Review
Biology
Yafet Abidi, Zsuzsanna Kovats, Aniko Bohacs, Monika Fekete, Saoussen Naas, Ildiko Madurka, Klara Torok, Levente Bogyo, Janos Tamas Varga
Summary: This review investigates the impact of training on exercise ability and quality of life in patients before and after lung transplant, and finds that rehabilitation programs have a positive effect on improving exercise ability and quality of life in these patients.
Article
Surgery
Michelle T. Jesse, Whitney E. Jackson, AnnMarie Liapakis, Swaytha Ganesh, Abhinav Humar, Nicolas Goldaracena, Josh Levitsky, David Mulligan, Elizabeth A. Pomfret, Daniela P. Ladner, John P. Roberts, Alisha Mavis, Carrie Thiessen, James Trotter, Gerald Scott Winder, Adam D. Griesemer, Anjana Pillai, Vineeta Kumar, Elizabeth C. Verna, Dianne LaPointe Rudow, Hyosun H. Han
Summary: Despite the excellent outcomes and expanding candidate indications for living donor liver transplantation (LDLT), there is still limited uptake of this option in the United States. To address this issue, the American Society of Transplantation organized a virtual consensus conference to identify barriers and recommend strategies. The barriers identified include lack of awareness, acceptance, and engagement among patients, providers, and institutions; data gaps and lack of standardization in candidate and donor selection; and data gaps regarding post-donation outcomes and resource needs. The strategies to address these barriers involve education and engagement, collaborative research, and institutional commitment and resources.
CLINICAL TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Jose Luis Campo-Canaveral De La Cruz, Ben Dunne, Philippe Lemaitre, Mindaugas Rackauskas, Jiri Pozniak, Yui Watanabe, Andrea Mariscal, Jonathan Yeung, Kazuhiro Yasufuku, Andrew Pierre, Marc de Perrot, Thomas K. Waddell, Marcelo Cypel, Shaf Keshavjee, Laura Donahoe
Summary: LLTx from deceased donors is used to address donor-recipient size mismatch for small recipients. While LLTx patients often have longer ICU stays and higher mortality rates than LTx patients, recent advancements have led to comparable survival rates between the two procedures.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Jesse M. Rappaport, Hafiz Umair Siddiqui, Lucy Thuita, Marie Budev, Kenneth R. McCurry, Eugene H. Blackstone, Usman Ahmad
Summary: The objective of this study was to investigate the effects of donor smoking and substance use on primary graft dysfunction, allograft function, and survival after lung transplant. The results showed that donor smoking was associated with decreased forced expiratory volume in 1 second after transplantation, while substance use did not affect allograft function. Therefore, donor smoking or substance use alone should not be a contraindication for lung donation or transplant.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Surgery
Matteo Di Nardo, Lorenzo Del Sorbo, Andrew Sage, Jin Ma, Mingyao Liu, Jonathan C. Yeung, Jerome Valero, Rasheed Ghany, Marcelo Cypel, Shaf Keshavjee
Summary: This study developed a mathematical model (EXPIRE model) using ex vivo lung perfusion technique to predict lung acceptance, which was successfully validated in a separate cohort. The model may help standardize lung assessment and improve transplant rates in centers using the Toronto EVLP technique.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Satona Tanaka, Jason M. Gauthier, Yuriko Terada, Tsuyoshi Takahashi, Wenjun Li, Kohei Hashimoto, Ryuji Higashikubo, Ramsey R. Hachem, Ankit Bharat, Jon H. Ritter, Ruben G. Nava, Varun Puri, Alexander S. Krupnick, Andrew E. Gelman, Daniel Kreisel
Summary: Our study demonstrates that bacterial products within donor grafts may prevent induction of lung allograft tolerance through a process mediated by recipient-derived monocytes, leading to acute cellular rejection.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Laura Seese, Arman Kilic, Harma K. Turbendian, Pablo G. Sanchez, Carlos E. Diaz-Castrillon, Victor O. Morell
Summary: This study evaluated the impact of drowning or asphyxiation donors in pediatric lung transplant recipients and found similar rates of complications and survival in a propensity-matched cohort.
Article
Cardiac & Cardiovascular Systems
Peter Riddell, Jin Ma, Ben Dunne, Matthew Binnie, Marcello Cypel, Laura Donahoe, Marc de Perrot, Andrew Pierre, Tom K. Waddell, Jonathan Yeung, Kazuhiro Yasufuku, George Tomlinson, Lianne G. Singer, Shaf Keshavjee
Summary: Matching donor-recipient size based on predicted total lung capacity ratio can improve post-lung transplantation outcomes for patients with restrictive lung disease.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Surgery
Antoine Roux, Vincent Bunel, Natalia Belousova, Jonathan Messika, Sebastien Tanaka, Mathilde Salpin, Arnaud Roussel, Laurence Beaumont-Azuar, Clement Picard, Olivier Brugiere, Jerome Devaquet, Edouard Sage, Morgan Le Guen, Jean-Luc Taupin, Magali Devriese, Mathieu Glorion, Francois Parquin
Summary: Lung transplant candidates who are highly sensitized against human leucocyte antigen present a challenge in finding suitable donors. Current desensitization strategies have limitations. Imlifidase, a novel agent derived from Streptococcus pyogenes, has been used successfully to remove antibodies and allow transplantation in kidney candidates. We present the first case of using imlifidase for antibody depletion in a highly sensitized lung transplant candidate who underwent a successful bilateral lung transplant.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Surgery
Michael B. Keller, Rohan Meda, Sheng Fu, Kai Yu, Moon Kyoo Jang, Ananth Charya, Gerald J. Berry, Charles C. Marboe, Hyesik Kong, Helen Luikart, Ileana L. Ponor, Pali D. Shah, Kiran K. Khush, Steven D. Nathan, Sean Agbor-Enoh
Summary: This study compared plasma dd-cfDNA levels in single and double lung transplant recipients in stable and acute rejection states, finding lower levels in single lung transplant recipients. Adjusting for differences in lung mass eliminated this difference, emphasizing the importance of considering such differences in interpreting dd-cfDNA testing.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Luke Benvenuto, Mark E. Snyder, Meghan Aversa, Shreena Patel, Joseph Costa, Lori Shah, Hilary Robbins, Frank D'Ovidio, Joshua Sonett, Bryan P. Stanifer, Philippe Lemaitre, Selim Arcasoy, Michaela R. Anderson
Summary: During the early months of the COVID-19 pandemic, there were significant regional disparities in lung transplantation practices, with a larger decrease in transplant volume in high COVID-19 prevalence areas. Waiting list activations decreased overall, while waiting list deaths remained similar regardless of local COVID-19 prevalence.
Review
Plant Sciences
Zhicheng Wei, Jing Chen, Fang Zuo, Julie Guo, Xiaodong Sun, Deming Liu, Conghai Liu
Summary: This review summarized the anti-lung cancer mechanisms of five types of monomeric compounds in traditional Chinese medicine (TCM), aiming to provide research ideas for the identification of new prospective medication candidates for the treatment of lung cancer (LC).
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Shyama Sathianathan, Geetha Bhat
Summary: The importance of donor selection criteria on heart transplant outcomes is reinforced by the latest research and the 2020 ISHLT heart transplant report. Donor risk factors and the methods for donor heart selection require further study and updating. The review examines extended donor criteria and proposes a model for donor selection.
CURRENT CARDIOLOGY REPORTS
(2022)
Article
Surgery
Erik H. Ander, Abul Kashem, Huaqing Zhao, Kelly Montgomery, Gengo Sunagawa, Roh Yanagida, Norihisa Shigemura, Yoshiya Toyoda
Summary: In patients with idiopathic pulmonary fibrosis, lung transplant type and donor age do not significantly affect survival.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Surgery
Shannon Mcginnis, Rebecca J. Free, Jacqueline Burnell, Sridhar Basavaraju, Trevor Kanaskie, Elizabeth J. Hannapel, Nottasorn Plipat, Kimberly Warren, Chris Edens
Summary: In July 2022, the Pennsylvania Department of Health received two reports of laboratory-confirmed Legionnaires disease in patients who had recently received lung transplants from the same donor at a single Pennsylvania hospital.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Jane Falconer, Rahul Mahida, Divya Venkatesh, Jeffrey Pearson, John H. Robinson
Article
Respiratory System
Rachel C. A. Dancer, Dhruv Parekh, Sian Lax, Vijay D'Souza, Shengxing Zheng, Chris R. Bassford, Daniel Park, D. G. Bartis, Rahul Mahida, Alice M. Turner, Elizabeth Sapey, Wenbin Wei, Babu Naidu, Paul M. Stewart, William D. Fraser, Kenneth B. Christopher, Mark S. Cooper, Fang Gao, David M. Sansom, Adrian R. Martineau, Gavin D. Perkins, David R. Thickett
Article
Surgery
L. A. Borthwick, M. I. Suwara, S. C. Carnell, N. J. Green, R. Mahida, D. Dixon, C. S. Gillespie, T. N. Cartwright, J. Horabin, A. Walker, E. Olin, M. Rangar, A. Gardner, J. Mann, P. A. Corris, D. A. Mann, A. J. Fisher
AMERICAN JOURNAL OF TRANSPLANTATION
(2016)
Article
Microbiology
Amanda L. Jones, Andrew. J. Fisher, Rahul Mahida, Kate Gould, John D. Perry, Margaret M. Hannan, Eoin P. Judge, Ros Brown, Kimberley Boagey, Michael Goodfellow
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2014)
Review
Respiratory System
Domokos Bartis, Nikica Mise, Rahul Y. Mahida, Oliver Eickelberg, David R. Thickett
Article
Respiratory System
Aaron Scott, Sebastian T. Lugg, Kerrie Aldridge, Keir E. Lewis, Allen Bowden, Rahul Y. Mahida, Frances Susanna Grudzinska, Davinder Dosanjh, Dhruv Parekh, Robert Foronjy, Elizabeth Sapey, Babu Naidu, David R. Thickett
Article
Critical Care Medicine
Dhruv Parekh, Rachel C. A. Dancer, Aaron Scott, Vijay K. D'Souza, Phillip A. Howells, Rahul Y. Mahida, Jonathan C. Y. Tang, Mark S. Cooper, William D. Fraser, LamChin Tan, Fang Gao, Adrian R. Martineau, Olga Tucker, Gavin D. Perkins, David R. Thickett
CRITICAL CARE MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Rahul Y. Mahida, Shotaro Matsumoto, Michael A. Matthay
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Physiology
James T. Ross, Nicolas Nesseler, Aleksandra Leligdowicz, Rachel L. Zemans, Rahul Y. Mahida, Emily Minus, Chaz Langelier, Jeffrey E. Gotts, Michael A. Matthay
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Letter
Respiratory System
Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Rowan S. Hardy, Gareth G. Lavery, Michael A. Matthay, Babu Naidu, Gavin D. Perkins, David R. Thickett
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Medicine, General & Internal
Rahul Y. Mahida, Aaron Scott, Dhruv Parekh, Sebastian T. Lugg, Kylie B. R. Belchamber, Rowan S. Hardy, Michael A. Matthay, Babu Naidu, David R. Thickett
Summary: Impairment in efferocytosis of alveolar macrophages induced by treatment with ARDS BAL fluid in an in vitro model mimics the dysfunction observed in patients with ARDS, while phagocytosis remains preserved. Partial restoration of efferocytosis can be achieved by inhibition of ROCK, suggesting a potential therapeutic target for ARDS. This in vitro model provides a useful tool to study the mechanisms underlying AM dysfunction in the inflammatory alveolar microenvironment of ARDS.
FRONTIERS IN MEDICINE
(2021)
Article
Physiology
Rahul Y. Mahida, Joshua Price, Sebastian T. Lugg, Hui Li, Dhruv Parekh, Aaron Scott, Paul Harrison, Michael A. Matthay, David R. Thickett
Summary: Recent studies suggest that EVs play important roles in the pathogenesis of ARDS and serve as potential biomarkers for ARDS. The study found that patients with sepsis-related ARDS have more monocyte-derived BAL EVs compared to sepsis patients without ARDS. However, esophagectomy patients who later developed ARDS had lower BAL EV numbers. Esophagectomy patients who developed ARDS also had higher levels of CD31+/CD63+ and CD31+/CD81+ endothelial-derived BAL EVs. Further research is needed to determine if CD31+ BAL EVs can predict ARDS in esophagectomy patients. Additionally, CD14+/CD81+ BAL EVs were significantly higher in sepsis-related ARDS patients who died within 30 days of ICU admission.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Rahul Y. Mahida, Michael A. Matthay
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2023)
Article
Respiratory System
Sebastian T. Lugg, Kerrie A. Alridge, Phillip A. Howells, Dhruv Parekh, Aaron Scott, Rahul Y. Mahida, Daniel Park, Olga Tucker, Fang Gao, Gavin D. Perkins, David R. Thickett, Rachel C. A. Dancer
Article
Respiratory System
Rahul Y. Mahida, Minesh Chotalia, Joseph Alderman, Chhaya Patel, Amber Hayden, Ruchi Desai, Emily Beesley, Louise E. Crowley, Marina Soltan, Mansoor Bangash, Dhruv Parekh, Jaimin Patel, David R. Thickett
BMJ OPEN RESPIRATORY RESEARCH
(2020)