Article
Engineering, Biomedical
Xiaogang Wang, Yuanman Yu, Luli Ji, Zhen Geng, Jing Wang, Changsheng Liu
Summary: Calcium phosphate-based materials, commonly used in bone graft substitutes, play a crucial role in bone healing. Recent studies have shown that osteoclast behaviors can greatly influence osteogenesis, with an appropriate Ca/P ratio promoting osteoclast differentiation and bone healing. This suggests the potential of manipulating osteoclast-mediated osteogenesis for improving osseointegration in materials.
BIOACTIVE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Joshua Bilello, Ikenna Okereke
Summary: Diseases of the upper gastrointestinal tract are becoming more common over time, with the microbiome playing a significant role in disease formation. Various factors such as medications, surgical procedures, and environmental changes can affect the microbiome of the upper gastrointestinal tract, potentially leading to the development of diseases.
Review
Engineering, Biomedical
I. Lodoso-Torrecilla, J. J. J. P. van den Beucken, J. A. Jansen
Summary: Synthetic calcium phosphate ceramics are widely used for bone regenerative treatments due to their bioactivity and osteoconductive properties. Injectable CPCs are appealing for minimally invasive surgery and filling irregular bone defects, but their poor degradability can be addressed by introducing macroporosity to accelerate new bone formation.
ACTA BIOMATERIALIA
(2021)
Review
Engineering, Biomedical
Matheus C. Tronco, Julia B. Cassel, Luis A. dos Santos
Summary: This review paper focuses on the synthesis and properties of alpha-tricalcium phosphate (alpha TCP), a promising material for bone repair and substitution. It discusses the complexity of alpha TCP synthesis, the impact of synthesis parameters on material properties, and provides guidance for selecting the most suitable process for each application.
ACTA BIOMATERIALIA
(2022)
Editorial Material
Gastroenterology & Hepatology
Eun Jeong Gong, Hye-Kyung Jung
Summary: This article is related to the papers by Gong et al. To access these articles, visit and.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Editorial Material
Gastroenterology & Hepatology
Peter Malfertheiner, Christian Schulz, Colin W. Howden
Summary: This article is related to Gong et al papers. To view these articles, visit the website.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Medicine, General & Internal
Elizabeth T. Jensen, Joe Yi, Wesley Jackson, Rachana Singh, Robert M. Joseph, Karl C. K. Kuban, Michael E. Msall, Lisa Washburn, Rebecca Fry, Andrew M. South, T. Michael O'Shea
Summary: Early acid suppressant use in extremely preterm infants may be associated with poorer neurodevelopmental outcomes, including decreased IQ scores, autism spectrum disorder, and epilepsy.
Article
Veterinary Sciences
Jaya M. Mehra, M. Katherine Tolbert, George E. Moore, Melissa J. Lewis
Summary: Gastrointestinal signs were common in dogs undergoing surgery for acute TL-IVDE, with diarrhea being the most common symptom and melena being rare. Pre-operative paraplegia and longer anesthesia duration were associated with more severe GI signs.Further investigation is needed to understand the influence of specific medications and neurologic severity on the development of GI signs.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Dragana Bjelic, Matjaz Finsgar
Summary: The use of therapeutic agents that inhibit bone resorption is important for the longevity of implants, revision surgeries, and the healthcare system. This review focuses on incorporating osteoclast inhibitors into bioactive coatings for bone implants and discusses the challenges of systemic treatment. It also explores the suitable concentrations, release times, and effects of the antiresorptive agents on nearby cells or bone tissue. However, further research is needed to optimize implant design and personalize the coating material and antiresorptive agent selection.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Johnmary T. Arinze, Maria A. J. de Ridder, Dina Vojinovic, Hanne van Ballegooijen, Emanuil Markov, Talita Duarte-Salles, Peter Rijnbeek, Katia M. C. Verhamme
Summary: This study aimed to investigate the impact of regulatory intervention on the use patterns of ranitidine-containing medicines and their therapeutic alternatives, and to report discernible trends in treatment discontinuation and switching to alternative medications.
Editorial Material
Oncology
Courtney M. Richman, David A. Leiman
Summary: Proton pump inhibitors (PPIs) are commonly used for digestive diseases, but there is conflicting data on the association between PPI use and gastric cancer risk. A pooled case-control study found that short-term PPI use was associated with increased risk of gastric cancer, but long-term use did not show this association. This study provides reassurance to patients and clinicians that long-term PPI use does not significantly increase gastric cancer risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Engineering, Biomedical
Agneta Vezenkova, Janis Locs
Summary: With the increase in global population, the demand for bone substitutes is growing. Calcium phosphate cements (CPCs) have the potential for various applications in bone regeneration due to their ability to self-set and resorb. However, finding an osteoinductive material that is suitable for injection remains a challenge.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
B. Le Gars Santoni, L. Niggli, S. Dolder, O. Loeffel, G. A. Sblendorio, R. Heuberger, Y. Maazouz, C. Staehli, N. Doebelin, P. Bowen, W. Hofstetter, M. Bohner
Summary: This study assessed the effect of small fractions of β-CPP on the in vitro osteoclastic resorption of β-TCP and found that β-CPP fractions significantly inhibited the resorption of β-TCP. The study also examined the impact of β-CPP and HA impurities on the physico-chemical properties of β-TCP powders and sintered cylinders.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Maki Nakamura, Katsuya Ueda, Yumiko Yamamoto, Kaoru Aoki, Minfang Zhang, Naoto Saito, Masako Yudasaka
Summary: Carbon nanohorns (CNHs) have been explored for drug delivery systems due to their unique properties, with OxCNH-CaP-IBN composite nanoparticles showing stronger cell-suppressive effects by releasing IBN through CaP dissociation.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Pharmacology & Pharmacy
Yan-Ting Su, Jian Zhang
Summary: This study aimed to improve the water solubility and stability of cannabidiol (CBD) using micelle technology. CBD-loaded mixed micelles (CBD-M) composed of Poloxamer 407 (P407) and rubusoside (RUB) were successfully prepared and showed significant improvement in solubility and encapsulation efficiency. The CBD-M solution remained stable and maintained the antioxidant activity of CBD after dilution and centrifugation. These findings suggest that CBD-M could serve as a promising formulation for enhanced CBD delivery.
CURRENT DRUG DELIVERY
(2024)
