Article
Chemistry, Multidisciplinary
Jia-Shiuan Tsai, Jian-Zhang Chen
Summary: This study investigated the impact of oxygen impurity on the inlet gas in a nitrogen atmospheric pressure plasma jet (APPJ). A numerical model was developed to simulate the nitrogen APPJ considering fluid dynamics, heat transfer, mass transfer, diffusion, and chemical reactions. Experimental tests were conducted to verify the plasma temperature characteristics on the treated surface. The findings revealed that the plasma temperature decreased with increasing oxygen impurity, affecting the excited and neutral species composition.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Jacob Manzi, Ariel E. E. Weltner, Tony Varghese, Nicholas McKibben, Mia Busuladzic-Begic, David Estrada, Harish Subbaraman
Summary: This paper demonstrates the use of plasma-jet printing (PJP) to deposit thermoelectric nanoflakes onto flexible substrates at room temperature, with substantial improvements in material adhesion and flexibility observed. The printed films exhibit electrical conductivity of 2.5 x 10(3) S m(-1) and a power factor of 70 mu W m(-1) K-2 at room temperature. This advancement in plasma jet printing promotes not only the development of energy harvesting but also large-scale flexible electronics and sensors for space and commercial applications.
Article
Physics, Applied
Pankaj Attri, Takamasa Okumura, Nozomi Takeuchi, Kunihiro Kamataki, Kazunori Koga, Masaharu Shiratani
Summary: The current research focuses on the conversion of carbon dioxide (CO2) under ambient conditions using streamer plasma. The study finds that treatment time and humidity play a role in CO2 conversion. The findings reveal a maximum CO2 conversion rate of 35.2%, with a high energy efficiency of 135% and a low energy cost of 2.17 eV/molecule. Optical emission and fourier-transform infrared spectroscopy spectroscopy were used to analyze the different dissociation products of CO2 and determine the percentage of CO2 conversion. Furthermore, a two-dimensional fluid dynamics model and a zero-dimensional chemistry model were employed to understand the reactor mechanism.
PLASMA PROCESSES AND POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Benedikt Eggers, Matthias Bernhard Stope, Jana Marciniak, Werner Goetz, Alexander Mustea, James Deschner, Marjan Nokhbehsaim, Franz-Josef Kramer
Summary: This study investigated the effect of a medical argon plasma device on gingival cells. The results showed that an application time of 30 seconds was most suitable for treating gingival cells and tissue biopsies, providing evidence for the potential use of NIPP in dentistry.
Review
Biochemistry & Molecular Biology
Hilal Turkoglu Sasmazel, Marwa Alazzawi, Nabeel Kadim Abid Alsahib
Summary: Atmospheric plasma treatment is an effective surface treatment technique for enhancing the biocompatibility of polymers in biomedical applications, without changing their bulk properties. This treatment plays a crucial role in promoting cell adhesion, proliferation, and growth on polymer surfaces.
Article
Physics, Applied
Delin Kong, Ping Zhu, Feng He, Ruoyu Han, Bingyan Yang, Manyu Wang, Jiting Ouyang
Summary: The experimental and numerical results demonstrated that the introduction of N-2 and O-2 admixture significantly affects the length and propagation velocity of a helium atmospheric-pressure plasma jet. The changes in electron density outside the grounded electrode are related to the modifications in jet length.
JOURNAL OF APPLIED PHYSICS
(2021)
Article
Physics, Multidisciplinary
Huiyu Yang, Lei Chen, Guohua Hu, Baohuai Wang, Shiang Wang, Wenjun Zhang, Xingyu Zhang, Peng Song
Summary: In order to widely apply the high concentration of active substances in plasma jets, it is necessary to increase the length of the jet and the contact area between the jet and the object of action. The effect of discharge voltage on plasma jet length was studied by measuring the discharge voltage and capturing images of the discharge.
Article
Chemistry, Multidisciplinary
Elias Abedelnour, Stephanie Ognier, Mengxue Zhang, Laurent Schio, Olivier Venier, Janine Cossy, Michael Tatoulian
Summary: The direct N-acylation of amines by esters in a microreactor using argon plasma is presented, resulting in high yields of amides.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jae Won Ha, Joon Yong Choi, Yong Chool Boo
Summary: The study aimed to identify amino acids with copper chelation activities that could alleviate oxidative stress and toxicity in skin cells exposed to copper ions. Cysteine and cysteinamide showed the highest copper chelation activity among the tested amino acids. Histidine and histidinamide were the most effective in preventing cell death induced by copper ions.
Article
Agricultural Engineering
Zihan Li, Ting Zhou, Qi Zhang, Tongying Liu, Jiangling Lai, Canbo Wang, Leipeng Cao, Yuhuan Liu, Roger Ruan, Mingxiong Xue, Yunpu Wang, Xian Cui, Cuixia Liu, Yan Ren
Summary: Cold atmospheric pressure plasma (CAPP) is an innovative non-thermal technique for preserving and decontaminating food. This study investigated the effects of CAPP power density on microorganism inactivation and the quality of Spirulina platensis (S. platensis) slurry. The results showed that high power density CAPP treatment effectively inactivated microorganisms within a short time, while also improving the nutrient content and bio-accessibility of S. platensis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Physics, Applied
J. Liu, L. Nie, Y. Xian, X. Lu
Summary: The study found that adding a small amount of nitrogen or oxygen to argon can make the plasma channel smooth, while the rotational frequency of the electrode does not affect the appearance of the plasma channel. Optical emission spectra show that adding O-2/N-2 reduces the emission intensity of transitions from excited argon levels to metastable states, leading to a transition of the discharge channel's nature.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Physics, Applied
K. Gazeli, M. Hadjicharalambous, Eleftherios Ioannou, O. Gazeli, C. Lazarou, C. Anastassiou, P. Svarnas, V. Vavourakis, G. E. Georghiou
Summary: We developed an in silico model to simulate the response of B16F10 melanoma cells to a helium atmospheric pressure plasma jet (APPJ) and doxorubicin drug (DOX). The simulation results showed that increasing plasma duration and DOX concentration resulted in increased cytotoxicity and a higher apoptosis probability compared to mitosis probability. Furthermore, combining plasma treatment and drug application enhanced cell cytotoxicity. This in silico model is valuable in the field of plasma medicine for understanding the response of different cancers to APPJ and cancer drugs.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Sunmi Lee, Jongbong Choi, Junghyun Kim, Yongwoo Jang, Tae Ho Lim
Summary: The application of atmospheric pressure plasma techniques in transdermal delivery is important for improving drug absorption rate. This technology may increase skin permeability by altering lipid composition of the stratum corneum.
APPLIED SCIENCES-BASEL
(2021)
Article
Nanoscience & Nanotechnology
T. Kladphet, V. P. Thai, W. T. L. S. Fernando, K. Takahashi, T. Kikuchi, T. Sasaki
Summary: In this study, a zero-dimensional numerical simulation was used to investigate the interaction between atmospheric pressure plasma (APP) and a liquid solution. The simulation predicted important parameters such as excitation temperature, electron temperature, and species population densities, providing insights for optimizing the conditions for chemical reactions and applications involving the synthesis of nanoparticles. The study specifically focused on the effect of pH values on the synthesis of gold nanoparticles and found that higher pH values are favorable for generating gold atoms for nano-synthesis. The simulation results were in agreement with experimental observations.
Article
Mechanics
Xuechen Li, Dongdong Wang, Junyu Chen, Jiacun Wu, Na Zhao, Pengying Jia, Kaiyue Wu
Summary: The study focuses on the behavior of an inert gas plasma jet operating in a streamer discharge mechanism and its interaction with positive ions clouds of different densities and scales. Results show that the streamer behavior is influenced by the density of positive ions, with rarefied ions resulting in free propagation and denser ions causing detouring paths. The detouring process is achieved through the relay of two streamers initiated at different points within the system. Additionally, the study examines the velocity of the streamer and the deflection amplitude of the detouring track based on varying factors such as ion densities, voltage amplitudes, and gap widths.
Article
Biochemistry & Molecular Biology
Lea Miebach, Eric Freund, Ramona Clemen, Klaus-Dieter Weltmann, Hans-Robert Metelmann, Thomas von Woedtke, Torsten Gerling, Kristian Wende, Sander Bekeschus
Summary: Gas plasma jet technology has been found to have potential in palliative treatment for cancer patients. Direct contact with tumor tissue showed higher therapeutic efficacy compared to remote treatment with reactive oxygen and nitrogen species. The study emphasizes the importance of standardized treatment distances in gas plasma exposure to cancer therapy.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Sander Bekeschus, Mikael Ispirjan, Eric Freund, Frederik Kinnen, Juliane Moritz, Fariba Saadati, Jacqueline Eckroth, Debora Singer, Matthias B. Stope, Kristian Wende, Christoph A. Ritter, Henry W. S. Schroeder, Sascha Marx
Summary: This study demonstrates the potential of gas plasma treatment in inducing cell cycle arrest, apoptosis, and immunomodulation in patient-derived GBM tissue samples. The findings suggest that gas plasma technology could be a valuable addition to current treatment strategies in neurosurgery and neuro-oncology.
Article
Chemistry, Medicinal
Mohsen Ahmadi, Felix Potlitz, Andreas Link, Thomas von Woedtke, Zahra Nasri, Kristian Wende
Summary: In this study, a proof of concept was presented to demonstrate that cold physical plasma (CPP) can initiate the activation of drug prodrugs by triggering reactive oxygen species (ROS). The results suggest that custom-tailored CPP-responsive prodrugs might become an evolving research field.
ARCHIV DER PHARMAZIE
(2022)
Article
Biochemistry & Molecular Biology
Zahra Nasri, Mohsen Ahmadi, Johanna Striesow, Mehdi Ravandeh, Thomas von Woedtke, Kristian Wende
Summary: Cold physical plasma, as a new field of oxidative stress-based therapy, has the potential to generate a variety of reactive oxygen and nitrogen species (RONS), making it a promising tool for biomedical applications. However, the impact of plasma-derived RONS on cell membrane lipids and properties is not fully understood. This study investigated the changes in lipid bilayer functionality and revealed the strong impact of cholesterol on membrane permeabilization by plasma-derived species. Additionally, the chemical composition of the head group was found to influence the maintenance of barrier properties, with phosphatidylcholines being more susceptible than other lipid classes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sander Bekeschus, Grit Liebelt, Jonas Menz, Debora Singer, Kristian Wende, Anke Schmidt
Summary: This study revealed a set of cell cycle-associated genes associated with inherent resistance or sensitivity to H2O2-induced cellular death through transcriptomic correlation analysis, highlighting the important roles of these genes in cell death.
Article
Polymer Science
Mehdi Ravandeh, Masoud Mehrjoo, Konstantin Kharitonov, Jan Schaefer, Antje Quade, Bruno Honnorat, Mabel Ruiz-Lopez, Barbara Keitel, Svea Kreis, Rui Pan, Seung-gi Gang, Kristian Wende, Elke Ploenjes
Summary: Polyethylene terephthalate (PET) is a widely used thermoplastic polyester in industry. Surface modification is required for printing and coating processes, and plasma treatment is commonly used to increase the hydrophilicity of PET films. This study used X-ray ptychography and scanning electron microscopy to investigate the effects of plasma treatment on the surface morphology of PET films. The results showed increased roughness and changes in morphology, as well as an increase in oxygen content and polarity without significant damage to the polymer.
Article
Immunology
Ramona Clemen, Kevin Arlt, Thomas von Woedtke, Sander Bekeschus
Summary: Protein vaccines can induce immune responses, but inflammation caused by reactive oxygen species (ROSs) can modify proteins and affect their functionality or immunogenicity. Gas plasma technology is used to study the immunogenicity of oxidized protein antigens. The findings suggest that gas plasma-modified proteins can induce dendritic cell maturation and activation.
Article
Chemistry, Multidisciplinary
Mohsen Ahmadi, Zahra Nasri, Thomas von Woedtke, Kristian Wende
Summary: The study investigates the oxidation of glucose by cold atmospheric plasma and identifies the reactive species responsible for the observed oxidative transformation. The results demonstrate the ability of oxygen-derived radicals to initiate the glucose oxidation cascade. Additionally, the presence of carbohydrates in cell culture media and other liquid targets is found to modulate the availability of plasma-generated species.
Article
Oncology
Lea Miebach, Hager Mohamed, Kristian Wende, Vandana Miller, Sander Bekeschus
Summary: This study suggests that gas plasma-oxidized liquids enriched with free radicals can be used as an additive option for treating pancreatic cancer, inducing tumor toxicity and provoking immunogenicity.
Article
Cell Biology
Ramona Clemen, Kevin Arlt, Lea Miebach, Thomas von Woedtke, Sander Bekeschus
Summary: This study investigated the effects of oxidized and native proteins on cell surface marker expression and cytokine release in human monocyte-derived cells. The results showed that oxidized proteins led to elevated expression levels of cell surface markers and modified release of cytokines. These findings are important for further exploring the application of oxidized proteins in cancer therapy.
Article
Biochemistry & Molecular Biology
Mohsen Ahmadi, Debora Singer, Felix Potlitz, Zahra Nasri, Thomas von Woedtke, Andreas Link, Sander Bekeschus, Kristian Wende
Summary: Cold physical plasma is a partially ionized gas that operates at body temperature and has applications in heat-sensitive technical and medical fields. It can be used to introduce oxidative modifications to biomolecules, including the activation of anticancer prodrugs. In a proof-of-concept study, a boronic pinacol ester fenretinide prodrug was activated using an atmospheric pressure argon plasma jet. The study demonstrated that the activation of the prodrug led to enhanced cytotoxic effects in vitro, making cold physical plasma-mediated prodrug activation a promising approach for combination cancer treatment studies.
Article
Chemistry, Analytical
Zahra Nasri, Seyedali Memari, Johanna Striesow, Klaus-Dieter Weltmann, Thomas von Woedtke, Kristian Wende
Summary: This study introduces the possibility of using scanning electrochemical microscopy as a powerful imaging technique to study the morphological changes of a solid-supported lipid bilayer model induced by reactive species. The method is not only applicable for investigating the effect of reactive species on the lipid bilayer, but also for understanding the morphological changes of the lipid bilayer due to the action of membrane proteins or antimicrobial peptides.
ANALYTICAL METHODS
(2022)
Review
Biochemistry & Molecular Biology
Mohsen Ahmadi, Sander Bekeschus, Klaus-Dieter Weltmann, Thomas von Woedtke, Kristian Wende
Summary: This article discusses the role of COX enzymes (COX-1 and COX-2) and their involvement in inflammation, as well as the use of selective COX-2 inhibitors in reducing pain and protecting against inflammation-related diseases. The focus is on the biological activity of recently discovered COX-2 inhibitors and their advantages compared to existing drugs.
RSC MEDICINAL CHEMISTRY
(2022)
