Article
Chemistry, Medicinal
Alexander P. Gerhard, Juergen Kruecken, Cedric Neveu, Claude L. Charvet, Abdallah Harmache, Georg von Samson-Himmelstjerna
Summary: The active drug ingestion by nematodes has been identified as a crucial factor affecting susceptibility, while P-glycoprotein efflux pumps play a role in tissue-specific resistance mechanisms.
Article
Biochemistry & Molecular Biology
Diogo Henrique Kita, Gisele Alves de Andrade, Juliana Morais Missina, Kahoana Postal, Viktor Kalbermatter Boell, Francielli Sousa Santana, Ingrid Fatima Zattoni, Isadora da Silva Zanzarini, Vivian Rotuno Moure, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Emanuel Maltempi de Souza, David A. Mitchell, Suresh Ambudkar, Giovana Gioppo Nunes, Glaucio Valdameri
Summary: The study found that polyoxovanadates can serve as inhibitors of ABC drug transporters, selectively inhibiting P-glycoprotein with V-10 and V-18 being the most promising compounds.
Article
Environmental Sciences
Marie-Theres Rauchschwalbe, Hendrik Fueser, Walter Traunspurger, Sebastian Hoess
Summary: The study found that microplastics can interfere with the feeding of nematodes on bacterial diet, reducing their consumption rate. Different materials and sizes of microbeads lead to different effects, and inhibited bacterial consumption is related to the nematodes' reduced pumping rate.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Medicinal
Sarah Lazzaro, Mark A. West, Soraya Eatemadpour, Bo Feng, Manthena V. S. Varma, A. David Rodrigues, Csilla Temesszentandrasi-Ambrus, Peter Kovacs-Hajdu, Zsuzsanna Nerada, Zsuzsanna Gaborik, Chester Costales
Summary: This study evaluated the impact of potential IC50 discrepancies between two commonly utilized assay methods (cell-based and vesicle-based) on P-gp. Non-P-gp substrates showed good correlation between the two methods, while IC50s of P-gp substrates were lower in the vesicle assays. IC50s obtained from two independent laboratories using the same method showed good correlation.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Genetics & Heredity
Muntasir Kamal, Levon Tokmakjian, Jessica Knox, Duhyun Han, Houtan Moshiri, Lilia Magomedova, Ken C. Q. Nguyen, Hong Zheng, Andrew R. Burns, Brittany Cooke, Jessica Lacoste, May Yeo, David H. Hall, Carolyn L. Cummins, Peter J. Roy
Summary: This study reveals the existence of a polar lipid barrier established by P-glycoprotein PGP-14 and sphingomyelin synthase SMS-5 in the pharyngeal cuticle of the nematode C. elegans. Loss of these proteins significantly affects the nematode's response to xenobiotics.
Article
Biochemistry & Molecular Biology
Yiwen Zhou, Michael Rothe, Wolf-Hagen Schunck, Liliane Ruess, Ralph Menzel
Summary: 17,18-Epoxyeicosatetraenoic acid (17,18-EEQ) is a potential signaling molecule in regulating the pharyngeal pumping activity of C. elegans. Serotonin induces the formation of 17,18-EEQ via the SER-7 receptor, and stimulation of pharyngeal activity by 17,18-EEQ is highly stereospecific to the (R,S)-enantiomer. These findings suggest that 17,18-EEQ may function as a second messenger of serotonin in promoting feeding behavior.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Plant Sciences
Sara Abdelfatah, Madeleine Boeckers, Maitane Asensio, Onat Kadioglu, Anette Klinger, Edmond Fleischer, Thomas Efferth
Summary: The study identified isopetasin and S-isopetasin as novel P-gp inhibitors, which can overcome multidrug resistance and induce ROS generation and apoptosis in cancer cells.
Review
Multidisciplinary Sciences
Carlos Pilotto Heming, Wanjiru Muriithi, Lucy Wanjiku Macharia, Paulo Niemeyer Filho, Vivaldo Moura-Neto, Veronica Aran
Summary: Acquired resistance during cancer treatment is often caused by ABC transporters, such as P-gp, which export chemotherapeutic molecules and contribute to multidrug resistance. In addition to its role in drug resistance, P-gp may also have other functions and serve as a biomarker in cancer.
Article
Medicine, Research & Experimental
Lara Garcia-Varela, Manuel Rodriguez-Perez, Antia Custodia, Rodrigo Moraga-Amaro, Nicola A. Colabufo, Pablo Aguiar, Tomas Sobrino, Rudi A. J. O. Dierckx, Aren van Waarde, Philip H. Elsinga, Gert Luurtsema
Summary: P-glycoprotein (P-gp) inducer MC111 increases P-gp functionality in the whole brain of rats, potentially offering a treatment option for neurodegenerative diseases.
MOLECULAR PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Gangyang Wang, Lingling Cao, Yafei Jiang, Tao Zhang, Hongsheng Wang, Zhuoying Wang, Jing Xu, Min Mao, Yingqi Hua, Zhengdong Cai, Xiaojun Ma, Shuo Hu, Chenghao Zhou
Summary: This study demonstrates that anlotinib can reverse multidrug resistance in osteosarcoma cells by inhibiting the efflux function of P-glycoprotein 1 (PGP1) and increasing the intracellular accumulation of chemotherapeutic agents. Anlotinib also stimulates the ATPase activity of PGP1. In animal studies, anlotinib combined with doxorubicin shows a significant decrease in tumor growth rate and tumor size.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pascalle Mossel, Wejdan M. Arif, Giordana Salvi De Souza, Lara Garcia Varela, Chris W. J. van der Weijden, Hendrikus H. Boersma, Antoon T. M. Willemsen, Ronald Boellaard, Philip H. Elsinga, Ronald J. H. Borra, Rudi A. J. O. Dierckx, Adriaan A. Lammertsma, Anna L. Bartels, Gert Luurtsema
Summary: The aim of this study was to determine the best pharmacokinetic model to describe [F-18]MC225 kinetics in the human brain and assess test-retest variability. The reversible two tissue compartment model corrected for plasma metabolites with an estimated blood volume (VB) showed the highest AIC weight score. The preferred parameter to describe P-gp function in the human BBB using this model was [F-18]MC225 VT, which had an average test-retest variability of 28%.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Biochemistry & Molecular Biology
Ekaterina Yu Rybalkina, Natalia Moiseeva, Aida F. Karamysheva, Daria Eroshenko, Anastasia Konysheva, Alexei Nazarov, Victoria V. Grishko
Summary: The semi-synthetic A-cycle modified triterpenic derivatives showed cytotoxicity against tumor cells and were similar to classical inhibitors in their action mechanism. Combining the modified triterpenic derivatives with doxorubicin improved the cytotoxic effect of the therapeutic drug against resistant tumor cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Liadys Mora Lagares, Yunierkis Perez-Castillo, Nikola Minovski, Marjana Novic
Summary: P-gp is an important protein involved in drug efflux and multidrug resistance. Molecular dynamics simulations can provide valuable insights into the binding behavior and conformational changes of P-gp in the presence of different compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yanli Xin, Shurui Peng, Shan Wei, Yang Lei, Shuaibing Zhang, Yuansen Hu, Yangyong Lv
Summary: This study investigates the antimicrobial and antibiofilm effects of p-anisaldehyde (PAA) from Pimpinella anisum L. against Vibrio parahaemolyticus, as well as its potential application in food preservation, specifically for salmon.
Article
Computer Science, Artificial Intelligence
Yuping Liu, Yuzhen Zhao
Summary: This work introduces the phenomenon of lateral inhibition in biological nervous systems into spiking neural P systems and proposes SN P systems with lateral inhibition (LISN P systems). By adjusting the lateral distance, lateral inhibition can affect the information transmission between neurons, and the designed LISN P systems can be used to generate arbitrary numbers and perform function computation, demonstrating computational completeness.