Article
Immunology
Sunil Kumar, Awanish Kumar
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal system that is increasing globally. The alteration in intestinal microbiota is associated with IBD, but the role of microbes in IBD is still controversial.
MICROBIAL PATHOGENESIS
(2022)
Article
Gastroenterology & Hepatology
Barbara Olendzki, Vanni Bucci, Caitlin Cawley, Rene Maserati, Margaret McManus, Effie Olednzki, Camilla Madziar, David Chiang, Doyle Ward, Randall Pellish, Christine Foley, Shakti Bhattarai, Beth A. McCormick, Ana Maldonado-Contreras
Summary: This study aims to investigate the impact of specific foods on the intestinal microbiome in patients with IBD and explore the interactions between diet and immunity to provide personalized nutrition guidance for IBD patients with dysbiosis-related conditions.
Article
Medicine, General & Internal
Tien-En Chang, Jiing-Chyuan Luo, Ueng-Cheng Yang, Yi-Hsiang Huang, Ming-Chih Hou, Fa-Yauh Lee
Summary: The study found that patients with IBD had decreased richness and diversity in their gut microbiota compared to healthy controls. There was no significant difference in the composition of fecal microbiota between different types of inflammatory bowel disease.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Review
Immunology
Walaa K. Mousa, Fadia Chehadeh, Shannon Husband
Summary: The interaction between gut microbes and the immune system plays a crucial role in the development and treatment of systemic autoimmune diseases. Understanding how gut microbes can trigger or protect from these diseases can help us tackle them through dietary and lifestyle changes, microbiome-based therapies, identification of diagnostic biomarkers, and intervention with microbial population changes. Considering the microbiome signature as a key player in systemic autoimmune diseases holds promise in transforming these untreatable diseases into manageable or preventable ones.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
HanZheng Zhao, WenHui Zhang, Die Cheng, LiuPing You, YueNan Huang, YanJie Lu
Summary: Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease that occurs in the intestinal tract, with its pathogenesis related to factors such as environment, immune disorders, genetic susceptibility, and intestinal microbes. Dysbiosis of the gut microbiota plays an important role in the occurrence and development of IBD, but the causal relationship between dysbiosis and inflammation is not fully elucidated.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Jongwook Yu, Jae Hee Cheon
Summary: Gut dysbiosis is a prominent feature in inflammatory bowel diseases (IBDs) with unknown causes. Research has focused on managing IBD by modulating and correcting gut dysbiosis, using methods such as antibiotics, probiotics, prebiotics, and fecal microbiota transplantation. However, studies on specific changes in the gut microbiota depending on the treatment options are limited.
Review
Cell Biology
Sheng Liu, Wenjing Zhao, Ping Lan, Xiangyu Mou
Summary: Inflammatory bowel disease (IBD) is a global disease with accelerating incidence worldwide, and dysbiosis of gut microbiota has been consistently associated with IBD. Some alterations in microbiome may have protective or causative effects on IBD. Therapeutic approaches targeting microbiome are a promising strategy for alleviating and curing IBD.
Article
Microbiology
Jason A. Rothman, Jenna L. Riis, Katrina R. Hamilton, Clancy Blair, Douglas A. Granger, Katrine L. Whiteson
Summary: Human oral microbial communities have significant implications for oral and systemic health due to their diversity. Understanding the differences between healthy and dysbiotic oral microbiomes is important, especially within and between families. This study investigates the changes in oral microbiome composition within individuals and the impact of factors such as environmental tobacco smoke exposure, metabolic regulation, inflammation, and antioxidant potential. The findings reveal differences in oral microbiomes between children and caregivers, with shared diversity but distinct differences, and highlight the associations between the oral microbiome and various salivary markers.
Review
Immunology
Samuel Adefisoye Lawal, Athalia Voisin, Hana Olof, Michael Bording-Jorgensen, Heather Armstrong
Summary: The gut microbiota plays a crucial role in the development of inflammatory bowel diseases, and there are significant differences in the microbiota communities of different intestinal sub-organs between healthy individuals and those with IBD. However, research focusing on the mycobiome and virome is limited, and the differences in microbiota composition in different segments of the intestinal tract in IBD remain largely unknown.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Mirae Lee, Eugene B. Chang
Summary: Inflammatory bowel diseases (IBD) result from the interaction of environmental, microbial, immunological, and genetic factors, with alterations in the gut microbiota playing a role in their development and progression. The use of microbiome-based therapies can potentially prevent, manage, and cure IBD, bridging the gap between basic sciences and clinical application through research findings.
Review
Immunology
Yusuke Yoshimatsu, Yohei Mikami, Takanori Kanai
Summary: The number of patients with inflammatory bowel disease is rapidly increasing in developed countries due to environmental changes causing dysbiosis. Bacteriotherapy, which corrects disturbed intestinal microbiota, is a promising treatment for this condition. Fecal microbiome transplantation in 2013 was a significant contribution to bacteriotherapy.
INFLAMMATION AND REGENERATION
(2021)
Article
Microbiology
Ilayda Akacin, Seymanur Ersoy, Osman Doluca, Mine Gungormusler
Summary: This review provides a comprehensive overview of recent literature on the utilization of TGS and NGS technologies in microbial metagenomics research. It discusses the advantages and limitations of these technologies and presents real-time examples of novel applications in clinical microbiology and public health, food and agriculture, energy and environment, arts and space.
MICROBIOLOGICAL RESEARCH
(2022)
Review
Food Science & Technology
Qianqian Yao, Huiying Li, Linlin Fan, Yangdong Zhang, Shengguo Zhao, Nan Zheng, Jiaqi Wang
Summary: Inflammatory bowel disease (IBD) is a global public health issue caused by factors such as environmental factors, gut microbiota, the immune system, and host genetics. Dysbiosis in the gut microbiota can trigger abnormal immune responses and reduce tolerance to commensal bacteria. Further research into the complex interactions between food, gut microbiota, and immune response will contribute to the diagnosis, treatment, and management of IBD.
Article
Ecology
Manolito G. Torralba, Claire Kuelbs, Kelvin Jens Moncera, Rhonda Roby, Karen E. Nelson
Summary: The study of microbial communities on artwork using molecular biology methods has immense potential in identifying potentially damaging species and addressing challenges in restoration and preservation efforts. Different types of artwork, such as paintings on wood, paintings on canvases, and stone sculptures, were found to have differing bacterial communities, with certain oxidase-positive genera potentially responsible for deterioration and fading. This genomics-based approach provides advantages in identifying harmful species that may not be detected using traditional methods and in overcoming challenges in preservation and restoration.
Article
Microbiology
Aleix Lluansi, Marc Lliros, Lia Oliver, Anna Bahi, Nuria Elias-Masiques, Marina Gonzalez, Patricia Benejam, Emilio Cueva, Miquel Termes, Sara Ramio-Pujol, Marta Malagon, Joan Amoedo, Marta Serrano, David Busquets, Leyanira Torreabla, Miriam Sabat, Maria Buxo, Maria Cambra, Mariona Serra-Pages, Silvia Delgado-Aros, Liberado Jesus Garcia-Gil, Isidre Elias, Xavier Aldeguer
Summary: The study evaluated the impact of different bread-making processes on the fecal colonic microbiota in IBD patients, finding that bread has potential prebiotic properties that can enhance short-chain fatty acid production and bacterial growth.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Colleen R. Kelly, Eugene F. Yen, Ari M. Grinspan, Stacy A. Kahn, Ashish Atreja, James D. Lewis, Thomas A. Moore, David T. Rubin, Alison M. Kim, Sonya Serra, Yanina Nersesova, Lydia Fredell, Dea Hunsicker, Daniel McDonald, Rob Knight, Jessica R. Allegretti, Joel Pekow, Imad Absah, Ronald Hsu, Jennifer Vincent, Sahil Khanna, Lyn Tangen, Carl Crawford, Mark C. Mattar, Lea Ann Chen, Monika Fischer, Razvan Arsenescu, Paul Feuerstadt, Jonathan Goldstein, David Kerman, Adam C. Ehrlich, Gary D. Wu, Loren Laine
Summary: This study demonstrated the high effectiveness and good safety profile of FMT for CDI. Assessment of new conditions at long-term follow-up will be important for determining the full safety profile of FMT as this registry grows.
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Erin Alexander, Sonia Ballal, Zev Davidovics, Michael Docktor, Michael Dole, Jonathan M. Gisser, Alka Goyal, Suchitra K. Hourigan, M. Kyle Jensen, Jess L. Kaplan, Richard Kellermayer, Judith R. Kelsen, Melissa A. Kennedy, Sahil Khanna, Elizabeth D. Knackstedt, Jennifer Lentine, Jeffery D. Lewis, Sonia Michail, Paul D. Mitchell, Maria Oliva-Hemker, Tiffany Patton, Karen Queliza, Sarah Sidhu, Aliza B. Solomon, David L. Suskind, Madison Weatherly, Steven Werlin, Edwin F. de Zoeten, Stacy A. Kahn
Summary: The efficacy of fecal microbiota transplantation (FMT) for recurrent Clostridioides difficile infection (rCDI) does not differ in children with inflammatory bowel disease (IBD). Key factors for a successful outcome include receiving FMT with fresh stool, absence of diarrhea prior to FMT, and a shorter time from rCDI diagnosis to FMT. Children with a failed FMT are more likely to have clinically active IBD and require hospitalization.
JOURNAL OF CROHNS & COLITIS
(2022)
Editorial Material
Gastroenterology & Hepatology
Maribeth R. Nicholson, Stacy A. Kahn
Summary: The study examines the perceptions of pediatric patients and parents regarding fecal microbiota transplantation for the treatment of ulcerative colitis.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Pediatrics
Jacob M. Parnell, Maribeth R. Nicholson, Richard Kellermayer, Stacy A. Kahn
Summary: FMT is an important treatment option for pediatric patients with rCDI as it directly targets the underlying gut dysbiosis. This article will summarize the indications, procedures, effectiveness, and safety of FMT for rCDI in children.
Article
Microbiology
Byron J. Smith, Richard A. Miller, Thomas M. Schmidt
Summary: The drug acarbose used to treat diabetes impacts the gut microbiome and its fermentation products by inhibiting starch breakdown in the small intestine. Specifically, certain bacteria from the Muribaculaceae family are more abundant and produce propionate, associated with gut health and longevity in mice. Genomic analysis suggests that these bacteria have specialized in starch fermentation, potentially providing a competitive advantage in the large intestine.
Review
Gastroenterology & Hepatology
Matthew K. Schnizlein, Vincent B. Young
Summary: Clostridioides difficile infection is a significant burden on health and economy worldwide. This review provides insights into the physiology of C. difficile, its survival mechanisms in the gut environment, and the relationships between host-microorganism and microorganism-microorganism.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Microbiology
Madeline R. Barron, Vincent B. Young
Summary: The relationship between the gut environment and bacterial colonization is of great significance. The complex interactions between multiple factors in the gut environment make it difficult to uncover the characteristics of the system using reductionist methods. The systems biology approach provides a more comprehensive perspective. This article explores the relationship between the gut environment and bacterial colonization from the perspective of systems biology, and provides guidance for future research.
Article
Microbiology
Madeline R. Barron, Kelly L. Sovacool, Lisa Abernathy-Close, Kimberly C. Vendrov, Alexandra K. Standke, Ingrid L. Bergin, Patrick D. Schloss, Vincent B. Young
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing C. difficile infection (CDI), even in the absence of antibiotic treatment. The mechanisms regulating C. difficile colonization in IBD patients remain unclear. In this study, a mouse model was used to demonstrate that intestinal inflammation alters microbiota composition, leading to susceptibility to C. difficile colonization. Treating inflammation with an anti-p40 monoclonal antibody restores colonization resistance. Microbiota transfer experiments confirm that the microbiota shaped in the setting of IBD is the primary driver of susceptibility to C. difficile colonization.
Article
Microbiology
Nicholas A. Lesniak, Alyxandria M. Schubert, Kaitlin J. Flynn, Jhansi L. Leslie, Hamide Sinani, Ingrid L. Bergin, Vincent B. Young, Patrick D. Schloss
Summary: Clostridioides difficile colonization can lead to a range of infection severities, from mild diarrhea to life-threatening conditions. While factors such as patient age, blood cell count, and C. difficile characteristics have been associated with disease severity, the role of specific gut bacteria in influencing severity is unclear. This study demonstrates that different gut bacterial communities can contribute to variations in Clostridioides difficile infection outcomes. Certain bacterial groups were associated with more severe outcomes, while others were associated with milder outcomes. Incorporating gut bacterial community data into severity models may aid in identifying at-risk patients and improving interventions.
Article
Public, Environmental & Occupational Health
Meghana Kamineni, Erkin Otles Meng, Jeeheh Oh, Krishna Rao, Vincent B. Young, Benjamin Y. Li, Lauren R. West, David C. Hooper, Erica S. Shenoy, John G. Guttag, Jenna Wiens, Maggie Makar
Summary: This article presents the prospective and retrospective evaluations of two CDI infection risk prediction models and discusses their robustness to data-set shifts.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Ecology
Marshall D. McDaniel, Jeffrey A. Bird, Jennifer Pett-Ridge, Erika Marin-Spiotta, Tom M. Schmidt, A. Stuart Grandy
Summary: Managing soil to retain new plant inputs is crucial for sustainable and regenerative agriculture. This study examined how diversifying and perennializing agroecosystems can decrease losses of new plant residue inputs and increase retention of carbon and nitrogen in the soil. It found that extended rotations and grassland restoration had significant effects on residue decomposition and retention dynamics.
ECOLOGICAL APPLICATIONS
(2023)
Article
Gastroenterology & Hepatology
Patricia P. Bloom, Krishna Rao, Christine Bassis, Borko Nojkov, Vincent B. Young, Anna S. F. Lok
Summary: Patients with cirrhosis have higher duodenal epithelial permeability and lower mucosal bacteria alpha diversity compared to controls, while no such differences are seen in the ileum or colon. Specific bacteria are associated with epithelial permeability and future hepatic decompensation.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Veronica Azcutia, Matthias Kelm, Seonyoung Kim, Anny-Claude Luissint, Sven Flemming, Lisa Abernathy-Close, Vincent B. Young, Asma Nusrat, Mark J. Miller, Charles A. Parkos
Summary: This study used real-time intravital microscopy and a new distal colon loop model to investigate PMN migration dynamics in response to acute colonic injury models. The results revealed different migratory patterns of PMNs under various conditions, suggesting potential mechanisms for regulating PMN migration and providing insights for future anti-inflammatory and pro-repair therapies.
Article
Microbiology
Catherine A. Pfister, Samuel H. Light, Brendan Bohannan, Thomas Schmidt, Adam Martiny, Nicole A. Hynson, Suzanne Devkota, Lawrence David, Katrine Whiteson
Summary: Whether microbe is free-living or associated with host, its existence depends on limited elements and electron donors and acceptors. Two different approaches, environment first research and microbe first research, can reveal the selection of microbial metabolisms, alterations to host microbiomes, and the implications of climate change on microbial function.
Article
Education & Educational Research
Jill M. Plevinsky, Michele H. Maddux, Laurie N. Fishman, Stacy A. Kahn, Rachel N. Greenley
Summary: This study examines the relationship between the perceived impact of IBD on high school academics and college planning and college adjustment. The findings indicate that IBD greatly affects college planning, decision-making, and adjustment, potentially leading to difficulties in academic adjustment, attachment to the institution, and social adjustment during college.
JOURNAL OF AMERICAN COLLEGE HEALTH
(2022)
