Review
Biology
Wei-qiao Rao, Konstantinos Kalogeropoulos, Morten E. Allentoft, Shyam Gopalakrishnan, Wei-ning Zhao, Christopher T. Workman, Cecilie Knudsen, Belen Jimenez-Mena, Lorenzo Seneci, Mahsa Mousavi-Derazmahalleh, Timothy P. Jenkins, Esperanza Rivera-de-Torre, Si-qi Liu, Andreas H. Laustsen
Summary: Snake venoms contain bioactive proteins that can be used for drug discovery, and the evolution of snake venom proteins is driven by gene duplication and positive selection. Snake genomics is still in its early stages but has the potential to provide insights into venom evolution and toxinology. The presence of repeat sequences in snake genomes poses challenges for DNA sequencing, but advances in sequencing technologies and computational tools have improved our understanding of snake venom evolution.
Review
Neurosciences
Yang Ying, Jian-Zhi Wang
Summary: Alzheimer's disease is the most common neurodegenerative disorder with no cure currently available. Dysfunction in neural circuits is the main mechanism behind the learning and memory deficits in AD patients. Understanding the structural features and mechanisms of deregulated circuits during AD progression is crucial for developing new tools for intervention. New experimental approaches and key techniques have been established to trace and manipulate neural circuits, aiding in the discovery of circuit mechanisms underlying beta-amyloid and tau pathologies in AD progression, as well as in the development of targeted treatments.
NEUROSCIENCE BULLETIN
(2021)
Article
Multidisciplinary Sciences
Rok Kostanjsek, Borge Diderichsen, Hans Recknagel, Nina Gunde-Cimerman, Cene Gostincar, Guangyi Fan, Dusan Kordis, Peter Trontelj, Hui Jiang, Lars Bolund, Yonglun Luo
Summary: Deciphering the genetic code of the cave salamander Proteus anguinus, also known as the olm, can help answer biological questions and provide insight into adaptive mechanisms. The formation of an international Proteus Genome Research Consortium aims to decode the large genome of the olm, which is challenging but promising for important outcomes.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Genetics & Heredity
Xabier Vergara, Ruben Schep, Rene H. Medema, Bas van Steensel
Summary: The traditional methods for studying DNA repair rely on fluorescence read-outs, while high throughput sequencing (HTS) has created new opportunities to understand the mechanisms behind double-strand break (DSB) repair.
Review
Chemistry, Multidisciplinary
Junseong Ahn, Hanhwi Jang, Yongrok Jeong, Seongsu Choi, Jiwoo Ko, Soon Hyoung Hwang, Jun-Ho Jeong, Yeon Sik Jung, Inkyu Park
Summary: This review comprehensively analyzes the development and application of nanotransfer printing (nTP) technology in response to the increasing demand for diverse nanostructures in physical/chemical devices. The review discusses the improvements made by researchers over the past decade in nTP technology and the methods and challenges for achieving high-yield and versatile printing through the control of adhesion force. Additionally, the review provides insights into potential applications of nanostructured devices and prospects for future developments and innovations.
Article
Chemistry, Multidisciplinary
Kyoka Sakamoto, Yuki Nagashima, Chao Wang, Kazunori Miyamoto, Ken Tanaka, Masanobu Uchiyama
Summary: The study developed a method for stannylation reactions of terminal alkynes and fluoroarenes, where stannyl anions are photoexcited to form excited triplet stannyl diradical species, showing distinct reactivity and selectivity. This methodology is straightforward, has wide functional group tolerance, high yield, and does not require any catalyst.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Qais Al Rawahi, Jose Luis Mijangos, Mehar S. Khatkar, Mohammed A. Al Abri, Mansoor H. AlJahdhami, Jennifer Kaden, Helen Senn, Katherine Brittain, Jaime Gongora
Summary: Through studying the genetic diversity of Arabian oryx, we found that individuals at the Al-Wusta Wildlife Reserve in Oman contain 58% of the total mtDNA diversity observed globally. We also identified three ancestral sources and three different groups of individuals. These findings are valuable for guiding breeding and reintroduction programs.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Shaoshan Zhang, Jun-zhang Qu-Bie, Ming-kang Feng, A-xiang Qu-Bie, Yanfei Huang, Zhi-feng Zhang, Xin-jia Yan, Yuan Liu
Summary: By combining NGS and SMRT, we generated a corrective full-length transcriptome with 30,827 unigenes of P. veitchii, and systematically characterized the enzymes involved in the biosynthesis of PMGs. Through WGCNA analysis, we identified the relationships between these genes and PMGs. We obtained 8 TPSs, 22 CYPs, 7 UGTs, and 2 BAHD genes, which are likely to be involved in the biosynthesis of PMGs.
Editorial Material
Biochemistry & Molecular Biology
Yichen Liu, E. Andrew Bennett, Qiaomei Fu
Summary: Ancient DNA techniques have advanced significantly in the past decade, enabling large-scale research independent of human remains. Future directions include expanding research scope and gaining insights into present-day human health.
Article
Astronomy & Astrophysics
Miguel G. Echevarria
Summary: The QED extension of the nucleon spin sum rule is investigated in this study. The LO QED evolution kernels of the quark/gluon helicity and orbital-angular momentum distributions are calculated, along with the introduced lepton and photon analog distributions. The study confirms the scale invariance of the nucleon spin sum rule in QCD x QED.
Article
Microbiology
Daniela Mollova, Mariyana Gozmanova, Elena Apostolova, Galina Yahubyan, Ilia Iliev, Vesselin Baev
Summary: Lactiplantibacillus plantarum is a diverse species of lactic acid bacteria found in various ecological niches. This study focused on the L. plantarum PU3 strain, which has potential as a probiotic agent. Genomic analysis revealed the strain's genetic determinants for various beneficial traits, while phenotypic analysis confirmed its tolerance to challenging environments. The absence of virulence factors and the presence of potential antimicrobial activity further highlight its promising potential for probiotic and therapeutic applications.
Article
Biology
Chu Cheng, Pengfeng Xiao
Summary: Next-generation sequencing holds great potential for precision medicine, but current technologies have limitations in accuracy. To overcome this, a correctable decoding sequencing strategy with conservative error rates is proposed. This strategy shows promise in sequence decoding, error correction, and sequencing accuracy, and can be used as an alternative to existing NGS platforms.
LIFE SCIENCE ALLIANCE
(2022)
Article
Medicine, Research & Experimental
Wen-Xuan Zhou, Shu Wang, Ting-Chao Wu, Ling-Chao Cheng, Yao Du, Wei Wu, Chen Lin, Xin-Ying Li, Zhong-Liang Hu
Summary: In this study, the transcriptome and DNA methylation profiles of parathyroid adenoma were analyzed, and several candidate genes that may be involved in the pathogenesis of PHPT were identified. Among them, hypermethylation of the POMC promoter may contribute to its low expression, which may be involved in the development of PHPT.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Biochemistry & Molecular Biology
Darshana Gupta, Chase L. Beisel
Summary: Two publications in Cell utilize a new high-throughput screen to study the relationship between DNA repair pathways and repair outcomes, providing insights into the mechanism of repair process and ways to shape editing outcomes.
Editorial Material
Multidisciplinary Sciences
Carla Umansky, Agustin E. Morellato, Lucas B. Pontel
Summary: The study introduced a genetically encoded sensor for formaldehyde detection in cells and tissues, shedding light on an elusive cellular metabolite and potentially revolutionizing formaldehyde research.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Robert D. Stewart, Marc D. Auffret, Amanda Warr, Andrew H. Wiser, Maximilian O. Press, Kyle W. Langford, Ivan Liachko, Timothy J. Snelling, Richard J. Dewhurst, Alan W. Walker, Rainer Roehe, Mick Watson
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Sarah J. Meale, Marc D. Auffret, Mick Watson, Diego P. Morgavi, Gonzalo Cantalapiedra-Hijar, Carol-Anne Duthie, Rainer Roehe, Richard J. Dewhurst
SCIENTIFIC REPORTS
(2018)
Article
Biochemical Research Methods
Robert D. Stewart, Marc D. Auffret, Timothy J. Snelling, Rainer Roehe, Mick Watson
Letter
Biotechnology & Applied Microbiology
Mick Watson, Amanda Warr
NATURE BIOTECHNOLOGY
(2019)
Article
Genetics & Heredity
Thomas W. Marchant, Elisabeth Dietschi, Ulrich Rytz, Peter Schawalder, Vidhya Jagannathan, Sheida Hadji Rasouliha, Corinne Gurtner, Andreas S. Waldvogel, Ronan S. Harrington, Michaela Droegemueller, Jeffrey Kidd, Elaine A. Ostrander, Amanda Warr, Mick Watson, David Argyle, Gert Ter Haar, Dylan N. Clements, Tosso Leeb, Jeffrey J. Schoenebeck
Article
Virology
Yaoyao Zhang, Na Tang, Jun Luo, Man Teng, Katy Moffat, Zhiqiang Shen, Mick Watson, Venugopal Nair, Yongxiu Yao
JOURNAL OF VIROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Fahmi W. Nazarie, Barbara Shih, Tim Angus, Mark W. Barnett, Sz-Hau Chen, Kim M. Summers, Karsten Klein, Geoffrey J. Faulkner, Harpreet K. Saini, Mick Watson, Stijn van Dongen, Anton J. Enright, Tom C. Freeman
NUCLEIC ACIDS RESEARCH
(2019)
Article
Virology
Anna Eleonora Karagianni, Deepali Vasoya, Jeanie Finlayson, Henny M. Martineau, Ann R. Wood, Chris Cousens, Mark P. Dagleish, Mick Watson, David J. Griffiths
JOURNAL OF VIROLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Robert D. Stewart, Marc D. Auffret, Amanda Warr, Alan W. Walker, Rainer Roehe, Mick Watson
NATURE BIOTECHNOLOGY
(2019)
Article
Genetics & Heredity
Joana Lima, Marc D. Auffret, Robert D. Stewart, Richard J. Dewhurst, Carol-Anne Duthie, Timothy J. Snelling, Alan W. Walker, Tom C. Freeman, Mick Watson, Rainer Roehe
FRONTIERS IN GENETICS
(2019)
Article
Microbiology
Laura Glendinning, Kellie A. Watson, Mick Watson
Article
Microbiology
Timothy J. Snelling, Marc D. Auffret, Carol-Anne Duthie, Robert D. Stewart, Mick Watson, Richard J. Dewhurst, Rainer Roehe, Alan W. Walker
Article
Biotechnology & Applied Microbiology
Derek M. Bickhart, Mick Watson, Sergey Koren, Kevin Panke-Buisse, Laura M. Cersosimo, Maximilian O. Press, Curtis P. Van Tassell, Jo Ann S. Van Kessel, Bradd J. Haley, Seon Woo Kim, Cheryl Heiner, Garret Suen, Kiranmayee Bakshy, Ivan Liachko, Shawn T. Sullivan, Phillip R. Myer, Jay Ghurye, Mihai Pop, Paul J. Weimer, Adam M. Phillippy, Timothy P. L. Smith
Article
Biodiversity Conservation
Sunitha Joseph, Rebecca E. O'Connor, Abdullah F. Al Mutery, Mick Watson, Denis M. Larkin, Darren K. Griffin
Review
Biotechnology & Applied Microbiology
Christine Tait-Burkard, Andrea Doeschl-Wilson, Mike J. McGrew, Alan L. Archibald, Helen M. Sang, Ross D. Houston, C. Bruce Whitelaw, Mick Watson
