Article
Microbiology
Yuki Iwaisako, Tadashi Watanabe, Mizuki Hanajiri, Yuichi Sekine, Masahiro Fujimuro
Summary: The KSHV ORF7 plays a key role in viral replication by regulating capsid formation, maintaining viral production, and promoting lytic replication through interactions with other terminase components.
Review
Biochemistry & Molecular Biology
Amanda de Oliveira Lopes, Pedro do Nascimento Marinho, Leticia d'Ambrosio de Souza Medeiros, Vanessa Salete de Paula
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a virus containing oncogenes and proteins that play a crucial role in regulating cellular functions and leading to Kaposi's sarcoma. Some of these genes have the potential to be therapeutic targets for Kaposi's sarcoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Yuan Fang, Wenli Li, Ying Zhang, Chang Zhou, Huanwu Wu, Yiting Zhang, Tao Dai, Jinzhi Wang, Lei Wang, Tongqing Chen, Yulin Zhu, Linding Wang
Summary: The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Gansu, China, especially among certain ethnic groups and syphilis patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Virology
Qinqin Sun, Fan Wang, Qingyang Chen, Ronit Sarid, Xiaojuan Li, Ersheng Kuang
Summary: The lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV) is enhanced by ORF45, which upregulates the expression of ATF4 and LAMP3, leading to reprogrammed cellular transcription and translation that supports viral protein production.
JOURNAL OF VIROLOGY
(2022)
Review
Virology
Lindsey Barrett, Lu Dai, Shanzhi Wang, Zhiqiang Qin
Summary: This article summarizes how KSHV utilizes extracellular vesicles (EVs) to create favorable environments for viral spread and persistence while evading immune responses. EVs play a significant role in the development and function of the immune system.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Virology
Yuki Iwaisako, Tadashi Watanabe, Youichi Suzuki, Takashi Nakano, Masahiro Fujimuro
Summary: Although the formation and function of the alpha- and betaherpesvirus terminase complexes are well understood, the Kaposi's sarcoma-associated herpesvirus (KSHV) terminase complex is still largely uncharacterized. We previously reported the presence of soccer ball-like capsids in ORF7-deficient KSHV-harboring cells. Here, we demonstrate that ORF67.5 is required for terminal repeat (TR) cleavage, infectious virus production, and enhancement of the interaction between ORF7 and ORF29.
JOURNAL OF VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Qian Chen, Jiangtao Chen, Yuqing Li, Dawei Liu, Yan Zeng, Zheng Tian, Akbar Yunus, Yong Yang, Jie Lu, Xinghua Song, Yan Yuan
Summary: The prevalence of KSHV infection is significantly elevated in Uyghur osteosarcoma patients, with the virus being associated with some osteosarcomas. The study suggests that KSHV infection is a risk factor for osteosarcoma, representing a newly identified viral-associated endemic cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Virology
Coral Orel Haddad, Inna Kalt, Yehuda Shovman, Lei Xia, Yehuda Schlesinger, Ronit Sarid, Oren Parnas
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is a transforming gammaherpesvirus with lifelong infection. CRISPR-Cas9 technology offers a novel strategy for targeting viral genes in KSHV, with findings showing that KSHV episomes can be targeted by CRISPR-Cas9. Furthermore, antibiotic selection may interfere with the outcome of targeting KSHV genomes.
Article
Microbiology
Chunhong Di, Guoxia Zheng, Yunheng Zhang, Enyu Tong, Yanli Ren, Yu Hong, Yang Song, Rong Chen, Xiaohua Tan, Lei Yang
Summary: The recombination signal binding protein for immunoglobulin kappa J region (RBPJ) plays a dual role in Kaposi's sarcoma-associated herpesvirus (KSHV) replication. Its interaction with replication and transcription activator (RTA) is essential for lytic replication, while the interaction with latency-associated nuclear antigen (LANA) facilitates latent infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Su-Kyung Kang, Myung-Ju Lee, Ho-Hyun Ryu, Jisu Lee, Myung-Shin Lee
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to various diseases, efficient virus production and isolation are crucial for research. DMSO shows promise in enhancing KSHV viral production by affecting its lytic genes, and the activation of JNK is implicated in this process.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Isaura Vanessa Gutierrez, Poulomee Sarkar, Cyprian C. Rossetto
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus that causes serious diseases in humans. During lytic replication, the virus produces new virions through a cascade of gene expression. ORF59, a viral factor expressed during this process, plays a crucial role in DNA synthesis and interacts with histones and cellular methyltransferases. Studies on ORF59 deletions show specific amino acid regions are required for histone interaction and nuclear localization but not for DNA synthesis, demonstrating its essential role during lytic replication.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Tate Tabtieng, Rachel C. Lent, Machika Kaku, Alvaro Monago Sanchez, Marta Maria Gaglia
Summary: Type I interferons play a crucial role in infectious and inflammatory diseases. Viruses have developed strategies to suppress the production of type I interferons, and apoptotic caspases have emerged as important regulators of type I interferon signaling. This study reveals that caspase activity inhibits the DNA sensor cGAS during KSHV infection, blocking the antiviral type I interferon response. These findings provide insights into the mechanisms of viral immune evasion and can inform targeted therapeutic strategies for viral infections.
Review
Oncology
Aude Jary, Marianne Veyri, Adelie Gothland, Valentin Leducq, Vincent Calvez, Anne-Genevieve Marcelin
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is an oncogenic virus with a complex structure and genome, contributing to the development of Kaposi's sarcoma through a combination of lytic and latent phases. The virus encodes various oncogenic proteins that modulate cellular pathways to promote characteristics of cancer, such as inhibition of apoptosis, proliferation stimulation, angiogenesis, inflammation, and immune escape. Variations in seroprevalence and transmission routes worldwide play a role in the differing epidemiological forms of Kaposi's sarcoma.
Article
Infectious Diseases
Jinchuan Shi, Gaoxiang Ying, Zhongdong Zhang
Summary: In the treatment of AIDS patients with Kaposi's sarcoma, the reconstitution of immune function and consecutive chemotherapy with doxorubicin liposome are crucial. Early recognition and histopathological verification of general symptoms such as thrombocytopenia and hemorrhagic purple papules in AIDS patients are necessary to achieve early diagnosis of KS and timely clinical intervention.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biochemistry & Molecular Biology
Yujun Liu, Yuan-Chuan Chen, Bin Yan, Fenyong Liu
Summary: In this study, ribozymes derived from RNase P catalytic RNA were engineered to target the mRNA encoding KSHV RTA. The functional ribozyme F-RTA efficiently sliced the RTA mRNA and suppressed KSHV production and gene expression. This study demonstrates the potential of RNase P ribozymes as a therapy against KSHV.