Review
Plant Sciences
Zhiyang Zhai, Jantana Keereetaweep, Hui Liu, Changcheng Xu, John Shanklin
Summary: Photosynthates such as glucose and sucrose play dual roles in plant cell metabolism, acting as substrates for fatty acid biosynthesis and signaling molecules. Recent research has shown that trehalose 6-phosphate and 2-oxoglutarate directly regulate fatty acid biosynthesis by modulating transcription factors and enzyme activities.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Maud Bernoux, Jian Chen, Xiaoxiao Zhang, Kim Newell, Jian Hu, Laurent Deslandes, Peter Dodds
Summary: Recent research has uncovered the activation mechanism of plant intracellular immune receptors, known as NLRs, in triggering immune responses upon pathogen effector recognition. The activation of TNLs induces receptor oligomerization and close proximity of the TIR domain, leading to TIR enzymatic activity. Signaling molecules produced by the TIR domain bind to EDS1 family proteins, which in turn activate downstream NLRs, resulting in immune responses and cell death. Understanding the subcellular localization requirements of TNLs and signaling partners is crucial for comprehending early NLR signaling.
Article
Plant Sciences
Leonor Margalha, Alexandre Elias, Borja Belda-Palazon, Bruno Peixoto, Ana Confraria, Elena Baena-Gonzalez
Summary: Plants need HOS1 as a signal integrator to respond to various stresses, including cold, heat, light, and salinity. Defects in HOS1 result in reduced induction of starvation genes and decreased tolerance to prolonged darkness, highlighting the importance of HOS1 for plant survival under low-energy conditions. HOS1 promotes the nuclear accumulation of SnRK1a1, which is crucial for plant tolerance to low-energy stress.
Review
Plant Sciences
Qingshuai Chen, Jing Zhang, Gang Li
Summary: This article summarizes recent progress in uncovering the epigenetic mechanisms involved in sugar signal transduction, as well as the interactions between sugar signaling and light, temperature, and phytohormone signaling pathways.
TRENDS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yutong Liu, Yunshu Bai, Ning Li, Mengting Li, Wenxin Liu, Dae-Jin Yun, Bao Liu, Zheng-Yi Xu
Summary: This study reveals that the glucose sensor HXK1 interacts with Polycomb Repressive Complex 2 subunits SWN and CLF to regulate glucose signaling in Arabidopsis thaliana. They target glucose-responsive genes and function in the same genetic pathway. HXK1 is also involved in histone modification and gene repression, and CLF and SWN affect the recruitment of HXK1 to chromatin.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Plant Sciences
Wang Chen, Yan Li, Ruibin Yan, Li Ren, Fan Liu, Lingyi Zeng, Shengnan Sun, Huihui Yang, Kunrong Chen, Li Xu, Lijiang Liu, Xiaoping Fang, Shengyi Liu
Summary: Plants have evolved strategies to combat pathogen infection, with SnRK1 playing a role in enhancing resistance. The interaction between PBZF1 and SnRK1.1 was found to inhibit the latter's biological functions, promoting plant susceptibility to clubroot disease. This study provides insights into plant resistance and genetic improvement against clubroot disease caused by the plant-pathogenic protist P. brassicae.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Plant Sciences
Tengfei Liu, Md Abu Kawochar, Shahnewaz Begum, Enshuang Wang, Tingting Zhou, Shenglin Jing, Tiantian Liu, Liu Yu, Bihua Nie, Botao Song
Summary: Cold-induced sweetening is a severe issue in the potato processing industry. This study identifies StTST1 as the sugar transporter with the highest expression in potato tubers during postharvest cold storage. Knockdown of StTST1 reduces sugar accumulation and improves the frying quality of cold-stored tubers. Suppression of StTST1 promotes starch synthesis and inhibits starch degradation, possibly through the down-regulation of beta-amylase StBAM1. These findings provide a new strategy to improve the quality of cold-stored potatoes and reduce acrylamide content in potato chips.
HORTICULTURE RESEARCH
(2023)
Review
Plant Sciences
Bruno Peixoto, Elena Baena-Gonzalez
Summary: SUCROSE NON-FERMENTING1 (SNF1)-RELATED KINASE 1 (SnRK1) is an important protein kinase in plant stress responses and metabolic homeostasis. It plays a key role in reconfiguring metabolism and gene expression to enhance stress tolerance and maintain sucrose levels.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Azkia Khan, Jintao Cheng, Anastasia Kitashova, Lisa Fuertauer, Thomas Naegele, Cristiana Picco, Joachim Scholz-Starke, Isabel Keller, H. Ekkehard Neuhaus, Benjamin Pommerrenig
Summary: The ERDL4 protein in Arabidopsis is involved in fructose allocation and regulation of monosaccharide balance in the vacuolar membrane. Overexpression of ERDL4 increases total sugar levels by upregulating TST2 expression. ERDL4 activity is regulated by diurnal rhythm and cold acclimation and contributes to plant organ development and stress tolerance.
Article
Plant Sciences
Anastasia Kitashova, Stephan O. Adler, Andreas S. Richter, Svenja Eberlein, Dejan Dziubek, Edda Klipp, Thomas Nagele
Summary: Cold acclimation is a complex process involving multiple genes in plants, which helps them increase their tolerance to freezing temperatures. The stabilization of photosynthesis and carbohydrate metabolism is crucial for this process. This study examined the regulation of primary and secondary metabolism in Arabidopsis thaliana during cold acclimation by exposing metabolic mutants with deficiencies in starch or flavonoid metabolism to 4 degrees C. The results showed that starch deficiency delayed the accumulation of soluble sugars during cold acclimation, while starch overaccumulation led to lower total amounts of sucrose and glucose. Additionally, anthocyanin amounts were decreased in both starch-deficient and starch-overaccumulating mutants. Mathematical modelling indicated that sucrose biosynthesis kinetics played a limiting role in carbon partitioning during cold exposure, suggesting the central role of sucrose phosphate synthase activity in stabilizing photosynthesis and metabolism at low temperatures.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Plant Sciences
Laura Kathrine Perby, Simon Richter, Konrad Weber, Alina Johanna Hieber, Natalia Hess, Christoph Crocoll, Helle Kildal Mogensen, Mathias Pribil, Meike Burow, Tom Hamborg Nielsen, Angelika Mustroph
Summary: This study focuses on four major cytosolic isoforms of PFK in A. thaliana and their effects on growth and metabolism. The results show that PFK1 and PFK7 play important roles in sugar homeostasis in leaf metabolism and source-sink relationships, while PFK3 and PFK6 have minor roles under normal growth conditions.
Review
Plant Sciences
Hsing-Yi Cho, Elena Loreti, Ming-Che Shih, Pierdomenico Perata
Summary: The main consequence of hypoxia is a significant reduction in energy production. Oxygen and energy sensing converge to induce an adaptive response at both the transcriptional and translational levels, ensuring survival and conserving energy consumption.
Article
Plant Sciences
Bhuwaneshwar Sharan Mishra, Mohan Sharma, Ashverya Laxmi
Summary: In the natural environment, plants utilize sugar molecules and phytohormones to coordinate growth and survival, affecting physiological processes from seed germination to senescence. Sugars not only serve as energy resources and structural components but also function as signaling molecules interacting with plant hormones, stress, and other pathways. Phytohormone auxin plays a crucial role in various stages of the plant life cycle and response to dynamic environments for optimal growth and development.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Environmental Sciences
Youngjae Pyo, Heewon Moon, Adji Baskoro Dwi Nugroho, Seong Wook Yang, Il Lae Jung, Dong-Hwan Kim
Summary: Strontium, particularly its radioactive isotope Sr-90, poses a global threat to the environment and human health. The molecular mechanisms underlying plant response to Sr toxicity remain largely unknown. This study used RNA-seq analysis to compare gene expression profiles between control and Sr-treated plants, revealing that the JA biosynthesis and/or signaling pathway may play important roles in plant response to Sr stress, maintaining proper growth and development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Multidisciplinary Sciences
Zhi-Ling Yang, Hussam Hassan Nour-Eldin, Sabine Haenniger, Michael Reichelt, Christoph Crocoll, Fabian Seitz, Heiko Vogel, Franziska Beran
Summary: The study identified glucosinolate transporters expressed in the Malpighian tubules of the herbivorous horseradish flea beetle, providing evidence that these transporters reabsorb glucosinolates from the tubule lumen to prevent their loss by excretion.
NATURE COMMUNICATIONS
(2021)
Article
Soil Science
Arindam Ghatak, Florian Schindler, Gert Bachmann, Doris Engelmeier, Prasad Bajaj, Martin Brenner, Lena Fragner, Rajeev K. Varshney, Guntur Venkata Subbarao, Palak Chaturvedi, Wolfram Weckwerth
Summary: Root exudates play a crucial role in shaping soil microbial communities, with genotype-specific responses observed under drought stress. Changes in root exudation under drought stress can influence soil microbial adaptation and survival mechanisms, highlighting the importance of understanding these interactions for plant resilience.
BIOLOGY AND FERTILITY OF SOILS
(2022)
Review
Biotechnology & Applied Microbiology
Nelofer Jan, Asif Mohi-Ud-Din Rather, Riffat John, Palak Chaturvedi, Arindam Ghatak, Wolfram Weckwerth, Sajad Majeed Zargar, Rakeeb Ahmad Mir, Mohd Anwar Khan, Reyazul Rouf Mir
Summary: Legumes are important crops in agriculture, but their productivity is reduced due to environmental stress. Proteomics provides a molecular approach to understand stress response in legumes. This review discusses different proteomic approaches and their role in identifying stress-responsive proteins in leguminous crops under various abiotic stresses. The analysis reveals the involvement of proteins related to photosynthesis, metabolism, defense, and stress adaptation in legume response to stress.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2023)
Editorial Material
Plant Sciences
Tom W. N. Walker, Jake M. Alexander, Pierre-Marie Allard, Oliver Baines, Virginie Baldy, Richard D. Bardgett, Pol Capdevila, Phyllis D. Coley, Bruno David, Emmanuel Defossez, Maria-Jose Endara, Madeleine Ernst, Catherine Fernandez, Dale Forrister, Albert Gargallo-Garriga, Vincent E. J. Jassey, Sue Marr, Steffen Neumann, Loic Pellissier, Josep Penuelas, Kristian Peters, Sergio Rasmann, Ute Roessner, Jordi Sardans, Franziska Schrodt, Meredith C. Schuman, Abrianna Soule, Henriette Uthe, Wolfram Weckwerth, Jean-Luc Wolfender, Nicole M. van Dam, Roberto Salguero-Gomez
Summary: We review the potential of the metabolome to enhance trait-based ecology and improve our understanding of plant and ecosystem functioning. We explore the relationship between the metabolome and plant functional traits, discuss life-history trade-offs and plasticity in shaping fitness, and propose solutions to challenges in acquiring and interpreting metabolome data. The Special Feature studies examine mechanisms behind plant community assembly, plant-organismal interactions, and effects of plants and soil microorganisms on ecosystem processes.
JOURNAL OF ECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maike Werning, Verena Dobretzberger, Martin Brenner, Ernst W. Mullner, Georg Mlynek, Kristina Djinovic-Carugo, David M. Baron, Lena Fragner, Almut T. Bischoff, Boriana Buchner, Thomas Klopstock, Wolfram Weckwerth, Ulrich Salzer
Summary: Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene. Metabolic changes in erythrocytes of PKAN patients are associated with reduced cytoplasmic acetyl-CoA levels in neurons and aberrant brain iron regulation.
Article
Health Care Sciences & Services
Felix Tretter, Eva M. J. Peters, Joachim Sturmberg, Jeanette Bennett, Eberhard Voit, Johannes W. Dietrich, Gary Smith, Wolfram Weckwerth, Zvi Grossman, Olaf Wolkenhauer, James A. Marcum
Summary: This paper argues that data-driven analysis alone is insufficient for understanding the COVID-19 pandemic and for justifying public health regulations. It emphasizes the need for over-arching hypothesis-related and/or theory-based rationales to conduct effective research on SARS-CoV2/COVID-19.
JOURNAL OF EVALUATION IN CLINICAL PRACTICE
(2023)
Article
Plant Sciences
Anastasia Kitashova, Stephan O. Adler, Andreas S. Richter, Svenja Eberlein, Dejan Dziubek, Edda Klipp, Thomas Nagele
Summary: Cold acclimation is a complex process involving multiple genes in plants, which helps them increase their tolerance to freezing temperatures. The stabilization of photosynthesis and carbohydrate metabolism is crucial for this process. This study examined the regulation of primary and secondary metabolism in Arabidopsis thaliana during cold acclimation by exposing metabolic mutants with deficiencies in starch or flavonoid metabolism to 4 degrees C. The results showed that starch deficiency delayed the accumulation of soluble sugars during cold acclimation, while starch overaccumulation led to lower total amounts of sucrose and glucose. Additionally, anthocyanin amounts were decreased in both starch-deficient and starch-overaccumulating mutants. Mathematical modelling indicated that sucrose biosynthesis kinetics played a limiting role in carbon partitioning during cold exposure, suggesting the central role of sucrose phosphate synthase activity in stabilizing photosynthesis and metabolism at low temperatures.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Biochemistry & Molecular Biology
Andreas S. Richter, Thomas Naegele, Bernhard Grimm, Kerstin Kaufmann, Michael Schroda, Dario Leister, Tatjana Kleine
Summary: Plastids communicate with the nucleus through retrograde signaling to regulate nuclear gene expression. Plastid biogenesis and responses of mature chloroplasts to environmental changes are controlled through biogenic and operational controls, respectively. The functions of GUN proteins in retrograde signaling and the controversy surrounding GUN1 are discussed in this review, along with recent progress in understanding chloroplast-derived signals in acclimation response and flavonoid biosynthesis.
PLANT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Max-Emanuel Zirngibl, Galileo Estopare Araguirang, Anastasia Kitashova, Kathrin Jahnke, Tobias Rolka, Christine Kuehn, Thomas Naegele, Andreas S. Richter
Summary: Plants use multiple strategies to adapt to rapid environmental changes, and during high light acclimation, the biosynthesis of photoprotective flavonoids is induced through carbon fixation, export of photosynthates, and an increase in cellular sugar content. Reactive oxygen species and phytohormones play a minor role, while sugar signaling is vital for the activation of anthocyanin biosynthesis.
PLANT COMMUNICATIONS
(2023)
Article
Agronomy
Jakob Sebastian Hernandez, Thomas Naegele
Summary: The photorespiratory pathway in plants, which involves metabolic reactions across different cellular compartments, is influenced by the dual function of Rubisco. This enzyme can either facilitate carboxylation or oxygenation of ribulose-1,5-bisphosphate, resulting in the production of different metabolites. The process of oxygenation stabilizes the Calvin-Benson-Bassham cycle and plant metabolism, suggesting a trade-off between carbon assimilation rates and metabolic regulation plasticity.
Article
Plant Sciences
Jakob Weiszmann, Dirk Walther, Pieter Clauw, Georg Back, Joanna Gunis, Ilka Reichardt, Stefanie Koemeda, Jakub Jez, Magnus Nordborg, Jana Schwarzerova, Iro Pierides, Thomas Naegele, Wolfram Weckwerth
Summary: The plasticity of primary metabolism in Arabidopsis accessions is influenced by their geographical origin. Variations in metabolism, growth parameters, and metabolite profiles were observed in 241 natural accessions grown under different temperature regimes. The plasticity of metabolism and growth rates could be predicted based on genetic variation, and habitat temperature was found to be the main driver of evolutionary cold adaptation processes.
Article
Multidisciplinary Sciences
Dario Leister, Anurag Sharma, Natalia Kerber, Thomas Naegele, Bennet Reiter, Viviana Pasch, Simon Beeh, Peter Jahns, Roberto Barbato, Mathias Pribil, Thilo Ruehle
Summary: In this study, it was found that the activity of Rubisco, the major catalyst in carbon dioxide conversion, is impaired by inhibitory sugars. The loss of two phosphatases in plants negatively affects plant growth and photosynthesis, but this effect can be reversed by introducing a XuBP phosphatase from Rhodobacter sphaeroides. This finding demonstrates the physiological importance of a metabolite damage-repair system in degradation of Rubisco by-products and has implications for carbon fixation optimization in photosynthetic organisms.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Georgi Dermendjiev, Madeleine Schnurer, Ethan Stewart, Thomas Naegele, Giada Marino, Dario Leister, Alexandra Thuer, Stefan Plott, Jakub Jez, Verena Ibl
Summary: Roots are important for plants to anchor themselves in soil and absorb water and nutrients. The root system is influenced by the surrounding environment, and it is crucial to study root development under natural conditions. A new device called DRD-BIBLOX has been developed to study roots in the dark, preventing light-induced changes in root morphology.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Anastasia Kitashova, Vladimir Brodsky, Palak Chaturvedi, Iro Pierides, Arindam Ghatak, Wolfram Weckwerth, Thomas Naegele
Summary: A plant's genome encodes the proteins necessary for metabolism, and its interactions with the environment affect its growth, development, and adaptation to adverse conditions. Despite advances in genome sequencing technologies, predicting metabolic phenotypes from genotype x environment interactions remains incomplete. Understanding the dependence and expression of molecular organization levels in growth conditions is a current challenge.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Article
Plant Sciences
Azkia Khan, Jintao Cheng, Anastasia Kitashova, Lisa Fuertauer, Thomas Naegele, Cristiana Picco, Joachim Scholz-Starke, Isabel Keller, H. Ekkehard Neuhaus, Benjamin Pommerrenig
Summary: The ERDL4 protein in Arabidopsis is involved in fructose allocation and regulation of monosaccharide balance in the vacuolar membrane. Overexpression of ERDL4 increases total sugar levels by upregulating TST2 expression. ERDL4 activity is regulated by diurnal rhythm and cold acclimation and contributes to plant organ development and stress tolerance.
Proceedings Paper
Computer Science, Interdisciplinary Applications
Jana Schwarzerova, Iro Pierides, Karel Sedlar, Wolfram Weckwerth
Summary: Metabolite analysis in human health care presents challenges and opportunities in the prevention and early detection of diseases, with the potential to create breakthroughs in diagnostic techniques. It is linked to biomedical applications and offers an ideal tool for preventive healthcare and the pharmaceutical industry.
BIOINFORMATICS AND BIOMEDICAL ENGINEERING, PT I
(2022)