Article
Radiology, Nuclear Medicine & Medical Imaging
Paulo Puac-Polanco, Nader Zakhari, Gerard H. Jansen, Carlos Torres
Summary: A 64-year-old man presented with a 6-month history of lightheadedness and intermittent balance and coordination difficulties. He also experienced speech difficulties and cognitive changes. Initial MRI revealed abnormal findings in the left supratentorial brain.
Article
Clinical Neurology
Ahmed Abdelhak, Kai Antweiler, Markus C. Kowarik, Makbule Senel, Joachim Havla, Uwe K. Zettl, Ingo Kleiter, Thomas Skripuletz, Axel Haarmann, Alexander Stahmann, Andre Huss, Stefan Gingele, Markus Krumbholz, Pascal Benkert, Jens Kuhle, Tim Friede, Albert C. Ludolph, Ulf Ziemann, Tania Kuempfel, Hayrettin Tumani
Summary: This study confirms the value of serum GFAP and NfL in PPMS and SPMS, and indicates that the combination of high GFAP and low NfL levels can help identify progression risk in people with progressive multiple sclerosis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Pediatrics
Dina Angelika, Risa Etika, Munawaroh Fitriah, Naomi Nathania Kusumawardani, Angelica Diana Vita, Roedi Irawan, Kian Djien Liem, I. Dewa Gede Ugrasena
Summary: This study analyzed the relationship between GFAP, GDNF, and FABP-2 in preterm infants and the incidence of NEC. It found that increased levels of GFAP and FABP-2 at birth were significantly associated with an increased risk of NEC. These findings suggest a link between early-onset NEC and intestinal injury during the perinatal or even prenatal period.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Jiao Li, Chentao Wang, Yulan Cao, Jijun Shi, Huihui Liu, Meili Zhou, Chunfeng Liu, Weidong Hu
Summary: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is a steroid-responsive autoimmune disease of the nervous system, and timely accurate diagnosis and appropriate treatment are crucial for improving patient outcomes.
Article
Clinical Neurology
Zhongmin Yuan, Huilu Li, Lu Huang, Congcong Fu, Yaotang Chen, Cheng Zhi, Wei Qiu, Youming Long
Summary: In autoimmune GFAP astrocytopathy (GFAP-A), there is a predominance of CD8(+) T cells with marked lymphocytic infiltration, especially adjacent to dystrophic neurons and astrocytes. Additionally, there is diffuse infiltration by CD68(+) and CD163(+) macrophages. CD8(+) astrocytes were identified in some samples, but no CD4(+) astrocytes were observed.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Shanice Beerepoot, Hans Heijst, Birthe Roos, Mirjam M. C. Wamelink, Jaap Jan Boelens, Caroline A. Lindemans, Peter M. van Hasselt, Edwin H. Jacobs, Marjo S. van der Knaap, Charlotte E. Teunissen, Nicole Wolf
Summary: This study compared neurofilament light chain and GFAP levels in patients with metachromatic leukodystrophy and healthy controls, suggesting that these two proteins may serve as biomarkers for clinical assessment and treatment decisions.
Article
Microbiology
Moises Garces, Isabel M. Guijarro, Diane L. Ritchie, Juan J. Badiola, Marta Monzon
Summary: Human prion diseases are fatal neurodegenerative diseases characterized by accumulation of pathological prion protein, neuronal death, and vacuolation. Glial cells, especially astrocytes and microglia, play a prominent role in the neurodegenerative process regardless of the prion type. Common pathological features such as gliosis were observed in all types of Creutzfeldt-Jakob disease.
Article
Medicine, General & Internal
Eun-Hee Kim, Young-Eun Jang, Sang-Hwan Ji, Ji-Hyun Lee, Sung-Ae Cho, Jin-Tae Kim, Hyunyee Yoon, Hee-Soo Kim
Summary: The study investigated changes in plasma glial fibrillary acidic protein concentration during sevoflurane anesthesia induction in children under 3 years old and found that three hours of anesthesia did not cause neuronal injury. However, co-administration of dexmedetomidine led to an increase in plasma glial fibrillary acidic protein levels after 180 minutes, indicating a potential effect on neuronal injury that requires further study.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Yingfang Liang, Gangqi Wang, Bixun Li, Guoliang Li, Hao Zeng
Summary: This study aimed to summarize the clinical features of Autoimmune Glial Fibrillary Acidic Protein Astrocytosis mimicking tuberculosis meningitis. The clinical manifestations, cerebrospinal fluid results, and imaging data of five patients were retrospectively analyzed. Anti-GFAP antibody testing should be routinely performed in patients with suspected tuberculosis meningitis to avoid misdiagnosis.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Claus V. B. Hviid, Michael E. Benros, Jesper Krogh, Merete Nordentoft, Silje H. Christensen
Summary: This study found that serum GFAP/NfL levels in patients with unipolar depression were lower compared to healthy controls, while NfL levels increased during the follow-up period. Although no consistent associations were found between GFAP/NfL and depression severity or cognitive function, the study may support the presence of glial dysfunction but limited neuron damage in depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Correction
Biochemistry & Molecular Biology
Claudia Sticozzi, Giuseppe Belmonte, Maria Frosini, Federica Pessina
Summary: There is a mistake in Fig. 7 of the original version of this article.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Pediatrics
Haixia Huang, Ke Bai, Yueqiang Fu, Siwei Lu, Yunni Ran, Hongxing Dang, Jing Li
Summary: Autoimmune GFAP astrocytopathy is a novel form of autoimmune meningoencephalitis related to GFAP autoantibodies, with few pediatric cases reported. Diagnosis is confirmed through MRI analysis and antibody testing, with treatment usually involving IVIG and intravenous steroids.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Christopher Kapitza, Rittika Chunder, Anja Scheller, Katherine S. Given, Wendy B. Macklin, Michael Enders, Stefanie Kuerten, Winfried L. Neuhuber, Juergen Woerl
Summary: This study aimed to identify glial and myelin markers as potential target structures for autoimmune processes in the esophagus, with results suggesting the involvement of enteric glial cells in the pathogenesis of dysphagia in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emanuela Paldino, Vincenza D'angelo, Mariangela Massaro Cenere, Ezia Guatteo, Simone Barattucci, Giorgia Migliorato, Nicola Berretta, Olaf Riess, Giuseppe Sancesario, Nicola Biagio Mercuri, Francesca Romana Fusco
Summary: This study used immunohistochemical studies to investigate neuropathological changes in a rat transgenic model of Parkinson's disease (PD). It found that in the advanced stages of the disease, there was neuronal loss in the dorsolateral part of the striatum, along with a dramatic loss of parvalbumin interneurons. A marked decrease in the neurotrophic factor called glial-derived neurotrophic factor (GDNF) was also observed in the striatum and substantia nigra of these animals. This confirms the involvement of the striatum in PD pathophysiology and the importance of GDNF in maintaining the health of the substantia nigra.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Amelie Darlix, Christophe Hirtz, Caroline Mollevi, Nelly Ginestet, Laurent Tiers, William Jacot, Sylvain Lehmann
Summary: In patients with metastatic breast cancer, elevated serum levels of GFAP are independently associated with the presence of brain metastases and poor outcomes, outperforming other biomarkers such as NfL, UCHL1, and tau. These findings suggest that GFAP may serve as a valuable diagnostic and prognostic factor for brain metastases in this patient population, although further validation in independent cohorts is necessary.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Behavioral Sciences
Ida Hageman, Marianne Nielsen, Gitta Wortwein, Nils Henrik Diemer, Martin Balslev Jorgensen
BEHAVIOURAL BRAIN RESEARCH
(2009)
Article
Neurosciences
Kate Lykke Lambertsen, Bettina Hjelm Clausen, Alicia Anne Babcock, Rikke Gregersen, Christina Fenger, Helle Hvilsted Nielsen, Laila Skov Haugaard, Martin Wirenfeldt, Marianne Nielsen, Frederik Dagnaes-Hansen, Horst Bluethmann, Nils Joakim Faergeman, Michael Meldgaard, Tomas Deierborg, Bente Finsen
JOURNAL OF NEUROSCIENCE
(2009)
Article
Behavioral Sciences
I. Hageman, M. Nielsen, G. Wortwein, N. H. Diemer, M. B. Jorgensen
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2008)
Article
Neurosciences
Maria Montero, Marianne Nielsen, Lars Christian B. Ronn, Arne Moller, Jens Noraberg, Jens Zimmer
Article
Pathology
Martin Wirenfeldt, Lasse Dissing-Olesen, Alicia Anne Babcock, Marianne Nielsen, Michael Meldgaard, Jens Zimmer, Inigo Azcoitia, Robert Graham Quinton Leslie, Frederik Dagnaes-Hansen, Bente Finsen
AMERICAN JOURNAL OF PATHOLOGY
(2007)
Article
Neurosciences
M Kolko, M Nielsen, NG Bazan, NH Diemer
JOURNAL OF NEUROSCIENCE RESEARCH
(2002)
Article
Neurosciences
CW Alsbo, ML Wrang, M Nielsen, NH Diemer
Article
Biochemistry & Molecular Biology
T Bruhn, LM Levy, M Nielsen, T Christensen, FF Johansen, NH Diemer
NEUROCHEMISTRY INTERNATIONAL
(2000)
Article
Neurosciences
M Nielsen, NH Diemer
NEUROSCIENCE RESEARCH COMMUNICATIONS
(2001)