Article
Biochemistry & Molecular Biology
Javad Esmaeili, Sorur Jadbabaee, Farnaz Mohebi Far, Mostafa Esmaeilpour Lukolayeh, Kevser Kubra Kirboga, Farnoush Sadat Rezaei, Aboulfazl Barati
Summary: Utilizing the stem of the Alstroemeria flower as a scaffold, this study fabricated a new scaffold material through decellularization and chitosan modification. The modified scaffold exhibited better porous structure, mechanical behavior, and biocompatibility compared to the unmodified scaffold. Modified tissue plants could be a promising candidate for tissue engineering of both soft and hard tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Composites
Heba Kandil, Basma Ekram, Mona A. M. Abo-Zeid, Bothaina M. Abd M. El-Hady, Amal Amin
Summary: A promising modified composite scaffold for bone tissue engineering was synthesized, which consisted of hydroxyapatite, hyperbranched polyitaconic acid, and chitosan. The modified scaffold showed improved mechanical strength and bioactivity, as well as anticancer properties and enhanced human skin fibroblasts proliferation.
POLYMER COMPOSITES
(2023)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Ya Su, Yue Kang, Deli Xu, Yuen Yee Cheng, Yi Nie, Hong Wang, Tianqing Liu, Kedong Song
Summary: Finding a bioink suitable for 3D bioprinting that can mimic the microenvironment of native skin and prevent bacterial infection remains a major challenge in skin tissue engineering. In this study, a tissue-specific extracellular matrix-based bioink was prepared, and a novel scaffold was obtained using an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The hybrid scaffold exhibited excellent properties including antibacterial activity, hemostatic effect, and biocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Yuemeng Zhu, Yidi Zhang, Yanmin Zhou
Summary: Bone tissue engineering has shown promise in replacing traditional treatment modalities, and chitosan-based composite scaffolds have proved to be a promising candidate for successful bone regeneration. Efforts have been made to modify chitosan to overcome its limitations and expand its applications in biomedical innovation and regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Teerawat Sukpaita, Suwabun Chirachanchai, Atiphan Pimkhaokham, Ruchanee Salingcarnboriboon Ampornaramveth
Summary: This review provides an overview of chitosan-based biomaterials for bone tissue engineering and their applications in treating bone defects. The focus is on the characteristics of chitosan, scaffold fabrication processes, advantages and disadvantages, and future directions in the field.
Article
Materials Science, Multidisciplinary
Deyu Yang, Zhou Fang, Rui Kang, Kehai Liu
Summary: A new composite electrospun scaffold for pelvic organ prolapse showed promising potential in physicochemical characterizations and cell tests, indicating good biocompatibility and potential for pelvic floor regeneration.
MATERIALS & DESIGN
(2021)
Article
Polymer Science
Katia Jarquin-Yanez, Efrain Rubio-Rosas, Gabriela Pinon-Zarate, Andres Castell-Rodriguez, Martha Poisot
Summary: The research synthesized four bio-nanocomposites based on cellulose and varying levels of chitosan, with the 10% chitosan composite showing better cell survival rates, making it suitable for further studies in bone tissue engineering.
Article
Nanoscience & Nanotechnology
Pengfei Cai, Chunchun Li, Yangfan Ding, Hanting Lu, Xiao Yu, Jie Cui, Fan Yu, Hongsheng Wang, Jinglei Wu, Mohamed EL-Newehy, Meera Moydeen Abdulhameed, Liang Song, Xiumei Mo, Binbin Sun
Summary: This research introduces a novel method that combines electrospun nanofibers with 3D printing techniques to fabricate composite scaffolds for bone defect treatment. Compared to nanoparticle-reinforced scaffolds, these scaffolds infused with nanofibers exhibit superior mechanical attributes and bioactivity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Jie Xu, Huan Fang, Shuangshuang Zheng, Liying Li, Zeren Jiao, Hong Wang, Yi Nie, Tianqing Liu, Kedong Song
Summary: A novel dECM/Gel/CS scaffold was successfully prepared with appropriate mechanical strength, good antibacterial activity, and high biocompatibility, showing potential for promoting cell growth and new tissue formation in skin tissue engineering. The presence of dECM effectively enhanced cell proliferation, making the scaffold a promising candidate for use in skin tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Fan Fei, Haiyan Yao, Yujiang Wang, Junchao Wei
Summary: Poly(lactide)/graphene oxide/parathyroid hormone (1-34) nanofiber membranes were prepared and showed improved tensile strength and alkaline phosphatase activity, making them promising candidate materials for bone tissue engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Runfeng Cao, Anqi Zhan, Zheng Ci, Cheng Wang, Yunlang She, Yong Xu, Kaiyan Xiao, Huitang Xia, Li Shen, Depeng Meng, Chang Chen
Summary: The study developed a biomimetic biphasic scaffold for osteochondral defect repair, controlling the composition, stiffness, and pore size to promote adhesion, proliferation, chondrogenic, and osteogenic differentiation of bone marrow stem cells. In vitro and in vivo results showed that the biphasic scaffold significantly enhanced concomitant repair of superficial cartilage and subchondral bone, demonstrating its promising osteochondral repair effect.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Sneh Gautam, Chhavi Sharma, Shiv Dutt Purohit, Hemant Singh, Amit Kumar Dinda, Pravin D. Potdar, Chia-Fu Chou, Narayan Chandra Mishra
Summary: The electrospun Gelatin-PCL-nHAp nanocomposite scaffold showed promising results for bone tissue engineering applications, with good viability and proliferation of human osteoblasts. Analysis also indicated efficient cellular attachment and characteristic polygonal morphology of osteoblasts on the scaffold surface, demonstrating its potential for BTE.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Engineering, Biomedical
Yogendra Pratap Singh, ShivDutt Purohit, Mukesh Kumar Gupta, Rakesh Bhaskar, Sung Soo Han, Sudip Dasgupta
Summary: Chitosan-gelatin-monetite (CGM)-based electrospun scaffolds have been developed that mimic the microstructure and composition of natural bone. The incorporation of 7% monetite into the scaffold enhances its mechanical properties and osteogenic potential, making it a potential candidate for bone tissue regeneration.
BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Jian Li, Jiaxing Wei, Ang Li, Hongyu Liu, Jingxue Sun, Hong Qiao
Summary: A novel BVHP66 scaffold was developed to enhance osteogenesis and angiogenesis in diabetic fracture healing, showing excellent biocompatibility and bioactive properties.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fatemeh Hakimi, Hamed Jafari, Samaneh Hashemikia, Siamak Shabani, Ali Ramazani
Summary: This study aimed to prepare a novel organic-mineral nanofiber/hydrogel of chitosan-polyethylene oxide (CS-PEO)/nanoclay-alginate (NC-ALG) and investigate its effects on mineralization and biocompatibility. The scaffolds composed of CS-PEO and NC-ALG were evaluated for their properties and characteristics. The results showed that the incorporation of NC particles in the scaffold enhanced bone-like apatite formation and demonstrated compatibility and safety for osteoblastic cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)