Article
Pharmacology & Pharmacy
Amandeep Kaur, Parveen Kumar, Loveneet Kaur, Rohit Sharma, Preeti Kush
Summary: This study optimized the preparation of Gem-TCh-NPs nanoparticles, which showed a small particle size, high encapsulation efficiency, and biphasic release pattern. The formulation exhibited superior mucoadhesion, permeation, and cytotoxicity compared to native Gem. In vivo pharmacokinetic analysis indicated that Gem-TCh-NPs could be a promising formulation for enhanced oral therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Zunaira Alvi, Muhammad Akhtar, Arshad Mahmood, Nisar ur-Rahman, Imran Nazir, Hadia Sadaquat, Muhammad Ijaz, Shahzada Khurram Syed, Muhammad Khurram Waqas, Yi Wang
Summary: The inclusion complexation of EPL with SBE7 was successfully fabricated into nanoparticles with improved drug release and antidiabetic activity. IC and NP showed promising applications for enhanced delivery and controlled release of poorly water-soluble drugs.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Applied
Jun Wang, Justin Liu, Dao-Qiang Lu, Lijing Chen, Rujia Yang, Dahai Liu, Bin Zhang
Summary: In this study, diselenide-crosslinked nanoparticles were successfully fabricated for doxorubicin delivery. The nanoparticles exhibited desirable morphology and size distribution, and the starting material used improved biocompatibility and physiological stability. The high drug encapsulation efficiency of the nanoparticles was achieved through electrostatic interactions between doxorubicin and the material. In vitro and in vivo experiments demonstrated that the doxorubicin-loaded diselenide-crosslinked nanoparticles had higher drug accumulation and enhanced growth inhibition compared to the control samples.
CARBOHYDRATE POLYMERS
(2022)
Article
Multidisciplinary Sciences
Ghulam Abbas, Akhtar Rasul, M. Fakhar-e-Alam, Malik Saadullah, Saima Muzammil, Omeira Iqbal, M. Atif, Muhammad Hanif, Shahid Shah, Shafiq Ahmad, Sulman Shafeeq, Muhammad Afzal
Summary: The study aimed to formulate nanoparticles of thiolated chitosan with enhanced mucoadhesion and controlled release behavior. Stable nanoparticles were prepared using an ionic gelation method, and their adhesion, swelling, and toxicity were evaluated. Drug release studies of non-thiolated and thiolated nanoparticles showed that the thiolated nanoparticles exhibited better controlled release. Animal experiments confirmed the superior pharmacokinetic properties of the thiolated nanoparticles compared to the marketed formulation.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Applied
Zheng Jin, Gaowei Hu, Kai Zhao
Summary: This study demonstrated that the synthesized M-N-2-HACC/N-CMCS nanoparticles showed high efficiency in mucosal delivery by utilizing the interaction with mucosal sites for drug release and delivery.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Richard Wibel, Doris E. Braun, Laurenz Haemmerle, Arne M. Joergensen, Patrick Knoll, Willi Salvenmoser, Christian Steinbring, Andreas Bernkop-Schnuerch
Summary: In this study, thiolated chitosan was used as a coating material for solid lipid nanoparticles, with the protection of thiol groups playing a key role in their interaction with mucosa. Different coating materials showed varying effects on mucus interaction and diffusion behavior on intestinal mucosa.
Article
Multidisciplinary Sciences
Anubhav Pratap-Singh, Yigong Guo, Alberto Baldelli, Anika Singh
Summary: Recent advances in peptide delivery and nanotechnology have led to the development of non-parenteral administration routes, replacing subcutaneous injections. Thiolated biopolymers, a new material, are being explored to enhance mucoadhesivity and permeability for oral delivery. This study focuses on improving the mucoadhesivity of thiolated chitosans by activating them with mercaptonicotinic acid to create a novel thiomerized chitosan. Insulin nanoparticles encapsulated with this new material showed reduced size and increased cellular uptake, insulin transport, and permeability compared to nanoparticles encapsulated with unmodified chitosan and thiolated chitosan. The results suggest that MNA-TG-chitosan holds promise for improved peptide oral delivery.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Wipada Samprasit, Praneet Opanasopit, Benchawan Chamsai
Summary: Alpha-Mangostin-loaded mucoadhesive nanoparticles were prepared using pH-dependent composite mucoadhesive nanoparticles. Different components and processing methods were found to affect the properties of the particles. In vitro experiments and anti-tumor activity tests confirmed the potential of these nanoparticles for colon-targeted drug delivery.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hadia Sadaquat, Muhammad Akhtar, Mazher Nazir, Rabbiya Ahmad, Zunaira Alvi, Naveed Akhtar
Summary: Cyclodextrins enhance the solubility of docetaxel, resulting in nanoparticles with smooth surfaces and increased drug release. Oral toxicity studies in rabbits show no harmful effects on cellular structure.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Touqeer Zahra, Hafiz Shoaib Sarwar, Muhammad Sarfraz, Muhammad Zaman, Hassan Ahmad, Aamir Jalil, Gul Shahnaz, Muhammad Farhan Sohail
Summary: The study successfully enhanced the oral bioavailability of tacrolimus by preparing TC-SLNs-Tac nanoparticles, which exhibited excellent mucoadhesion and controlled release.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Instruments & Instrumentation
Mona Ebrahim Elmoghayer, Noha Mohamed Saleh, Irhan Ibrahim Abu Hashim
Summary: The study aimed to prepare and evaluate Hsd-loaded sulfobutylether-beta-cyclodextrin/chitosan nanoparticles (Hsd/CD/CS NPs) for improving the oral delivery and hypoglycemic activity of Hsd. The results showed that Hsd/CD/CS NPs could enhance the oral delivery and antidiabetic activity of Hsd, with good stability and biocompatibility.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
N. T. Thu Thao, H. M. S. M. Wijerathna, R. Saravana Kumar, Dongrack Choi, S. H. S. Dananjaya, A. P. Attanayake
Summary: Novel N-SuC NPs films with antimicrobial and wound healing properties were successfully synthesized and tested, demonstrating excellent efficacy in both in vitro and in vivo studies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biophysics
Rajesh Singh Jadon, Gajanand Sharma, Neeraj K. Garg, Nikunj Tandel, Kavita R. Gajbhiye, Rajesh Salve, Virendra Gajbhiye, Ujjawal Sharma, Om Prakash Katare, Manoj Sharma, Rajeev K. Tyagi
Summary: The study developed pH-sensitive lipid polymer hybrid nanoparticles (pHS-LPHNPs) for specific cytosolic delivery of DTX, showing improved cellular uptake, cytotoxicity, and therapeutic efficacy against breast cancer cells, making it a promising platform for breast cancer therapeutic interventions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Atida Selmani, Elisabeth Seibert, Carolin Tetyczka, Doris Kuehnelt, Ivan Vidakovic, Karin Kornmueller, Markus Absenger-Novak, Borna Radatovic, Ivana Vinkovic Vrcek, Gerd Leitinger, Eleonore Frohlich, Andreas Bernkop-Schnurch, Eva Roblegg, Ruth Prassl
Summary: This study aimed to design a hybrid oral liposomal delivery system for selenium nanoparticles to improve the bioavailability of selenium. Thiolated chitosan was used for surface functionalization of the liposomal nanoparticles. The thiolated liposomal nanoparticles showed good mucoadhesive properties and were stable in a simulated microenvironment of the small intestine. This study provides a promising solution for oral selenium delivery.
Article
Pharmacology & Pharmacy
Ying Wang, Mimi Guo, Dingmei Lin, Dajun Liang, Ling Zhao, Ruizhi Zhao, Yan Wang
Summary: The study successfully prepared EXO-DTX with a particle size of 149.5 nm, showing significantly greater cytotoxicity than DTX monomers and better targeting and cellular uptake both in vitro and in vivo. The potential of tumor cell-derived exosomes as a drug delivery system targeting the parent cancer was also explored, suggesting exosomes might be used as a potential antitumor drug delivery system (DDS).
Review
Pharmacology & Pharmacy
Solmaz Mojarad-Jabali, Somayeh Mahdinloo, Masoud Farshbaf, Muhammad Sarfraz, Yousef Fatahi, Fatemeh Atyabi, Hadi Valizadeh
Summary: TfR serves as a valuable target for cancer therapy, with potential for TfR-targeted liposomes as promising drug delivery vehicles. Despite the attention gained, the full assessment of TfR ligands applied for liposomal targeted delivery still needs to be accomplished.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Armina Shirangi, Fatemeh Mottaghitalab, Sajad Dinarvand, Fatemeh Atyabi
Summary: A nanoparticle system for targeted delivery of ROR1 siRNA in the treatment of triple-negative breast cancer was designed and tested. The nanoparticles showed good properties and effectively suppressed tumor cell growth both in vitro and in vivo. The accumulation of nanoparticles in breast tumors was increased by magnetic field guidance. This therapeutic strategy has potential in the treatment of triple-negative breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Correction
Pharmacology & Pharmacy
Hosniyeh Hosseinzadeh, Fatemeh Atyabi, Behrang Shiri Varnamkhasti, Reza Hosseinzadeh, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Rassoul Dinarvand
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Summary: Infectious diseases pose serious threats to global health and socio-economic conditions. Vaccination is crucial for disease prevention, but challenges such as inadequate efficiency and immunogenicity exist. Advanced vaccine delivery systems, with suitable efficiency, safety, and immune-modulatory activity, could be helpful, but their capabilities to cover various types of pathogens have not been systematically reviewed. The rise of antibiotic-resistant strains and limitations in antibiotic testing have increased the need for more accurate and specific treatment strategies, including nanotechnology-based ones. Nanobionics, based on charge storage and transport in molecular structures, could play a key role in molecular diagnostics and highly-specific electro-analytical methods or devices. Early disease diagnostics using such devices could be critically significant against various diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Abbas Ali Hosseinpour Feizi, Sajjad Vakili-Samiani, Vahid Karpisheh, Ali Masjedi, Sepideh Izadi, Sara Adibfar, Afshin Nikkhoo, Mohammad Hojjat-Farsangi, Fatemeh Atyabi, Omid Joodi Khanghah, Ali Akbar Movassaghpour, Saeed Solali, Mehdi Yousefi, Farhad Jadidi-Niaragh
Summary: This study used TAT-PEG-CCMD nanoparticles to deliver anti-WEE1 siRNA and Dox to ALL cells, which effectively inhibited WEE1 kinase overexpression and enhanced the apoptotic effects of Dox. These findings suggest that this combination therapy could be a promising approach for treating ALL.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Seyed Yaser Vafaei, Amir Hossein Abdolghaffari, Reza Mahjub, Seyyed Majid Eslami, Motahareh Esmaeili, Mohammad Abdollahi, Fatemeh Atyabi, Rassoul Dinarvand
Summary: This study investigated the therapeutic potential of budesonide-loaded hyaluronic acid nanoparticles (BDS-HANPs) for inflammatory bowel disease (IBD). The results showed that BDS-HANPs significantly improved the symptoms of colitis and had a better therapeutic effect than the same dose of the free drug.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Chemistry, Multidisciplinary
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Summary: The emerging pathological conditions and growing drug resistance call for the application of advanced technologies to discover therapeutic candidates and gain comprehensive understanding about their targets, action mechanisms, and interactions within the body. Physics- and chemistry-based techniques can be used for theranostic purposes, including preparing smart carriers, local drug or gene delivery, and enhancing pharmaceutical bioavailability. Crystal engineering and other techniques such as artificial intelligence and quantum-based methods can play a crucial role in manufacturing efficient pharmaceuticals and reducing adverse events.
JOURNAL OF CONTROLLED RELEASE
(2023)
Correction
Pharmacology & Pharmacy
Farhad Alvandifar, Baharnaz Ghaffari, Navid Goodarzi, Nazanin Shabani Ravari, Fahimeh Karami, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Mehdi Esfandyari-Manesh, Razieh Mohammad Jafari, Fatemeh Atyabi, Shiva Irani, Rassoul Dinarvand
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Retraction
Chemistry, Multidisciplinary
Armin Mahmoud Salehi, Farnaz Kheshti, Farnaz Hajizadeh, Asal Barshidi, Bentolhoda Rashidi, Farbod Ebrahimi, Simin Bahmanpour, Vahid Karpisheh, Fatemeh Karimian Noukabadi, Fariba Karoon Kiani, Hadi Hassannia, Fatemeh Atyabi, Seyed Hossein Kiaie, Fatah Kashanchi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Rafieh Bagherifar, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Seyed Reza Heydari, Mahnoush Samadi, Armina Shirangi, Mehdi Farokhi, Ayda Moradi, Reza Bafkary, Fatemeh Atyabi, Fatemeh Mottaghitalab, Rassoul Dinarvand
Summary: In this study, dual responsive mesoporous silica nanoparticles (MSNs) were designed to effectively deliver PB to osteosarcoma cancer cells. PB loaded MSNs showed higher drug release in the tumor microenvironment and enhanced cytotoxicity against cancer cells. This study provides a promising method for osteosarcoma treatment using PB loaded MSNs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nazanin Shabani Ravari, Maryam Ghareh Sheikhlou, Navid Goodarzi, Bahar Kharazian, Mohsen Amini, Fatemeh Atyabi, Saman A. A. Nasrollahi, Rassoul Dinarvand
Summary: Researchers used CPP as a carrier to create CPP-BoNT/A nanocomplexes by PEC method, aiming to increase toxin entrapment, reduce diffusion, and prolong the effect. The nanocomplexes showed higher cellular toxicity than the toxin and had a slower onset and longer duration of action on muscles.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sepideh Nezhadi, Parisa Norouzi, Azadeh Rasouli, Hamid Akbari Javar, Seyed Nasser Ostad, Farid Dorkoosh
Summary: This study aims to design a co-delivery system to suppress the growth and migration of triple negative breast cancer (TNBC) cells. The co-loaded mixed micelles of paclitaxel (PTX) and regorafenib (REG) showed promising potential in inhibiting proliferation and migration of TNBC cells and enhancing the therapeutic efficacy of PTX.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Ophthalmology
Elham Delrish, Mahmoud Jabbarvand, Fariba Ghassemi, Fahimeh Asadi Amoli, Fatemeh Atyabi, Saeed Heidari Keshel, Alireza Lashay, Farnaz Sadat Mirzazadeh Tekie, Masoud Soleimani, Rassoul Dinarvand
Summary: This study aimed to evaluate the efficacy of thiolated chitosan-dextran nanoparticles (TPH-CMD-TCS-NPs) in improving intravitreal chemotherapy of retinoblastoma in a rabbit xenograft model. The results showed that the NPs had a mean diameter of 30 +/- 4 nm, a polydispersity index of 0.24 +/- 0.03, and a zeta potential of +10 +/- 3 mV. The TPH-CMD-TCS-NPs group showed a significant decrease in tumor volume compared to the control group (P = 0.039).
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2023)
Article
Materials Science, Biomaterials
Hamidreza Motasadizadeh, Mohamadreza Tavakoli, Sheyda Damoogh, Fatemeh Mottaghitalab, Mahdi Gholami, Fatemeh Atyabi, Mehdi Farokhi, Rassoul Dinarvand
Summary: In this study, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffold containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPs) was introduced for the treatment of chronic osteomyelitis. The results showed sustained and pH-sensitive release of TEC and PM from the hydrogel scaffold, with higher release rates at alkaline pH compared to neutral and acidic pH. The released TEC maintained its antibacterial activity for 35 days at different pH values. Cell studies also demonstrated that the scaffolds containing PMSFNPs promoted cell viability, ALP activity, and matrix mineralization. In vivo evaluations on infected rat bones showed lower infection and higher regeneration in the group treated with the hydrogel scaffold containing PMSFNPs and TEC compared to other groups. Therefore, this dual-drug delivery system holds promise for effective treatment of chronic bone infection.
BIOMATERIALS ADVANCES
(2022)
