期刊
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
卷 71, 期 -, 页码 668-670出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2053230X15005907
关键词
HIRAN domain; HLTF; template switching; DNA-binding domain
资金
- KAKENHI [23770125, 25291017]
- Protein 3000 Project
- Targeted Protein Research Program (TPRP)
- Takeda Science Foundation
- Naito Foundation
- Grants-in-Aid for Scientific Research [26440034, 23770125] Funding Source: KAKEN
HLTF is a pivotal protein in the template-switching pathway that allows DNA synthesis to continue even in the presence of DNA damage by utilizing a newly synthesized undamaged strand as a template. HLTF has a novel DNA-binding domain termed HIRAN that has been recently found in various proteins, although its detailed function remains unclear. In this study, the HIRAN domain of human HLTF was successfully crystallized. The crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 130.0, c = 150.1 angstrom.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据