Review
Virology
Svetlana Kalinichenko, Dmitriy Komkov, Dmitriy Mazurov
Summary: So far, only HIV and HTLV-1 have been recognized as pathogenic retroviruses for humans. These viruses primarily infect CD4+ T lymphocytes and are transmitted between individuals through various modes of transmission.
Review
Microbiology
Joshua J. Tu, Victoria Maksimova, Lee Ratner, Amanda R. Panfil
Summary: HTLV-1 is an oncogenic human retrovirus that causes lifelong infection. It can lead to aggressive malignancies or progressive neurodegenerative diseases. Treatment options for HTLV-1-associated diseases are limited and the prognosis for ATL is poor. Early acquisition of the virus increases the risk of disease development. Currently, there is no cure or reliable prevention measure for HTLV-1 infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Victoria Maksimova, Susan Smith, Jaideep Seth, Cameron Phelps, Stefan Niewiesk, Yorifumi Satou, Patrick L. Green, Amanda R. Panfil
Summary: The enhancer element of HTLV-1 plays a crucial role in regulating viral gene expression, but does not determine persistent infection or disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Roberto S. Accolla
Summary: This review discusses the expression of HTLV-1 basic leucine-zipper factor HBZ during HTLV-1 infection, providing a deeper understanding of HTLV-1 infection and oncogenesis mechanisms, and suggesting new directions for further research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Thomas Joris, Jana Haddow, Graham P. Taylor, Lucy B. M. Cook, Aileen G. Rowan
Summary: Detection of HTLV-1 proviral DNA in blood plasma cfDNA may be used for diagnosis and monitoring of HTLV-1 carriers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Robert C. Gallo, Yutaka Tagaya
Summary: The report reflects on the author's preparation for human retroviruses starting in 1970 and highlights the exceptional characteristics of HTLV-1, emphasizing the needs of the field. The author believes that existing reviews on HTLV-1 lack a comprehensive emphasis on its truly exceptional features.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Hematology
Jake S. O'Donnell, Stewart K. Hunt, Keith J. Chappell
Summary: The human T-lymphotropic virus type 1 (HTLV-1) retrovirus infects millions of people globally, causing lifelong infection and immune suppression. It is associated with adult T-cell leukaemia or lymphoma (ATLL) in a small percentage of cases, with poor treatment outcomes. Recent advancements have shed light on the genetic, molecular, and immunological events occurring in HTLV-1 infection and ATLL progression. A four-step disease model has been proposed, providing insights into potential biomarkers and therapeutic targets. This model aims to promote research interest and guide the development of effective treatments for this neglected virus and its associated rare cancer.
LANCET HAEMATOLOGY
(2023)
Article
Microbiology
Carolina Rosadas, Timothy Woo, Jana Haddow, Aileen Rowan, Graham P. Taylor
Summary: This study found that anti-HTLV-1/2 IgG is present in breastmilk in similar proportion as in blood, but in lower quantity. HTLV-1/2 proviral DNA in breastmilk correlates with blood, while antibody titer is significantly higher in blood.
Article
Microbiology
Debora Glenda Lima de la-Roque, Elaine Vieira Santos, Evandra Strazza Rodrigues, Pericles Natan Mendes da Costa, Veronica Soares Brauer, Fausto Almeida, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima
Summary: The expression of viral transcripts in serum-derived sEVs of HTLV-1 carriers is related to the PVL presented by the infected individual, and tax+ HBZ+ sEVs can induce the production of inflammatory cytokines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Chihiro Motozono, Mako Toyoda, Jiri Zahradnik, Akatsuki Saito, Hesham Nasser, Toong Seng Tan, Isaac Ngare, Izumi Kimura, Keiya Uriu, Yusuke Kosugi, Yuan Yue, Ryo Shimizu, Jumpei Ito, Shiho Torii, Akiko Yonekawa, Nobuyuki Shimono, Yoji Nagasaki, Rumi Minami, Takashi Toya, Noritaka Sekiya, Takasuke Fukuhara, Yoshiharu Matsuura, Gideon Schreiber, Terumasa Ikeda, So Nakagawa, Takamasa Ueno, Kei Sato
Summary: Research has shown that certain mutations in SARS-CoV-2 variants can escape HLA-restricted cellular immunity, increase affinity for host cells, promote viral replication, and potentially affect the evolution of viral phenotypes.
CELL HOST & MICROBE
(2021)
Article
Microbiology
Akihito Koseki, Natsumi Araya, Makoto Yamagishi, Junji Yamauchi, Naoko Yagishita, Naoki Takao, Katsunori Takahashi, Yasuo Kunitomo, Daisuke Honma, Kazushi Araki, Kaoru Uchimaru, Tomoo Sato, Yoshihisa Yamano
Summary: In this study, elevated expression of EZH2 was found in patients with HAM. EZH1/2 selective inhibitors and EZH1/2 inhibitors suppressed the proliferation of HTLV-1-infected cells in HAM by inducing apoptosis and modulating immune response, suggesting the potential of these inhibitors as therapeutic agents for HAM.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mariela Caputo, Julieta Trinks, Marcela Azcurra, Daniel Coracht
Summary: HTLV-1 and HTLV-2 are present in different high-risk populations and have different pathogenic consequences and clinical manifestations. Accurate diagnosis of HTLV-1 and 2 infection is crucial. This study proposes a simple method for the rapid identification of HTLV-1 and 2.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Immunology
Beth E. Grace, Coralie M. Backlund, Duncan M. Morgan, Byong H. Kang, Nishant K. Singh, Brooke D. Huisman, C. Garrett Rappazzo, Kelly D. Moynihan, Laura Maiorino, Connor S. Dobson, Taeyoon Kyung, Khloe S. Gordon, Patrick Holec, Overbeck C. Takou Mbah, Daniel Garafola, Shengwei Wu, J. Christopher Love, K. Dane Wittrup, Darrell J. Irvine, Michael E. Birnbaum
Summary: This study characterized the CD8(+) T cell response to melanoma, identified a dominant tumor-associated antigen, and generated mimotopes that induced robust functional T cell responses with cross-reactivity to the endogenous antigen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Fan Wang, Yu-Hsien Hung, Ching-Han Tsao, Cho-Ying Chiang, Pak-Guan Teoh, Meng-Lin Chiang, Wei-Han Lin, Daniel K. Hsu, Hau-Ming Jan, Hsiu-Chu Lin, Chun-Hung Lin, Fu-Tong Liu, Huan-Yuan Chen
Summary: The study reveals that GAL3 promotes cell-to-cell transmission of HIV-1 in CD4 T cells by regulating lipid raft components. GAL3 is co-transferred with Gag to recipient cells and facilitates viral synapse formation at the cell-cell interface.
Article
Virology
Lili Wang, Alice Sandmeyer, Wolfgang Huebner, Hongru Li, Thomas Huser, Benjamin K. Chen
Summary: HIV-1 infection is enhanced by cell-cell adhesions called virological synapses (VS), in which infected and uninfected T cells interact. This study used a replication-competent HIV-1 clone to track the movement of HIV-1 envelope glycoprotein (Env) within infected cells. The results showed that Env was dynamically exchanged at the VS, while the viral structural protein, Gag, remained immobile. Further experiments revealed that continuous internalization and targeted secretion were involved in the accumulation of Env at the VS and its incorporation into nascent particles.
Article
Oncology
Ambroise Marcais, Laetitia Waast, Julie Bruneau, Katia Hanssens, Vahid Asnafi, Philippe Gaulard, Felipe Suarez, Patrice Dubreuil, Antoine Gessain, Olivier Hermine, Claudine Pique
Article
Microbiology
Damien Groussaud, Mostafa Khair, Armelle I. Tollenaere, Laetitia Waast, Mei-Shiue Kuo, Marianne Mangeney, Christophe Martella, Yann Fardini, Solene Coste, Mouloud Souidi, Laurence Benit, Claudine Pique, Tarik Issad
Article
Microbiology
Milica Milivojevic, Anne-Sophie Dangeard, Christoph Alexander Kasper, Therese Tschon, Mario Emmenlauer, Claudine Pique, Pamela Schnupf, Julie Guignot, Cecile Arrieumerlou
News Item
Medicine, Research & Experimental
Claudine Pique, Tarik Issad
M S-MEDECINE SCIENCES
(2018)
Article
Virology
Chloe Journo, Amandine Bonnet, Arnaud Favre-Bonvin, Jocelyn Turpin, Jennifer Vinera, Emilie Cote, Sebastien Alain Chevalier, Youmna Kfoury, Ali Bazarbachi, Claudine Pique, Renaud Mahieux
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Sabrina Pene, Laetitia Waast, Amandine Bonnet, Laurence Benit, Claudine Pique
JOURNAL OF VIROLOGY
(2014)
Article
Multidisciplinary Sciences
Patrycja Nzounza, Maxime Chazal, Chloe Guedj, Alain Schmitt, Jean-Marc Masse, Clotilde Randriamampita, Claudine Pique, Bertha Cecilia Ramirez
Article
Multidisciplinary Sciences
Maxime Chazal, Patrycja Nzounza, Claudine Pique, Bertha Cecilia Ramirez
Article
Virology
Amandine Bonnet, Voahangy Randrianarison-Huetz, Patrycja Nzounza, Martine Nedelec, Maxime Chazal, Laetitia Waast, Sabrina Pene, Ali Bazarbachi, Renaud Mahieux, Laurence Benit, Claudine Pique
Article
Microbiology
Greta Forlani, Marco Baratella, Alessandra Tedeschi, Claudine Pique, Steve Jacobson, Roberto S. Accolla
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Virology
Christophe Martella, Armelle Inge Tollenaere, Laetitia Waast, Benoit Lacombe, Damien Groussaud, Florence Margottin-Goguet, Bertha Cecilia Ramirez, Claudine Pique
JOURNAL OF VIROLOGY
(2020)
Article
Oncology
Ambroise Marcais, Ludovic Lhermitte, Maria Artesi, Cecile Laurent, Keith Durkin, Vincent Hahaut, Nicolas Rosewick, Felipe Suarez, David Sibon, Morgane Cheminant, Veronique Avettand-Fenoel, Julie Bruneau, Michel Georges, Claudine Pique, Anne Van den Broeke, Vahid Asnafi, Olivier Hermine
Summary: The study revealed that mutations affecting TCR/NF-kB pathway are associated with disease progression and shorter overall survival in adult T-cell leukemia/lymphoma patients. Additionally, certain subtypes of the disease may have a high risk of transformation based on mutational signatures.
Article
Medicine, Research & Experimental
Christophe Martella, Laetitia Waast, Claudine Pique
Summary: Retroviruses like HTLV-1 exploit the cellular RNA polymerase II transcription machinery for their own gene transcription. This process is controlled by the viral protein Tax, which recruits various cellular factors and cofactors to initiate and continue the transcription process. This review provides an overview of the unique mechanism of viral transcription, including the epigenetic release of the viral promoter and the elongation of the newly synthesized viral silencing transcripts.
M S-MEDECINE SCIENCES
(2022)
Article
Hematology
Morgane Cheminant, Ludovic Lhermitte, Julie Bruneau, Helene Sicard, Cecile Bonnafous, Aurore Touzart, Estelle Bourbon, Nicolas Ortonne, Laurent Genestier, Philippe Gaulard, Patricia Palmic, Felipe Suarez, Laurent Frenzel, Louise Naveau, Ali Bazarbachi, Mickael Dussiot, Laetitia Waast, Veronique Avettand-Fenoel, Chantal Brouzes, Claudine Pique, Yves Lepelletier, Vahid Asnafi, Ambroise Marcais, Olivier Hermine
Summary: This study investigated the expression of natural killer receptors (NKRs) in adult T-cell leukemia (ATL). The results showed that KIR3DL2 was the only frequently expressed NKR in ATL and was associated with acute-type ATL. The study also found a correlation between KIR3DL2 expression and promoter demethylation, which may be triggered by HTLV-1 infection.
Review
Virology
Sophie Lambert, Manuella Bouttier, David Ghez, Oliver Hermine, Claudine Pique