Article
Gastroenterology & Hepatology
Xinrong Zhang, Terry Cheuk-Fung Yip, Yee-Kit Tse, Vicki Wing-Ki Hui, Guanlin Li, Huapeng Lin, Lilian Yan Liang, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Stephen Lam Chan, Alice Pik-Shan Kong, Grace Lai-Hung Wong, Vincent Wai-Sun Wong
Summary: This study found that a longer duration of type 2 diabetes (T2D) is associated with a higher risk of liver-related events and all-cause mortality in patients with non-alcoholic fatty liver disease (NAFLD).
Article
Multidisciplinary Sciences
Eyitayo Omolara Owolabi, Daniel Ter Goon, Anthony Idowu Ajayi, Oladele Vincent Adeniyi
Summary: This study examined the level of diabetes knowledge and its associated factors among individuals with diabetes in Eastern Cape Province, South Africa. The findings showed a low level of knowledge on various components of diabetes management in this setting. Context-specific interventions are needed to improve diabetes knowledge, with a focus on unemployed individuals and community health centers in the region.
Review
Endocrinology & Metabolism
Wenqi Fan, Haipeng Pang, Zhiguo Xie, Gan Huang, Zhiguang Zhou
Summary: Diabetes mellitus is an endocrine disorder characterized by a lack of insulin. The pathogenesis of this disease remains unclear. Recent studies have shown the significant roles of circular RNAs in diabetes, suggesting their potential as biomarkers and treatment tools.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chi-Shin Wu, Le-Yin Hsu, Yi-Jiun Pan, Shi-Heng Wang
Summary: This nationwide retrospective cohort study found that regular antidepressant use was associated with lower risk of advanced diabetic complications and mortality in patients with depression and diabetes mellitus, compared to poor adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Jie Wang(a), Shudong Wang, Jie Wang(b), Mengjie Xiao, Yuanfang Guo, Yufeng Tang, Jingjing Zhang, Junlian Gu
Summary: SIRT1 plays a crucial role in diabetic complications by regulating transcription factors and epigenetic mechanisms to influence the development and progression of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Subrat Kumar Bhattamisra, Hui Min Koh, Shin Yean Lim, Hira Choudhury, Manisha Pandey
Summary: Catalpol isolated from Rehmannia glutinosa shows potent antioxidant properties and has been investigated for its effects on diabetes mellitus and its complications. The molecular pathways involved include promoting IRS-1/PI3K/AKT/GLUT2 activity, suppressing PEPCK and G6Pase expression in the liver, inducing myogenesis in skeletal muscles, and exerting antioxidant effects in the pancreas and liver. Catalpol also demonstrates neuroprotective, cardioprotective, and osteoblast stimulating effects, as well as potential in preventing neurodegeneration in the retina.
Article
Endocrinology & Metabolism
Clementine E. M. Verhulst, Julia I. P. van Heck, Therese W. Fabricius, Rinke Stienstra, Steven Teerenstra, Rory J. McCrimmon, Cees J. Tack, Ulrik Pedersen-Bjergaard, Bastiaan E. de Galan
Summary: Iatrogenic hypoglycemia activates the immune system and is associated with an increased risk of atherosclerotic disease. The study found that hypoglycemia induces a sustained inflammatory response at the cellular and protein level, which is present in both individuals with type 2 diabetes and control subjects.
Review
Medicine, General & Internal
Ruxandra Mare, Ioan Sporea
Summary: Digestive complications and liver diseases are common chronic complications in patients with diabetes mellitus. This review provides information on the prevalence, diagnosis, and therapeutic solutions for these complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Abraham Shaked, Bao-Li Loza, Elisabet Van Loon, Kim M. Olthoff, Weihua Guan, Pamala A. Jacobson, Andrew Zhu, Claire E. Fishman, Hui Gao, William S. Oetting, Ajay K. Israni, Giuliano Testa, James Trotter, Goran Klintmalm, Maarten Naesens, Sumeet K. Asrani, Brendan J. Keating
Summary: T2D PRS can identify transplant candidates at high risk of PTDM, aiding in preemptive diabetes management and donor selection.
Article
Endocrinology & Metabolism
Yue Dong, Zhenyuan Chen, Yanhong Gong, Yanping Han, Hanbing Yu, Xiaozhou Zeng, Zimei Chen, Rongrong An, Na Sun, Xiaoxv Yin
Summary: The study found that weight changes over 18 months among patients with type 2 diabetes, especially weight change >= 5%, may be a warning sign of adverse cardiovascular outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Xu Li, Jingxian Wu, Fanxing Xu, Chun Chu, Xiang Li, Xinyi Shi, Wen Zheng, Zhenzhong Wang, Ying Jia, Wei Xiao
Summary: Ferulic acid, a natural compound found in medicinal herbs and daily diet, has been found to have beneficial pharmacological effects for the management of diabetes and its complications.
Review
Medicine, General & Internal
Olga Adamska, Artur Stolarczyk, Agata Gondek, Bartosz Maciag, Jakub Swiderek, Pawel Czuchaj, Krzysztof Modzelewski
Summary: Connective tissue ageing is accelerated by the accumulation of advanced glycation end products (AGEs) and affects specific proteins, such as fibrillar collagens. This leads to reduced healing capacity, flexibility, and quality in ligaments, tendons, bones, and skin. Further research is needed to understand the exact mechanisms and complications associated with ligament alteration in diabetes. This review emphasizes the importance of investigating ligament changes in diabetes-related complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Yuyan Zhu, Xuan Xia, Qian He, Qing-Ao Xiao, Decheng Wang, Meirong Huang, Xiaolin Zhang
Summary: Neutrophil extracellular traps (NETs) are released by activated neutrophils and consist of antimicrobial proteins and DNA. NETosis, a form of neutrophilic cell death, plays a crucial role in diabetes and its complications. Increased levels of NETs in the blood of diabetic patients confirm the association between NETosis and complications such as impaired wound healing, retinopathy, and atherosclerosis. This article summarizes the mechanisms of NETosis and discusses potential therapeutic targets using small molecule compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Nan Li, Liang Zhang, Xintang Wang, Yue Zhou, Lijing Gong
Summary: This review provides a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of diabetes mellitus (DM) and its complications. Exercise can inhibit pyroptosis through the regulation of inflammasome pathways, offering promising potential for expanding preventive and therapeutic strategies for DM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Marc Gregory Yu, Daniel Gordin, Jialin Fu, Kyoungmin Park, Qian Li, George Liang King
Summary: The chronic complications of diabetes, which contribute significantly to the morbidity and mortality of the disease, result from various metabolic disorders. Previously, these complications were categorized as microvascular and macrovascular but should be revised to include vascular, parenchymal, and hybrid tissue origins. Recent research has shifted focus towards the interplay between risk and protective factors in the pathogenesis of complications, highlighting the importance of protective responses in modulating their severity. However, a comprehensive review on protective factors and their mechanisms of action is currently lacking.
