Article
Medicine, Research & Experimental
Hui Xu, Fengshu Zhao, Di Wu, Yunxia Zhang, Xueyang Bao, Fangfang Shi, Yunlang Cai, Jun Dou
Summary: The immune effects of cancer stem cells (CSCs) vaccines on ovarian cancer (OC) were evaluated. The CSC vaccines were capable of significantly provoking immune responses to autologous tumor antigens in vaccinated mice, resulting in inhibited tumor growth, prolonged survival, and decreased CSC counts in OC tissues. The antitumor efficacy of the vaccines was reduced when the mucin-1 expression in CSC vaccines was down-regulated.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nanoscience & Nanotechnology
Lan Sun, Hong-Juan Yao, Jing-Cao Li, Bao-Quan Zhao, Yong -An Wang, Ying-Ge Zhang
Summary: A nanodrug delivery system using activated carbon nanoparticles (ACNP) as carriers and metformin (MET) as drug (ACNP-MET) was developed, which can selectively eliminate hepatocellular cancer stem cells (CSCs) and enhance the therapeutic effects of MET on hepatocellular cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Medicine, Research & Experimental
Jin Qian, Bauer L. LeSavage, Kelsea M. Hubka, Chenkai Ma, Suchitra Natarajan, Joshua T. Eggold, Yiren Xiao, Katherine C. Fuh, Venkatesh Krishnan, Annika Enejder, Sarah C. Heilshorn, Oliver Dorigo, Erinn B. Rankin
Summary: Ovarian cancer-associated mesothelial cells play a critical role in promoting chemoresistance and stemness in ovarian cancer. The secreted factor osteopontin drives mesothelial-mediated chemoresistance and stemness, and therapeutic targeting of osteopontin may enhance platinum sensitivity in ovarian cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Oncology
Daniela Simcikova, Dominik Gardas, Katerina Hlozkova, Martin Hruda, Petr Zacek, Lukas Rob, Petr Heneberg
Summary: The study revealed that depletion of HK1, but not HK2, in ovarian cancer cells increased sensitivity to high-dose metformin during glucose starvation. Additionally, HK1 was found to play a glycolysis-independent role in metabolism, even in glucose-free conditions, suggesting its involvement in a previously unknown HK1-metformin axis.
CANCER & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Patrycja Gralewska, Arkadiusz Gajek, Agnieszka Marczak, Aneta Rogalska
Summary: This study demonstrated that the combination treatment of olaparib and metformin had a significant inhibitory effect on HR-proficient ovarian cancer cells, inducing apoptosis by increasing ROS levels. The synergistic effect was observed in cells with mutant or null p53, providing a new approach for the treatment of gynecologic cancers. The results support the use of metformin to enhance the sensitivity of EOC to olaparib therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Sarah E. Taylor, Daniel K. Chan, Dongli Yang, Tulia Bruno, Richard Lieberman, Javed Siddiqui, Thing Rinda Soong, Lan Coffman, Ronald J. Buckanovich
Summary: Metformin may impact the tumor microenvironment by reducing the number of cancer-associated mesenchymal stem cells and regulatory T cells, potentially inhibiting tumor growth. It shows potential clinical utility in the prevention and treatment of early-stage cancer.
Article
Cardiac & Cardiovascular Systems
Chenyang Zhang, Bin Zhang, Xuelian Zhang, Min Wang, Xiaobo Sun, Guibo Sun
Summary: This study found that Panax notoginseng saponin (PNS) can attenuate heart dysfunction in diabetic mice by reducing lipotoxicity, modulating oxidative stress, and improving mitochondrial function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Xiaowu Bai, Hong Wei, Weixin Liu, Olabisi Oluwabukola Coker, Hongyan Gou, Changan Liu, Liuyang Zhao, Chuangen Li, Yunfei Zhou, Guoping Wang, Wei Kang, Enders Kwok-wai Ng, Jun Yu
Summary: Cigarette smoke exposure alters the gut microbiota and related metabolites, leading to an increased risk of colorectal cancer. Mice exposed to cigarette smoke had dysbiosis of the gut microbiota, increased bile acid metabolites, activated oncogenic signaling pathways, and impaired gut barrier function.
Article
Biochemistry & Molecular Biology
Jia-yi Guo, Yong-jun Wang, Si-qi Li, Yu-ping Wu
Summary: This study used network pharmacology to analyze potential targets of metformin against ovarian cancer. Pharmacodynamic targets were predicted and gene expression analysis was performed to identify differentially expressed genes. Protein-protein interaction analysis and enrichment analysis were used to determine the core targets of metformin, and pathway analysis was performed. The study provides preliminary insights into the critical targets and pathways of metformin against ovarian cancer.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Oncology
Jiayu Zhao, Mei Li, Jiao Xu, Wei Cheng
Summary: Ion channels play a crucial role in regulating ion balance, generating electrical and chemical signals, and their dysfunction is associated with cancer and cancer chemo-resistance.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Upasana Ray, Prabhu Thirusangu, Ling Jin, Yinan Xiao, Christopher L. Pathoulas, Julie Staub, Courtney L. Erskine, Keith Dredge, Edward Hammond, Matthew S. Block, Scott H. Kaufmann, Jamie N. Bakkum-Gamez, Viji Shridhar
Summary: PG545 is a highly sulfated small molecule that inhibits heparanase and disrupts signaling mediated by heparan-binding-growth factors. It induces DNA damage in ovarian cancer cells by inducing DNA single- and double-strand breaks, reducing RAD51 expression, and inhibiting homologous recombination repair. PG545 also synergizes with PARP inhibitors in ovarian cancer cell lines and primary cultures of patient-derived ascites samples. In addition, it shows increased antitumor effects and survival in xenograft and immunocompetent syngeneic OC models. Targeting DEK-HSPG interactions through PG545 may inhibit DNA repair and sensitize cells to PARP inhibitors.
Article
Plant Sciences
Wenhao Liao, Lanlan Zhang, Xian Chen, Juyi Xiang, Qiao Zheng, Nianzhi Chen, Maoyuan Zhao, Gang Zhang, Xiaolin Xiao, Gang Zhou, Jinhao Zeng, Jianyuan Tang
Summary: This review examines the effects and mechanisms of phytochemicals on colorectal cancer stem cells (CSCs) and summarizes different phytochemicals based on their mechanisms of action. It was found that phytochemicals can inhibit the self-renewal, migration, invasion, chemoresistance, and induce apoptosis and differentiation of CSCs through regulating various signaling pathways. These findings suggest that phytochemicals have potential as novel therapeutic agents for colorectal CSCs.
Article
Medicine, General & Internal
Hsiao-Wei Kao, Kuo-Wang Tsai, Wen-chang Lin
Summary: The study found that the antidiabetic drug metformin inhibits gastric cancer cell growth and in combination with the proton pump inhibitor lansoprazole, it has a synergistic effect in inhibiting cancer cell growth. This is achieved by suppressing cell cycle progression and inducing apoptosis. These findings provide a new and safe treatment protocol for stomach cancers.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jing-Jing Wang, Michelle Kwan-Yee Siu, Yu-Xin Jiang, Thomas Ho-Yin Leung, David Wai Chan, Huo-Gang Wang, Hextan Yuen-Sheung Ngan, Karen Kar-Loen Chan
Summary: PD-L1 blockade is used in ovarian cancer treatment, with investigations into combination treatments to improve response rates. The dependence on glutamine in tumors, including ovarian cancer, is observed, with GLS promoting tumorigenesis. Combining GLS inhibitor 968 with PD-L1 blockade enhances immune response against ovarian cancer, withGLS levels predicting poor survival and correlating with the immunosuppressive microenvironment.
Article
Biochemistry & Molecular Biology
Jing Ji, Jinyu Lv, Mingxiao Lv, Aixin Jing, Menghan Xu, Qing Yuan, Xinhui Ma, Qilan Qian, Weiling Wang, Ting Geng, Yuanyuan Ding, Jingting Qin, Yuanyuan Liu, Jiayan Yang, Jiaojiao Zhou, Ling Ma, Yasong Wang, Lingyi Zuo, XiuJun Wang, Shaojie Ma, Bin Liu
Summary: The deubiquitinating enzyme USP14 is a crucial regulator in various diseases by stabilizing its substrate proteins. Our study identified new potential substrate proteins for USP14 and demonstrated its key role in heme metabolism and tumor invasion through stabilizing BACH1 protein. The NRF2-USP14-BACH1 axis was found to be important in regulating ovarian cancer cell invasion and heme metabolism, suggesting its potential as a therapeutic target in related diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Se Ik Kim, Taek Min Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jeong Yeon Cho, Yong Sang Song
Article
Surgery
Elisabeth Jacomine Lier, Barend A. W. van den Beukel, Larsa Gawria, Philip J. van der Wees, Leontine van den Hil, Nicole D. Bouvy, Ying Cheong, Rudy-Leon de Wilde, Harry van Goor, Martijn W. J. Stommel, Richard P. G. ten Broek
Summary: The study developed a new clinical adhesion score (CLAS) to measure the overall clinical morbidity of adhesion-related complications in abdominal and pelvic surgery. Through Delphi study and pilot study, the CLAS includes 22 outcomes and 23 weight factors, correcting the likelihood of symptoms being related to adhesions through scoring.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Nutrition & Dietetics
Hee Yang, Min Jeong Kang, Gihyun Hur, Tae Kyung Lee, In Sil Park, Sang Gwon Seo, Jae Gak Yu, Yong Sang Song, Jung Han Yoon Park, Ki Won Lee
Article
Oncology
Hee Seung Kim, Sang-Yoon Park, Chan-Yong Park, Young Tae Kim, Beob-Jong Kim, Yong Jung Song, Byoung-Gie Kim, Yong Beom Kim, Chi-Heum Cho, Jong-Hyeok Kim, Yong Sang Song
Summary: This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer, showing that belotecan was not inferior to topotecan in terms of overall response rate. Additionally, belotecan was associated with improved overall survival compared with topotecan, especially in patients with PRROC and non-HGSC. Toxicity did not differ significantly between the two treatment groups.
BRITISH JOURNAL OF CANCER
(2021)
Article
Plant Sciences
In Sil Park, Youngjin Han, HyunA Jo, Ki Won Lee, Yong Sang Song
Summary: Resveratrol and piceatannol, major stilbene compounds found in natural foods, exhibit inhibitory effects on lipid accumulation and adipogenesis, with piceatannol showing superior anti-adipogenic properties compared to resveratrol in a model of visceral obesity.
Article
Oncology
Suhyun Hwangbo, Se Ik Kim, Ju-Hyun Kim, Kyung Jin Eoh, Chanhee Lee, Young Tae Kim, Dae-Shik Suh, Taesung Park, Yong Sang Song
Summary: The study aimed to develop machine learning models predicting platinum sensitivity in patients with high-grade serous ovarian carcinoma (HGSOC). Six variables associated with platinum sensitivity were selected using clinical data from multiple hospitals, and the LR-based model was found to perform the best. A web-based nomogram was developed for clinical use based on the LR model results.
Article
Oncology
Chae Young Han, David A. Patten, Se Ik Kim, Jung Jin Lim, David W. Chan, Michelle K. Y. Siu, Youngjin Han, Euridice Carmona, Robin J. Parks, Cheol Lee, Li-Jun Di, Zhen Lu, Karen K. L. Chan, Ja-Lok Ku, Elizabeth A. Macdonald, Barbara C. Vanderhyden, Anne-Marie Mes-Masson, Hextan Y. S. Ngan, Annie N. Y. Cheung, Yong Sang Song, Robert C. Bast, Mary-Ellen Harper, Benjamin K. Tsang
Summary: This study highlights the functional interaction between HKII and activated P-p53 (Ser15) in the regulation of bioenergetics and chemosensitivity, emphasizing the increased nuclear HKII-P-p53 (Ser15) interaction as a potential prognostic biomarker in ovarian cancer.
Article
Oncology
Se Ik Kim, Sungyoung Lee, Chel Hun Choi, Maria Lee, Dong Hoon Suh, Hee Seung Kim, Kidong Kim, Hyun Hoon Chung, Jae Hong No, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Yong Beom Kim
Summary: The study developed models predicting survival outcomes according to the surgical approach for radical hysterectomy in early cervical cancer, with hybrid ensemble models performing the best.
Review
Biochemistry & Molecular Biology
Juwon Lee, Youngjin Han, Wenyu Wang, HyunA Jo, Heeyeon Kim, Soochi Kim, Kyung-Min Yang, Seong-Jin Kim, Danny N. Dhanasekaran, Yong Sang Song
Summary: The use of immune checkpoint inhibitors shows promise in cancer treatment but is hindered by severe immunogenic side effects and lack of response against many cancer types. Plant-derived natural compounds offer regulation on various signaling cascades and have the potential for cancer treatment. Studies have shown that some plant compounds can effectively modulate immune checkpoints in various cancers.
Article
Biochemistry & Molecular Biology
Ji Hee Ha, Muralidharan Jayaraman, Mingda Yan, Padmaja Dhanasekaran, Ciro Isidoro, Yong Sang Song, Danny N. Dhanasekaran
Summary: Increased expression of the GNAi2 gene has been correlated with late-stage progression of ovarian cancer, playing a role in transducing signals from LPA-activated receptors to oncogenic responses in cancer cells. The gip2 oncogenic program involves the stimulation of oncogenic and growth-promoting genes, with potential therapeutic targets identified in the network of genes upregulated by gip2.
Article
Biochemistry & Molecular Biology
Ji Hee Ha, Muralidharan Jayaraman, Revathy Nadhan, Srishti Kashyap, Priyabrata Mukherjee, Ciro Isidoro, Yong Sang Song, Danny N. Dhanasekaran
Summary: Through metabolomics analysis, we identified five distinct metabolic groups in HGSOC cells, with most cancer cells showing an increase in metabolites associated with aerobic glycolysis and phospholipid metabolism. Additionally, subsets of HGSOC cells exhibited elevated levels of 5-Hydroxytryptamine, gamma-aminobutyrate, or glutamate. These findings suggest these metabolites could serve as oncometabolites and potential therapeutic targets in ovarian cancer.
Review
Cell Biology
Revathy Nadhan, Ciro Isidoro, Yong Sang Song, Danny N. Dhanasekaran
Summary: This review summarizes the structure and function of long non-coding RNAs (lncRNAs) in cellular signaling networks, as well as their mechanisms of action. It provides insights into the pathogenesis of cardiovascular diseases, neurological disorders, cancers, and diabetes mellitus, highlighting the role of lncRNAs. The review suggests that lncRNAs could be potential therapeutic targets.
Review
Biochemistry & Molecular Biology
Revathy Nadhan, Srishti Kashyap, Ji Hee Ha, Muralidharan Jayaraman, Yong Sang Song, Ciro Isidoro, Danny N. Dhanasekaran
Summary: Peritoneal cancers pose significant challenges in clinical practice and have a poor prognosis. Understanding cancer cell metabolism and cancer-promoting metabolites in peritoneal cancers can provide new insights into tumor progression mechanisms, identify therapeutic targets and biomarkers, and improve treatment outcomes for patients.
Article
Cell Biology
Rebecca Yun, Eunji Hong, Junil Kim, Bora Park, Staci Jakyong Kim, Bona Lee, Yong Sang Song, Seong-Jin Kim, Sujin Park, Jin Muk Kang
Summary: This study reveals the crucial role of N-linked glycosylation in the functional post-translational modification of KIAA1324, which is important for suppressing cancer cell proliferation and migration in gastric cancer. Inhibition of glycosylation and fucosylation also inhibits KIAA1324-induced cell growth inhibition and apoptosis. Additionally, the study shows that N-linked glycosylation decreases protein stability through rapid proteasomal degradation. Overall, this research highlights the significance of post-translational modifications in KIAA1324 for gastric cancer progression.
CELL DEATH & DISEASE
(2023)
Article
Medicine, General & Internal
Se Ik Kim, Tae Hun Kim, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Taek Sang Lee, Hye Won Jeon, Jae Weon Kim, Noh Hyun Park, Yong Sang Song
Summary: This study found that high LNR was associated with a higher disease recurrence rate in node-positive, early-stage cervical cancer patients, particularly among those who received minimally invasive surgery for radical hysterectomy.
YONSEI MEDICAL JOURNAL
(2021)
