Review
Immunology
Yoke Chan Chow, Hok Chai Yam, Baskaran Gunasekaran, Weng Yeen Lai, Weng Yue Wo, Tarun Agarwal, Yien Yien Ong, Siew Lee Cheong, Sheri-Ann Tan
Summary: Porphyromonas gingivalis, a major pathogenic bacterium involved in periodontitis, utilizes gingipain R and bacterial peptidyl arginine deiminase to citrullinate host proteins, leading to the development of non-communicable diseases. Inhibiting these enzymes can provide new therapeutic solutions for periodontitis and diseases involving bacterial citrullination.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Sheri-Ann Tan, Hok Chai Yam, Siew Lee Cheong, Yoke Chan Chow, Chui Yin Bok, Jia Min Ho, Pei Yin Lee, Baskaran Gunasekaran
Summary: This study evaluated the inhibitory activity of Cratoxylym cochinchinense leaves extract on PPAD. The results demonstrated that the extract exhibited high antioxidant potential and contained abundant phenolic and flavonoid compounds. In vitro and in vivo experiments showed dose-dependent inhibition of PPAD by the extract. Molecular docking simulation suggested potential phytochemicals responsible for the observed inhibitory activities.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Maria Teresa Martin Monreal, Alexandra Stripp Rebak, Laura Massarenti, Santanu Mondal, Ladislav Senolt, Niels Odum, Michael L. Nielsen, Paul R. Thompson, Claus H. Nielsen, Dres Damgaard
Summary: Citrullination plays a role in breaking self-tolerance in anti-CCP-positive rheumatoid arthritis, with PAD2 and PAD4 being key pathogenic factors. Inhibitors like AFM-30a and GSK199 show potential in inhibiting citrullination, with AFM-30a being an efficient inhibitor of PAD2 and a combination of AFM-30a and GSK199 showing promise in inhibiting PAD activity without cytotoxic effects seen in BB-Cl-amidine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Diana Marcela Castillo, Gloria Ines Lafaurie, Consuelo Romero-Sanchez, Nathaly Andrea Delgadillo, Yormaris Castillo, Wilson Bautista-Molano, Cesar Pacheco-Tena, Juan Manuel Bello-Gualtero, Philippe Chalem-Choueka, Jaime E. Castellanos
Summary: This study found that antibodies against arginine-gingipain A (RgpA) and the double positivity of RgpA and peptidyl arginine deiminase (PPAD) may serve as biomarkers for rheumatoid arthritis (RA), improving its diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Tan Wan Jiun, Haslina Taib, Wan Majdiah Wan Mohamad, Suharni Mohamad, Wan Syamimee Wan Ghazali
Summary: This study found no significant association between the bacterial load of Porphyromonas gingivalis (P. gingivalis), a primary periodontal pathogen, and the levels of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with rheumatoid arthritis (RA) and periodontitis. Despite the prevalence of periodontitis among RA patients, the bacterial load does not have an impact on the production of anti-CCP antibodies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Gabriel D. Roman-Melendez, Daniel R. Monaco, Janelle M. Montagne, Rachel S. Quizon, Maximilian F. Konig, Mekbib Astatke, Erika Darrah, H. Benjamin Larman
Summary: The study successfully utilized phage display technology to profile antibody reactivities in rheumatoid arthritis patients and quantify differences among patients, identifying specific antibody profiles. This provides a powerful tool for research on autoimmune diseases.
Review
Immunology
Dongwei Zhu, Wei Song, Zehui Jiang, Haopeng Zhou, Shengjun Wang
Summary: Citrullination is a reaction that converts arginine residues in protein peptide chains to citrulline residues. It plays a regulatory role in various physiological processes and is also implicated in the development of autoimmune diseases.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Marie F. Hemon, Nathalie C. Lambert, Fanny Arnoux, Jean Roudier, Isabelle Auger
Summary: The critical immunological event in rheumatoid arthritis is the production of antibodies to citrullinated proteins. A peptide array method was used to analyze the fine specificity of anti-citrullinated peptide antibodies and the results showed that different mouse strains have different IgG responses to citrullinated peptides.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jacqueline Rodriguez, Gloria Ines Lafaurie, Wilson Bautista-Molano, Lorena Chila-Moreno, Juan Manuel Bello-Gualtero, Consuelo Romero-Sanchez
Summary: The study demonstrated an association between overweight or obesity and the diagnosis of eRA, with individuals with eRA exhibiting higher levels of leptin and vaspin. The presence of periodontitis and related markers only affected leptin levels in individuals with eRA.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Genetics & Heredity
Zahra Bagheri-Hosseinabadi, Mohammad Reza Mirzaei, Ozrasadat Esmaeili, Fatemeh Asadi, Hassan Ahmadinia, Banafshe Shamsoddini, Mitra Abbasifard
Summary: This study found that the PADI4 gene rs1748033 single nucleotide polymorphism (SNP) is associated with an increased risk of rheumatoid arthritis (RA). The mRNA expression of PADI4 was significantly upregulated in RA patients compared to controls, and it was positively correlated with anti-CCP level, RF level, and CRP level.
BMC MEDICAL GENOMICS
(2023)
Review
Pathology
Nicole Hartwig Trier, Gunnar Houen
Summary: The serological biomarker anti-citrullinated protein antibodies (ACPAs) are important for the diagnosis of rheumatoid arthritis (RA) and can improve our understanding of the disease etiology. This review provides an overview of ACPAs and highlights their diagnostic and etiological significance in RA.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jerian Gonzalez-Febles, Mariano Sanz
Summary: Rheumatoid arthritis and periodontitis are chronic inflammatory diseases characterized by the destruction of cartilage and periodontal tissues, with emerging evidence suggesting a possible link between specific bacterial periodontal pathogens and the development of autoantibodies in rheumatoid arthritis patients. Research is ongoing to explore the epidemiologic association and biological mechanisms between these two diseases, as well as the potential impact of periodontal treatment on the initiation and progression of rheumatoid arthritis.
PERIODONTOLOGY 2000
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yin Hui Lee, Nor Adinar Baharuddin, Siew Wui Chan, Mohammad Tariqur Rahman, P. Mark Bartold, Sargunan Sockalingam, Rathna Devi Vaithilingam
Summary: The study found that the number of cells containing citrullinated and carbamylated proteins in gingival tissues from patients with periodontitis, with or without rheumatoid arthritis, was significantly higher compared to healthy controls. The local accumulation of these proteins in inflamed gingival tissue may play a role in the pathogenesis of rheumatoid arthritis.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Cell Biology
Satoru Shindo, Roodelyne Pierrelus, Atsushi Ikeda, Shin Nakamura, Alireza Heidari, Maria Rita Pastore, Elizabeth Leon, Sunniva Ruiz, Harsh Chheda, Rhea Khatiwala, Tomoki Kumagai, George Tolson, Islam Elderbashy, Kazuhisa Ouhara, Xiaozhe Han, Maria Hernandez, Saynur Vardar-Sengul, Hideki Shiba, Toshihisa Kawai
Summary: It has been shown that autoantibodies to citrullinated vimentin can promote osteoclastogenesis and bone resorption in periodontitis patients. However, an experiment in vitro demonstrated that an anti-CV antibody can suppress bone resorption in periodontitis. Therefore, the release of CV may play a role in promoting bone resorption in the pathogenesis of periodontitis.
Review
Biochemistry & Molecular Biology
Yi Teng, Yuhang Chen, Xinyi Tang, Shengjun Wang, Kai Yin
Summary: In this review, the role of PAD2-mediated citrullination in tumor pathology and the regulation of tumor-associated immune cells is systematically illustrated. The article also discusses the feasibility of anti-PAD2 therapy to treat tumors and the urgent problems to be solved. Finally, recent developments in the development of PAD2 inhibitors are reviewed.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)