Review
Plant Sciences
Su Yin Phua, Barbara De Smet, Claire Remacle, Kai Xun Chan, Frank Van Breusegem
Summary: The evolution of photosynthesis in plants has been crucial but has also led to challenges in the form of reactive oxygen species (ROS) production. Multiple forms of ROS are generated in various plant cell compartments, requiring a sophisticated network of ROS detoxification and signaling tailored to individual organelles to safeguard the cell as a whole.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Biochemistry & Molecular Biology
Kexing Xin, Ting Pan, Shan Gao, Shunping Yan
Summary: The study revealed that the transcription factor NAC102 in Arabidopsis localizes in both chloroplasts and the nucleus, and interacts with chloroplast RNA polymerases, functioning as a repressor in chloroplasts. This discovery indicates that transcription factors are new regulators of chloroplast gene expression and can also operate in chloroplasts, besides the nucleus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemical Research Methods
Shintaro Ichikawa, Shota Kato, Yuta Fujii, Kazuya Ishikawa, Keiji Numata, Yutaka Kodama
Summary: In this study, we artificially controlled chloroplast-chloroplast interactions in living plant cells using the organelle glue (ORGL) technique. By targeting different fragments of a fluorescent protein to specific locations, we modulated the frequency of chloroplast-chloroplast interactions.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shao-Ting Chiu, Wen-Wei Tseng, An-Chi Wei
Summary: Mitochondria, semi-autonomous organelles in eukaryotic cells, play a crucial role in energy production and metabolism. This study proposed a mathematical model to simulate the signaling process between mitochondria and the nucleus in response to mitochondrial damage. The dynamics and robustness of the signaling pathway were analyzed, providing insights for drug design against yeast and fungi.
Review
Biochemistry & Molecular Biology
Janine Hertzog Santos
Summary: Epigenetic modifications are influenced by the metabolites generated in the mitochondria, particularly acetyl-CoA and alpha-ketoglutarate, which play critical roles in histone marks and nuclear DNA methylation patterns. Proper mitochondrial function is essential for maintaining the epigenetic landscape, and dysfunction in mitochondria can have a negative impact on epigenetics and gene expression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Kasim Khan, Olivier Van Aken
Summary: The article uses phylogenetics to track the evolutionary origins of factors involved in plant mitochondrial retrograde regulation (MRR). It shows that the transition to land was a major driving force for developing plant MRR pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Duorong Xu, Qian Tang, Ping Xu, Anton R. Schaeffner, Dario Leister, Tatjana Kleine
Summary: Plants have evolved mechanisms to cope with drought, including changes in nuclear gene expression and post-transcriptional processing. RNA-sequencing revealed that splicing affects 9% of expressed nuclear genes and identified 927 isoform switching events. These regulatory mechanisms enhance drought tolerance and provide new strategies for improving plant performance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Cell Biology
Kwanuk Lee, Dario Leister, Tatjana Kleine
Summary: Chloroplast-localized mTERF2 plays a crucial role in plant development, with its complete loss of function leading to embryo lethality and its reduction affecting plant development and chlorophyll content. Additionally, mTERF2 is required for the splicing of group IIB introns of ycf3 and rps12, highlighting its importance in regulating gene expression in chloroplasts.
Review
Cell Biology
Jinliang Huang, Sipeng Wu, Pengcheng Wang, Geng Wang
Summary: Mitochondria are not only the main hubs for cellular energy production, but also play important roles in biosynthesis pathways and signaling. Mitochondrial biosynthesis requires collaboration of nuclear and mitochondrial gene expression systems, and rapid responses to changes inside and outside the cells. Recent studies suggest that non-coding RNAs may contribute to communication between mitochondria and other cellular compartments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Genetics & Heredity
Julia Nguyen, Quinn Le, Phyo W. Win, Kathleen A. Hill, Shiva M. Singh, Christina A. Castellani
Summary: Bidirectional communication between the mitochondria and the nucleus is crucial for maintaining proper cell function. The signals sent from the mitochondria to the nucleus, particularly through the use of mitochondrial-encoded ncRNAs, have garnered great interest due to their impact on diseases. The study of these ncRNAs provides insights into the role of the mitochondria in cellular control and opens up possibilities for disease treatment.
Article
Biochemistry & Molecular Biology
Yunlong Wang, Yihua Wang, Xiaopin Zhu, Yulong Ren, Hui Dong, Erchao Duan, Xuan Teng, Huanhuan Zhao, Rongbo Chen, Xiaoli Chen, Jie Lei, Hang Yang, Yunlu Tian, Liangming Chen, Xi Liu, Shijia Liu, Ling Jiang, Haiyang Wang, Jianmin Wan
Summary: This study investigates the effects of tetrapyrrole biosynthesis-related GUN mutants on nuclear and plastid gene expression in rice. The results show that the TPB-related GUN genes control retrograde plastid signaling by regulating the expression of plastid-encoded genes.
PLANT COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Thi Hoang Diu Bui, Karolina Labedzka-Dmoch
Summary: The mitochondrial retrograde signaling pathway in yeast regulates cellular metabolism by reprogramming nuclear gene expression in response to mitochondrial triggers. The main components of this pathway are the Rtg1 and Rtg3 transcription factors, along with positive and negative regulators. Retrograde regulation is integrated with other cellular processes such as stress response and nutrient sensing. This review discusses the metabolic changes observed upon retrograde stimulation and the progress made in understanding the underlying mechanisms of regulatory circuit integration.
Article
Plant Sciences
Tingting Li, Wenqiu Pan, Yiyuan Yuan, Ying Liu, Yihan Li, Xiaoyu Wu, Fei Wang, Licao Cui
Summary: This study identified 60 mTERFs in the barley genome and categorized them into nine subfamilies through phylogenetic analysis. The expression analysis suggested that many HvmTERFs may play important roles in barley development and abiotic stresses, while the nucleotide diversity of HvmTERFs decreased by 4.5% during the process of barley domestication.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Agronomy
Rachel E. Taylor, Christopher E. West, Christine H. Foyer
Summary: Environmental stresses threaten food security, and understanding the function of proteins that regulate plant responses to stress is crucial for crop improvement strategies. The WHY family of proteins play important roles in organelles and nuclei, regulating synthesis of phytohormones and growth and stress responses. They also contribute to DNA and RNA metabolism and genome stability. WHY proteins have flexible localization and overlapping functions, and are potential targets for breeding stress-tolerant and sustainable crops.
FOOD AND ENERGY SECURITY
(2023)
Review
Plant Sciences
Masood Jan, Zhixin Liu, Jean-David Rochaix, Xuwu Sun
Summary: This article reviews the current understanding of multiple plastid retrograde signaling pathways and potential plastid signaling molecules. It also discusses how retrograde signaling regulates nuclear gene expression within a multilayered network of transcription factors.
FRONTIERS IN PLANT SCIENCE
(2022)