Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4+ T cells tolerized by peptide immunotherapy

CD8+CD205+ Splenic Dendritic Cells Are Specialized to Induce Foxp3+ Regulatory T Cells

(2014) S. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Effector and central memory T helper 2 cells respond differently to peptide immunotherapy

(2014) K. J. Mackenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation and methylcytosine oxidation in cell fate decisions

(2013) Kian Peng Koh et al.   CURRENT OPINION IN CELL BIOLOGY

TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

(2013) Rachel Deplus et al.   EMBO JOURNAL

T-cell memory differentiation: insights from transcriptional signatures and epigenetics

(2013) Ben Youngblood et al.   IMMUNOLOGY

TET enzymes, TDG and the dynamics of DNA demethylation

(2013) Rahul M. Kohli et al.   NATURE

Dynamic changes in 5-hydroxymethylation signatures underpin early and late events in drug exposed liver

(2013) John P. Thomson et al.   NUCLEIC ACIDS RESEARCH

Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes

(2013) James P Reddington et al.   GENOME BIOLOGY

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline

(2012) J. A. Hackett et al.   DEVELOPMENT

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

(2012) Nir Yogev et al.   IMMUNITY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source

(2012) M. D. Leech et al.   JOURNAL OF IMMUNOLOGY

Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

(2012) N. Patsoukis et al.   Science Signaling

Non-genotoxic carcinogen exposure induces defined changes in the 5-hydroxymethylome

(2012) John P Thomson et al.   GENOME BIOLOGY

Immune Cell Entry to Central Nervous System - Current Understanding and Prospective Therapeutic Targets

(2012) Catriona Prendergast et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

The negative costimulatory molecule PD-1 modulates the balance between immunity and tolerance via miR-21

(2011) Dimitrios Iliopoulos et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

(2011) C. E. Nestor et al.   GENOME RESEARCH

Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells

(2011) Ben Youngblood et al.   IMMUNITY

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

(2011) Charlly Kao et al.   NATURE IMMUNOLOGY

Prenatal Dexamethasone Programs Expression of Genes in Liver and Adipose Tissue and Increased Hepatic Lipid Accumulation But Not Obesity on a High-Fat Diet

(2010) Amanda J. Drake et al.   ENDOCRINOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

PD-1 signalling in CD4+T cells restrains their clonal expansion to an immunogenic stimulus, but is not critically required for peptide-induced tolerance

(2010) Joanne E. Konkel et al.   IMMUNOLOGY

Myelin-Reactive, TGF- -Induced Regulatory T Cells Can Be Programmed To Develop Th1-Like Effector Function but Remain Less Proinflammatory Than Myelin-Reactive Th1 Effectors and Can Suppress Pathogenic T Cell Clonal Expansion In Vivo

(2010) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine

(2010) Chun-Xiao Song et al.   NATURE BIOTECHNOLOGY

Epitope-specific immunotherapy of rheumatoid arthritis: Clinical responsiveness occurs with immune deviation and relies on the expression of a cluster of molecules associated with T cell tolerance in a double-blind, placebo-controlled, pilot phase II trial

(2009) Eva C. Koffeman et al.   ARTHRITIS AND RHEUMATISM

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo

(2009) S. Chikuma et al.   JOURNAL OF IMMUNOLOGY

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology