Article
Cell & Tissue Engineering
Christian Ploner, Tina Rauchenwald, Catherine E. Connolly, Karin Joehrer, Johannes Rainer, Christof Seifarth, Martin Hermann, Markus Nagl, Susanne Lobenwein, Doris Wilflingseder, Giuseppe Cappellano, Evi M. Morandi, Gerhard Pierer
Summary: The presence of adipocytes in wound tissue indicates a prevailing anti-inflammatory environment that can be promoted by NCT treatment, and may be associated with improved healing outcomes.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Yi-lin Zhang, Ying An, Li-Juan Sun, Hong-Lei Qu, Xuan Li, Xiao-Tao He, Rui-Xin Wu, Fa-Ming Chen, Bei-Min Tian, Yuan Yin
Summary: Diabetes mellitus is a risk factor for periodontal disease that worsens periodontal inflammation and destruction. High glucose conditions impair the osteogenic differentiation of PDLSCs through excessive ROS accumulation. Inhibiting NADPH synthesis enhances osteogenic differentiation and reduces cellular ROS accumulation in PDLSCs under high glucose conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Mersad Bagherpour Kalo, Mohsen Rezaei
Summary: The study found that low concentrations of pyruvate have a protective effect on mitochondria, while high concentrations in combination with arsenic trioxide lead to decreased complex II activity, increased mitochondrial ROS production, lipid peroxidation, GSH depletion, mitochondrial membrane damage, and swelling. These results suggest that pre-diabetics exposed to low concentrations of arsenic through food and water may develop mitochondrial dysfunction that accelerates their progression to diabetes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Dongsheng Jiang, Ruiji Guo, Hans-Gunther Machens, Yuval Rinkevich
Summary: Wound healing disorders pose a significant burden on society, clinical practice, and healthcare. Fibroblasts, a diverse group of cells, play a crucial role in the wound healing process. These fibroblasts can vary in function due to their different embryonic origins and distribution throughout the skin. Understanding the heterogeneity of fibroblasts and their physiological functions could lead to innovative therapies for promoting wound healing and preventing excessive scarring.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY
(2023)
Article
Cell Biology
Vinicius de Paiva Goncalves, Joao Paulo Steffens, Carlos Rossa Junior, Luis Carlos Spolidorio
Summary: This study aimed to evaluate the effects of testosterone depletion and supraphysiological testosterone supplementation on early phase wound healing in animals. The results showed that supraphysiological testosterone supplementation improved wound healing by enhancing angiogenesis and reducing wound contraction.
INFLAMMATION RESEARCH
(2022)
Article
Medical Laboratory Technology
Nicole C. Nowak, Daniela M. Menichella, Richard Miller, Amy S. Paller
Summary: Type 2 diabetes is associated with complications such as impaired wound healing, chronic ulcers, and the need for amputation. The role of nerves in wound healing in diabetic patients is not fully understood, but studying these mechanisms may lead to targeted treatments for chronic diabetic wounds.
TRANSLATIONAL RESEARCH
(2021)
Review
Veterinary Sciences
Nadia Ayurini Anantama, Charis Du Cheyne, Ann Martens, Susanne Pauline Roth, Janina Burk, Ward De Spiegelaere, Jule Kristin Michler
Summary: Exuberant granulation tissue (EGT) is commonly observed in horses during second intention wound healing. The mechanisms leading to EGT are still unclear, and effective strategies to prevent and treat EGT are lacking. This study conducted a systematic search and scoping review to consolidate the literature on EGT and identify knowledge gaps and research opportunities. The results highlight the need for evidence-based recommendations on EGT treatment and the importance of incorporating basic research knowledge into clinical trials.
VETERINARY JOURNAL
(2022)
Review
Anatomy & Morphology
Sana Ullah, Sumaiya Mansoor, Aaima Ayub, Momina Ejaz, Hajrah Zafar, Fizza Feroz, Ayyaz Khan, Muhammad Ali
Summary: Burn wounds can have long-lasting devastating effects on the human body, and conventional therapies are often ineffective at completely healing them. Stem cells have shown promising potential in promoting healing of burn wounds, offering advantages such as faster healing, reduced inflammation, and scar progression, making them a potential more efficient alternative to current treatments.
Article
Surgery
Mario A. Martinez-Jimenez, Samuel Kolosovas-Machuca, Francisco Alcocer, Luis Carlos Ortiz-Dosal, Mariana C. Gonzalez-Grijalva, Gibran A. Delsol-Revuelta, Francisco I. Gaitan-Gaona, Francisco J. Valadez-Castillo, Jose L. Ramirez-GarciaLuna
Summary: The topical administration of insulin glargine appears to be safe and promotes wound healing and tissue repair in nondiabetic patients with chronic venous ulcers.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Immunology
Tina Rauchenwald, Florian Handle, Catherine E. Connolly, Antonia Degen, Christof Seifarth, Martin Hermann, Christoph H. Tripp, Doris Wilflingseder, Susanne Lobenwein, Dragana Savic, Leo Poelzl, Evi M. Morandi, Dolores Wolfram, Ira-Ida Skvortsova, Patrizia Stoitzner, Johannes Haybaeck, Marko Konschake, Gerhard Pierer, Christian Ploner
Summary: This study explores the cellular interactions in chronic wounds and reveals that pro-inflammatory M1 macrophages influence the fate of preadipocytes, leading to a pro-fibrotic response. Anti-inflammatory M2 macrophages have limited effects. These findings provide important information for the potential therapeutic use of adipose-derived stem cells in human wound healing.
INFLAMMATION AND REGENERATION
(2023)
Article
Chemistry, Multidisciplinary
Ahmed A. H. Abdellatif, Osamah Al Rugaie, Fahad A. Alhumaydhi, Nahla Sameh Tolba, Ayman M. Mousa
Summary: Eco-friendly synthesis of silver nanoparticles using Nitrosalsola vermiculata as a reducing agent showed potential for wound healing. The synthesized SN-SV were characterized and formulated into a cream with suitable properties. The cream was evaluated for its effectiveness in skin tissue regeneration using ex vivo and in vivo studies in a rat model.
APPLIED SCIENCES-BASEL
(2023)
Review
Cell Biology
Siyu Fan, Xin Sun, Chuanchao Su, Yiwen Xue, Xiao Song, Runzhi Deng
Summary: Bone healing is crucial for various orthopedic conditions, and the involvement of macrophages and bone marrow mesenchymal stem cells (BMSCs) in this process has been highlighted. The interaction between these two cell types plays a vital role in regulating the balance between inflammation and regeneration, and any disruption in this balance can lead to impaired bone healing. Understanding the function and relationship of macrophages and BMSCs in bone regeneration can provide new insights to enhance bone healing. This review paper discusses the role of macrophages and BMSCs in bone healing, as well as the mechanism and significance of their interaction. It also explores several new therapeutic approaches targeting the crosstalk between these cell types to regulate the inflammatory response in bone healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
G. Sabarees, G. P. Tamilarasi, V. Velmurugan, V. Alagarsamy, Belay Zeleke Sibuh, Mohini Sikarwar, Pankaj Taneja, Akhilesh Kumar, Piyush Kumar Gupta
Summary: Drug delivery systems based on silk fibroin protein have been widely studied for their advantages in immunogenicity, sterilization, biocompatibility, and biodegradability. Silk fibroin has been used in wound healing and influences various cell types during the healing process. Electrospun nanofibers, with the ability to incorporate bioactive chemicals and enhance biological activity, have shown promise in treating challenging wounds. Silk nanofiber biomaterials have potential in drug delivery and tissue engineering applications.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Assel Sarsenbayeva, Bipasha Nandi Jui, Giovanni Fanni, Pedro Barbosa, Fozia Ahmed, Robin Kristofi, Jing Cen, Azazul Chowdhury, Stanko Skrtic, Peter Bergsten, Tove Fall, Jan W. Eriksson, Maria J. Pereira
Summary: Inhibition of HMG-CoA reductase is associated with insulin resistance. Clinical data suggests a potential association between statin treatment and the HOMA-IR index, but statins have a mild direct effect on adipose tissue and pancreas.