascular and cancer outcomes based on baseline estimated glomerular filtration rate (eGFR). The effects on serum 25(OH)D and parathyroid hormone (PTH) concentrations also did not differ at different eGFR levels.
Article
Urology & Nephrology
Benjamin Lidgard, Leila Zelnickv, Amanda H. Anderson, Harold Feldman, Alan Go, Jiang He, Mayank Kansal, Madhumita Jena Mohanty, Rupal Mehta, Michael G. Shlipak, Elsayed Soliman, Matt R. Weir, Nisha Bansal
Summary: This study analyzed the association between several cardiac biomarkers and atherosclerotic cardiovascular disease in patients with CKD. The results showed that NT-proBNP, hsTnT, GDF-15, and sST2 were significantly associated with atherosclerotic diseases such as myocardial infarction and stroke.