期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 4, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fcimb.2014.00069
关键词
Boffelia burgdorferi; Lyme arthritis; eicosanoids; resolution of inflammation; inflammation
资金
- Department of Veterinary Pathobiology, University of Missouri, Columbia, MO
Experimental Lyme arthritis is an inflammatory arthritis caused by infection of mice with the spirochete, Borrelia burgdorferr It recapitulates many of the disease parameters seen in human patients with Lyme arthritis, and thus serves as a model system for the investigation of disease pathogenesis. While much progress has been made in defining components of the immune response to Borrelia infection, an overall understanding of the host response leading to arthritis resistance or susceptibility remains elusive. In this review, we will focus on recent advancements of our understanding of the roles of eicosanoids as inflammatory mediators in the regulation of experimental Lyme arthritis. Eicosanoids, such as PGE(2) and LTB4, are powerful regulators of inflammatory responses and thus may be important mediators of Lyme arthritis.
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