Review
Infectious Diseases
Kathryn Cater, Ryszard Miedzybrodzki, Vera Morozova, Slawomir Letkiewicz, Marzanna Lusiak-Szelachowska, Justyna Rekas, Beata Weber-Dabrowska, Andrzej Gorski
Summary: Bacterial sexually transmitted infections (BSTIs) are becoming increasingly concerning as antibiotic treatment options decrease. Phage therapy has been utilized in some countries for bacterial illnesses, but has not yet been used for BSTIs. The potential efficacy of phage therapy in treating BSTIs requires further research and exploration, as it presents a possible alternative to traditional antibiotic treatments.
Article
Biochemistry & Molecular Biology
Bogna J. Smug, Grazyna Majkowska-Skrobek, Zuzanna Drulis-Kawa
Summary: The study presents a publicly available web tool PhREEPred for predicting the effectiveness of phage cocktails or phage/deploymerase combinations against encapsulated bacterial pathogens, allowing informed choices in their design.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Microbiology
Patricia E. Sorensen, Duncan Y. K. Ng, Luc Duchateau, Hanne Ingmer, An Garmyn, Patrick Butaye
Summary: This study investigated the impact of bacteriophages on bacterial growth dynamics and identified seven distinct growth patterns, with phage species being the most influential factor. The results highlighted the importance of phage-host dynamics in determining a phage's ability to eliminate bacteria, and suggested that phage therapy development should take into consideration these dynamics. Candidates from Group 2, characterized by high bacterial killing, were identified as the most promising for phage therapy.
Review
Environmental Sciences
Karthik Basthi Shivaram, Pankaj Bhatt, Bruce Applegate, Halis Simsek
Summary: Wastewater treatment is crucial for public health and sustainability. The interaction between bacteriophages and bacteria in a treatment plant plays a significant role. Phage therapy has been proposed as an alternative to conventional methods, as they can target specific bacteria without harming beneficial ones.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Microbiology
Anna G. Mankovich, Kristen Maciel, Madison Kavanaugh, Erin Kistler, Emily Muckle, Christine L. Weingart
Summary: In this study, a bacteriophage named KP1 was isolated from raw sewage, and it was found to infect Burkholderia cenocepacia. KP1 phage showed significant efficacy in reducing B. cenocepacia populations, especially in the duckweed model. These results suggest that the use of KP1 phage may be a potential strategy for treating B. cenocepacia infections, either alone or in combination with antibiotics.
Article
Virology
Medhavi Vashisth, Shikha Yashveer, Taruna Anand, Nitin Virmani, Bidhan Chand Bera, Rajesh Kumar Vaid
Summary: Careful selection of specific antibiotics is crucial in combination therapy of bacteriophages and antibiotics, as different antibiotics can have different effects on phage lytic activity. This study found that antibiotics targeting bacterial protein synthesis pathways significantly reduce the lytic activity of bacteriophages, highlighting the importance of screening these compounds before their use in combination treatment.
Review
Infectious Diseases
Chengxi Liu, Qixuan Hong, Rachel Yoon Kyung Chang, Philip Chi Lip Kwok, Hak-Kim Chan
Summary: This review paper summarizes the progress of phage-antibiotic therapy, including the mechanisms of Phage-Antibiotic Synergy (PAS) and its therapeutic performance. The choice of phages and antibiotics, administration time and sequence, and concentrations of the two agents have different impacts on bacterial inhibitory effects.
Article
Microbiology
Lucie Kuntova, Ivana Maslanova, Radka Oborilova, Hana Simeckova, Adela Finstrlova, Pavol Bardy, Marta Siborova, Liudmyla Troianovska, Tibor Botka, Petr Gintar, Ondrej Sedo, Zdenek Farka, Jiri Doskar, Roman Pantucek
Summary: This study describes a resistance mechanism targeting kayviruses that is encoded by a prophage. The mechanism belongs to a broader group of abortive infections, characterized by suicidal behavior of infected cells that are unable to produce phage progeny, thus ensuring the survival of the host population. Since the majority of staphylococcal strains are lysogenic, our findings are relevant for the advancement of phage therapy.
Article
Chemistry, Medicinal
Silvia Wuerstle, Jana Stender, Jens Andre Hammerl, Kilian Vogele, Kathrin Rothe, Christian Willy, Joachim Jakob Bugert
Summary: This study aims to establish an efficient personalized phage delivery pipeline and provide guidelines and evaluation tools. By adjusting the components and set points of the pipeline, the efficiency of the process was successfully improved. This is of great importance for treating critically ill patients with multidrug-resistant Gram-negative bacterial infections.
Article
Microbiology
Cheng-Hung Luo, Ya-Han Hsu, Wen-Jui Wu, Kai-Chih Chang, Chen-Sheng Yeh
Summary: Bacteriophages are viruses that infect bacteria by using host resources, with specific proteins for recognizing and degrading their host. Tail fiber protein from bacteriophages can target and degrade exopolysaccharide in bacteria, potentially leading to temporary resistance to last-resort antibiotics like colistin in treating multidrug-resistant infections.
Review
Medicine, General & Internal
Andrew A. Umansky, Louis Charles Fortier
Summary: With the antibiotic crisis and the rise in antimicrobial resistance, new therapeutic alternatives are urgently needed. Phage therapy shows promise as an alternative, but there are challenges in treating pathogens like Clostridioides difficile. No strictly lytic phages have been identified for C. difficile, and its antiphage mechanisms and spore resistance complicate therapeutic interventions. However, recent advances in phage engineering and host recognition offer potential solutions for phage therapy in C. difficile.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Siyu Liu, Hongyun Lu, Shengliang Zhang, Ying Shi, Qihe Chen
Summary: Bacterial biofilms have high resistance to antimicrobial agents, posing a challenge in treating biofilm-based infections caused by drug-resistant bacteria. Bacteriophages, as natural enemies of bacteria, offer potential alternatives due to their specificity, safety, and non-toxicity.
Article
Microbiology
N. L. Haddock, L. J. Barkal, P. L. Bollyky
Summary: Bacteriophages are abundant at sites of bacterial colonization, but their ecology at sites of active infection remains unclear. In this study, we investigated bacteriophage populations in cell-free DNA collected from infection sites and found that phages reflect the relative abundance of their bacterial hosts at these sites. These findings may have implications for future investigative and diagnostic approaches utilizing phages and bacterial cell-free DNA.
Review
Microbiology
Su Jin Jo, Jun Kwon, Sang Guen Kim, Seung-Jun Lee
Summary: Bacterial infections have become a global threat, and bacteriophages are gaining attention as promising alternatives due to their distinctive attributes and genetic modification abilities. Phage engineering can enhance diagnostics, drug delivery, and therapy, and holds promise in transforming precision medicine, addressing antibiotic resistance, and advancing diverse applications.
Review
Cell Biology
Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knezevic, Cyprian Winogradow, Karolina Amaro, Ewa Jonczyk-Matysiak, Beata Weber-Dabrowska, Justyna Rekas, Andrzej Gorski
Summary: Combining phages with antibiotics can enhance bacterial clearance and reduce biofilm formation, demonstrating a synergistic effect. Some studies have also shown that antibiotics can induce the production of phages by bacteria. In clinical applications, simultaneous treatment with phages and antibiotics has been found to improve treatment outcomes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Yicheng Xie, Jeffrey W. Savell, Ashley N. Arnold, Kerri B. Gehring, Jason J. Gill, T. Matthew Taylor
JOURNAL OF FOOD PROTECTION
(2016)
Article
Environmental Sciences
Steven Hand, Jason Gill, Kung-Hui Chu
SCIENCE OF THE TOTAL ENVIRONMENT
(2016)
Article
Biochemistry & Molecular Biology
Denish Piya, Leonardo Vara, William K. Russell, Ry Young, Jason J. Gill
MOLECULAR MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Reed M. Stubbendieck, Dakota J. Brock, Jean-Philippe Pellois, Jason J. Gill, Paul D. Straight
JOURNAL OF ANTIBIOTICS
(2018)
Article
Virology
A. C. Hernandez-Morales, L. L. Lessor, T. L. Wood, D. Migl, E. M. Mijalis, J. Cahill, W. K. Russell, R. F. Young, J. J. Gill
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Yicheng Xie, Laith Wahab, Jason J. Gill
Article
Multidisciplinary Sciences
Jason J. Gill, Baixin Wang, Emily Sestak, Ryland Young, Kung-Hui Chu
SCIENTIFIC REPORTS
(2018)
Article
Virology
Chi Zeng, Eddie B. Gilcrease, Roger W. Hendrix, Yicheng Xie, Michael J. Jalfon, Jason J. Gill, Sherwood R. Casjens
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Denish Piya, Lauren Lessor, Brian Koehler, Ashley Stonecipher, Jesse Cahill, Jason J. Gill
SCIENTIFIC REPORTS
(2020)
Article
Virology
Miguel F. Gonzales, Denish K. Piya, Brian Koehler, Kailun Zhang, Zihao Yu, Lanying Zeng, Jason J. Gill
Summary: This study reports the proteome of bacteriophage P1 and identifies five previously unknown essential genes. The processing site of the major capsid protein of P1 is also determined. Furthermore, the study reveals the defense mechanism of P1 against restriction and its potential as a nanomachine for cellular delivery.
Article
Biochemical Research Methods
Jolene Ramsey, Helena Rasche, Cory Maughmer, Anthony Criscione, Eleni Mijalis, Mei Liu, James C. Hu, Ry Young, Jason J. Gill
PLOS COMPUTATIONAL BIOLOGY
(2020)
Article
Microbiology
Rachele M. Bonasera, Abby Korn, Heather Newkirk, Chandler O'Leary, Jason Gill, Mei Liu
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Microbiology
Adam J. Salazar, Lauren Lessor, Chandler O'Leary, Jason Gill, Mei Liu
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2019)
Article
Microbiology
Robert T. Schooley, Biswajit Biswas, Jason J. Gill, Adriana Hernandez-Morales, Jacob Lancaster, Lauren Lessor, Jeremy J. Barr, Sharon L. Reed, Forest Rohwer, Sean Benler, Anca M. Segall, Randy Taplitz, Davey M. Smith, Kim Kerr, Monika Kumaraswamy, Victor Nizet, Leo Lin, Melanie D. McCauley, Steffanie A. Strathdee, Constance A. Benson, Robert K. Pope, Brian M. Leroux, Andrew C. Picel, Alfred J. Mateczun, Katherine E. Cilwa, James M. Regeimbal, Luis A. Estrella, David M. Wolfe, Matthew S. Henry, Javier Quinones, Scott Salka, Kimberly A. Bishop-Lilly, Ry Young, Theron Hamilton
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Microbiology
Sruti Parvataneni, Eleni M. Mijalis, Gabriel F. Kuty Everett, Eric S. Rasche, Mei Liu, Jason J. Gill
GENOME ANNOUNCEMENTS
(2017)