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Biochemistry & Molecular Biology
Charlotte H. Hurst, Dionne Turnbull, Kaltra Xhelilaj, Sally Myles, Robin L. Pflughaupt, Michaela Kopischke, Paul Davies, Susan Jones, Silke Robatzek, Cyril Zipfel, Julien Gronnier, Piers A. Hemsley
Summary: Plant receptor kinases play a crucial role in transducing extracellular stimuli and are regulated by post-translational modifications. This study demonstrates the essential role of S-acylation in plant receptor kinases FLS24 and EFR for their function in immune signaling and resistance to bacterial infection. S-acylation stabilizes and promotes retention of activated receptor kinase complexes at the plasma membrane to increase signaling efficiency.
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Environmental Sciences
Sina Shahabi-Ghahfarokhi, Mahboubeh Rahmati-Abkenar, Leonie Jaeger, Sarah Josefsson, Henric Djerf, Changxun Yu, Mats Astroem, Marcelo Ketzer
Summary: This study investigates the release of metals during the oxidation of sediments in anoxic areas. Results show that several metals are released into the water column during the reoxygenation process, and some of them are found in higher concentrations than previously measured in the area.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Physiology
Alice Main, Andri Boguslavskyi, Jacqueline Howie, Chien-Wen Kuo, Aileen Rankin, Francis L. L. Burton, Godfrey L. L. Smith, Roger Hajjar, George S. S. Baillie, Kenneth S. S. Campbell, Michael J. J. Shattock, William Fuller
Summary: Palmitoylation of cardiac substrates is altered in hypertrophy and heart failure, and expression of zDHHC5 is dysregulated in both conditions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jarrett R. Remsberg, Radu M. Suciu, Noemi A. Zambetti, Thomas W. Hanigan, Ari J. Firestone, Anagha Inguva, Amanda Long, Nhi Ngo, Kenneth M. Lum, Cassandra L. Henry, Stewart K. Richardson, Marina Predovic, Ben Huang, Melissa M. Dix, Amy R. Howell, Micah J. Niphakis, Kevin Shannon, Benjamin F. Cravatt
Summary: The covalent inhibitor ABD957 selectively impairs N-Ras depalmitoylation in AML cells, showing potential as a targeted therapy for NRAS-mutant cancers. It acts on dynamically palmitoylated proteins at the plasma membrane, causing partial effects on N-Ras palmitoylation with greater proteome selectivity compared to Palmostatin M. Additionally, ABD957 inhibits N-Ras signaling and AML cell growth, synergizing with MEK inhibition.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Joel R. McDade, Molly T. Naylor, Daniel E. Michele
Summary: By studying the dynamin-dependent endocytosis and calcium flux, the role of dynamin in wounded skeletal muscle fibers is revealed. Dysferlin deficiency leads to increased FM1-43 dye uptake in muscle fibers, affecting membrane repair mechanisms.
Article
Multidisciplinary Sciences
Stylianos Papaioannou, Michael Dimitriou
Summary: During preparation for voluntary movements, goal-dependent modulation reduces human muscle afferent activity and also adjusts stretch reflex gains in shoulder and upper arm muscles. Central preparatory activity plays a role in tuning muscle stiffness through independent control of muscle spindle sensors based on task goals.
Article
Multidisciplinary Sciences
Ji-Ung Jung, Melanie H. Cobb
Summary: The protein kinase WNK1 influences the trafficking and actin polymerization of membrane proteins. This study discovered a connection between WNK1 and TRIM27, which regulates endosomal actin polymerization. Depletion of WNK1 disrupted WASH ubiquitination and endosomal actin polymerization, affecting endosomal trafficking. Depletion of WNK1 or TRIM27 increased the degradation of EGFR in cancer cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Sara R. Roig, Silvia Cassinelli, Maria Navarro-Perez, Mireia Perez-Verdaguer, Irene Estadella, Jesusa Capera, Antonio Felipe
Summary: The Kv beta family is a group of modulators that regulate Kv channels, with Kv beta 2.1 clustering into immunological synapses during leukocyte activation. The localization of Kv beta 2.1 is mainly affected by S-acylation and a pair of C-terminal cysteines, and its targeting to lipid raft microdomains is influenced by various stimuli.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Neurosciences
Jiyeon Seo, Hongik Hwang, Yuri Choi, Sunmin Jung, Jung-Hwa Hong, Bong-June Yoon, Hyewhon Rhim, Mikyoung Park
Summary: Many psychiatric disorders are associated with deficits in cognitive functions and synaptic plasticity, which are linked to abnormal lipid modifications of neuronal proteins. Cyclin Y (CCNY), located in the postsynaptic compartment, plays an inhibitory role in synaptic plasticity and spatial learning through myristoylation and palmitoylation.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Physiology
Robert Solsona, Romeo Deriaz, Fabio Borrani, Anthony M. J. Sanchez
Summary: This study compared muscle deoxygenation and reoxygenation kinetics during a sprint interval protocol under four different modalities. It found that reoxygenation was delayed in the blood flow restriction condition, and reoxygenation was slower in the gravity-induced blood flow restriction condition.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hongbin Li, Vishaal Rajani, Lu Han, Danielle Chung, James E. Cooke, Ameet S. Sengar, Michael W. Salter
Summary: NMDA receptors (NMDARs) are a principal subtype of excitatory neurotransmitter receptor, composed of two GluN1 and two GluN2 subunits. Alternative splicing of GluN1 can affect the signaling of glycine, which is crucial for the nonionotropic signaling by NMDARs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell & Tissue Engineering
Zhentao Zhang, Wenhui Zhang, Robert Blakes, Lauren J. Sundby, Zengdun Shi, Don C. Rockey, James M. Ervasti, Young-Jae Nam
Summary: By tracing fibroblast lineages following cardiac reprogramming in vitro, it has been found that most mature iCMs are derived directly from fibroblasts, without transitioning through the MF state. This direct conversion is due to mutually exclusive induction of cardiac sarcomeres and MF cytoskeletal structures in the cytoplasm of fibroblasts during reprogramming.
Article
Physiology
Andrius Ramonas, Paul B. B. Laursen, Micalla Williden, Wee-Leong Chang, Andrew E. E. Kilding
Summary: Muscle glycogen state and carbohydrate supplementation can impact responses to high-intensity interval training (HIIT). This study found that CHO ingestion improved performance and did not suppress fat oxidation during HIIT in a glycogen depleted state. Further research is needed to understand the significance of altered muscle oxygenation patterns during exercise.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Monika Zareba-Koziol, Anna Bartkowiak-Kaczmarek, Matylda Roszkowska, Krystian Bijata, Izabela Figiel, Anup Kumar Halder, Paulina Kaminska, Franziska E. Mueller, Subhadip Basu, Weiqi Zhang, Evgeni Ponimaskin, Jakub Wlodarczyk
Summary: Sex differences in the brain are associated with differences in neuronal morphology, synaptic plasticity, and molecular signaling pathways. S-PALM mechanism plays a crucial role in regulating synaptic integrity and neuronal signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Sonke Rudnik, Saskia Heybrock, Paul Saftig, Markus Damme
Summary: The spatiotemporal cellular distribution of lysosomes relies on active transport driven by microtubule proteins. TMEM55B and TMEM55A are S-palmitoylated proteins that play a critical role in lysosomal positioning and sorting.
JOURNAL OF CELL SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Celine Simonin, Mahendra Awale, Michael Brand, Ruud van Deursen, Julian Schwartz, Michael Fine, Gergely Kovacs, Pascal Haefliger, Gergely Gyimesi, Abilashan Sithampari, Roch-Philippe Charles, Matthias A. Hediger, Jean-Louis Reymond
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
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Biochemistry & Molecular Biology
Benjamin Clemencon, Michael Fine, Matthias A. Hediger
Article
Multidisciplinary Sciences
Philip Schmiege, Michael Fine, Gunter Blobel, Xiaochun Li
Article
Biochemistry & Molecular Biology
Philip Schmiege, Michael Fine, Xiaochun Li
Article
Physiology
Donald W. Hilgemann, Gucan Dai, Anthony Collins, Vincenzo Lariccia, Simona Magi, Christine Deisl, Michael Fine
JOURNAL OF GENERAL PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Benjamin Clemencon, Benjamin P. Luescher, Michael Fine, Marc U. Baumann, Daniel V. Surbek, Olivier Bonny, Matthias A. Hediger
Article
Multidisciplinary Sciences
Michael Fine, Philip Schmiege, Xiaochun Li
NATURE COMMUNICATIONS
(2018)
Article
Biochemistry & Molecular Biology
Donald W. Hilgemann, Mei-Jung Lin, Michael Fine, Christine Deisl
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2020)
Article
Physiology
Christine Deisl, Michael Fine, Orson W. Moe, Donald W. Hilgemann
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2019)
Editorial Material
Cell Biology
Xiaochun Li, Michael Fine
Review
Cell Biology
Michael Fine, Xiaochun Li, Shangyu Dang
Editorial Material
Neurosciences
Michael Fine, Xiaochun Li
Summary: TRPA1 is identified as a promising target for novel treatments of chronic pain. The study introduces a new non-covalent TRPA1-biased agonist, GNE551, which reveals a unique binding pocket and activation properties that lay the groundwork for new avenues in chronic pain treatment.
Article
Biochemistry & Molecular Biology
Philip Schmiege, Michael Fine, Xiaochun Li
Summary: TRPML1 regulates lysosomal calcium signaling, lipid trafficking, and autophagy-related processes. Small molecules like ML-SI3 have been shown to modulate channel activity by targeting the TRPML family. The cryo-EM structure of TRPML1 with ML-SI3 provides insights into how these molecules and native lipids regulate TRPML1 activity.
Article
Multidisciplinary Sciences
Christine Deisl, Donald W. Hilgemann, Ruhma Syeda, Michael Fine
Summary: Cells locally regulate their surface expansion and retraction in response to environmental factors through mechanisms involving membrane adapter dynamin and lipid scramblase TMEM16F. These mechanisms allow cells to dynamically adjust their plasma membrane to changes in membrane tension and phospholipid scrambling, ultimately maintaining cellular homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Daniel Schaffhauser, Michael Fine, Miyuki Tabata, Tatsuro Goda, Yuji Miyahara