Review
Biology
Xun Fu, Jiang Liu, Xin Yan, Michael E. DiSanto, Xinhua Zhang
Summary: Prostate cancer is the second most common cancer in aging men globally, but its exact pathogenesis is not fully understood. The heat shock protein (HSP) family plays a significant role in promoting tumor growth and protecting cancer cells from death. HSP molecules are closely involved in important biological processes such as cell differentiation, epithelial-mesenchymal transition, and fibrosis. Agents and inhibitors targeting the critical structure of HSP molecules have been developed for their potent antitumor effects. However, only a small number of them have been clinically tested. Further clinical studies are needed to establish the relationship between HSP70 family, HSP90 molecule, and prostate cancer treatment.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Vladislav A. Kalmykov, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: Cardiovascular diseases are a major cause of death worldwide, with molecular chaperones like HSP90 playing a crucial role in heart protection and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Enzo M. Scutigliani, Yongxin Liang, Marloes IJff, Hans Rodermond, Xionge Mei, Miriam P. Korver, Vaneesha S. Orie, Ron A. Hoebe, Daisy Picavet, Arlene Oei, Roland Kanaar, Przemek M. Krawczyk
Summary: Summary Hyperthermia can improve the effects of radio- and chemotherapy, but its efficacy is limited by the heat stress response (HSR). In this study, we evaluated the HSP90 inhibitor ganetespib in promoting the effects of radiotherapy or cisplatin combined with hyperthermia. Our results showed that ganetespib could enhance the efficacy of hyperthermia when combined with radiation.
Article
Parasitology
Desmond O. Agwunobi, Tongxuan Wang, Meng Zhang, Tianhong Wang, Qingying Jia, Miao Zhang, Xinyue Shi, Zhijun Yu, Jingze Liu
Summary: In this study, genes of hsp70 and hsp90 cDNA were cloned and characterized from the tick Dermacentor silvarum, and their functions in cold stress were evaluated. Results showed that Dshsp70 and Dshsp90 play essential roles in the low-temperature adaptation of ticks. This study contributes to understanding the survival and acclimatization of overwintering ticks.
PARASITES & VECTORS
(2021)
Article
Plant Sciences
Yunxie Wei, Hongqiu Zeng, Wen Liu, Xiao Cheng, Binbin Zhu, Jingru Guo, Haitao Shi
Summary: This study systematically analyzed the correlation between HSP90 and autophagy signaling in cassava, and investigated their effects on plant disease response and underlying mechanisms through functional genomics and genetic phenotype assay. The study found that the potential MeHSP90.9-MeSGT1-MeRAR1 chaperone complex interacts with MeATGs and triggers autophagy signaling, enhancing disease resistance to cassava bacterial blight.
Article
Medicine, Research & Experimental
Ho Jin Lee, Hye-Young Min, Young-Sik Yong, Jihyae Ann, Cong Truong Nguyen, Minh Thanh La, Seung Yeob Hyun, Huong Thuy Le, Hyewon Kim, Hyukjin Kwon, Gibeom Nam, Hyun-Ju Park, Jeewoo Lee, Ho-Young Lee
Summary: This study revealed that Hsp90 inhibitors that block the N-terminal ATP-binding pocket activate STAT3, leading to the transcriptional upregulation of Wnt ligands and promoting cell survival in NSCLC. NCT-80 effectively reduced NSCLC cell viability, migration, and CSC-like phenotypes, and inhibited the growth of patient-derived xenograft tumors.
Article
Biochemistry & Molecular Biology
Raquel Alves, Diogo Santos, Joana Jorge, Ana Cristina Goncalves, Steve Catarino, Henrique Girao, Joana Barbosa Melo, Ana Bela Sarmento-Ribeiro
Summary: Heat shock protein 90 (HSP90) plays a crucial role in stabilizing and protecting client proteins. Alvespimycin, an HSP90 inhibitor, has shown potential in overcoming imatinib resistance in chronic myeloid leukemia (CML) cell lines. This study found that Alvespimycin effectively reduced metabolic activity and induced cell death, apoptosis, and cell cycle arrest in imatinib-sensitive and imatinib-resistant CML cells. It also increased HSP70 expression as a marker of HSP90 inhibition. These findings suggest that Alvespimycin could be a promising therapeutic approach for CML treatment, even in cases of imatinib resistance.
Article
Oncology
Zeynep Eroglu, Y. Ann Chen, Inna Smalley, Jiannong Li, Joseph K. Markowitz, Andrew S. Brohl, Leticia Tetteh, Hayley Taylor, Vernon K. Sondak, Nikhil I. Khushalani, Keiran S. M. Smalley
Summary: In this study, the efficacy and safety of vemurafenib and cobimetinib in combination with different doses of the HSP90 inhibitor XL888 for the treatment of advanced melanoma were explored. The study found that this combination therapy showed activity in some patients, but also had significant toxicity.
Article
Biochemistry & Molecular Biology
Tanya Ju-Ngam, Nichanun McMillan, Mamoru Yoshimizu, Hisae Kasai, Ratree Wongpanya, Prapansak Srisapoome
Summary: This research conducted molecular characterization and biofunctional analyses of Hsp40 and Hsp90 genes in giant river prawns under various stress conditions. The highest similarity scores of these genes were found with crustaceans. Expression patterns of Mr-hsp40 and Mr-hsp90 were different under Aeromonas hydrophila challenge and heat-cold shock conditions, highlighting their significant roles in stress responses.
Review
Biochemistry & Molecular Biology
Lisa Marie Ramirez, Markus Zweckstetter
Summary: Proteostasis is maintained by a network of molecular chaperones, with Hsp90 being a prominent member. While the chaperone function of Hsp90 has been extensively studied, its interaction with intrinsically disordered proteins (IDPs) remains poorly understood. This review highlights recent advances in understanding the mechanisms of Hsp90-mediated chaperoning of IDPs, focusing on tau and α-synuclein, and provides insights into the modulation of chaperone-client interaction in neurodegenerative diseases.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2023)
Review
Cell Biology
Xiude Ren, Tao Li, Wei Zhang, Xuejun Yang
Summary: Heat-shock protein 90 (HSP90) is an important molecule chaperone associated with tumorigenesis and malignancy. It plays a role in the malignant behaviors of cancer cells, but currently there are no effective single-agent treatments. Combining HSP90 inhibitors with other anticancer therapies may be a better strategy.
Article
Toxicology
Min Su, Shuhong Zhou, Jun Li, Nan Lin, Tao Chi, Mengdi Zhang, Xiaoli Lv, Yuxia Hu, Tuya Bai, Fuhou Chang
Summary: This study aimed to clarify the new mechanism of Benzo(a)pyrene (BaP) regulating chaperone-mediated autophagy (CMA) through heat shock protein 90 (HSP90). The results demonstrated that BaP induced CMA and caused DNA damage through HSP90.
TOXICOLOGY LETTERS
(2023)
Article
Biochemical Research Methods
Heather Desaire, Kaitlyn E. Stepler, Rena A. S. Robinson
Summary: Recent research has shown that proteomics can be used to identify potential biomarker candidates for Alzheimer's disease in different populations. By applying machine learning to proteomics data, APP and HSPB1 were identified as high-performing biomarkers, although their performance varied among different racial and ethnic groups. HSPB1 was particularly effective in African American/Black participants. These findings contribute to the exploration of AD biomarkers.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Wene Wei, Jiahui Zhou, Lipeng Chen, Haizhou Liu, Fuyong Zhang, Jilin Li, Shufang Ning, Shirong Li, Chen Wang, Yi Huang, Chang Zou, Litu Zhang
Summary: The study showed that plasma Hsp90 alpha levels were significantly higher in colorectal cancer patients and were associated with disease progression, certain tumor biomarkers, and immune cells. However, plasma Hsp90 alpha failed to demonstrate a prognostic value in progression-free survival for colorectal cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He, Bo Han
Summary: Hsp90 is a crucial molecular chaperone that plays a critical role in biological pathways and cellular operations. It is closely linked to cancer and has been studied as a potential drug target. Combining Hsp90 inhibitors with other tumor inhibitors has shown synergistic antitumor effects, making the development of Hsp90 dual-target inhibitors a promising strategy in cancer treatment.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ke-Liang Chen, He Wang, Gui-Xian Zhao, Lei Wei, Yu-Yuan Huang, Shi-Dong Chen, Jian Sun, Qiang Dong, Mei Cui, Jin-Tai Yu
Summary: A novel homozygous RNF216 p.E650X mutation causing Gordon Holmes syndrome was identified in this study, expanding the genetic knowledge of GHS and extending the ethnic distribution of RNF216 mutations.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Jia-Hui Hou, Ya-Nan Ou, Wei Xu, Peng-Fei Zhang, Lan Tan, Jin-Tai Yu
Summary: This study found that peripheral immune cells and the ratio of these cells were associated with cognitive function, neuroimaging, and AD pathology. These associations may be mediated by beta-amyloid and tau pathology.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Environmental Sciences
He-Ying Hu, Ya-Hui Ma, Yue-Ting Deng, Ya-Nan Ou, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu
Summary: This study found an association between residential greenness and dementia incidence, indicating that increasing greenspace can reduce the risk of dementia. The protective effect of greenness may be mediated through the reduction of particulate air pollution.
ENVIRONMENTAL RESEARCH
(2023)
Article
Clinical Neurology
Rong-Ze Wang, Shu-Yi Huang, Hong-Qi Li, Yu-Xiang Yang, Shi-Dong Chen, Jin-Tai Yu
Summary: Using a Mendelian randomization approach, this study found that genetically determined levels of lipids in small LDL were associated with the risk of stroke, especially large-artery atherosclerotic stroke. Higher cholesterol levels in high-density lipoprotein (HDL-C) were associated with the risk of intracerebral haemorrhage. However, no significant association was found between genetic predisposition to circulating metabolites and magnetic resonance imaging markers of cerebral small vessel disease and microstructural injury.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiaolifan Aerqin, Zuo-Teng Wang, Kai-Min Wu, Xiao-Yu He, Qiang Dong, Jin-Tai Yu
Summary: This review summarizes the progress made in the discovery of reliable Alzheimer's disease (AD) biomarkers using genomics, transcriptomics, proteomics, and metabolomics. The importance of these biomarkers in the diagnosis and treatment of AD is discussed.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Medicine, General & Internal
Hui-Fu Wang, Wei Zhang, Edmund T. Rolls, Yuzhu Li, Linbo Wang, Ya-Hui Ma, Jujiao Kang, Jianfeng Feng, Jin-Tai Yu, Wei Cheng
Summary: This study investigated the association of hearing performance with cognitive function, brain structure, and cerebrospinal fluid (CSF) proteins. The findings revealed that poor hearing performance was related to worse cognitive function, brain atrophy, and tau pathology.
Review
Clinical Neurology
Na Zhang, Ke-Liang Chen, Yu-Yuan Huang, Shu-Fen Chen, Qiang Dong, Lan Tan, Jin-Tai Yu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2023)
Article
Neurosciences
Zuo-Teng Wang, Yan Fu, Shi-Dong Chen, Yu-Yuan Huang, Ya-Hui Ma, Yan-Jiang Wang, Lan Tan, Jin-Tai Yu
Summary: This study is the first to identify significant associations between TREM1 rs2062323 and AD risk. The rs2062323T may be involved in AD by regulating the expression of TREM1, TREML1, TREM2, and sTREM2. The TREM family is expected to be a potential therapeutic target for AD.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Yan Fu, Yan Sun, Zhi-Bo Wang, Dan-Dan Zhang, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: This study used the American Heart Association's Life's Simple 7 (LS7) metric to define cardiovascular and brain health and found that ideal LS7 cardiovascular health factors are associated with both macrostructural and microstructural markers of brain health. The results suggest that better LS7 profiles are linked to better brain health.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yan Sun, Yu Guo, Hong-Qi Li, Lan Tan, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: White matter hyperintensities (WMH) are strongly associated with stroke, dementia, and early mortality. This study investigated the relationship between WMH and circulating metabolites in a large sample of individuals from the UK Biobank. The results showed that several metabolites, including high-density lipoprotein (HDL), fatty acids, and glycoprotein acetyls, were associated with WMH. Age and sex also had a significant influence on these associations. The findings suggest that specific metabolomic features accompany WMH and may provide insights into the implications of WMH in different populations.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Yu He, Shu-Yi Huang, Hui-Fu Wang, Wei Zhang, Yue-Ting Deng, Ya-Ru Zhang, Qiang Dong, Jian-Feng Feng, Wei Cheng, Jin-Tai Yu
Summary: Cohort studies have shown inconsistent associations between omega-3 polyunsaturated fatty acids (n-3 PUFA) or fish oil and dementia risk. This study included a large number of participants and found that higher plasma levels of PUFA and fish oil supplementation were associated with a lower risk of developing dementia.
Article
Biochemistry & Molecular Biology
Shu-Yi Huang, Ya-Ru Zhang, Liu Yang, Yu-Zhu Li, Bang-Sheng Wu, Shi-Dong Chen, Jian-Feng Feng, Qiang Dong, Wei Cheng, Jin-Tai Yu
Summary: Identifying circulating metabolites associated with dementia, cognition, and brain volume could provide new insights into the pathogenesis of dementia. This cohort study found 26 metabolites associated with incident dementia, including specific associations with Alzheimer's disease (AD) and vascular dementia (VD). Circulating levels of certain lipoproteins were found to be associated with the risk of AD and AD phenotypes, while another lipoprotein was associated with the risk of VD.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ji-Yun Cheng, Yue-Ting Deng, Jin-Tai Yu
Summary: Through a more robust analysis, we found potential associations between circulating levels of amino acids and the risk of neurodegenerative diseases. Increase in circulating levels of Glutamine (Gln) was associated with lower risk of Alzheimer's disease (AD), while increase in circulating levels of Leucine (Leu) was associated with lower risk of Parkinson's disease (PD). Replication tests further confirmed the potential association between circulating Gln levels and AD risk.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Wei-Shi Liu, Ya-Ru Zhang, Yi-Jun Ge, Hui-Fu Wang, Wei Cheng, Jin-Tai Yu
Summary: This study identified the association between TREM2, temporal lobe, and AD using genetic and transcriptomic data, and explored the complex associations among inflammation, brain structure, and neurodegenerative disorders, particularly AD.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Hai-Shan Jiao, Peng Yuan, Jin-Tai Yu
Summary: Mutations in the TMEM106B gene are risk factors for various neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.
MOLECULAR NEURODEGENERATION
(2023)