Article
Medicine, General & Internal
Katarina Lopusna, Pawel Nowialis, Jana Opavska, Ajay Abraham, Alberto Riva, Rene Opavsky
Summary: The study revealed that Dnmt3b's catalytic activity is largely dispensable for mouse development but critical for preventing tumorigenesis by controlling events involved in cellular transformation. The lack of Dnmt3b's catalytic activity promoted fibroblast transformation in vitro and accelerated the development of certain types of leukemia and lymphoma in vivo.
Article
Cell Biology
Yi Liu, Demin Cheng, Yue Wang, Sichuan Xi, Ting Wang, Wenqing Sun, Guanru Li, Dongyu Ma, Siyun Zhou, Ziwei Li, Chunhui Ni
Summary: This study identified the involvement of Uhrf1 in mediating ferroptosis of chemically injured AEC2 cells through de novo promoter-specific methylation of GPX4 and FSP1 genes, thus accelerating the process of pulmonary fibrosis. Inhibition of Uhrf1 can prevent the formation of ferroptosis and block the progression of pulmonary fibrosis.
CELL DEATH & DISEASE
(2022)
Article
Biology
Filippo Macchi, Eric Edsinger, Kirsten C. Sadler
Summary: The study reveals that the epigenetic machinery of DNA methylation and histone modification is conserved in cephalopods, with DNA methylation enriching gene bodies of highly expressed genes and not decorating transposable elements. This indicates a potential cooperation between 5-methyl-cytosine and the histone code in regulating tissue-specific gene expression in octopuses.
Review
Immunology
Liangjie Xu, Cuicui Zhou, Yi Liang, Tinpan Fan, Fen Zhang, Xinxin Chen, Wei Yuan
Summary: This article reviews the interaction between epigenetic modifications and the functions of myeloid-derived suppressor cells (MDSCs), and briefly introduces how the accumulation and function of MDSCs caused by epigenetic modifications impact disease development, providing a promising therapeutic strategy for related disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Zhichao Zhang, Shuai Yu, Jing Li, Yanbin Zhu, Siqi Jiang, Haoran Xia, Yue Zhou, Daqiu Sun, Meiling Liu, Cong Li, Yanshu Zhu, Yanye Ruan, Xiaomei Dong
Summary: A total of 691 possible imprinted genes were identified in the sunflower endosperm, showing conservation and intraspecific variation, with limited imprinted loci found in other species. The study suggests that demethylation in the maternal CG context may induce genomic imprinting in the endosperm.
Review
Oncology
Yanzi Pei, Yujie Qian, Hao Wang, Li Tan
Summary: This article summarizes the recent advances in understanding the epigenetic mechanisms that control the expression of ferroptosis-associated genes and the process of ferroptosis. The potential value of epigenetic drugs in targeting or synergizing ferroptosis during cancer therapy is also discussed.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Huimin Liu, Dongxu Wang, Zhijing Yang, Shuangji Li, Han Wu, Jingcheng Xiang, Shaoning Kan, Ming Hao, Weiwei Liu
Summary: Epigenetic modifications play crucial roles in regulating the tumor microenvironment of head and neck tumors, influencing tumor development by altering gene expression and behavior of cells in TME.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleonora Zorzan, Ramy Elgendy, Giorgia Guerra, Silvia Da Ros, Maria Elena Gelain, Federico Bonsembiante, Giulia Garaffo, Nicoletta Vitale, Roberto Piva, Laura Marconato, Luca Aresu, Mauro Dacasto, Mery Giantin
Summary: This study investigates the epigenetic deregulation in canine diffuse large B-cell lymphoma (cDLBCL) by analyzing the DNA methylome and identifying potential tumor suppressor genes subjected to DNA methylation. CiDEA, MAL, and PCDH17 were found to be hypermethylated and suppressed in DLBCL samples, and they showed responsiveness to hypomethylating drugs and histone deacetylase inhibitors. In silico analysis predicted that AP2, MZF1, NF-kB, PAX5, and SP1 transcription factors are involved in the methylation-dependent inhibition of these genes. This research provides insights into the epigenetically-dysregulated pathways in cDLBCL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Kazem Nejati-Koshki, Chris-Tiann Roberts, Ghader Babaei, Mojgan Rastegar
Summary: Epigenetic mechanisms control gene expression and cellular identity, with DNA methylation being an important epigenetic modification. Methyl-CpG-Binding Protein 2 (MeCP2) is a reader of DNA methylation and plays key roles in cellular identity and function. Recent studies have uncovered MeCP2's involvement in tumorigenesis of various human cancers, highlighting its potential oncogenic properties. This article provides an overview of the emerging role of MeCP2 as an oncogene in different types of human cancer.
Article
Cell Biology
Keren Xu, Shaobo Li, Ivo S. Muskens, Natalina Elliott, Swe Swe Myint, Priyatama Pandey, Helen M. Hansen, Libby M. Morimoto, Alice Y. Kang, Xiaomei Ma, Catherine Metayer, Beth A. Mueller, Irene Roberts, Kyle M. Walsh, Steve Horvath, Joseph L. Wiemels, Adam J. Smith
Summary: The study revealed that accelerated epigenetic aging in the blood of Down syndrome (DS) patients begins prenatally and is associated with somatic GATA1 mutations. DS newborns showed a significant increase in DNAmSkinBloodClock, but were not associated with epigenetic gestational age acceleration.
Article
Cell Biology
Pierre Balmer, William V. J. Hariton, Beyza S. Sayar, Vidhya Jagannathan, Arnaud Galichet, Tosso Leeb, Petra Roosje, Eliane J. Muller
Summary: This study investigates the functional role of SUV39H2 in maintaining the pool of stem and progenitor cells by restricting gene expression through inhibitory H3K9me3 marks on gene promoters. Loss of SUV39H2 function leads to premature exit of progenitor cells from the cell cycle due to enhanced Wnt activity, compromising epidermal differentiation and genome stability. SUV39H2 is identified as a major gatekeeper in regulating progenitor fate conversion through H3K9me3 rate-limiting road blocks in basal layer keratinocytes.
JOURNAL OF CELL BIOLOGY
(2021)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Article
Multidisciplinary Sciences
Amir D. Hay, Noah J. Kessler, Daniel Gebert, Nozomi Takahashi, Hugo Tavares, Felipe K. Teixeira, Anne C. Ferguson-Smith
Summary: A study found that DNA methylation is generally stable at hypo- and hypermethylated sites, but not at intermediately methylated sites. The lack of clonal inheritance at these sites challenges the current model of epigenetic inheritance and has implications for the functional relevance and interpretability of DNA methylation as a stable epigenetic mark.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Waseem Ashraf, Tanveer Ahmad, Nicolas Reynoird, Ali Hamiche, Yves Mely, Christian Bronner, Marc Mousli
Summary: Cancer is a major cause of death worldwide, and its incidence and mortality rates are increasing annually. Abnormal genetic and epigenetic regulations, including the role of the epigenetic regulator UHRF1, contribute to cellular transformation and tumorigenesis. UHRF1, overexpressed in most cancers, regulates DNA methylation and histone modifications, leading to the silencing of tumor-suppressor genes, drug resistance, and uncontrolled proliferation. Natural compounds that downregulate UHRF1 have shown potential in reactivating tumor-suppressor genes and inhibiting cell growth. This review discusses the underlying mechanisms and potential of natural and synthetic compounds in inhibiting/minimizing UHRF1's oncogenic activities and expression.
Article
Biochemistry & Molecular Biology
Yuxi Zhang, Tao Zhang, Fuhui Si, Xueting Wang, Chunying Liu, Yanchao Yuan, Weirong Feng, Shupeng Gai
Summary: DNA methylation plays a crucial role in regulating gene expression and promoting bud dormancy release and growth in tree peonies. Chilling accumulation was found to modulate specific gene expression through DNA methylation modification, leading to dormancy release and shoot growth in tree peonies.
DNA AND CELL BIOLOGY
(2021)