Editorial Material
Biology
Carolina Oliveira de Santana, Pieter Spealman, Gabriel G. Perron
Summary: The global spread of antibiotic resistance may be caused by various factors, not only the previous assumption of antibiotic overuse in agriculture and medicine.
Article
Biology
Lea Pradier, Stephanie Bedhomme
Summary: Antibiotic consumption alone does not fully explain the persistence of antibiotic resistance, as shown by the widespread presence of aminoglycoside-modifying enzyme (AME) genes in bacteria from various ecological contexts. This study demonstrates that the prevalence of AME-carrying bacteria is influenced by ecological factors more than antibiotic use. Analysis of resistome compositions reveals the importance of exchanges between soil, wildlife, and human samples in the dissemination of AME genes. Intervention strategies should consider both reducing antibiotic use and controlling exchanges between ecosystems.
Article
Infectious Diseases
Ashley N. Crotteau, Veronica B. Hubble, Santiana A. Marrujo, Anne E. Mattingly, Roberta J. Melander, Christian Melander
Summary: The Centers for Disease Control and Prevention (CDC) reported five million deaths associated with antimicrobial resistance in 2019. Acinetobacter baumannii, a Gram-negative bacterial pathogen, is considered an urgent threat. Previous research has shown that 2-aminoimidazole (2-AI) adjuvants can enhance the activity of macrolide antibiotics against A. baumannii. This study identified several of these adjuvants that also sensitize A. baumannii to aminoglycoside antibiotics.
Article
Veterinary Sciences
Adam Redpath, Gayle D. Hallowell, Ian Mark Bowen
Summary: The veterinary use of aminoglycoside antibiotics, specifically gentamicin, was investigated through an online questionnaire study involving generalist equine veterinarians and internal medicine specialists. The study found that gentamicin was commonly used without susceptibility testing, with differences in prescribing practices between generalists and specialists. Intravenous administration of gentamicin was most common, with varying routes and dosages observed. Recommendations for better stewardship of aminoglycosides, including more frequent use of susceptibility testing and regional administration, especially in foals, were highlighted.
VETERINARY MEDICINE AND SCIENCE
(2021)
Article
Infectious Diseases
Minjeong Kang, Tae-Rim Choi, Soyeon Ahn, Hee Young Heo, Hyerim Kim, Hye Soo Lee, Yoo Kyung Lee, Hwang-Soo Joo, Philip S. Yune, Wooseong Kim, Yung-Hun Yang
Summary: Bacteria can evade antibiotics through acquiring resistance genes and switching to a dormant state. Our study found that the cold-adapted bacterium Pseudomonas sp. B14-6 showed resistance and tolerance to aminoglycosides, and this ability appears to be related to reduced metabolic activity.
Review
Chemistry, Multidisciplinary
Yang Ding, Zheng Li, Chenchen Xu, Wenjing Qin, Qiong Wu, Xuchun Wang, Xiamin Cheng, Lin Li, Wei Huang
Summary: Beta-lactam antibiotics are important inventions in treating infections, but the emergence of beta-lactamase in bacteria leads to drug resistance. Various detection methods and inhibitors are available, and designing improved probes may help overcome bacterial resistance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Linda B. S. Aulin, Apostolos Liakopoulos, Piet H. van der Graaf, Daniel E. Rozen, J. G. Coen van Hasselt
Summary: Collateral sensitivity-based antibiotic treatments have the potential to limit the emergence of antimicrobial resistance, the efficacy of which depends critically on the design of treatment schedules.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Environmental
Xuesong Hui, Yanqiong Wang, Huan Zhang, Wenjun Fang, Huiling Liu, Xiaohu Dai
Summary: A green novel approach using tea polyphenols as the polyphenol donor was established to remove kanamycin. The results showed that kanamycin could be effectively removed under alkaline conditions with tea polyphenols, with a highest removal efficiency of 99.9%.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Microbiology
Manon Lang, Andre Carvalho, Zeynep Baharoglu, Didier Mazel
Summary: This review aims to consolidate existing and recent knowledge about the uptake of aminoglycosides (AGs), explore the connection between AG-dependent bacterial stress and drug uptake, and present new strategies to enhance AG uptake for more efficient antibiotic therapies, with a focus on the connection between sugar transport and AG potentiation.
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Sky Price, Radhika Mehta, Dominique Tan, Abigail Hinojosa, Pei W. Thomas, Tawanda Cummings, Walter Fast, Emily L. Que
Summary: A library of reversible fluorescent turn-on probes has been developed for studying metallo-beta-lactamases, evaluating the structure-function relationships with regards to inhibitory strength and fluorescence turn-on response for three representative enzymes.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Review
Microbiology
Jon Y. Takemoto, Guillermo A. Altenberg, Naveena Poudyal, Yagya P. Subedi, Cheng-Wei T. Chang
Summary: Due to antibiotic resistance and toxicity, widely-used Streptomyces-derived antibacterial aminoglycosides are mainly used for topical applications in medicine. However, chemical modification can enhance their efficacy against bacterial pathogens and broaden their antibacterial spectra to other pathogens and diseases related to hyperactive connexin hemichannels.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Autumn S. Dove, Dominika I. Dzurny, Wren R. Dees, Nan Qin, Carmen C. Nunez C. Rodriguez, Lauren A. Alt, Garrett L. Ellward, Jacob A. Best, Nicholas G. Rudawski, Kotaro Fujii, Daniel M. Czyz
Summary: Silver nanoparticles (AgNPs) have significant antimicrobial activity without cytotoxicity to mammalian cells. Additionally, they exhibit synergy with clinically relevant antibiotics, reducing the minimum inhibitory concentrations. Therefore, AgNPs have potential clinical applications as standalone therapy or antibiotic adjuvants.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kody A. Klupt, Zongchao Jia
Summary: The alpha-kinase eEF2K phosphorylates eEF2 at its threonine 56 residue to inhibit protein translation. Investigation into eEF2K targeting involves structure-based drug design using computational techniques. eEF2K plays diverse roles in diseases like cancer and neurological disorders, and inhibiting it is considered a potential treatment option. This review discusses the use of homology modeling with crystal structures of related alpha-kinases to improve inhibitor design, as well as the history of eEF2K-related drug discovery and future prospects with the availability of eEF2K crystal structure.
Article
Biochemistry & Molecular Biology
Angela Zaccagnino, Bozhena Vynnytska-Myronovska, Michael Stoeckle, Kerstin Junker
Summary: The study found that the tyrosine kinase inhibitor cabozantinib can inhibit the growth of sunitinib-resistant cell lines in metastatic renal cell carcinoma. However, the response to cabozantinib varies among different cell lines, and the MET and AXL expression levels do not affect the responsiveness to cabozantinib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Ruth Nussinov, Mingzhen Zhang, Ryan Maloney, Chung-Jung Tsai, Bengi Ruken Yavuz, Nurcan Tuncbag, Hyunbum Jang
Summary: Precision oncology benefits from early effective drug discovery decisions, with drugs targeting inactive protein conformations showing success. Cancer driver mutations mimic protein activation mechanisms, guiding target selection. Structural perturbations from double driver mutations may offer new insights for drug design.
MEDICINAL RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Angelia V. Bassenden, Dmitry Rodionov, Kun Shi, Albert M. Berghuis
ACS CHEMICAL BIOLOGY
(2016)
Article
Clinical Neurology
Barbara Rivera, Tenzin Gayden, Jian Carrot-Zhang, Javad Nadaf, Talia Boshari, Damien Faury, Michele Zeinieh, Romeo Blanc, David L. Burk, Somayyeh Fahiminiya, Eric Bareke, Ulrich Schueller, Camelia M. Monoranu, Ronald Straeter, Kornelius Kerl, Thomas Niederstadt, Gerhard Kurlemann, Benjamin Ellezam, Zuzanna Michalak, Maria Thom, Paul J. Lockhart, Richard J. Leventer, Milou Ohm, Duncan MacGregor, David Jones, Jason Karamchandani, Celia M. T. Greenwood, Albert M. Berghuis, Susanne Bens, Reiner Siebert, Magdalena Zakrzewska, Pawel P. Liberski, Krzysztof Zakrzewski, Sanjay M. Sisodiya, Werner Paulus, Steffen Albrecht, Martin Hasselblatt, Nada Jabado, William D. Foulkes, Jacek Majewski
ACTA NEUROPATHOLOGICA
(2016)
Article
Biochemistry & Molecular Biology
Brahm J. Yachnin, Peter C. K. Lau, Albert M. Berghuis
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2016)
Article
Biochemistry & Molecular Biology
Oliver M. Baettig, Kun Shi, Brahm J. Yachnin, David L. Burk, Albert M. Berghuis
Article
Biochemistry & Molecular Biology
Eva E. Avila, Orlando I. Rodriguez, Jaqueline A. Marquez, Albert M. Berghuis
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Shane J. Caldwell, Yue Huang, Albert M. Berghuis
Review
Biochemistry & Molecular Biology
Valjean R. Bacot-Davis, Angelia V. Bassenden, Albert M. Berghuis
Article
Chemistry, Medicinal
Jaeok Park, Chun Yuen Leung, Alexios N. Matralis, Cyrus M. Lacbay, Michail Tsakos, Guillermo Fernandez De Troconiz, Albert M. Berghuis, Youla S. Tsantrizos
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Valjean R. Bacot-Davis, Angelia V. Bassenden, Tara Sprules, Albert M. Berghuis
Article
Biochemistry & Molecular Biology
Desiree H. Fong, David L. Burk, Jonathan Blanchet, Amy Y. Yan, Albert M. Berghuis
Article
Multidisciplinary Sciences
Jaeok Park, Michal Zielinski, Alexandr Magder, Youla S. Tsantrizos, Albert M. Berghuis
NATURE COMMUNICATIONS
(2017)
Article
Microbiology
Shane J. Caldwell, Albert M. Berghuis
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Multidisciplinary Sciences
Jaeok Park, Dmitry Rodionov, Joris W. De Schutter, Yih-Shyan Lin, Youla S. Tsantrizos, Albert M. Berghuis
Article
Oncology
Barbara Rivera, Massimo Di Iorio, Jessica Frankum, Javad Nadaf, Somayyeh Fahiminiya, Suzanna L. Arcand, David L. Burk, Damien Grapton, Eva Tomiak, Valerie Hastings, Nancy Hamel, Rabea Wagener, Olga Aleynikova, Sylvie Giroux, Fadi F. Hamdan, Alexandre Dionne-Laporte, George Zogopoulos, Francois Rousseau, Albert M. Berghuis, Diane Provencher, Guy A. Rouleau, Jacques L. Michaud, Anne-Marie Mes-Masson, Jacek Majewski, Susanne Bens, Reiner Siebert, Steven A. Narod, Mohammad R. Akbari, Christopher J. Lord, Patricia N. Tonin, Alexandre Orthwein, William D. Foulkes