Article
Biology
Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M. Young
Summary: This study reveals the key regulatory role of Rac1 in synaptic transmission, mainly through modulating the dynamics of synaptic vesicle priming and potentially the release probability, affecting synaptic strength and short-term plasticity.
Article
Biochemistry & Molecular Biology
Callista B. Harper, Eva-Maria Blumrich, Michael A. Cousin
Summary: The study highlights the crucial role of the cytoplasmic C terminus of synaptophysin (Syp) in facilitating the accurate retrieval of synaptobrevin-II (SybII) during synaptic vesicle endocytosis. Neurons lacking Syp show defects in SybII retrieval, emphasizing the importance of a conformational change within the Syp C terminus for proper binding and retrieval. Importantly, the study suggests that Syp's presynaptic role is specifically related to the control of SybII retrieval, without affecting the kinetics of synaptic vesicle endocytosis at physiological temperatures.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Nozomu Takata, Jason M. Miska, Marc A. Morgan, Priyam Patel, Leah K. Billingham, Neha Joshi, Matthew J. Schipma, Zachary J. Dumar, Nikita R. Joshi, Alexander V. Misharin, Ryan B. Embry, Luciano Fiore, Peng Gao, Lauren P. Diebold, Gregory S. McElroy, Ali Shilatifard, Navdeep S. Chandel, Guillermo Oliver
Summary: Using eye organoids and mouse models, the authors demonstrate that lactate plays a bioenergetic independent role as a cell signaling molecule during early eye formation in mice. The study reveals the importance of aerobic glycolysis in retinal development and identifies specific glucose transporters and glycolytic genes involved. Lactate-mediated upregulation of eye-field transcription factors is controlled by epigenetic modifications.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Carolina Montenegro-Venegas, Debarpan Guhathakurta, Eneko Pina-Fernandez, Maria Andres-Alonso, Florian Plattner, Eckart D. Gundelfinger, Anna Fejtova
Summary: This study reveals that the protein bassoon organizes the release of neurotransmitters by regulating synaptic phosphorylation and cAMP homeostasis. Synapses lacking bassoon exhibit decreased release competence of synaptic vesicles and increased resting pool of vesicles. Furthermore, the CDK5/PDE4/cAMP signaling pathway plays a crucial role in the regulation of neurotransmitter release.
Article
Multidisciplinary Sciences
Meng Zhang, Aili Cao, Lin Lin, Ying Chen, Yuan Shang, Chao Wang, Mingjie Zhang, Jinwei Zhu
Summary: The truncated guanylate kinase (GK) domain of MAGI2 interacts with its adjacent PDZ0 domain to form a supramodule capable of recognizing phosphoproteins. Identification of a phosphorylation-dependent binding motif for PDZ0-GK leads to the discovery of previously unknown binding partners. The structure and function of the MAGI2-target complex is explored using an inhibitory peptide derived from the consensus motif, revealing the action mechanism of cryptic MAGI GKs and broadening our understanding of target recognition rules of phosphoprotein binding modules.
Article
Multidisciplinary Sciences
Ji-Ung Jung, Melanie H. Cobb
Summary: The protein kinase WNK1 influences the trafficking and actin polymerization of membrane proteins. This study discovered a connection between WNK1 and TRIM27, which regulates endosomal actin polymerization. Depletion of WNK1 disrupted WASH ubiquitination and endosomal actin polymerization, affecting endosomal trafficking. Depletion of WNK1 or TRIM27 increased the degradation of EGFR in cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Chun-Qing Zhang, Mackenzie A. Catron, Li Ding, Caitlyn M. Hanna, Martin J. Gallagher, Robert L. Macdonald, Chengwen Zhou
Summary: The study revealed that physiologically similar states to slow-wave sleep can enhance excitatory synaptic currents in cortical neurons, potentially involving signaling pathways of homeostatic synaptic plasticity. In genetic generalized epilepsy models, the enhanced excitatory synaptic currents in this state may lead to epileptic seizures.
Article
Plant Sciences
Kannan Pachamuthu, Vivek Hari Sundar, Anushree Narjala, Rahul R. Singh, Soumita Das, Harshith C. Y. Avik Pal, Padubidri Shivaprasad
Summary: This study identifies a nitrate-responsive miR444-OsMADS27 signaling cascade involved in the regulation of rice root growth and stress responses.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Rui Sun, Xuemei Gu, Chao Lei, Liang Chen, Shenghui Chu, Guangzhong Xu, Mark A. Doll, Yi Tan, Wenke Feng, Leah Siskind, Craig J. McClain, Zhongbin Deng
Summary: This study reveals the critical role of Neutral ceramidase (NcDase) in regulating intestinal immune cells. Lack of NcDase leads to altered composition of intestinal immune cells and impairs the clearance of bacteria in mice. Mechanistically, the generation of sphingosine by NcDase promotes immune response in macrophages. Furthermore, dietary sphingomyelin and inhibition of SphK1 can protect against infection.
Article
Cell Biology
Mehdi Hooshmandi, Vinh Tai Truong, Eviatar Fields, Riya Elizabeth Thomas, Calvin Wong, Vijendra Sharma, Ilse Gantois, Patricia Soriano Roque, Kleanthi Chalkiadaki, Neil Wu, Anindyo Chakraborty, Soroush Tahmasebi, Masha Prager-Khoutorsky, Nahum Sonenberg, Aparna Suvrathan, Alanna J. Watt, Christos G. Gkogkas, Arkady Khoutorsky
Summary: Recent studies have shown that overactivated mTORC1 in the cerebellum can lead to autism-like features and cognitive deficits, whereas ablation of 4E-BP2 in Purkinje cells causes reduced cell numbers, increased regularity of action potential firing, and deficits in motor learning. Surprisingly, mice with selective ablation of 4E-BP2 exhibit impaired spatial memory but normal social interaction and no deficits in repetitive behavior, suggesting independent cerebellar mechanisms controlling social behavior and memory formation downstream of mTORC1/4E-BP2.
Article
Cell Biology
Ru-Huei Fu, Hui-Jye Chen, Syuan-Yu Hong
Summary: C9orf72 mutations are the most common cause of familial amyotrophic lateral sclerosis (C9-ALS). This study found that PR-DPR induces inclusion of a cryptic exon of UNC13A mRNA, leading to reduced protein expression. The researchers also discovered that the RNA-binding protein NOVA1 interacts with PR-DPR and that inhibition of this interaction using betulin can prevent CE inclusion of UNC13A mRNA and protein reduction. This study provides insight into the molecular mechanisms underlying C9-ALS and suggests a potential therapeutic strategy.
Review
Neurosciences
Marco Fuenzalida, Chiayu Q. Chiu, Andres E. Chavez
Summary: Long-term changes in synaptic transmission, particularly the spike-timing-dependent plasticity, play a crucial role in learning and memory. Acetylcholine modulates this plasticity through diverse muscarinic receptors, allowing flexibility and adaptability in brain network activity during complex behaviors. Understanding the mechanisms of muscarinic modulation of synaptic plasticity can provide insights into shaping learning and memory in the hippocampus.
Article
Cell Biology
Xuan Ling Hilary Yong, Lingrui Zhang, Liming Yang, Xiumin Chen, Jing Zhi Anson Tan, Xiaojun Yu, Mintu Chandra, Emma Livingstone, Jocelyn Widagdo, Marta M. Vieira, Katherine W. Roche, Joseph W. Lynch, Angelo Keramidas, Brett M. Collins, Victor Anggono
Summary: The study reveals that phosphorylation of GluN2A at Ser-1459 by CaMKII alpha in response to glycine stimulation enhances the endosomal recycling of NMDARs through interaction with SNX27-retromer complex. Mutations of Ser-1459 prolong the decay times of NMDAR-mediated synaptic currents, including the S1459G variant associated with epilepsy, by increasing channel opening duration. These findings highlight the critical role of Ser-1459 phosphorylation in regulating NMDAR function.
Article
Multidisciplinary Sciences
Peter T. Ajayi, Prasanna Katti, Yingfan Zhang, T. Bradley Willingham, Ye Sun, Christopher K. E. Bleck, Brian Glancy
Summary: This study reveals three mechanisms that regulate muscle cell connectivity. The authors identified the presence of a myofibrillar matrix in fruit fly muscles and found that the loss of the transcription factor H15 increases sarcomere branching frequency. They also demonstrated that misexpression of neurochondrin leads to myofibrillar connectivity in flight muscles.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Tomasz Boczek, Ludmila Zylinska
Summary: The activity of specific populations of neurons in different brain areas plays a critical role in decision-making processes related to synaptic transmission, adaptations to external signals, and the maintenance of neural function. The endocannabinoid system (ECS) is identified as a vital control system in the central nervous system (CNS), allowing for rapid responses to synaptic processes and inducing long-term changes. Endocannabinoids are bioactive lipid mediators that act primarily through two receptors, CB1R and CB2R, which can regulate downstream Ca2+ signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Huidong Wang, Fang-Ying Gong, Sally Newman, Zhao-Cheng Zeng
Summary: The study examines the sensitivity of observation networks to anthropogenic emissions in cities, specifically focusing on the weekday-weekend effect. The analysis is based on observations from different platforms in the Los Angeles megacity, and shows significant agreement in the observed data. The study also investigates the impact of the COVID-19 lockdown on emissions.
ATMOSPHERIC ENVIRONMENT
(2022)
Article
Cell Biology
Yuhki Saito, Ben R. Hawley, M. Rhyan Puno, Shreya N. Sarathy, Christopher D. Lima, Samie R. Jaffrey, Robert B. Darnell, Scott Keeney, Devanshi Jain
Summary: In this study, the researchers investigated how the N-6-methyladenosine (m(6)A) reader and RNA helicase YTHDC2 regulate gene expression during meiosis. They found that YTHDC2 can bind transcripts independent of m(6)A status and regulate gene expression through distinct mechanisms during multiple stages of meiosis. Mutation of the m(6)A-binding pocket of YTHDC2 had no effect on gametogenesis, suggesting that YTHDC2's function is m(6)A-independent. However, mutation in the ATPase motif of YTHDC2 blocked meiotic prophase I progression, causing sterility.
GENES & DEVELOPMENT
(2022)
Article
Computer Science, Artificial Intelligence
Huidong Wang, Yao Zhang, Chuanzheng Bai
Summary: This paper proposes a new DTRSs model based on q-rung orthopair uncertain linguistic variables for solving three-way group decision-making problems. By defining a score function and deriving decision rules, the expected losses of alternative options are compared, and the influence of different conditional probabilities and parameter values on decision results is comprehensively discussed.
JOURNAL OF INTELLIGENT & FUZZY SYSTEMS
(2022)
Article
Energy & Fuels
Huidong Wang, Jianlong Xiu, Lixin Huang, Li Yu, Bo Wu
Summary: Microbial flooding technology using Bacillus subtilis strain SL-2 and its lipopeptide surfactin has shown promising oil recovery results in laboratory simulations, with improved efficiency and stability compared to traditional water flooding methods. This new bio-oil-displacement system has the potential for cost-effective field applications in the petroleum industry.
ENERGY SCIENCE & ENGINEERING
(2022)
Article
Computer Science, Artificial Intelligence
Md Sakib Ullah Sourav, Huidong Wang
Summary: In this study, an intelligent model based on transfer learning and deep convolutional neural networks was developed for fast and accurate identification of jute pests. The model showed good performance in classifying jute pests and has been integrated into mobile applications for practical use.
NEURAL PROCESSING LETTERS
(2023)
Article
Energy & Fuels
Guowei Ma, Yun Chen, Huidong Wang, Tuo Li, Wen Nie
Summary: A three-dimensional two-phase acidizing model was developed to simulate the acid treatment in fractured carbonate rocks. The study investigated the impact of fractures, wettability, and porosity heterogeneity on wormhole propagation in fractured carbonate rocks through numerical methods.
JOURNAL OF NATURAL GAS SCIENCE AND ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Huidong Wang, Xiankun Cao, Jiadong Guo, Xiao Yang, Xiaojiang Sun, Zhiyi Fu, An Qin, Yujie Wu, Jie Zhao
Summary: The artificially synthesized compound BNTA has antioxidant and anti-inflammatory properties, and can effectively inhibit the activation and overproliferation of osteoclasts, reducing bone resorption. It may be a potential drug for preventing inflammatory osteolytic bone diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematics
Ying Wu, Huidong Wang, Chunguang Xia
Summary: This article introduces a class of Lie conformal superalgebras and discusses the classification of their free conformal modules and finite irreducible conformal modules.
COMMUNICATIONS IN ALGEBRA
(2023)
Article
Automation & Control Systems
Fengjun Chen, Jianhang Huang, Jialiang Xu, Huidong Wang, Tian Hu
Summary: This paper proposes a grinding wheel blade wear detection method based on a fiber optic sensor, and studies the principles, hardware system composition, and detection signal triggering process of the method. The influencing factors of detection accuracy and efficiency were analyzed by changing the optical fiber power response mode, brightness setpoint, and signal capture detection speed. The performance verification experiment under optimized parameters showed a maximum measurement error of 3.8 μm, meeting the industrial requirement.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Engineering, Geological
Meiyu Li, Guowei Ma, Tuo Li, Yun Chen, Huidong Wang
Summary: In this study, an equivalent discontinuum analysis (EDA) method is proposed to deal with complexly fractured rock masses, which effectively maintains stress variability and displacement discontinuity while improving computational efficiency.
INTERNATIONAL JOURNAL OF ROCK MECHANICS AND MINING SCIENCES
(2023)
Article
Construction & Building Technology
Huidong Wang, Fengfeng Song, Yun Chen, Tuo Li, Guowei Ma
Summary: The extended key block theory proposed in this study considers the forces between blocks and block rotation, which improves the accuracy and efficiency of analyzing the stability of fractured rock masses. By incorporating a displacement constraint method and analyzing block rotatability, the extended method provides more accurate forces between blocks and considers the influence of block rotation on stability.
TUNNELLING AND UNDERGROUND SPACE TECHNOLOGY
(2023)
Article
Cell Biology
Yoko Tajima, Keiichi Ito, Yuan Yuan, Mayu O. Frank, Yuhki Saito, Robert B. Darnell
Summary: We investigated the role of NOVA1 in postnatal motor inhibition by studying a patient with NOVA1 haploinsufficiency and a behavioral motor hyperactivity disorder. Through the generation of a conditional Nova1-null mouse, we found similarities between the phenotypes of these mice and the patient, indicating a function of Nova1 in the hypothalamus. Furthermore, NOVA1 loss in Gad2-positive neurons led to the dysregulation of downstream expression of Impact mRNA and other related factors, which are involved in translation and metabolism. These findings demonstrate the importance of NOVA1 in adult hypothalamic neurons and its role in human neurologic disease.
Article
Mathematics, Applied
Huidong Wang, Chunguang Xia, Xiufu Zhang
Summary: In this paper, the non-weight representations of two classes of Lie algebras and two classes of Block type Lie superalgebras are studied. The free U(h)-modules of rank one or two over these Lie superalgebras are completely classified and the simplicity and isomorphism classes of these modules are determined. Additionally, the non-weight representation results for a class of non-semisimple finitely graded extensions of the Virasoro algebra are obtained.
JOURNAL OF GEOMETRY AND PHYSICS
(2023)
Article
Cell Biology
Camille Brewer, Tobias Lanz, Caryn R. Hale, Gregory D. Sepich-Poore, Cameron Martino, Austin D. Swafford, Thomas S. Carroll, Sarah Kongpachith, Lisa K. Blum, Serra E. Elliott, Nathalie E. Blachere, Salina Parveen, John Fak, Vicky Yao, Olga Troyanskaya, Mayu O. Frank, Michelle S. Bloom, Shaghayegh Jahanbani, Alejandro M. Gomez, Radhika Iyer, Nitya S. Ramadoss, Orr Sharpe, Sangeetha Chandrasekaran, Lindsay B. Kelmenson, Qian Wang, Heidi Wong, Holly L. Torres, Mark Wiesen, Dana T. Graves, Kevin D. Deane, V. Michael Holers, Rob Knight, Robert B. Darnell, William H. Robinson, Dana E. Orange
Summary: This study found that periodontal disease is more common in individuals with rheumatoid arthritis (RA) who have detectable anticitrullinated protein antibodies (ACPAs), suggesting a link between oral mucosal inflammation and RA pathogenesis. The researchers also discovered that RA patients with periodontal disease experienced repeated oral bacteremias associated with transcriptional signatures of specific monocyte subsets observed in inflamed RA synovia and blood during RA flares. The bacteremia was caused by citrullinated oral bacteria and resulted in activation of ACPA B cells, promoting affinity maturation and epitope spreading to citrullinated human antigens.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Krithi Irmady, Caryn R. Hale, Rizwana Qadri, John Fak, Sitsandziwe Simelane, Thomas Carroll, Serge Przedborski, Robert B. Darnell
Summary: The ability to predict the outcomes of Parkinson's disease using blood samples would be clinically valuable. By analyzing the molecular profiles of postmortem brain tissue and peripheral blood, researchers identified molecular signatures associated with cognitive and motor complications, disease onset, and duration. These findings highlight the potential pathophysiologic and prognostic importance of molecular changes in the brain and peripheral blood of Parkinson's disease patients.
NATURE COMMUNICATIONS
(2023)
