Article
Oncology
Shreya Desai, Michelle J. Zhu, Ilana Lapidos-Salaiz
Summary: Low- and middle-income countries bear a high burden of preventable cervical cancer cases and deaths, with human papillomavirus DNA-based testing increasingly being the preferred screening method. This commentary discusses next steps and key considerations for the expansion of this screening approach.
Review
Medicine, General & Internal
Flavia M. Correa, Arn Migowski, Liz M. De Almeida, Marcelo A. Soares
Summary: This review discusses the current strategies in Brazil for screening, treatment, and prevention (HPV vaccination) against cervical cancer, highlighting the country's large public health system and the disparities in access to healthcare. It also explores the potential integration of newer technologies to eliminate cervical cancer.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Uraiwan Khomphaiboonkij, Nattapong Sreamsukcharoenchai, Supakorn Pitakkarnkul, Kristsanamon Rittiluechai, Siriwan Tangjitgamol
Summary: Knowledge about cervical cancer screening and HPV is important for women's awareness and adherence to the screening program. This study found that only 26.9% of women had good knowledge about cervical cancer screening, and similarly, only 20.1% of women who had heard about HPV had good knowledge about it. Providing information about these topics could improve women's knowledge and increase their participation in screening procedures.
Review
Public, Environmental & Occupational Health
Mohan Narasimhamurthy, Santhosh Upadhyaya Kafle
Summary: Nepal has a high burden of cervical cancer due to limited screening programs. Despite efforts by the Ministry of Health and Population and international collaborations, the current prevention and treatment methods are inadequate to meet WHO's goals. This article provides an overview of Nepal's efforts to address the growing burden of cervical cancer and discusses potential challenges and solutions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Medicine, General & Internal
Rebecca B. Perkins, Nicolas Wentzensen, Richard S. Guido, Mark Schiffman
Summary: Each year in the US, about 100,000 people are treated for cervical precancer, 14,000 are diagnosed with cervical cancer, and 4,000 die from it. Almost all cervical cancers worldwide are caused by certain HPV genotypes. HPV vaccination at ages 9 to 12 can prevent over 90% of cervical precancers and cancers. Cervical cancer can be prevented through screening and treatment of cervical precancer in individuals with a cervix aged 21 to 65.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Jacquelyn Dillon, Ling Chen, Alexander Melamed, Caryn M. St Clair, June Y. Hou, Fady Khoury-Collado, Allison Gockley, Melissa Accordino, Dawn L. Hershman, Jason D. Wright
Summary: Cervical cancer screening is frequently overused among average-risk Medicaid beneficiaries, with women who do not undergo screening also unlikely to receive routine gynecological examinations.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Oncology
Shuang Zhao, Liuye Huang, Partha Basu, Efren Javier Domingo, Wisit Supakarapongkul, Woo Yin Ling, Dwiana Ocviyanti, Remila Rezhake, Youlin Qiao, Eng Hseon Tay, Fanghui Zhao
Summary: Multiple barriers hinder the implementation of cervical cancer screening in ASEAN countries, including inequity, lack of service availability, knowledge deficit, and insufficient funding. Only a few countries have initiated population-based screening programs with low participation rates. Tailored solutions and improved health education are crucial in promoting cervical cancer prevention efforts.
Article
Public, Environmental & Occupational Health
B. Serrano, R. Ibanez, C. Robles, P. Peremiquel-Trillas, S. de Sanjose, L. Bruni
Summary: Self-sampling for HPV screening is increasingly recognized as a valid alternative to clinician collection, reaching underscreened women effectively. The global use of HPV self-sampling is currently limited, but efforts are being made to increase its adoption in the coming years. The COVID-19 pandemic has accelerated the introduction of HPV self-sampling as a key element in expanding screening coverage.
PREVENTIVE MEDICINE
(2022)
Review
Oncology
Alexandros Daponte, George Michail, Athina-Ioanna Daponte, Nikoletta Daponte, George Valasoulis
Summary: Despite significant advancements in cervical cancer prevention, many women still miss the opportunity for early detection. Self-sampling HPV modalities have shown promise in addressing this issue and are considered a feasible alternative strategy with enhanced population coverage.
Article
Immunology
Jing Zhang, Di Yang, Xiaoli Cui, Guangcong Liu, Zhumei Cui, Chunyan Wang, Haozhe Piao
Summary: This study evaluated the performance of the Aptima HPV (AHPV) assay in cervical cancer screening in China and analyzed different triage strategies. The results showed that AHPV testing had higher sensitivity and specificity in detecting high-grade squamous intraepithelial lesion or worse. Furthermore, AHPV genotyping with reflex LBC triage may be a feasible strategy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
David Robert Grimes, Edward M. A. Corry, Talia Malagon, Ciaran O'Riain, Eduardo L. Franco, Donal J. Brennan
Summary: The study compared different cervical cancer screening modalities on a simulated population of women aged >= 25 years, considering the increasing uptake of the HPV vaccine. HPV-based modalities outperformed LBC-based approaches, with reflex approaches and appropriate test intervals maximizing therapeutic efficacy. Increasing HPV vaccination rates resulted in fewer unnecessary colposcopies with HPV-based screening approaches.
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Review
Oncology
Nikoletta Daponte, George Valasoulis, Georgios Michail, Ioulia Magaliou, Athina-Ioanna Daponte, Antonios Garas, Ioanna Grivea, Dimitrios P. Bogdanos, Alexandros Daponte
Summary: Dynamic adaptations in global health during the SARS-CoV-2 pandemic have led to the increased use of self-sampling for cervical screening, which plays a crucial role in improving screening uptake and coverage. Self-sampling is an important component of the WHO's global strategy to eliminate cervical cancer and has the potential to reduce health disparities. However, there is a need for effective strategies to ensure follow-up testing and management for individuals with positive self-sampling results.
Editorial Material
Virology
Guorong Li, Maryame Lamsisi, Sara Chenafi, Louise Moniod, Abdelhamid Benlghazi, Moulay Mustapha Ennaji, Celine Chauleur, Thomas Bourlet
Summary: Cervical cancer can be prevented by detecting the human papillomavirus (HPV). The World Health Organization called for the elimination of cervical cancer by 2030 and regular screening programs are crucial. However, low screening rates in both developing and developed countries hinder progress due to women's reluctance to participate in gynecologic examinations. Urine-based HPV detection is a convenient and affordable solution to improve screening coverage, but standardized tests are currently lacking. Optimizing protocols and standardizing urinary HPV detection will facilitate its clinical implementation, contributing significantly to WHO's goal of global elimination of cervical cancer.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Marc Arbyn, Philip E. Castle, Mark Schiffman, Nicolas Wentzensen, Brandy Heckman-Stoddard, Vikrant V. Sahasrabuddhe
Summary: This study conducted a meta-analysis to compare the test agreement and concordance between HPV testing in self-collected and clinician-collected samples. The overall agreement was found to be 88.7%, with higher agreement observed for target amplification-based DNA assays.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Jacqueline Mix, Mona Saraiya, Benjamin D. Hallowell, Brian Befano, Li C. Cheung, Elizabeth R. Unger, Julia W. Gargano, Lauri E. Markowitz, Philip E. Castle, Tina Raine-Bennett, Joan Walker, Rosemary Zuna, Mark Schiffman, Nicolas Wentzensen, Julia C. Gage
Summary: Racial and ethnic differences exist in the attribution of cervical precancer and cancer to HPV types. The 9-valent HPV vaccine is effective in preventing most cases of precancers and invasive cancers among major racial and ethnic groups. Adding HPV35 to vaccines could provide additional protection, particularly for Black women.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Environmental Sciences
Kyoko Miura, Minas Coroneo, Jean Claude Dusingize, Catherine M. Olsen, Rick Tinker, Ken Karipidis, Ian Hosegood, Adele C. Green
Summary: This study estimated the prevalence of cataract in pilots by analyzing medical records of commercial airline pilots diagnosed with cataract between 2011 and 2016. The results showed that the prevalence of cataract in pilots aged 60 and above was 11.6%, while it was only 0.5% in pilots aged below 60. The study also found that there was no significant difference in cataract prevalence based on the ambient ultraviolet radiation levels, although the lowest prevalence was observed in the low-UV state of Victoria. Furthermore, cataracts in pilots aged 60 and above were mostly bilateral and mild, while cataracts in pilots below 60 were more likely to be unilateral and severe.
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2023)
Article
Dermatology
David C. Whiteman, Catherine M. Olsen, Stuart MacGregor, Matthew H. Law, Bridie Thompson, Jean Claude Dusingize, Adele C. Green, Rachel E. Neale, Nirmala Pandeya
Summary: This study suggests that people who undergo skin screening or biopsies have higher rates of biopsies and melanoma, even after adjusting for all known risk factors. This indicates that increased surveillance leads to the diagnosis of melanomas that may not have otherwise been detected.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Oncology
Philip E. Castle, Nicolas Wentzensen
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Camryn M. Cohen, Nicolas Wentzensen, Philip E. Castle, Mark Schiffman, Rosemary Zuna, Rebecca C. Arend, Megan A. Clarke
Summary: This study conducted an integrated population-based analysis on histologic subtype-specific cervical cancer incidence, survival, and incidence-based mortality among different races and ethnicities. The results showed that Black and Hispanic women had the highest incidence rates of cervical squamous cell carcinoma, while Hispanic and White women had the highest incidence rates of cervical adenocarcinoma. Black women had the highest overall mortality rates and lowest 5-year relative survival.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Letter
Dermatology
Jean Claude Dusingize, Catherine M. M. Olsen, Matthew H. H. Law, Nirmala Pandeya, Rachel E. E. Neale, Stuart MacGregor, David C. C. Whiteman, Jue-Sheng Ong
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Oncology
Lori M. Minasian, Paul Pinsky, Hormuzd A. Katki, Tony Dickherber, Paul K. J. Han, Lyndsay Harris, Christos Patriotis, Sudhir Srivastava, Carol J. Weil, Philip C. Prorok, Philip E. Castle
Summary: This article introduces a blood-based assay for multicancer early detection and highlights the need for a randomized controlled trial (RCT) to determine its clinical effectiveness. Screening for multiple cancers simultaneously presents new challenges, including diagnostic workup, follow-up, potential harms, dissemination strategies, and ethical implications. The development of a flexibly designed RCT is necessary to fully understand the benefits and risks of this promising technology.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Biochemical Research Methods
Chelsey A. Smith, Megan M. Chang, Kathryn A. Kundrod, Emilie N. Novak, Sonia G. Parra, Leticia Lopez, Celda Mavume, Cesaltina Lorenzoni, Mauricio Maza, Mila P. Salcedo, Jennifer L. Carns, Ellen Baker, Jane Montealegre, Michael Scheurer, Philip E. Castle, Kathleen M. Schmeler, Rebecca R. Richards-Kortum
Summary: This study developed a low-cost and point-of-care cervical cancer screening test using a two-dimensional paper network. The test can detect high-risk HPV DNA within an hour, overcoming the limitations of expensive and complicated laboratory-based tests. Its performance was evaluated in both controlled laboratory settings and field settings, showing promise for use in low-resource settings.
Article
Health Care Sciences & Services
Madleen Orumaa, Suzanne Campbell, Nathalie C. Stoer, Philip E. Castle, Sagar Sen, Ameli Trope, Adebola Adedimeji, Mari Nygard
Summary: Exposure to the FightHPV mobile app gamified educational content significantly increased cervical cancer screening attendance and improved detection of women with high risk for cervical cancer.
JMIR SERIOUS GAMES
(2022)
Article
Virology
Louiza S. Veientzis, David Hawkes, Michael Caruanaa, Julia ML. Brotherton, Megan A. Smith, Lara Roeske, Khurram A. Karim, Suzanne M. Garland, C. David Wrede, Jeffery Tan, Cosette Wheeler, Philip E. Castle, Marion Saville, Karen Canfell
Summary: Australia's cervical screening program transitioned to HPV testing in December 2017 and we investigated the impact of the HPV vaccination program on HPV16/18 prevalence. The results showed a significant reduction in HPV16/18 prevalence after vaccination compared to pre-vaccination levels.
TUMOUR VIRUS RESEARCH
(2023)
Editorial Material
Oncology
Marc Arbyn, Stefanie Costa, Ardashel Latsuzbaia, Eliane Kellen, Paolo Girogi Rossi, Clementina E. Cocuzza, Partha Basu, Philip E. Castle
Summary: In 2017, cervical cancer screening in the Netherlands was switched to HPV testing using cobas 4800. Women were provided with a self-sampling kit for free and could collect samples at home. Initially, only 7% of tests were done through self-sampling, but with improved promotion and accessibility, the proportion increased to 16% in 2020. Self-sampling showed lower HPV positivity and detection rate of precancer compared to clinician sampling, suggesting a need for optimization in handling and testing protocols.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Jack Cuzick, Rachael Adcock, Walter E. Kinney, Philip E. Castle, Michael M. Robertson, Ruth M. H. McDonald, Mark H. Stoler, Ruofei M. Du, Cosette M. Wheeler
Summary: HPV testing increases the diagnosis of precancer and reduces the incidence of cervical cancer more than cytology alone. A real-world evidence study conducted in New Mexico showed that adding HPV testing to cytology substantially increased the detection of CIN2+ and CIN3+ cases, supporting primary HPV-only screening in the United States.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Editorial Material
Oncology
Philip E. Castle
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Dermatology
Nirmala Pandeya, Jean Claude Dusingize, Catherine M. Olsen, Stuart Macgregor, Rachel E. Neale, Matthew H. Law, David C. Whiteman
Summary: Genetic risk is weakly associated with melanoma incidence and screening behavior, but it does not explain the higher rate of melanoma detection between screened and unscreened individuals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
