Article
Cardiac & Cardiovascular Systems
Min Ji Cho, Dong Gwang Lee, Jeong Woong Lee, Byungtae Hwang, Sung-Jin Yoon, Seon-Jin Lee, Young-Jun Park, Seung-Ho Park, Hee Gu Lee, Yong-Hoon Kim, Chul-Ho Lee, Jangwook Lee, Nam-Kyung Lee, Tae-Su Han, Hyun-Soo Cho, Jeong Hee Moon, Ga Seul Lee, Kwang-Hee Bae, Geum-Sook Hwang, Sang-Hak Lee, Sang J. Chung, Sungbo Shim, Jaehyung Cho, Goo Taeg Oh, Young-Guen Kwon, Jong-Gil Park, Jeong-Ki Min
Summary: This study investigates the role of protein tyrosine phosphatase type IVA1 (PTP4A1) in the negative regulation of the NF-kappa B signalling pathway in endothelial cells (ECs). The findings suggest that PTP4A1 regulates NF-kappa B inactivation through the USF1/A20 axis, and its expression or activation in ECs may be useful for the treatment of vascular inflammatory diseases.
CARDIOVASCULAR RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Junqi Wang, Xiaoping Chen
Summary: This review summarizes the roles of JAMs in the development of atherosclerosis and predicts future research directions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, Research & Experimental
Joshua Fowler, Martin Tsz-Ki Tsui, Jessica Chavez, Safeera Khan, Hassan Ahmed, Lena Smith, Zhenquan Jia
Summary: Methyl mercury is linked to cardiovascular disease development by inducing monocyte adhesion to endothelial cells and upregulating proinflammatory cytokines. It also activates the NF-kappa B signaling pathway, leading to increased monocyte binding to endothelial cells. Furthermore, methyl mercury causes necrotic cell death at higher concentrations without inducing apoptosis.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah
Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Food Science & Technology
Bianca C. Zychar, Patricia B. Clissa, Eneas Carvalho, Adilson S. Alves, Cristiani Baldo, Eliana L. Faquim-Mauro, Luis Roberto C. Goncalves
Summary: In this study, different domains of SVMPs were found to induce expression of adhesion molecules similarly, promoting leukocyte recruitment. Despite differences in hemorrhagic activities and domain composition, SVMPs behaved similarly in this aspect.
Review
Biochemistry & Molecular Biology
Diana Jhoseline Medina-Leyte, Oscar Zepeda-Garcia, Mayra Dominguez-Perez, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina, Leonor Jacobo-Albavera
Summary: The development of coronary artery disease (CAD) is closely tied to endothelial dysfunction and inflammation activation. Identifying new biomarkers and therapeutic strategies is crucial in preventing atherosclerosis and CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xinyu Zhu, Jiangtong Peng, Liuye Yang, Yi Guo, Pengchao Wang, Kaiyuan Liu, Jingbo Zhu, Shan Deng, Minglu Liang
Summary: This study demonstrates the inhibitory effect of 7-Mif on endothelial inflammation by reducing the expression of endothelial adhesion molecules and monocyte adhesion.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuan Fu, Junxiong Qiu, Jianhua Wu, Lisui Zhang, Feng Wei, Liuyi Lu, Chao Wang, Zhaopei Zeng, Shi Liang, Junmeng Zheng
Summary: Atherosclerosis, a chronic inflammatory condition linked to cardiovascular diseases, is a global public health concern. This study found that USP14, a deubiquitinating enzyme, is downregulated in atherosclerosis patients and stimulated endothelial cells. Overexpression of USP14 inhibits endothelial proinflammatory activation by suppressing NF-xB activation and adhesion molecule production. In vivo experiments confirmed that USP14 adenovirus injection in mice reduced atherosclerotic lesions and restricted disease progression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Cardiac & Cardiovascular Systems
Carina Mauersberger, Julia Hinterdobler, Heribert Schunkert, Thorsten Kessler, Hendrik B. Sager
Summary: This article comprehensively reviews the process of leukocyte recruitment relevant to atherosclerosis, with a focus on endothelial cells, monocytes and macrophages, neutrophils, T lymphocytes and platelets. Therapeutic options targeting leukocyte recruitment into atherosclerotic lesions, as well as potential insights into its precise mechanisms, are also highlighted.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Plant Sciences
Jiah Ning Tan, Khairana Husain, Zakiah Jubri, Kok Meng Chan, Ibrahim Jantan, Norsyahida Mohd Fauzi
Summary: This study aimed to evaluate the inhibitory effect of 80% ethanol extract of Gynura procumbens leaves (GPE) on the adherence of monocytes to activated human endothelial cells and its underlying mechanism.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Chuan-Rong Zhao, Jingyi Li, Zhi-Tong Jiang, Juan-Juan Zhu, Jia-Nan Zhao, Qian-Ru Yang, Weijuan Yao, Wei Pang, Ning Li, Miaorong Yu, Yong Gan, Jing Zhou
Summary: The study demonstrates that disk-shaped nanoparticles have a superior ability to target areas with disturbed blood flow and exhibit better therapeutic effects in treating atherosclerosis compared to spherical nanoparticles.
Review
Immunology
Shuren Guo, Xiaohuan Mao, Jun Liu
Summary: CTRPs family members play critical roles in the development and progression of AS by influencing inflammatory response, modulating glucose and lipid metabolism, regulating endothelial functions, and the proliferation of vascular smooth muscle cells (VSMCs).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao-Hong Chen, Yu Tan, ShuQin Yu, Lijun Lu, Youqing Deng
Summary: This study found that pinitol has the potential to reduce endothelial dysfunction caused by oxidized low-density lipoprotein (ox-LDL). Pinitol can decrease the production of reactive oxygen species, reduce the expression of IL-6 and monocyte chemoattractant protein-1, and decrease the attachment of monocytes to endothelial cells. Additionally, pinitol decreases the expression of LOX-1 and rescues the expression of KLF2.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cell Biology
Alexandre Bergeron, Andra Brezai, Rami Shukr, Louis Villeneuve, Bruce G. Allen, Wasay M. S. Qureshi, Kathryn E. Hentges, Angelino Calderone
Summary: The study found that the appearance of nestin in neonatal rat ventricular cardiomyocytes was associated with a migratory phenotype, and the cotreatment with p38 mitogen-activated protein kinase inhibitor promoted the synthesis of nestin. Additionally, the reorganization of nonmuscle myosin IIB and its physical interaction with nestin may act together to facilitate the migratory phenotype in cardiomyocytes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Doa'a G. F. Al-U'datt, Bruce G. Allen, Roddy Hiram, Nasr Alrabadi
Summary: Peptidylarginine deiminase (PAD) family members play a critical role in maintaining ECM stability during remodelling in various heart diseases, yet the specific mechanisms and therapeutic properties have not been fully explored.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthieu Ruiz, Maya Khairallah, Dharmendra Dingar, George Vaniotis, Ramzi J. Khairallah, Benjamin Lauzier, Simon Thibault, Joelle Trepanier, Yanfen Shi, Annie Douillette, Bahira Hussein, Sherin Ali Nawaito, Pramod Sahadevan, Albert Nguyen, Fatiha Sahmi, Marc-Antoine Gillis, Martin G. Sirois, Matthias Gaestel, William C. Stanley, Celine Fiset, Jean-Claude Tardif, Bruce G. Allen
Summary: The study showed that MK2(-/-) mice exhibited signs of possible early diastolic dysfunction at 12 weeks of age; they also had lower body temperature, decreased body weight, and altered expression of certain metabolic genes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemical Research Methods
Pramod Sahadevan, Bruce G. Allen
Summary: Cardiac fibroblasts play a critical role in maintaining the extracellular matrix, wound healing, and cardiac interstitial fibrosis. A method for isolating and maintaining these fibroblasts in vitro allows for a better understanding of their biology and response to fibrotic stimuli.
Review
Cardiac & Cardiovascular Systems
Olina Dagher, Pauline Mury, Nathalie Thorin-Trescases, Pierre Emmanuel Noly, Eric Thorin, Michel Carrier
Summary: The vascular endothelium plays crucial roles in maintaining cardiovascular homeostasis, regulating vascular tone, and processing biochemical substances. Dysfunction of endothelial cells may lead to chronic age-related cardiovascular diseases such as ischemic heart disease. Studies have shown that flavonoid compound quercetin, found in various food sources, may help mitigate the risk factors of endothelial dysfunction such as atherosclerosis and hypertension.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Cardiac & Cardiovascular Systems
Eric Thorin, Nathalie Thorin-Trescases
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Mozhdeh Mehdizadeh, Martin Aguilar, Eric Thorin, Gerardo Ferbeyre, Stanley Nattel
Summary: This review discusses the role of cellular senescence in cardiac disease, outlines therapeutic strategies for targeting senescence, and considers potential implications for improving the management of patients with heart disease. The complex senescence-associated secretory phenotype (SASP) of senescent cells has important effects on cell and tissue biology. Future research is needed to better understand the precise role of senescent cells in various cardiac pathologies and develop strategies for preventing their accumulation.
NATURE REVIEWS CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yohann Rautureau, Marianne Berlatie, Daniel Rivas, Kurunradeth Uy, Alexandre Blanchette, Geraldine Miquel, Marie-Eve Higgins, Melanie Mecteau, Audrey Nault, Louis Villeneuve, Veronique Lavoie, Gabriel Theberge-Julien, Genevieve Brand, Line Lapointe, Maxime Denis, Camille Rosa, Annik Fortier, Lucie Blondeau, Marie-Claude Guertin, Marie-Pierre Dube, Eric Thorin, Jonathan Ledoux, David Rhainds, Eric Rheaume, Jean-Claude Tardif
Summary: ADCY9 gene plays a role in determining atherosclerotic outcomes in patients and in mice it has been shown to potentiate endothelial function and inhibit atherogenesis. The inactivation of Adcy9 leads to increased cAMP accumulation in response to certain activators and enhances endothelial-dependent vasodilation. Additionally, ADCY9 can regulate endothelial permeability and actin cytoskeleton in response to thrombin, affecting the development of atherosclerosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gerald Coulis, Avinash D. Londhe, R. Sudheer Sagabala, Yanfen Shi, David P. Labbe, Alexandre Bergeron, Pramod Sahadevan, Sherin A. Nawaito, Fatiha Sahmi, Marie Josse, Valerie Vinette, Marie-Claude Guertin, Gerard Karsenty, Michel L. Tremblay, Jean-Claude Tardif, Bruce G. Allen, Benoit Boivin
Summary: Increased production of reactive oxygen species is essential in the pathogenesis of several diseases, including cardiac hypertrophy. The reversible oxidation and inactivation of protein tyrosine phosphatase 1B (PTP1B), along with its substrate argonaute 2 (AGO2), play crucial roles in cardiac hypertrophy.
Article
Environmental Sciences
Florent Besnier, Beatrice Berube, Jacques Malo, Christine Gagnon, Catherine-Alexandra Gregoire, Martin Juneau, Francois Simard, Philippe L'Allier, Anil Nigam, Josep Iglesies-Grau, Thomas Vincent, Deborah Talamonti, Emma Gabrielle Dupuy, Hanieh Mohammadi, Mathieu Gayda, Louis Bherer
Summary: The COVID-Rehab study investigates the effectiveness of an eight-week cardiopulmonary rehabilitation program for long-term COVID-19 patients. The study examines multiple outcomes including cardiorespiratory fitness, quality of life, and cognition. The findings will provide important guidance for the rehabilitation of long-term COVID-19 patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Cell Biology
Grace R. Mazarura, Juliana C. C. Dallagnol, David Chatenet, Bruce G. Allen, Terence E. Hebert
Summary: The role of G protein-coupled receptors (GPCRs) in the cardiovascular system has been well studied in cardiomyocytes and vascular smooth muscle cells (VSMCs). This article focuses on the relatively less understood effects of GPCRs in cardiac fibroblasts, examining the key signaling events and cellular communications involved in their activation and differentiation. The study highlights the importance of the localization of GPCRs and their associated signaling machinery in these cells, particularly the nuclear membrane-localized receptors, in cardiac fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Barnabas Gellen, Nathalie Thorin-Trescases, Eric Thorin, Elise Gand, Stephanie Ragot, David Montaigne, Yann Pucheu, Kamel Mohammedi, Philippe Gatault, Louis Potier, Evelyne Liuu, Samy Hadjadj, Pierre-Jean Saulnier
Summary: The study found that increased serum S100A12 concentration is independently associated with a higher risk of heart failure (HF) in patients with type 2 diabetes, but not with major adverse cardiovascular events (MACE). S100A12 may be a candidate for a multimarker approach for assessing heart failure risk in diabetic patients.
Article
Neurosciences
Besnier Florent, Boidin Maxime, Gregoire Catherine-Alexandra, Gagnon Christine, Thorin-Trescases Nathalie, Thorin Eric, Nigam Anil, Juneau Martin, Tremblay Jonathan, Gayda Mathieu, Bherer Louis
Summary: This study aimed to compare cognitive functions, cardiorespiratory fitness, and trophic biomarkers in physically active coronary heart disease (CHD) patients and healthy controls. The results showed that despite similar physical activity levels, CHD patients had lower cardiorespiratory fitness, cognitive performances, and BDNF concentrations compared to controls.
Editorial Material
Cardiac & Cardiovascular Systems
Jean-Claude Tardif, Eric Thorin
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Biology
Pauline Labbe, Victoria Munoz Goyette, Nathalie Thorin-Trescases, Louis Villeneuve, Ines Desanlis, Constance Delwarde, Yan-Fen Shi, Cecile Martel, Carol Yu, Azadeh Alikashani, Maya Mamarbachi, Frederic Lesage, Samuel Mathieu, Jean-Claude Tardif, Patrick Mathieu, Marie Kmita, Eric Thorin
Summary: A study has found that Angiopoietin-like 2 (ANGPTL2) plays a crucial role in valve development during embryogenesis. Knockout mice for the Angptl2 gene exhibit abnormal thickening of the valve leaflets and dysregulation in the balance between cell apoptosis, senescence, and proliferation, as well as a decrease in Notch signaling. These abnormalities lead to spontaneous aortic valve stenosis in adult mice.
COMMUNICATIONS BIOLOGY
(2022)