期刊
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
卷 29, 期 4, 页码 529-543出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.beem.2015.07.003
关键词
miRNA; lncRNA; nuclear receptor; breast cancer; prostate cancer; Alzheimer's disease; metabolism; neural stem cell; gestational diabetes; atherosclerosis
资金
- Medical Research Council [MR/M018687/1] Funding Source: Medline
- Department of Health [NIHR-RP-011-053] Funding Source: Medline
- Cancer Research UK [14549] Funding Source: researchfish
- Medical Research Council [MR/M018687/1] Funding Source: researchfish
- National Institute for Health Research [NIHR-RP-011-053] Funding Source: researchfish
- MRC [MR/M018687/1] Funding Source: UKRI
Nuclear receptors belong to a superfamily of proteins that play central roles in human biology, orchestrating a large variety of biological functions in both health and disease. Understanding the interactions and regulatory pathways of NRs will allow development of potential therapeutic interventions for a multitude of disease processes. Non-coding RNAs have recently been discovered to have significant interactions with NR signalling pathways via a variety of biological connections. This review summarises the known interactions between ncRNAs and the NR superfamily in health, embryogenesis and a plethora of human diseases. (C) 2015 Elsevier Ltd. All rights reserved.
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