期刊
CHEMISTRYOPEN
卷 2, 期 2, 页码 63-68出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.201300002
关键词
cross-metathesis; cycloaddition; enediynes; first-generation Grubbs catalyst; triynes
资金
- Shanghai Municipal Committee of Science and Technology [11JC1402600]
- National Basic Research Program of China (973) [2009CB825300]
- National Natural Science Foundation of China [21102166, 20872162, 21072206, 20672127, 21121062, 20732008]
[2+2+2] Cycloadditions can be applied to specifically build up derivatives of benzene and cyclohexadiene and, therefore, have attracted much attention. Herein, we present an intramolecular [2+2+2] cycloaddition of triynes catalyzed by the first-generation Grubbs ruthenium complex (Ru gen-1), which can efficiently afford benzene derivatives in good yields under mild conditions. Moreover, we also report on a novel tandem cross-metathesis transformation of intramolecular enediynes also catalyzed by Ru gen-1, which has not been observed previously in related reports. On the basis of deuterium labeling experiments, a possible reaction mechanism is presented.
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