Review
Infectious Diseases
Md Ramim Tanver Rahman, Ismail Fliss, Eric Biron
Summary: The overuse and misuse of antibiotics has led to the rise and spread of multidrug-resistant bacteria. Many countries have restricted the use of antibiotics and promoted the development of alternatives to address this global public health threat. In food-animal production, various alternatives to antibiotics have been identified and studied. However, there are still limitations in their use and concerns about resistance development.
Article
Agriculture, Dairy & Animal Science
Mohamed E. Abd El-Hack, Mohamed T. El-Saadony, Heba M. Salem, Amira M. El-Tahan, Mohamed M. Soliman, Gehan B. A. Youssef, Ayman E. Taha, Soliman M. Soliman, Ahmed E. Ahmed, Attalla F. El-Kott, Khalid M. Al Syaad, Ayman A. Swelum
Summary: The poultry industry plays a significant role in addressing the nutritional gap in many countries by providing protein-rich meat and eggs at a lower cost than other animal meat sources. Following the ban of antibiotic growth promoters, natural alternatives such as probiotics, prebiotics, organic acids, essential oils, and other feed additives have gained popularity in the poultry industry for their unique properties and positive impact on poultry production. They can easily be mixed with other feed ingredients, improve feed intake and conversion rate, enhance bird immunity and digestion, reduce antibiotic usage, and provide healthy organic products for human consumption.
Review
Biochemistry & Molecular Biology
Betty Schwartz, Vaclav Vetvicka
Summary: The occurrence of microbial challenges in commercial poultry farming leads to significant economic losses, and antibiotics have been widely used to control diseases. However, with the increasing problem of antibiotic resistance, producers are under pressure to reduce antibiotic use and are looking for feed additives to stimulate the immune system of poultry to resist microbial infection.
Article
Agriculture, Dairy & Animal Science
Estefania Novoa Rama, Matthew Bailey, Sanjay Kumar, Cortney Leone, Henk C. den Bakker, Harshavardhan Thippareddi, Manpreet Singh
Summary: Meat from broilers raised without the use of antibiotics is gaining popularity among consumers. This study aimed to investigate the dynamics of gut microbial populations in broilers raised under conventional and no antibiotics ever (NAE) practices. The results showed that the cecal microbiota of NAE broilers differed from that of conventional broilers, with the latter having a rich but less diverse microbiota. The ileal microbiota of NAE broilers was primarily populated by Lactobacillus, which exhibited a higher abundance compared to conventional broilers.
Article
Agriculture, Dairy & Animal Science
Cassio Antonio Ficagna, Gabriela Miotto Galli, Emerson Zatti, Bruno Milhoreto Sponchiado, Bruno Giorgio de Oliveira Cecere, Guilherme L. Deolindo, Lara Tarasconi, Vitor W. Horn, Ricardo E. Mendes, Bianca F. Bissacotti, Maria Rosa Chitolina Schetinger, Marcel Manente Boiago, Aleksandro S. da Silva
Summary: This study aimed to investigate the potential of butyric acid glycerides as a substitute for conventional growth promoters. The results showed that the addition of butyric acid can provide antimicrobial and antioxidant activity, improving productive performance, intestinal health, and metabolism in birds. Butyric acid glycerides are an effective alternative to conventional growth promoters.
ARCHIVES OF ANIMAL NUTRITION
(2022)
Review
Immunology
Youngsub Lee, Mingmin Lu, Hyun S. Lillehoj
Summary: This review summarizes the current understanding of the host immune response to avian coccidiosis and discusses various non-antibiotic strategies being developed for coccidiosis control. The use of immune-based strategies can improve host defense against parasites and reduce intestinal damage caused by parasite-induced inflammation.
Review
Environmental Sciences
Alireza Seidavi, Masomeh Tavakoli, Marina Slozhenkina, Ivan Gorlov, Nesrein M. Hashem, Fariborz Asroosh, Ayman E. Taha, Mohamed E. Abd El-Hack, Ayman A. Swelum
Summary: In the context of banning antibiotic growth promoters and consumer preference for antibiotic-free livestock products, it is crucial to research effective growth promoter alternatives in organic poultry production. Certain spice plants have been shown to be effective choices in this regard.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Infectious Diseases
Steve Kgotlelelo Mahlake, Caven Mguvane Mnisi, Cebisa Kumanda, Doctor Mziwenkosi Nhlanhla Mthiyane, Peter Kotsoana Montso
Summary: The misuse of antibiotics in poultry feeds has negative impacts on production, but green tea products show potential as alternatives that can improve growth performance and health status of poultry, contributing to sustainable and organic production systems.
Review
Biotechnology & Applied Microbiology
Gisele Rodrigues, Mariana Rocha Maximiano, Octavio Luiz Franco
Summary: This review discusses the use of antibiotic growth promoters in livestock and the negative consequences, proposing the use of antimicrobial peptides as an alternative approach to control antimicrobial resistance.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Janghan Choi, Amit Kumar Singh, Xi Chen, Jirong Lv, Woo Kyun Kim
Summary: Finding alternatives to antibiotic growth promoters (AGP) is crucial after their restriction in the broiler industry. Organic acids (OAs) and essential oils (EOs) have been considered promising alternatives, as they have strong antimicrobial and antioxidant effects. This study evaluated the effects of OAs, EOs, and their combinations as AGP alternatives in broiler chickens and found that OAs improved feed efficiency in the finisher phase, while EOs improved feed efficiency in the starter phase. Consequently, the supplementation of EOs and OAs could potentially replace AGP in different phases of broiler production.
Review
Food Science & Technology
Ayesha Lone, Walid Mottawea, Youcef Mehdi, Riadh Hammami
Summary: The livestock industry is seeking alternatives to antibiotics to maintain productivity and health, with a particular focus on bacteriocinogenic probiotics that can produce bacteriocins to benefit the host. These probiotics have promising features in inhibiting pathogens, improving animal health, and being safe for consumption. Additional research is needed to further understand the safety and effectiveness of these probiotics in livestock.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Green & Sustainable Science & Technology
Anna Xexaki, Dimitrios K. Papadopoulos, Maria V. Alvanou, Ioannis A. Giantsis, Konstantinos V. Papageorgiou, Georgios A. Delis, Vangelis Economou, Spyridon K. Kritas, Evangelia N. Sossidou, Evanthia Petridou
Summary: This study aimed to examine the presence of antibiotic-resistant Escherichia coli strains in poultry farms. The results showed that the highest resistance rates were observed for sulfamethoxazole (81.1%), nalidixic acid (73.6%), tetracycline (70.8%), and streptomycin (70.8%). The isolates exhibited lower resistance levels to third generation cephalosporins, with ceftazidime (2.8%), ceftriaxone (3.7%), cefoxitin (4.7%), and cefotaxime (4.7%). Phenotypic tests revealed that 13.6% and 10.2% of the isolates produced ESBL, while 2.7% and 1% produced AmpC β-lactamase, in broiler and laying hens, respectively. The prevalence of the mcr-1 gene was 22.7%, detected only in broiler isolates. Based on these findings, E. coli antibiotic resistance represents a critical control point in poultry production, which may have implications for public health.
Review
Infectious Diseases
Rifat Ullah Khan, Adia Fatima, Shabana Naz, Marco Ragni, Simona Tarricone, Vincenzo Tufarelli
Summary: Research on enhancing gut health has been accelerated following the European Union's restriction on antibiotic growth promoters. Fennel seeds have been found to have various beneficial effects on poultry, including improved performance, higher immune cell proliferation, reduced oxidative stress, and increased antibody titers against infectious diseases. This review focuses on the effects of fennel seeds as a feed additive on poultry growth, blood biochemistry, antioxidant activity, immunity, and microbiological aspects.
Article
Immunology
Gabriela M. Galli, Tiago G. Petrolli, Edemar Aniecevski, Alicia D. Santo, Felipe Leite, Luiz G. Griss, Vanessa Dazuk, Marcel M. Boiago, Helio dos Santos, Claudia A. D. P. Simoes, Roger Wagner, Bianca F. Bissacotti, Maria Rosa Schentiger, Aleksandro S. Da Silva
Summary: The study found that replacing conventional antibiotics and anticoccidial agents with a phytogenic blend may control bacteria and coccidia, but ultimately has a negative impact on the health and production of chickens.
MICROBIAL PATHOGENESIS
(2021)
Review
Infectious Diseases
Rifat Ullah Khan, Shabana Naz, Davide De Marzo, Michela M. Dimuccio, Giancarlo Bozzo, Vincenzo Tufarelli, Caterina Losacco, Marco Ragni
Summary: In the past 50 years, there has been a growing global demand for poultry meat due to increased concerns for health, ecology, safety, and equity. However, organic poultry farming, particularly the use of medicinal herbs, has gained significant attention and public demand recently, mainly due to concerns about antibiotic resistance. The ban on antibiotics in the poultry industry has led to increased interest in herbs as antibiotic alternatives. Aloe vera has been shown in various research studies to have nutritional benefits for improving poultry growth, immune status, and acting as an antibacterial and anticoccidial agent.
Article
Microbiology
Maxime Lamontagne Boulet, Charles Isabelle, Isabelle Guay, Eric Brouillette, Jean-Philippe Langlois, Pierre-Etienne Jacques, Sebastien Rodrigue, Ryszard Brzezinski, Pascale B. Beauregard, Kamal Bouarab, Kumaraswamy Boyapelly, Pierre-Luc Boudreault, Eric Marsault, Francois Malouin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Microbiology
S. Pichette-Jolette, G. Millette, E. Demontier, D. Bran-Barrera, M. Cyrenne, C. Ster, D. Haine, G. Keefe, F. Malouin, J. P. Roy
VETERINARY MICROBIOLOGY
(2019)
Article
Microbiology
Evelyne Lacasse, Eric Brouillette, Audrey Larose, Thomas R. Parr, Aileen Rubio, Francois Malouin
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2019)
Letter
Microbiology
Julie Jeukens, Luca Freschi, Irena Kukavica-Ibrulj, Jean-Guillaume Emond-Rheault, Christian Allard, Jean Barbeau, Andre Cantin, Steve J. Charette, Eric Deziel, Francois Malouin, Julie Milot, Dao Nguyen, Clara Popa, Brian Boyle, Roger C. Levesque
JOURNAL OF CLINICAL MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Julie Cote-Gravel, Eric Brouillette, Francois Malouin
Article
Multidisciplinary Sciences
Jocelyn Bernier-Lachance, Julie Arsenault, Valentine Usongo, Eric Parent, Josee Labrie, Mario Jacques, Francois Malouin, Marie Archambault
Article
Microbiology
Guillaume Millette, Jean-Philippe Langlois, Eric Brouillette, Eric H. Frost, Andre M. Cantin, Francois Malouin
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Jean-Philippe Langlois, Guillaume Millette, Isabelle Guay, Alexis Dube-Duquette, Suzanne Chamberland, Pierre-Etienne Jacques, Sebastien Rodrigue, Kamal Bouarab, Eric Marsault, Francois Malouin
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Microbiology
Fabrice Betoudji, Taha Abd El Rahman, Marvin J. Miller, Manuka Ghosh, Mario Jacques, Kamal Bouarab, Francois Malouin
Article
Pharmacology & Pharmacy
Jose Carratala, Eric Brouillette, Naroa Serna, Alejandro Sanchez-Chardi, Julieta M. Sanchez, Antonio Villaverde, Anna Aris, Elena Garcia-Fruitos, Neus Ferrer-Miralles, Francois Malouin
Article
Immunology
Celine Ster, Marianne Allard, Julie Cote-Gravel, Simon Boulanger, Pierre Lacasse, Francois Malouin
Summary: The study developed a vaccine formulation for Staphylococcus aureus mastitis using recombinant proteins and adjuvants, successfully inducing immune responses in cows. Different antigens in the vaccine elicited different immune responses, with one antigen causing a balanced immune response and others causing a predominant Th2 response. Vaccinated cows showed a sustained reduction in milk somatic cell counts, indicating a correlation between somatic cell counts and Staphylococcus aureus counts in milk. Further research is needed to understand how different antigens stimulate varying immune responses using the same adjuvant.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
S. Bennett, I. Fliss, L. Ben Said, F. Malouin, P. Lacasse
Summary: The study evaluated the reduction of bacterial populations through the application of bacteriocin-based teat formulas. The results showed that nisin and the bacteriocin consortium showed the most promise as a teat disinfectant by reducing staphylococci, streptococci, and total bacteria counts.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Infectious Diseases
Guillaume Millette, Evelyne Lacasse, Renaud Binette, Veronique Belley, Louis-Philippe Chaumont, Celine Ster, Francis Beaudry, Kumaraswamy Boyapelly, Pierre-Luc Boudreault, Francois Malouin, Amira A. Moawad, Hosny El-Adawy, Heinrich Neubauer
Summary: Staphylococcus aureus is a major pathogen causing bovine mastitis, and the development of new antibiotics for veterinary use is important due to its virulence and antibiotic resistance. One such antibiotic, PC206, has been found to have specific narrow-spectrum activity against S. aureus and shows promising results in in vitro and in vivo experiments.
Review
Biochemistry & Molecular Biology
Julien A. Delbrouck, Michael Desgagne, Christian Comeau, Kamal Bouarab, Francois Malouin, Pierre-Luc Boudreault
Article
Veterinary Sciences
Auemphon Mordmuang, Eric Brouillette, Supayang Piyawan Voravuthikunchai, Francois Malouin
VETERINARY RESEARCH
(2019)