Article
Neurosciences
Katharina Hierl, Ilona Croy, Laura Schaefer
Summary: This study extends the previous methodological repertoire of body odour sampling, indicating that the axilla, breast, and head of adults as well as infants serve as informative odour sources. Mothers were able to recognize their own and their own infant's odour above chance and rated their own and their infant's odour as less intense compared with unfamiliar samples.
Review
Geriatrics & Gerontology
Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan
Summary: Decades of research have shown that amyloid-beta (Aβ) plays an undeniable role in the development of Alzheimer's disease (AD). However, the focus on the pathological effects of Aβ may overshadow the significance of its metabolic precursor, amyloid precursor protein (APP), in the occurrence and progression of AD. This review explores the various roles of APP in AD, including its structure, functions, enzymatic processing, and potential therapeutic approaches to targeting APP to ameliorate AD pathologies and halt disease progression.
Article
Chemistry, Applied
Diana Owsienko, Leo Schwinn, Bjoern M. Eskofier, Eva Kiesswetter, Helene M. Loos
Summary: It has been reported that there is a distinct 'old person smell' that can develop with age, but this smell has not been adequately described in previous research. This pilot study used a trained panel to evaluate and gain initial insights into the 'old person smell' by analysing body odour samples from a younger and older age group. The results showed that although the odour profiles of the samples were similar for both age groups, the trained panellists were able to predict the age group with significantly higher accuracy than expected by chance, indicating that age does have an impact on body odour.
FLAVOUR AND FRAGRANCE JOURNAL
(2023)
Editorial Material
Cell Biology
Melissa Vos, Christine Klein
Summary: PINK1 plays a critical role in the pathogenesis of Parkinson's disease, connecting to both mitophagy and energy production. Accumulation of ceramide in mitochondria triggers ceramide-induced mitophagy, while negatively affecting SS-oxidation.
Article
Multidisciplinary Sciences
Xiaohui He, Hao Zhang, Xingcong Zhang, Ying Zhang, Qian He, Hongyu Chen, Yujie Cheng, Mi Peng, Xuetao Qin, Hongbing Ji, Ding Ma
Summary: This article introduces a precursor-atomization strategy for the synthesis of single atom catalysts (SACs), which has versatility and scalability and can successfully produce a series of SACs and derivatives. Additionally, the method can be scaled up using a homemade production line with a daily productivity over 1 kg. This research lays the foundation for further investigation and potential industrial applications of SACs.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Minhye Kim, Young Jin Ko, Da Woon Jeong, Wu-Young Jeong, Sung Ok Han
Summary: This study introduced a new biosynthetic process for L-carnosine, which enhanced production and exhibited antioxidant and antiglycation effects, showing potential as a treatment for metabolic disorders.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Chemistry, Organic
Andrea Zanetti, Geoffrey Schwertz, Marllon Nascimento de Oliveira, Mario Andres Gomez Fernandez, Zacharias Amara, Janine Cossy
Summary: A regioselective Pd-catalyzed allylic oxidation of amorphadiene, a key precursor to artemisinin, is described, which can substitute P450 enzymes in artemisinin biosynthesis and enhance the value of waste in the industrial semisynthetic process.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Geochemistry & Geophysics
F. Bissig, A. Khan, D. Giardini
Summary: This paper presents a new dataset of global PP and SS precursor waveforms. By jointly inverting these waveforms with fundamental-mode and higher-order Rayleigh-wave phase velocities, the authors are able to gain insights into the structure of the upper mantle and mantle transition zone (MTZ). The results show variations in thermal, compositional, and discontinuity structure, with correlations to tectonic settings. The findings also reveal that the MTZ beneath continents and subduction zones is colder compared to oceans and hotspots, indicating differences in composition. Additionally, the study suggests that a mechanically mixed mantle matches seismic data better than an equilibrated mantle.
GEOPHYSICAL JOURNAL INTERNATIONAL
(2023)
Article
Chemistry, Multidisciplinary
David Reger, Kilian Schoell, Frank Hampel, Harald Maid, Norbert Jux
Summary: In this work, a novel precursor design was used for the solution-synthesis of pyridine analogues to hexa-peri-hexabenzocoronene (HBC), which are referred to as superpyridines. Classical pyridine chemistry was shown to be applicable to the pi-extended analogue, and basic physical chemical characterizations of the newly synthesized molecules were presented. This novel synthetic strategy aims to unlock the pyridine chemistry of nanographenes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
You Wang, Kexue Li, Zhangjian Zhou, Kai Chen, Ling Li, Zhao Shen, Xiaoqin Zeng
Summary: This study investigated the impact of surface grinding on the corrosion behavior of an austenitic stainless steel in supercritical CO2. The results showed that the ground surface had a thinner oxide scale compared to the polished surface, with the presence of Cr2O3, SiO2, and Mn2O3. Additionally, a lamellar structure enriched with carbon was observed in the oxide scale of the ground surface.
Article
Geochemistry & Geophysics
Shuyang Sun, Ying Zhou
Summary: This study investigates the nature of the Earth's asthenosphere by analyzing seismic data recorded over 12 years. Strong reflections from the upper and lower boundaries of the asthenosphere are observed globally, with average depths of 120 and 255 km respectively. The reflections indicate a significant reduction in seismic velocity and suggest localized melt in the oceanic asthenosphere. The study also reveals that the asthenosphere is not a homogeneous layer and is likely associated with strong and heterogeneous small-scale convection in the oceanic mantle.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2023)
Article
Biotechnology & Applied Microbiology
Mario Mutz, Dominic Koesters, Benedikt Wynands, Nick Wierckx, Jan Marienhagen
Summary: This study successfully achieved the efficient synthesis of p-coumaric acid with C. glutamicum by introducing a heterologous tyrosine ammonia-lyase gene and optimizing the shikimate pathway. Reducing the carbon flux into the phenylalanine and tryptophan branches, along with the introduction of feedback-resistant enzyme variants, were the key factors for success.
MICROBIAL CELL FACTORIES
(2023)
Article
Materials Science, Multidisciplinary
Hailong Dai, Shouwen Shi, Can Guo, Xu Chen
Summary: The research indicates that the SCC susceptibility of 316L stainless steel in HF vapor reaches almost 77%, mainly due to the preferential reaction between F and (Fe, Cr) elements leading to the formation of granular corrosion product and dealloying region, which in turn triggers transgranular SCC.
Article
Chemistry, Multidisciplinary
Naishen Shi, Qingbo Yu, Yuqi Li, Qingping Wang, Jia Pan, Xinxin Ren, Shuli Deng
Summary: The photocatalytic performance of graphitic phase carbon nitride (g-C3N4) can be improved by the introduction of sodium ions into the precursor structure, which results in the formation of FD-CN with an amino-rich structure. Compared to the original g-C3N4, FD-CN exhibited 2.19 times higher photocatalytic activity for the degradation of methylene blue.
Article
Environmental Sciences
Peiwei Xu, Zhe Mo, Lizhi Wu, Weizhong Chen, Shengliang He, Yuan Chen, Dandan Xu, Jie Xiang, Zhijian Chen, Xiaoming Lou, Zhen Wang, Xiaofeng Wang
Summary: This study found that residents living near electroplating industries have elevated body burdens of Cd levels, as well as slight renal dysfunction and DNA oxidation damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)