Article
Multidisciplinary Sciences
Akshay Markanday, Sungho Hong, Junya Inoue, Erik De Schutter, Peter Thier
Summary: The study shows that the cerebellum's ability for multidimensional computations allows it to flexibly control multiple movement parameters to ensure movement precision.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Omid A. Zobeiri, Kathleen E. Cullen
Summary: Accurately controlling posture and spatial orientation during self-motion requires integration of vestibular and neck proprioceptive inputs. The anterior vermis of the cerebellum is believed to play a crucial role in transforming sensory information into an estimate of body motion. The response dynamics of Purkinje cells in the anterior vermis show heterogeneity and they encode an intermediate representation of self-motion between head and body motion. This heterogeneity is proposed to underlie the cerebellum's ability to compute the dynamic representation of body motion for postural control and perceptual stability.
Article
Multidisciplinary Sciences
Ehsan Sedaghat-Nejad, Jay S. Pi, Paul Hage, Mohammad Amin Fakharian, Reza Shadmehr
Summary: The ability of the brain to control movement accurately relies on the cerebellum. Recent research has found that cerebellar P cells transmit information by synchronizing their spikes and utilizing disinhibition to convey important signals for movement control.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Jinya Soga, Masayuki Matsuyama, Hiroaki Miura, Stephen Highstein, Robert Baker, Yutaka Hirata
Summary: Multiple frequency components in motor motions require adjustment through motor learning, with the cerebellum playing a crucial role in frequency competitive motor learning. The study on goldfish VOR shows that both gain-up and gain-down learning are involved in motor skill acquisition, with the unique ability of the oculomotor system to handle different frequency components.
Article
Multidisciplinary Sciences
Naveen Sendhilnathan, Anna Ipata, Michael E. Goldberg
Summary: The role of complex spikes in reinforcement learning and their interaction with simple spikes remain unclear. This study reveals that complex spikes carry multiple context-based signals independent of motor kinematics and unlikely to guide concurrent simple spike activity through an error-based mechanism. The diverse neural encoding in the cerebellum supports flexible stimulus-action-reward relationships in different contexts and learning states.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Akshay Markanday, Junya Inoue, Peter W. Dicke, Peter Thier
Summary: The discharge of Purkinje cells in the cerebellar cortex involves high-frequency simple spikes and low-frequency complex spikes. While simple spikes are believed to convey information for optimizing movement kinematics, the function of complex spikes remains controversial, with the possibility of contributing to other aspects of motor behavior.
Article
Neurosciences
Liansheng Chang, Shahid Hussain Soomro, Hongfeng Zhang, Hui Fu
Summary: Ankfy1 protein plays a critical role in the development and maintenance of Purkinje cells in the cerebellum. Its absence leads to loss of most Purkinje cells in the cerebellum, resulting in impaired motor function.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Shu-Tao Xie, Wen-Chu Fan, Xian-Sen Zhao, Xiao-Yang Ma, Ze-Lin Li, Yan-Ran Zhao, Fa Yang, Ying Shi, Hui Rong, Zhi-San Cui, Jun-Yi Chen, Hong-Zhao Li, Chao Yan, Qipeng Zhang, Jian-Jun Wang, Xiao-Yang Zhang, Xiao-Ping Gu, Zheng-Liang Ma, Jing-Ning Zhu
Summary: Specific medications for cerebellar ataxias are still lacking, but the activation of cerebellar microglia has been found to be common in ataxic patients and rodent models. This study provides direct evidence that activating cerebellar microglia induces ataxia symptoms and worsens motor deficits in a mouse model of cerebellar ataxia. The activation of microglia leads to the hyperexcitation of Purkinje cells which triggers ataxia, and inhibiting microglia activation can alleviate motor deficits in mice.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biology
Sol Pose-Mendez, Paul Schramm, Barbara Winter, Jochen C. Meier, Konstantinos Ampatzis, Reinhard W. Koester
Summary: Zebrafish are capable of regenerating neurons in the central nervous system, including Purkinje cells. The study demonstrates that when the Purkinje cells are ablated, they can quickly recover, regain their electrophysiological properties, and restore cerebellum-controlled behavior. Furthermore, the study also shows that Purkinje cell progenitors are present in both larvae and adults, and adult zebrafish are able to regenerate different types of Purkinje cells to restore behavioral impairments.
Review
Neurosciences
Kim van Dun, Pia Brinkmann, Siel Depestele, Stefanie Verstraelen, Raf Meesen
Summary: Bimanual coordination involves a large neural network, with the anterior cerebellum playing a role in anti-phase and complex coordination, and the posterior cerebellum having an exclusive role in complex bimanual movements. Complexity manipulation also impacts the involvement of the anterior and posterior cerebellum vermis.
Review
Behavioral Sciences
E. J. Tehovnik, E. Froudarakis, F. Scala, S. M. Smirnakis, S. S. Patel, A. S. Tolias
Summary: In this study, a comparative evaluation of the visual systems of mice and macaque monkeys was conducted, discussing differences and similarities in various aspects of visual processing. Insights into how the neocortex mediates conscious vision in these species were provided, emphasizing the need for a comparative analysis of how the brain generates visuomotor responses in these two species.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Aasef G. Shaikh
Summary: This article discusses the relationship between clear vision and gaze shift and holding, highlighting the importance of the cerebellum in gaze control. The author reviews the research progress on cerebellar involvement in gaze control over the past three centuries and highlights the development of computational models in this field.
Article
Multidisciplinary Sciences
Martijn Schonewille, Allison E. Girasole, Philippe Rostaing, Caroline Mailhes-Hamon, Annick Ayon, Alexandra B. Nelson, Antoine Triller, Mariano Casado, Chris De Zeeuw, Guy Bouvier
Summary: The study reveals that NMDARs are present and functional in presynaptic terminals of adult rodents, playing a crucial role in bidirectional synaptic plasticity and cerebellar motor learning.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Takayuki Michikawa, Takamasa Yoshida, Satoshi Kuroki, Takahiro Ishikawa, Shinji Kakei, Ryo Kimizuka, Atsushi Saito, Hideo Yokota, Akinobu Shimizu, Shigeyoshi Itohara, Atsushi Miyawaki
Summary: The study demonstrates that the cerebellum utilizes segment-based, distributed-population coding to represent the conditional probability of sensory events.
Article
Clinical Neurology
Ester Perez-Martin, Rodrigo Munoz-Castaneda, Marie-Jo Moutin, Carmelo A. avila-Zarza, Jose M. Munoz-Castaneda, Carlos Del Pilar, Jose R. Alonso, Annie Andrieux, David Diaz, Eduardo Weruaga
Summary: The study found that OEA can prevent morphological changes in Purkinje cells and reduce cell death in mice before neurodegeneration occurs, leading to improvements in motor, cognitive, and social functions.
Article
Biochemistry & Molecular Biology
Chih-Yang Chen, Alla Ignashchenkova, Peter Thier, Ziad M. Hafed
Article
Neurosciences
Daniel Arnstein, Marc Junker, Aleksandra Smilgin, Peter W. Dicke, Peter Thier
JOURNAL OF NEUROSCIENCE
(2015)
Article
Biology
Karolina Marciniak, Peter W. Dicke, Peter Thier
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2015)
Article
Neurosciences
Akshay Markanday, Julian Messner, Peter Thier
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Marc Junker, Dominik Endres, Zong Peng Sun, Peter W. Dicke, Martin Giese, Peter Thier
Article
Multidisciplinary Sciences
Mohammad Farhan Khazali, Hamidreza Ramezanpour, Peter Thier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Letter
Multidisciplinary Sciences
Marius Goerner, Hamidreza Ramezanpour, Ian Chong, Peter Thier
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Neurosciences
P. M. Kraemer, M. Gorner, H. Ramezanpour, P. W. Dicke, P. Thier
Article
Biology
Nick Taubert, Michael Stettler, Ramona Siebert, Silvia Spadacenta, Louisa Sting, Peter Dicke, Peter Thier, Martin A. Giese
Summary: The study found that human observers were able to quickly learn cross-species expressions, indicating that face dynamics are largely represented independently of facial shape. This result supports the co-evolution of visual processing and motor control of facial expressions, while challenging appearance-based neural network theories of dynamic expression recognition.
Article
Neurosciences
Hamidreza Ramezanpour, Marius Gorner, Peter Thier
Summary: Recent studies have shown that neuronal discharge variability in the gaze-following patch (GFP) of the primate brain is related to task performance and can predict upcoming correct or wrong decisions, indicating that variability in neuronal discharge is an informative measure in the study of complex social behaviors. The quenching of neural variability and the relationship between task selectivity, firing rates, and variability quenching in the GFP region suggest that both firing rates and variability quenching play a role in facilitating optimal behavioral performance.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Oleg Spivak, Peter Thier, Shabtai Barash
Summary: The study examines the impact of prior training experience on sensorimotor behavior in monkeys. Monkeys habituated to working in dark environments displayed a significantly larger upshift in gaze direction compared to those habituated in bright light. This suggests that the size of the upshift reflects long-term cumulative experience, indicating a relationship between the function of the upshift and vision in dark environments.
Letter
Neurosciences
Akshay Markanday, Junya Inoue, Paul Vialkowitsch, Peter Thier
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
M. S. Breu, H. Ramezanpour, P. W. Dicke, P. Thier
Summary: Gaze following is a crucial aspect of non-verbal communication and plays a significant role in successful social interactions. This study utilized event-related fMRI to investigate the neural mechanisms underlying the cognitive control of gaze following. The findings suggest that overactivation of frontoparietal circuits might contribute to deficits in gaze following observed in clinical populations.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Akshay Markanday, Sungho Hong, Junya Inoue, Erik De Schutter, Peter Thier
Summary: The study shows that the cerebellum's ability for multidimensional computations allows it to flexibly control multiple movement parameters to ensure movement precision.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Mohammad Farhan Khazali, Nabil Daddaoua, Peter Thier
Summary: When humans tilt their heads in the dark, the noise in vestibular information makes it difficult to accurately report the orientation of objects with respect to Earth's vertical axis. This difficulty can be reduced if there is a vertical visual background. Tilted visual backgrounds create the illusion of head tilt. A study found that monkeys also have similar perceptual mechanisms.
JOURNAL OF NEUROPHYSIOLOGY
(2023)