Article
Biochemistry & Molecular Biology
Yong-mei Zhang, Hai-chao Zong, Ying-bei Qi, Liu-liu Chang, Ya-nan Gao, Ting Zhou, Tao Yin, Meng Liu, Kai-jun Pan, Wen-gang Chen, Hao-ran Guo, Fei Guo, Yan-min Peng, Min Wang, Lin-yin Feng, Yi Zang, Yang Li, Jia Li
Summary: In this study, it was found that anxiety reduces AMPK activity in the medial prefrontal cortex (mPFC), and treatment with metformin or AMPK overexpression can restore normal AMPK activity and reduce anxiety-like behaviors. The activation of AMPK in inhibitory neurons in the mPFC is suggested to underlie the anxiolytic effects of metformin.
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Guglielmina Froldi, Francine Medjiofack Djeujo, Nadia Bulf, Emma Caparelli, Eugenio Ragazzi
Summary: This study evaluated the activity of baicalein and baicalin compared to metformin as potential antiglycation, anti-radical, and anti-alpha-glucosidase agents. Baicalein showed the most activity in reducing glycation, alpha-glucosidase activity, and free radicals. Baicalin exhibited similar activities but did not inhibit the enzyme alpha-glucosidase.
Article
Biochemistry & Molecular Biology
Charles Arineitwe, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba Khanye, Andile Khathi, Ntethelelo Sibiya
Summary: Diabetes mellitus (DM) and its complications have a significant impact on healthcare systems worldwide. In this study, four novel thiazolidinedione (TZD)-derivatives were synthesized and evaluated for their anti-diabetic properties. The derivatives showed strong binding to peroxisome proliferator-activated receptor-gamma (PPAR-gamma), similar to rosiglitazone. TZDD2 increased glucose uptake in liver cells compared to control. The derivatives exhibited inhibition activity in various enzymatic assays, including alpha-amylase, alpha-glucosidase, aldose reductase, and dipeptidyl peptidase-4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Jie Hao, Zhiming Qian, Zijian Liu, Guirong Zhang, Di Wang, Weiwei Han
Summary: The aim of this study was to provide a practical experimental basis for the development of Neocryptotanshinone (NCTS) as an effective hypoglycemic drug and a theoretical method for the rapid screening of natural compounds with hypoglycemic effects. The results demonstrated that NCTS effectively lowered blood glucose in db/db mice by regulating the expression of PTP1B in the liver and muscle.
Article
Medicine, Research & Experimental
Pengpeng Zhang, Wei Wei, Xiaohai Zhang, Chaoling Wen, Chitchamai Ovatlarnporn, Opeyemi Joshua Olatunji
Summary: This study found that the ethanolic extract of Krat has significant antidiabetic and antihyperlipidemic effects on type 2 diabetic rats. These results for the first time demonstrated the potential of Mitragyna speciosa in the treatment of diabetes and provide scientific reinforcement for its traditional use.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Chemistry, Medicinal
Razieh Choghakhori, Amir Abbasnezhad, Mohammad Yazdi, Hassan Ahmadvand
Summary: This meta-analysis examined the pharmaceutical applications of Pistacia atlantica (PA) in diabetes prevention and treatment by assessing preclinical studies. The findings indicated that PA supplementation significantly decreased blood glucose, insulin resistance, total cholesterol, triglyceride, and malondialdehyde levels, while increasing insulin and superoxide dismutase levels in diabetic animals. However, HDL-cholesterol levels were not significantly affected. Subgroup analysis supported the beneficial effects of longer duration and higher doses of PA supplementation, as well as the use of extracts. Methodological diversity and concerns about bias were noted in the studies. Further high-quality studies are needed to confirm the clinical efficacy of PA.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Rasha M. H. Rashied, Mohamed A. O. Abdelfattah, Hesham A. El-Beshbishy, Assem M. ElShazly, Mona F. Mahmoud, Mansour Sobeh
Summary: This study investigated the antidiabetic activities of the bioactive leaf extracts of Syzygium samarangense. In silico docking studies showed that the compounds in the extract had good binding activity to PPAR gamma and GLP-1 receptors. Furthermore, in vivo experiments on streptozotocin-induced diabetic rats confirmed the antidiabetic potential of the extract.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Plant Sciences
Nuniek Ina Ratnaningtyas, Hernayanti Hernayanti, Nuraeni Ekowati, Fajar Husen
Summary: The extract of Coprinus comatus can be used as herbal medicine to reduce diabetic symptoms.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jin-long Dong, Bin Wen, Zhen Song, Jie Chai, Bin Liu, Wen-juan Tian, Gang Liang, Bin-sheng Yang
Summary: The study synthesized a chromium(III) complex, characterized its structure, evaluated its bioactivities and toxicity, revealing that the complex has beneficial effects on T2DM and is safe for organisms.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Wei-Tse Hung, Yuan-Jung Chen, Chun-Yu Cheng, Bruce Ovbiagele, Meng Lee, Chia-Yu Hsu
Summary: Combination therapy (metformin plus a low hypoglycemic risk antidiabetic drug) achieves better glycemic control without an increased risk of hypoglycemia in patients with untreated type 2 diabetes mellitus compared to standard metformin monotherapy.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Ghulam Md Ashraf, Debarati DasGupta, Mohammad Zubair Alam, Saleh S. Baeesa, Badrah S. Alghamdi, Firoz Anwar, Thamer M. A. Alqurashi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Mohammed A. Alyousef, Fahad A. Alhumaydhi, Anas Shamsi
Summary: Microtubule affinity regulating kinase 4 (MARK4) plays a crucial role in regulating microtubules and its inhibition by metformin shows potential as a treatment for neurodegenerative diseases associated with diabetes.
Article
Nutrition & Dietetics
Cerile Ypolyte Woumbo, Dieudonne Kuate, Danielle Gaelle Metue Tamo, Hilaire Macaire Womeni
Summary: This study optimized the extraction conditions of polyphenolic compounds from okra seeds using microwave-assisted extraction. The optimized extract showed strong antioxidant and antidiabetic activities. Animal experiments demonstrated the effectiveness of the extract in treating diabetes.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Salma M. Khirallah, Heba M. M. Ramadan, Hossam Aladl Aladl Aladl, Najla O. Ayaz, Lina A. F. Kurdi, Mariusz Jaremko, Samar Zuhair Alshawwa, Essa M. Saied
Summary: This study investigates the potential of 1,3,5-trisubstituted-2-thioxoimidazolidin-4-ones as inhibitors of diabetes development. Compound 5a shows the highest inhibitory activity and also displays cytotoxicity and antioxidant activity.
Article
Biochemistry & Molecular Biology
Pedro Ramon, Daniela Bergmann, Hussain Abdulla, Jean Sparks, Felix Omoruyi
Summary: With rising healthcare costs, alternative medicine is becoming a popular choice for patients looking for treatment. This study investigated the effects of combining natural product Kalanchoe Pinnata (K. pinnata) with metformin on antioxidant activity in human skeletal muscle myoblasts. The results showed that the combination increased enzymatic activity and levels of antioxidants in both non-diabetic and diabetic cells, suggesting potential for treating oxidative-stress-mediated complications in type II diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Kasim Takim, Akin Yigin, Ismail Koyuncu, Ruya Kaya, Ilhami Gulcin
Summary: The study investigated the phytochemical content and pharmaceutical activity of methanol extracts of Allium tuncelianum (MAT), revealing potential alternative treatments for prostate cancer, diabetes, and some neurodegenerative diseases. The extracts showed anticancer, anticholinesterase, and antidiabetic activities, making them promising candidates for further research and development in the field of medicine.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Article
Education, Scientific Disciplines
Niraj Kumar Singh, Debapriya Garabadu
Summary: The study investigated the correlation between mitochondrial dysfunction and the expression level of alpha 7 nAChRs in STZ challenged brain regions of rats. Results showed that STZ caused significant impairment in memory and learning, with decreased expression of alpha 7 nAChRs and cholinergic functions in rat hippocampus, pre-frontal cortex and amygdala. STZ administration also attenuated mitochondrial function and increased A beta level in all selected brain regions.
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2021)
Article
Neurosciences
Vibhav Varshney, Debapriya Garabadu
Summary: Naringin shows potential therapeutic effects against AD-like animals induced by A beta, improving cognitive function, cholinergic function, and mitochondrial function. The results indicate that naringin could be a potential alternative in the management of AD.
NEUROTOXICITY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Vibhav Varshney, Debapriya Garabadu
Summary: The Renin-Angiotensin System plays a significant role in the pathophysiology of Alzheimer's disease, with Ang (1?7) showing potential in ameliorating cognitive impairment. Injection of A842 induced changes in behavior, biochemistry, and molecular observations in rats.
Article
Neurosciences
Niraj Kumar Singh, Debapriya Garabadu
Summary: Quercetin showed protective effects against STZ-induced brain mitochondrial toxicity in AD-like rats by activating the α7nAChR/Nrf2/HO-1 pathway, suggesting its potential therapeutic value in managing AD.
NEUROTOXICITY RESEARCH
(2021)
Article
Plant Sciences
Mahima Sharma, Pankaj Kumar Gupta, Pankaj Gupta, Debapriya Garabadu
Summary: Bacopa monnieri, also known as Brahmi, has shown significant therapeutic activity against neuropathic pain in animal models. This study aimed to evaluate the anti-nociceptive potential of methanolic extract of Bacopa monnieri in adult zebrafish model of pain. The results demonstrated that the standardized methanolic extract of Bacopa monnieri exhibited antioxidant effects and antinociceptive activity in adult zebrafish.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Mahima Sharma, Pankaj Gupta, Debapriya Garabadu
Summary: Bacopa monnieri, commonly known as Brahmi, has been traditionally used as a nootropic agent and exhibits significant analgesic activity in zebrafish models. It significantly attenuates glutamate-induced pain and mitochondrial toxicity in the brain of adult zebrafish, suggesting its potential as an alternative drug candidate for pain management.
METABOLIC BRAIN DISEASE
(2022)
Review
Pharmacology & Pharmacy
Ahsas Goyal, Sainu Gopika, Abhishek Kumar, Debapriya Garabadu
Summary: Parkinson's disease is a chronic and progressive neurodegenerative disorder with limited treatment options. However, Brahmi, a herbal medicine, has been found to exert neuroprotective effects in Parkinson's disease by reducing oxidative stress and inflammation, and enhancing dopamine levels.
CURRENT DRUG TARGETS
(2022)
Review
Clinical Neurology
Abhipsa Amarjeet, Raja Babu, Abhipsa Mohapatra, Bhaskaranand Pancholi, Debapriya Garabadu, Anjali Sharma, Ashwani Sharma, Md. A. K. Azad
Summary: Myelin is a vital component in the nervous system and its dysfunction can lead to demyelinating diseases. Ceramide, a major component in myelin, plays a crucial role in regulating mitochondrial function and cell death. Imbalance in ceramide levels can disrupt the electron transport chain and result in neuronal and glial cell death, leading to demyelination. Various factors, including inflammation, oxidative stress, and genetic and environmental factors, can influence the interaction between ceramide and mitochondria.
ACTA NEUROLOGICA SCANDINAVICA
(2023)
Retraction
Endocrinology & Metabolism
Debapriya Garabadu, Deepanshu Singh
METABOLIC BRAIN DISEASE
(2023)
Retraction
Endocrinology & Metabolism
Mahima Sharma, Pankaj Gupta, Debapriya Garabadu
METABOLIC BRAIN DISEASE
(2023)
Retraction
Neurosciences
Yati Sharma, Debapriya Garabadu
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Chemistry, Medicinal
Salok Jaiswal, Ahsas Goyal, Debapriya Garabadu
Summary: The study investigates the potential neuroprotective and anti-amnesic effects of daidzein, a phytoestrogen derived from plants, on ovariectomized rats. The results show that daidzein can attenuate cognitive deficits induced by ovariectomy through the caveolin-1/eNOS/VEGF-mediated signaling pathway, making it a potential therapeutic option for the treatment of cognitive deficits in postmenopausal women.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Chemistry, Medicinal
Gayathri Aparnasai Reddy, Mayank Handa, Debapriya Garabadu, Ravindra Kumar, Pramod Kumar Kushawaha, Rahul Shukla
Summary: This study investigates the incorporation of transferrin as an effective coating material for targeted drug delivery. Nanoparticles were prepared and transferrin was surface modified using layer-by-layer methodology. Their properties, drug release, antibacterial activity, and cellular uptake were evaluated.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Mayank Handa, Kamlesh Kumar, Debapriya Garabadu, Pramod Kumar Kushawaha, Rahul Shukla
Summary: The aim of this study was to develop a fixed-dose combination of bilayer tablets for management of inflammatory response, with piroxicam as immediate-release layer and curcumin as sustained-release layer. The sustained-release layer was prepared using curcumin polycaprolactone microparticles obtained by spray drying. The tablet layers contained Pearlitol 200SD, Microcrystalline cellulose PH101, Aerosil 200, and talc. The results showed that the microparticles were spherical according to SEM studies, and were amorphous according to PXRD and DSC studies. In vitro studies demonstrated an immediate release and sustained release of piroxicam and curcumin after 2 hours. Cellular uptake studies confirmed complete internalization of the microparticles by RAW 264.7 cells. Therefore, microparticles can be used to formulate a unit dosage form for the management of inflammation.
THERAPEUTIC DELIVERY
(2022)
Article
Pharmacology & Pharmacy
Ahsas Goyal, Neetu Agrawal, Ankit Jain, Jeetendra Kumar Gupta, Debapriya Garabadu
Summary: Caveolin interacts with eNOS to suppress its activity, leading to reduced NO production. Ischemic preconditioning disrupts this interaction, activating eNOS and providing cardioprotection. Estrogen deficiency upregulates Caveolin-1 expression, increasing the risk of coronary artery diseases in postmenopausal women.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)