期刊
FRONTIERS IN MICROBIOLOGY
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2011.00101
关键词
Salmonella; microbiome; microbiota; colonization resistance
类别
资金
- NIH [AI043521, AI066208, AI073971]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI043521, R01AI073971] Funding Source: NIH RePORTER
Salmonella spp. are major cause of human morbidity and mortality worldwide. Upon entry into the human host, Salmonella spp. must overcome the resistance to colonization mediated by the gut microbiota and the innate immune system. They successfully accomplish this by inducing inflammation and mechanisms of innate immune defense. Many models have been developed to study Salmonella spp. interaction with the microbiota that have helped to identify factors necessary to overcome colonization resistance and to mediate disease. Here we review the current state of studies into this important pathogen/microbiota/host interaction in the mammalian gastrointestinal tract.
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