Article
Oncology
Panagiotis Giannos, Konstantinos S. Kechagias, Sarah Bowden, Neha Tabassum, Maria Paraskevaidi, Maria Kyrgiou
Summary: The study investigated gene markers associated with CIN and CC, with PCNA identified as a highly ranked hub gene in both sample types. Additionally, PCNA was found to be overexpressed in CC tissues and correlated with favorable prognosis and tumor purity in CC patients.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Xin Hou, Guangyang Shen, Liqiang Zhou, Yinuo Li, Tian Wang, Xiangyi Ma
Summary: Cervical cancer is a major threat to women's health, but it can be prevented through early screening and diagnosis. Artificial intelligence has great potential in the screening and diagnosis of cervical cancer, offering benefits such as reduced time consumption, reduced need for professionals, and elimination of subjective bias.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Lina Zhang, Xinyi Shi, Qing Zhang, Zhilei Mao, Xiaoyu Shi, Jun Zhou, Aili Jian, Renying Zhu, Shisong Jiang, Wenshu Lu
Summary: High-risk human papillomavirus (HPV) infection is the main cause of cervical cancer, and the specific T cell response to HPV16 E7 in peripheral blood mononuclear cells is related to HPV16 clearance and protection against malignant development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marina Dudea-Simon, Dan Mihu, Laura Ancuta Pop, Razvan Ciortea, Andrei Mihai Malutan, Doru Diculescu, Cristina Alexandra Ciocan, Roxana Maria Cojocneanu, Vasile Simon, Carmen Bucuri, Radu Mocan-Hognogi, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: Cervical cancer is a common and deadly form of cancer in women. Detecting the precursor, CIN, can prevent cervical cancer. This study found that certain genes, such as MEG3, DAPK1, MLH1, MALAT1, TIMP3, and SOX1, had abnormal expression levels in both CIN and cancer samples compared to normal samples. Lower expression of MEG3 and miR-205-5p could serve as early warning signals for the development of invasive cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chaohui Bao, Na An, Hong Xie, Ling Xu, Boping Zhou, Jun Luo, Wanqiu Huang, Jian Huang
Summary: By conducting whole-exome sequencing and systematic bioinformatics analysis, we identified C>T transitions in both CINs and CCs, with significantly higher somatic mutations in CCs compared to CINs. Additionally, potential driver genes were identified and new neoantigens were found, providing a solid foundation for further research on the pathogenesis of CC and the development of novel immunotherapeutic approaches.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yingxin Han, Liyan Ji, Yanfang Guan, Mengya Ma, Pansong Li, Yinge Xue, Yinxin Zhang, Wanqiu Huang, Yuhua Gong, Li Jiang, Xipeng Wang, Hong Xie, Boping Zhou, Jiayin Wang, Junwen Wang, Jinghua Han, Yuliang Deng, Xin Yi, Fei Gao, Jian Huang
Summary: Cervical cancer is the second leading cause of cancer death among women globally. Epigenetic dysregulation through DNA methylation and hydroxymethylation plays a crucial role in tumorigenesis. This study found genome-wide hypo-methylation and hypo-hydroxymethylation in CC, along with local hyper-methylation and hyper-hydroxymethylation. Additionally, novel differentially methylated/hydroxymethylated-associated genes were identified as potential epigenetic biomarkers for CC prognosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Matejka Rebolj, Christopher S. Mathews, Francesca Pesola, Alejandra Castanon, Henry Kitchener
Summary: International cervical screening guidelines suggest that high-risk human papillomavirus (HR-HPV) testing is more effective than liquid-based cytology (LBC) for diagnosing cervical cancer in women aged 24 to 29, as it not only accelerates cancer diagnosis, but also increases the detection of CIN2/3.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Mayumi Saito, Aarthi Rajesh, Carrie Innes, Rachael van der Griend, Peter Fitzgerald, Bryony Simcock, Peter Sykes, Merilyn Hibma
Summary: The progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with Blimp-1 positive cell staining in the lesion and low numbers of infiltrating CD4 cells in the dermal region beneath the lesion.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Review
Biology
Eliano Cascardi, Gerardo Cazzato, Antonella Daniele, Erica Silvestris, Gennaro Cormio, Giovanni Di Vagno, Antonio Malvasi, Vera Loizzi, Salvatore Scacco, Vincenzo Pinto, Ettore Cicinelli, Eugenio Maiorano, Giuseppe Ingravallo, Leonardo Resta, Carla Minoia, Miriam Dellino
Summary: This article focuses on the composition of the cervical microbiota and its interaction with human papillomavirus (HPV), aiming to identify the risk factors for developing Cervical Intraepithelial Neoplasia and discover new therapeutic strategies. The heterogeneity of the cervico-vaginal microbiota and its role in immunity, inflammation, and precancerous lesions of the cervical epithelium are discussed. Further research is needed to fully understand the relationship between microbiota, immunity, and HPV-related cervical tumors.
Review
Oncology
Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos, Carla Martins Kaneto
Summary: Cervical cancer is a preventable disease but remains a significant public health problem. The Pap smear has achieved great success, but has limitations, leading to the need for new approaches for early diagnosis and biomarker discovery. miRNAs have been identified as non-invasive biomarkers and have potential clinical value for early-stage cervical intraepithelial neoplasia screening. This study reviewed the expression of circulating miRNAs in the development of cervical cancer and identified potential biomarkers.
Article
Public, Environmental & Occupational Health
Yang Liu, Changjun Xu, Jing Pan, Chunyi Sun, Honglin Zhou, Yushi Meng
Summary: The study revealed that among women who underwent cervical biopsy, a higher high-risk HPV viral load in cervical lesions was associated with a higher risk of high-grade cervical lesions. High viral load of HPV was independently associated with CIN 1, CIN 2, CIN 3, and cervical cancer.
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Multidisciplinary Sciences
Jixuan Liu, Sanmei Su, Yafang Liu
Summary: This study analyzed the role of p16 and Ki67 immunohistochemical staining in assisting cervical squamous intraepithelial lesions. The results showed that Ki67 had high specificity and sensitivity in diagnosing LSIL, while the practical application of p16 staining still posed some problems.
SCIENTIFIC REPORTS
(2022)
Review
Pharmacology & Pharmacy
Xue Wang, Shi Liu, Yuyao Guan, Jun Ding, Chong Ma, Zhigang Xie
Summary: Traditional methods for treating cervical cancer may have complications, leading to interest in new pharmaceutical forms based on nanotechnology. Vaginal drug delivery, with advantages like mucosa penetration and controlled drug release, is becoming a focus for the treatment of cervical cancer.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Infectious Diseases
Hong-Fang Zhi, Liu-Feng Yang, Jing Ge, Xuan-Tao Yang
Summary: This study analyzed the status of human papillomavirus (HPV) infections in women in Yunnan, China and their correlation with the grade of cervical intraepithelial neoplasia (CIN). The study found that HPV infection in Yunnan was dominated by single infection and high-risk HPV types. Patients aged 30 to 45 years had a higher incidence of high-grade squamous intraepithelial lesions (HSIL), and the most common high-risk HPV subtypes were HPV16, HPV58, and HPV52.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Health Care Sciences & Services
Thomas Piggott, Miranda W. Langendam, Elena Parmelli, Jan Adolfsson, Elie A. Akl, David Armstrong, Jeffrey Braithwaite, Romina Brignardello-Petersen, Jan Brozek, Markus Follmann, Ina Kopp, Joerg J. Meerpohl, Luciana Neamtiu, Monika Nothacker, Amir Qaseem, Paolo Giorgi Rossi, Zuleika Saz-Parkinson, Philip J. van der Wees, Holger J. Schunemann
Summary: The study aimed to develop an extension of the GIN-McMaster Guideline Development Checklist and Tool for the integration of quality assurance and improvement (QAI) schemes with guideline development. A mixed-methods approach was used, incorporating evidence from a systematic review, an expert workshop, and a survey of experts. The result was a 40-item checklist extension, addressing steps for the integration of QAI into guideline development.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Psychology, Developmental
Francesca Roncaglia, Laura Bonvicini, Sally Kendall, Costantino Panza, Monica Ferraroni, Paolo Giorgi Rossi
Summary: This study aimed to validate the Italian version of the Tool to Measure Parenting Self-Efficacy (TOPSE). The results showed that TOPSE had good internal reliability in most domains, except for Emotion, Self-acceptance, and Learning. The external reliability was moderate due to the changes in parents over 12 months. The TOPSE questionnaire was responsive, especially in the Emotion and Empathy domains.
CHILD CARE HEALTH AND DEVELOPMENT
(2023)
Article
Nutrition & Dietetics
Massimo Pellegrini, Giulia Besutti, Marta Ottone, Simone Canovi, Efrem Bonelli, Francesco Venturelli, Roberto Fari, Angela Damato, Candida Bonelli, Carmine Pinto, Guido Ligabue, Pierpaolo Pattacini, Paolo Giorgi Rossi, Marwan El Ghoch
Summary: The aim of this study was to evaluate the association of adipose tissue characteristics with survival in rectal cancer patients. The results showed that increasing adipose tissue area may have a protective effect on survival, while increasing density was associated with poorer survival. Adipose tissue density influenced survival in rectal cancer patients, indicating the importance of further research in this area.
Article
Hematology
Chiara Marraccini, Davide Schiroli, Pamela Mancuso, Giuseppe Molinari, Agnese Razzoli, Gaia Gavioli, Tommaso Fasano, Roberto Baricchi, Paolo Giorgi Rossi, Lucia Merolle
Summary: Plasmapheresis donation is generally safe, but its long-term effects remain unclear. The amount of anticoagulant used in the process varies, and it is influenced by factors such as hematocrit, total blood processed, plasma collected, and donor characteristics. This study found that the unit weight setting and sex have an impact on anticoagulant distribution and post-donation citrate metabolism.
TRANSFUSION MEDICINE AND HEMOTHERAPY
(2023)
Article
Oncology
Elena Demuru, Silvia Rossi, Leonardo Ventura, Luigino Dal Maso, Stefano Guzzinati, Alexander Katalinic, Sebastien Lamy, Valerie Jooste, Corrado Di Benedetto, Roberta De Angelis
Summary: Comparable indicators on complete cancer prevalence are needed in Europe. Two alternative approaches, empirical indices derived from European registries and pre-calculated indices derived from US-SEER cancer registries, were compared to standard estimates using data from 62 registries in 27 countries. Empirical estimates differ little from standard estimates for elderly-diagnosed tumors, but may underestimate complete prevalence for early-onset cancers. SEER estimates are comparable to standard ones for most cancers, even derived from short time series, but longer observations are needed for certain cancers with remarkable differences in incidence and prognosis between European and US populations.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marta Ottone, Letizia Bartolini, Laura Bonvicini, Paolo Giorgi Rossi
Summary: The study compares the effects of diabetes and diabetes-related pathologies on the risk of COVID-19 infection and death in Highly-Developed-Country (HDC) population, including Italians, and immigrants from High-Migratory-Pressure-Countries (HMPC). The incidence and mortality rate ratios are reported to estimate the effect of diabetes on SARS-CoV-2 infection and COVID-19 mortality. The results show that the effect of diabetes on infection and death from COVID-19 is slightly higher in the HMPC population compared to the HDC population.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Biochemistry & Molecular Biology
Valli De Re, Maria Lina Tornesello, Vito Racanelli, Marcella Prete, Agostino Steffan
Summary: Several studies are being conducted to investigate the role of immunity in the development of hepatocellular carcinoma and to identify individuals who would benefit most from systemic therapy based on the etiology of their tumor. Human leukocyte antigens (HLAs) are crucial for antigen presentation to T cells and play a crucial role in the defense against pathogens and tumor cells. Interactions between HLA and innate lymphoid cell receptors, such as natural killer cells and innate lymphoid cell type 2, have been found to activate immune function in liver diseases. Recent studies have highlighted the importance of non-classical HLA-Ib molecules and FAT10, a transcript adjacent to the HLA-F locus, in hepatocarcinoma.
Review
Biochemistry & Molecular Biology
Luigi Buonaguro, Beatrice Cavalluzzo, Angela Mauriello, Concetta Ragone, Anna Lucia Tornesello, Franco M. Buonaguro, Maria Lina Tornesello, Maria Tagliamonte
Summary: Cancer prevention is a top priority to reduce the burden of cancer diagnosis and treatment. Vaccines are the most efficient strategy for preventing cancer, as they can elicit an anti-cancer immune response that can prevent tumor progression.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Environmental Sciences
Francesco Venturelli, Pamela Mancuso, Massimo Vicentini, Marta Ottone, Cinzia Storchi, Francesca Roncaglia, Eufemia Bisaccia, Chiara Ferrarini, Patrizio Pezzotti, Paolo Giorgi Rossi
Summary: This study aimed to assess whether the effect of high temperature on mortality differed in COVID-19 survivors and naive individuals. Data from summer mortality and COVID-19 surveillances were used. The results showed a 3.8% excess risk in summer 2022 compared to 2015-2019, with a 20% increase in the last fortnight of July, the period with the highest temperature. The increase in mortality rates during this period was higher among naive individuals compared to COVID-19 survivors. Time series analysis confirmed the association between temperatures and mortality in naive individuals but not in COVID-19 survivors.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Infectious Diseases
Carla Molina Grane, Pamela Mancuso, Massimo Vicentini, Francesco Venturelli, Olivera Djuric, Mattia Manica, Giorgio Guzzetta, Valentina Marziano, Agnese Zardini, Valeria d'Andrea, Filippo Trentini, Eufemia Bisaccia, Elisabetta Larosa, Silvia Cilloni, Maria Teresa Cassinadri, Patrizio Pezzotti, Marco Ajelli, Paolo Giorgi Rossi, Stefano Merler, Piero Poletti
Summary: Different monitoring and control policies have been implemented in schools to minimize the spread of SARS-CoV-2. Transmission in schools has been hard to quantify due to the large proportion of asymptomatic carriers in young individuals. Studies show that 42.5% (95%CrI: 29.5-54.3%) of infections among school attendees were caused by school contacts during 87 outbreak investigations.
Review
Medicine, General & Internal
Olivera Djuric, Francesco Venturelli, Maria Chiara Bassi, Giuseppe Gorini, Eugenio Paci, Paola Mantellini, Paolo Giorgi Rossi
Summary: This study aims to systematically review the strategies used to recruit the adult population at risk of lung cancer to low-dose CT within lung cancer screening programs. The effectiveness of interventions identified to reach the potentially eligible population, increase participation and informed choice, and ensure equitable access will be estimated.
Article
Oncology
Lucia Mangone, Domenico Penna, Francesco Marinelli, Francesca Roncaglia, Isabella Bisceglia, Francesco Merli, Alessia Ruffini, Barbara Gamberi, Alessia Tieghi, Riccardo Valli, Laura Albertazzi, Mauro Iori, Paolo Giorgi Rossi, Claudia Vener, Fortunato Morabito, Antonino Neri, Stefano Luminari
Summary: The accurate registration of hematological malignancies (HMs) is challenging due to the de-hospitalization of patients and the transition to molecular diagnosis. However, the Reggio Emilia Province Cancer Registry (RE-CR) successfully registered HMs by adopting a software capable of automatically identifying suspected cases. The study highlights the importance of collecting information from multiple sources and the need for the digitalization of cancer registries to improve efficiency.
FRONTIERS IN ONCOLOGY
(2023)
Editorial Material
Cell Biology
Dino Bekric, Maria Lina Tornesello, Matthias Ocker, Christian Mayr, Tobias Kiesslich, Daniel Neureiter
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Giovanni Delli Carpini, Paolo Giorgi Rossi, Luca Giannella, Jacopo Di Giuseppe, Nicolo Clemente, Francesco Sopracordevole, Maggiorino Barbero, Giorgio Bogani, Rosa De Vincenzo, Massimo Origoni, Francesco Cantatore, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Carlo Antonio Liverani, Anna Viscardi, Alessio Pagan, Andrea Amadori, Chiara Alessi, Matteo Andolfatto, Paolo Cattani, Annalisa Pieralli, Guido Stevenazzi, Andrea Ciavattini
Summary: This study evaluates the impact of healthcare reorganization during the COVID-19 pandemic on Italian colposcopy clinic activities, specifically focusing on cervical excision procedures, follow-ups for conservative management of low-grade lesions, and follow-ups post cervical excision. The results show a reduction in the number of cervical excisions by 8.8% during the pandemic period compared to pre-pandemic. There were also significant reductions in the follow-ups for low-grade lesion management and follow-up appointments after cervical excision.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Valentina Iotti, Paolo Giorgi Rossi, Laura Canovi, Monica Guberti, Andrea Nitrosi, Davide Giosue Lippolis, Vanessa Marchesi, Giulia Besutti, Marta Ottone, Rita Vacondio, Pierpaolo Pattacini
Summary: By comparing self-compression to radiographer-led compression in mammography, it was found that self-compression achieved stronger compression of the breast with comparable image quality, but did not significantly reduce glandular dose and had a similar rate of attendance for follow-up mammography.
EUROPEAN RADIOLOGY
(2023)
