Article
Immunology
Ming Qi, Zhipeng Cao, Peng Shang, Hui Zhang, Riaz Hussain, Khalid Mehmood, Zhenyu Chang, Qingxia Wu, Hailong Dong
Summary: The study investigated the adverse effects of pathogenic E. coli on the gut microbiota of Tibetan piglets with a history of yellow and white dysentery. Differences in microbial diversity at phylum and family levels were observed between healthy and infected piglets. Pathological alterations induced by E. coli in piglets with dysentery may provide support for effective control of diarrhoeal disease.
MICROBIAL PATHOGENESIS
(2021)
Article
Pediatrics
Brian A. Juber, Timothy J. Boly, Graeme J. Pitcher, Steven J. McElroy
Summary: In this study, a retrospective analysis of infants showed that routine probiotic supplementation did not significantly alter the rates of modified Bell's stage >= 2a NEC or all-cause pre-discharge mortality in very low birth weight (VLBW) infants at the institution.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Alexander Y. G. Yip, Olivia G. King, Oleksii Omelchenko, Sanjana Kurkimat, Victoria Horrocks, Phoebe Mostyn, Nathan Danckert, Rohma Ghani, Giovanni Satta, Elita Jauneikaite, Frances J. Davies, Thomas B. Clarke, Benjamin H. Mullish, Julian R. Marchesi, Julie A. K. McDonald
Summary: The intestine serves as a primary colonisation site for carbapenem-resistant Enterobacteriaceae (CRE) and acts as a reservoir for invasive infections. Antibiotics disrupt the colonisation resistance provided by gut microbiota, which leads to an expansion of CRE within the intestine. This study demonstrates that antibiotic-induced reduction of gut microbial populations results in the enrichment of nutrients and the depletion of inhibitory metabolites, promoting the growth of CRE.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Soichiro Kawata, Shimpei Morimoto, Kosuke Kosai, Yasuhide Kawamoto, Yumiko Nakashima, Yoshitomo Morinaga, Katsunori Yanagihara, Lay-Myint Yoshida, Hiroyuki Moriuchi
Summary: This study aimed to clarify the carriage status of ESBL-E and CRE among Japanese infants in the community. The results showed that the carriage rate of ESBL-E was 19.3% in the Japanese community, while no CRE carriers were detected. The study found that environmental factors, especially delivery facilities, influenced the colonization of ESBL-E among infants aged 4-5 months.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mohammed Khalid Harasani, Sarah Abdulrahman Almosaiteer, Faisal Saleh Aloraini, Saleh Khalid Aldakhil, Jamilah Sulaiman Alsaiari, Abdulrahman Muhaidib Almuhaidib, Omar Muhaidib Almuhaidib, Mohammed Atiah Alisi, Othman Majed Alothman, Thamer Saleh Alanazi, Asalah Tariq Alsaigh
Summary: The potential benefits of probiotics in preventing necrotizing enterocolitis and feeding intolerance in preterm infants are mainly seen in low birth-weight infants, while their impact on extremely low-birth-weight infants remains controversial. The systematic review found no significant impact of probiotics administration on outcomes such as mortality and NEC in ELBW infants, but did show improvements in growth rates, particularly head circumference growth. Further research is encouraged to verify these findings for ELBW infants.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Letter
Pediatrics
Marianne Samyn, Kai Hensel, Nedim Hadzic, Giorgina Mieli-Vergani
JOURNAL OF PEDIATRICS
(2022)
Article
Biology
Elisa Wirthgen, Melanie Hornschuh, Ida Maria Wrobel, Christian Manteuffel, Jan Daebritz
Summary: This study investigates the effects of shear flow on blood-derived monocytes, demonstrating that mimicking blood flow during ex vivo culture results in an anti-inflammatory cytokine response and higher migratory capacity, potentially improving the efficacy of monocyte-based therapeutic products.
Review
Pediatrics
Kai O. Hensel, John Powell
Summary: Technology is driving a revolution in healthcare, but paediatric services have not fully harnessed the potential. Digital health solutions in paediatrics are yet to meet their promise, including electronic health records, telemedicine, and research. Families and children are increasingly embracing digital health, but clinicians remain skeptical and more rigorous studies are needed to prove safety and efficacy.
ARCHIVES OF DISEASE IN CHILDHOOD
(2022)
Review
Immunology
Rosaely Casalegno Garduno, Jan Dabritz
Summary: Studies on the role of CD8(+) T cells in inflammatory bowel disease have shown contradictory outcomes, possibly due to the heterogeneity of the cells. Different subsets of CD8(+) T cells, such as Tc1 and Tc17 cells, may play a role in the pathogenesis of IBD. Regulatory CD8(+) T cells are abundant at sites of inflammation and can exhibit pro-inflammatory features.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hilte F. Geerdes-Fenge, Saskia Klein, Hans-Martin Schuldt, Micha Lobermann, Kerstin Koller, Jan Dabritz, Emil Christian Reisinger
Summary: This retrospective analysis examined 272 cases of laboratory-confirmed influenza in a university hospital in northern Germany during the 2017-2018 winter season. The study found that patients with influenza should be monitored for secondary pneumonia and myocardial infarction, and vaccination should be enforced especially in patients with coronary heart disease and cardiac insufficiency.
WIENER MEDIZINISCHE WOCHENSCHRIFT
(2022)
Review
Cell Biology
Carolin Baehren, Eleni Buedding, Aliyah Bellm, Frank Schult, Anton Pembaur, Stefan Wirth, Anja Ehrhardt, Friedrich Paulsen, Jan Postberg, Malik Aydin
Summary: This review discusses the roles of bacteria, fungi, and archaea in the upper respiratory tract microbiome, as well as their relationship with respiratory diseases and atopic disorders. The aim is to summarize the latest contributions in this field published in the past decade and to establish a bridge between basic and clinical science.
Review
Biochemistry & Molecular Biology
Florian Schmid, Cho-Ming Chao, Jan Dabritz
Summary: Pulmonary manifestation of inflammatory bowel disease in children is a rare condition with unclear pathogenesis. Different pathophysiological concepts have been proposed and case reports in children have been published. Most pediatric IBD patients with pulmonary manifestation are asymptomatic, but may show abnormalities in pulmonary function tests and breathing tests. Initial treatment is based on corticosteroids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Torsten Kucharzik, Raja Atreya, Oliver Bachmann, Daniel C. Baumgart, Jan Daebritz, Ulf Helwig, Johannes Janschek, Peter Kienle, Jost Langhorst, Jonas Mudter, Carsten Schmidt, Andreas G. Schreyer, Michael Vieth, Johannes Wessling, Christian Maaser
Summary: This study provides standardized reporting methods and terminology for intestinal ultrasound findings in patients with inflammatory bowel disease (IBD), aiming to improve communication between different specialties and ensure the quality of diagnosis.
ZEITSCHRIFT FUR GASTROENTEROLOGIE
(2022)
Article
Virology
Jonas Scholz, Patrick Philipp Weil, Daniel Pembaur, Georgia Koukou, Malik Aydin, Dorota Hauert, Jan Postberg, Florian Kreppel, Claudia Hagedorn
Summary: Only two decades after discovering miRNAs, our understanding of their functional effects in disease development, particularly cancer, has greatly expanded. This has led to the development of miRNA-based diagnostic markers and therapeutic strategies. We have established an Ad-based miRNA vector platform that allows efficient delivery and expression of high levels of miRNAs, providing accurate dosing and potential downregulation of target RNAs.
Article
Biochemistry & Molecular Biology
Carolin Baehren, Anton Pembaur, Patrick P. Weil, Nora Wewers, Frank Schult, Stefan Wirth, Jan Postberg, Malik Aydin
Summary: Microbiome analyses often overlook archaea and eukaryotes, focusing primarily on bacteria. However, due to difficulties in culturing these microorganisms, little is known about their relevance to human health and diseases. The use of next generation sequencing techniques has enabled a stronger focus on archaea and eukaryotes, but refinement is needed to achieve a holistic view of the microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
M. Leiz, M. Knorr, K. Moon, L. Tischler, K. Sohrabi, S. Cantez, J. Daebritz, J. de Laffolie, N. van den Berg
Summary: This study aimed to analyze whether the diagnostic process of pediatric-onset inflammatory bowel disease (PIBD) in German and Austrian region is in line with the international guidelines ('Porto criteria'). The results showed that the registry reflects the guideline's recommendations, but the proportion of documented diagnostic examinations varies between different diagnoses.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Pediatrics
Juliane Klamt, Jan de Laffolie, Elisa Wirthgen, Sebastian Stricker, Jan Daebritz
Summary: This study analyzed data of pediatric Crohn's disease patients and confirmed previously suggested risk factors while identifying new ones. Utilizing these risk factors can help better assess individual patient risk and choose appropriate treatment strategies.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pediatrics
Lotta Elonen, Lena Woelfle, Jan de Laffolie, Carsten Posovszky, CEDATA-GPGE-Study-Grp
Summary: This study investigates the clinical features of isolated Crohn's colitis in pediatric patients, finding that the disease is characterized by extraintestinal manifestations, mainly joint involvement and perianal fistulas or abscesses requiring surgery and biologic therapy, which can influence treatment strategies.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, General & Internal
Benjamin Schiller, Michael Radke, Christina Hauenstein, Carsten Mueller, Christian Spang, Daniel A. Reuter, Jan Daebritz, Johannes Ehler
Summary: Intramural duodenal hematoma (IDH) is a rare complication in children after esophagogastroduodenoscopy. Conservative management is usually effective, but interventional treatment should be considered for patients who do not respond or have complications.
MEDICINA-LITHUANIA
(2022)
Article
Health Care Sciences & Services
Hanne Lademann, Karl Abshagen, Anna Janning, Jan Dabritz, Dirk Olbertz
Summary: Therapeutic hypothermia is beneficial for neuroprotection in term newborns with perinatal asphyxia, but its effects on preterm infants remain unclear. This pilot study compared the long-term outcomes of late preterm asphyctic infants with and without therapeutic hypothermia to term infants. The study found that preterm infants had better mental outcomes with therapeutic hypothermia, highlighting the importance of further research in this area.
