Article
Gastroenterology & Hepatology
Takeshi Kuwada, Masahiro Shiokawa, Yuzo Kodama, Sakiko Ota, Nobuyuki Kakiuchi, Yasuhito Nannya, Hajime Yamazaki, Hiroyuki Yoshida, Takeharu Nakamura, Shimpei Matsumoto, Yuya Muramoto, Shuji Yamamoto, Yusuke Honzawa, Katsutoshi Kuriyama, Kanako Okamoto, Tomonori Hirano, Hirokazu Okada, Saiko Marui, Yuko Sogabe, Toshihiro Morita, Tomoaki Matsumori, Atsushi Mima, Yoshihiro Nishikawa, Tatsuki Ueda, Kazuyoshi Matsumura, Norimitsu Uza, Tsutomu Chiba, Hiroshi Seno
Summary: The study found that a significant majority of patients with ulcerative colitis had IgG antibodies against integrin alpha v beta 6, which may serve as a potential diagnostic biomarker with high sensitivity and specificity.
Article
Biochemistry & Molecular Biology
Yuji Yamada, Toru Onda, Ayami Hagiuda, Ryuji Kan, Masumi Matsunuma, Keisuke Hamada, Yamato Kikkawa, Motoyoshi Nomizu
Summary: This study elucidated the role of RGD neighboring sequences on iPSC adhesion and found that RGDX(1)X(2) sequences are necessary, and X1X2 residues play a key role in adhesion via integrin αvβ5.
Article
Chemistry, Applied
Xiaodan Gong, Haojie Yu, Li Wang, Jian Hu, Luming Wang, Chengjiang Li
Summary: This study reported an antifogging coating with persistent fogging prevention by introducing an amphiphilic polymer and interfacial layer. By using benzophenone (BP) groups, both bulk cross-linking and interfacial bonding were achieved to prevent relative macroscopic motions of the coating from the substrate under extreme conditions. The coating could maintain fog-free behavior even after 50-cycle antifogging tests and 90 days of aging under harsh conditions. Remarkably, both in vitro (pig larynx) and in vivo (living rabbit) outcomes demonstrated excellent fog-repellency of the polymer-coated endoscope.
PROGRESS IN ORGANIC COATINGS
(2023)
Article
Materials Science, Multidisciplinary
Joanna Jagiello, Marcin Kusmierz, Ewa Kijenska-Gawronska, Magdalena Winkowska-Struzik, Wojciech Swieszkowski, Ludwika Lipinska
Summary: Graphene oxide (GO) shows good cell affinity in cell culturing, and can enhance its adhesion ability by modifying with biomolecules and peptides. For L929 cells, both graphene oxide and GO modified with RGD peptide demonstrate good biocompatibility and cellular response.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Zhenqiang Zhang, Qingyi Xie, Guoliang Zhang, Chunfeng Ma, Guangzhao Zhang
Summary: Researchers have developed a novel antifouling coating that exhibits both superior anti-adhesion ability and strong substrate adhesion, making it suitable for various applications. The coating is composed of bis-silane-terminated polyurea and a reactive amphiphilic polymer with fluorocarbon and poly(ethylene glycol) side chains. The coating demonstrates high transparency, high tensile strength, resistance to protein and bacterial fouling, and strong adhesion to various substrates.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Biotechnology & Applied Microbiology
Meng Yang, Zheng-Chu Zhang, Yan Liu, You-Rong Chen, Rong-Hui Deng, Zi-Ning Zhang, Jia-Kuo Yu, Fu-Zhen Yuan
Summary: The RGD peptide family is considered as a specific recognition site for the integrin receptors, which play a key role in cell communication. Further research is needed to understand the potential therapeutic and regenerative effects of RGD peptides in bone and cartilage tissue engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yuji Yamada, Caleb F. F. Anderson, Joel P. P. Schneider
Summary: Peptide sequence periodicity is a useful design tool for generating functional peptide-based surface coatings. The de novo-designed peptide N-3-PEG-VK16 binds avidly to polystyrene surfaces, converting them into a wettable and electrostatically charged environment that facilitates cell attachment. This technology enables adhesion, expansion, and long-term culture of human induced pluripotent stem cells, as well as control of neurite outgrowth using functional ligands.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Zherui Chen, Weiguo Liu, Jingyue Sun, Cong Chen, Yongchen Song
Summary: Adding amphiphilic peptides as green KHIs substitutes can effectively inhibit hydrate growth by utilizing the vdW interaction between hydrophobic groups and water molecules. Peptides consisting of alanine and lysine (5AK) and alanine and threonine (5AT) have been studied, and it is found that 5AK with more hydrophobic binding sites exhibits a higher inhibitory effect. Additionally, the addition of threonine further improves the inhibitory effect of the peptide. These findings provide theoretical guidance for the development of new KHIs.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Jenni Leppiniemi, Zeeshan Mutahir, Alexander Dulebo, Piia Mikkonen, Markus Nuopponen, Paula Turkki, Vesa P. Hytonen
Summary: The successful conjugation of avidin to nanocellulose and its functional retention in the resulting hydrogel was demonstrated in this study. The Avd-NFC hydrogel showed shear-thinning and gel-forming properties, as well as the ability to bind biotinylated molecules. The 3D cell culture experiments showed that Avd-NFC hydrogels functionalized with biotinylated proteins significantly improved cell proliferation rates and integrin-mediated adhesions.
Article
Pharmacology & Pharmacy
Si-Yuan Yao, Jia-Fan Wang, Zheng Xu, Yue Meng, Yue Xue, Fan Yang, Wen-Bing Yao, Xiang-Dong Gao, Song Chen
Summary: SNP-9 is a neuroprotective peptide that can decrease oligomeric amyloid beta (Aβ) levels by co-assembling with toxic Aβ oligomers. The peptide also regulates abnormal hyperphosphorylation of tau by binding to calcyclin-binding protein. These findings suggest that SNP-9 may be a potential therapeutic intervention for Alzheimer's disease (AD).
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kohta Mohri, Kim Phuong Huynh Nhat, Maki Zouda, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, Shunsuke Tagami, Hidefumi Mukai
Summary: In this study, we generated a PET probe based on MccJ25 analog with an RGD motif and investigated its utility for tumor imaging. The probe showed high accumulation in tumors with integrin alpha v beta 3 expression and low non-specific accumulation in other tissues. These results suggest that MccJ25 variants can be useful tools for cancer molecular imaging.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
Zhou Fang, Junjian Chen, Ye Zhu, Guansong Hu, Haoqian Xin, Kunzhong Guo, Qingtao Li, Liangxu Xie, Lin Wang, Xuetao Shi, Yingjun Wang, Chuanbin Mao
Summary: The study demonstrates the use of a click immobilization strategy to create gradients of two different functional peptides on a surface for rapid optimization. Optimizing the concentration of different functional peptides on a surface can be a complex process.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Kinga Dora Kovacs, Martin Novak, Zoltan Hajnal, Csaba Hos, Balint Szabo, Inna Szekacs, Ye Fang, Attila Bonyar, Robert Horvath
Summary: Fluidic flow is crucial in colloid and interface sciences, and monitoring cell response to varied flow velocities using optical biosensors presents a challenging yet innovative approach. By rotating liquid over a biosensor array, the study demonstrated the capability to measure cell adhesion and detachment at different flow velocities simultaneously, providing insights into cellular behavior under mechanical and chemical stimulation. This setup offers a new avenue for investigating interface phenomena under controlled flow conditions.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Rosa, Lucas de Mello, Valeria Castelletto, Mark L. Dallas, Antonella Accardo, Jani Seitsonen, Ian W. Hamley
Summary: This study investigates the conformation and self-assembly behavior of four lipopeptides, and examines their potential applications in tissue engineering based on cytocompatibility assessments. The results show that all four lipopeptides can self-assemble into nanostructures at specific concentrations. Furthermore, these lipopeptides demonstrate promising prospects in tissue engineering.
Article
Chemistry, Multidisciplinary
Jingwu Zhu, Jiang Tian, Chao Yang, Junpeng Chen, Lihuang Wu, Mengni Fan, Xiaojun Cai
Summary: This study presents a novel synergistic antibacterial strategy based on PDT and NO gas therapy using Ce6@Arg-ADP as a carrier, which shows enhanced biofilm penetration and antibacterial effects. The combination of O-1(2) and NO offers notable synergistic effects, promoting wound healing effectively.
Review
Oncology
Rahul Bhattacharjee, Sabya Sachi Das, Smruti Sudha Biswal, Arijit Nath, Debangshi Das, Asmita Basu, Sumira Malik, Lamha Kumar, Sulagna Kar, Sandeep Kumar Singh, Vijay Jagdish Upadhye, Danish Iqbal, Suliman Almojam, Shubhadeep Roychoudhury, Shreesh Ojha, Janne Ruokolainen, Niraj Kumar Jha, Kavindra Kumar Kesari
Summary: This article comprehensively discusses the structural organization and biological functions of all early proteins of human papilloma virus (HPV) and their contribution to the progression of cervical cancer (CC). The study reveals that E6 and E7 proteins are major causes of HPV-mediated CC progression, while E1, E2, and E5 proteins play supporting roles. The article also highlights the significance of targeting E6 and E7 proteins in therapeutic strategies for CC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lucas R. de Mello, Vinicius Carrascosa, Eduardo Rebelato, Maria A. Juliano, Ian W. Hamley, Valeria Castelletto, Sandra V. Vassiliades, Wendel A. Alves, Clovis R. Nakaie, Emerson R. da Silva
Summary: Peptide-based hydrogels are promising biomaterials that can mimic the 3D microenvironment of the extracellular matrix. This study demonstrates that a synthetic decapeptide can form highly stable hydrogel matrices that retain a high water content and induce morphogenesis in interacting cells.
Article
Neurosciences
Ankit Jana, Arkadyuti Bhattacharjee, Sabya Sachi Das, Avani Srivastava, Akshpita Choudhury, Rahul Bhattacharjee, Swagata De, Asma Perveen, Danish Iqbal, Piyush Kumar Gupta, Saurabh Kumar Jha, Shreesh Ojha, Sandeep Kumar Singh, Janne Ruokolainen, Niraj Kumar Jha, Kavindra Kumar Kesari, Ghulam Md Ashraf
Summary: Alzheimer's disease is a complex neurological disorder characterized by memory loss and cognitive dysfunction. Conventional therapies only provide symptomatic relief, while novel hybrid therapeutic compounds targeting multiple pathogenic pathways show promise for effective treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Rosa, Lucas de Mello, Valeria Castelletto, Mark L. Dallas, Antonella Accardo, Jani Seitsonen, Ian W. Hamley
Summary: This study investigates the conformation and self-assembly behavior of four lipopeptides, and examines their potential applications in tissue engineering based on cytocompatibility assessments. The results show that all four lipopeptides can self-assemble into nanostructures at specific concentrations. Furthermore, these lipopeptides demonstrate promising prospects in tissue engineering.
Article
Chemistry, Multidisciplinary
Nada Aljuaid, Jani Seitsonen, Janne Ruokolainen, Francesca Greco, Ian W. Hamley
Summary: This study found that analogues of benzene-1,3,5-tricarboxamide can self-assemble into micelles or nanotapes in aqueous solution, depending on the architecture of alkyl and PEG chains. The compounds exhibit selective cytotoxicity to breast cancer cells, showing strong stability in acidic tumor conditions and cell culture media.
Article
Biotechnology & Applied Microbiology
Anastassia Kostenko, Che J. Connon, Stephen Swioklo
Summary: Over the last decade, significant progress has been made in three-dimensional (3D) bioprinting, which has the potential to create complex structures with live cells for drug discovery and tissue engineering. To ensure successful clinical applications, the logistics of bioprinting need to be considered, including storage and transportation. The use of alginate, a natural biopolymer, for both storage and on-demand bioprinting of cells has not been previously investigated.
BIOENGINEERING-BASEL
(2023)
Review
Nanoscience & Nanotechnology
Ian W. Hamley
Summary: This review focuses on the self-assembly, structural and functional properties of peptide conjugates containing bulky terminal aromatic substituents, with a particular emphasis on bioactivity. The driving force for self-assembly comes from pi-stacking and hydrophobic interactions, as well as hydrogen bonding, electrostatics, and other forces between short peptides. The balance of these interactions leads to a propensity for self-assembly, even for single amino acid conjugates. The resulting molecules often form hydrogels built from beta-sheet fibrils, with applications in biomaterials, drug delivery, catalysis, and optoelectronics.
ACS APPLIED BIO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Valeria Castelletto, Jani Seitsonen, Ian W. W. Hamley
Summary: This study investigates the self-assembly behavior of two monodisperse lipid A derivatives based on bacterial LPS structures in water and compares them to native Escherichia coli LPS using small-angle X-ray scattering and cryogenic transmission electron microscopy. The critical aggregation concentration and conformation are characterized using fluorescence probe experiments and circular dichroism spectroscopy, respectively. The E. coli LPS forms wormlike micelles, while the synthetic analogues self-assemble into nanosheets or vesicles depending on the number of lipid chains and saccharide head groups. These findings can be rationalized based on the surfactant packing parameter.
Article
Chemistry, Multidisciplinary
Biswanath Hansda, Jhilam Majumder, Biplab Mondal, Akash Chatterjee, Subhadeep Das, Sourav Kumar, Ratan Gachhui, Valeria Castelletto, Ian W. Hamley, Prosenjit Sen, Arindam Banerjee
Summary: A histidine-based amphiphilic peptide (P) was discovered to form an injectable transparent hydrogel with inherent antibacterial property in phosphate buffer solution. The peptide self-assembles into a nanofibrillar network structure and exhibits efficient antibacterial activity against both Gram-positive and Gram-negative bacteria. The hydrogel can also encapsulate and selectively release drugs, making it a potential antibacterial and drug delivering agent.
Article
Biochemistry & Molecular Biology
Valeria Castelletto, Lucas de Mello, Emerson Rodrigo da Silva, Jani Seitsonen, Ian W. Hamley
Summary: Considerable interest has been shown in peptides with the Fmoc protecting group, as it can promote self-assembly and has applications in cell culture biomaterials. New amino acid analogues with the Smoc protecting group have been developed for water-based peptide synthesis. Self-assembly of Smoc-Ala, Smoc-Phe, and Smoc-Arg occurs above the critical aggregation concentration (CAC) and forms nanosheet, nanoribbon, or nanotube structures. Smoc-amino acids show excellent biocompatibility and are taken up by fibroblast cells without cytotoxicity.
Article
Chemistry, Physical
Thiago C. Lourenco, Lucas R. de Mello, Marcelo Y. Icimoto, Renata N. Bicev, Ian W. Hamley, Valeria Castelletto, Clovis R. Nakaie, Emerson R. da Silva
Summary: This study presents a strategy for fabricating highly ordered 1D nanostructures of Bradykinin (BK) using DNA fragments as a template for self-assembly. The nanoscale structure of BK-DNA complexes was revealed, showing the formation of ordered nanofibrils. The complexes retained the native bioactivity of BK and could induce a limited uptake of nucleotides by HEK-293t cells, which has not been previously reported.
Article
Chemistry, Physical
Elisabetta Rosa, Carlo Diaferia, Lucas De Mello, Jani Seitsonen, Ian W. Hamley, Antonella Accardo
Summary: Short and ultra-short peptides are now being used as building blocks for self-assembled materials, with peptide aggregation being influenced by the amino acids in the sequence as well as their ability to interact with each other. By modifying peptides with polymeric moieties, alkyl chains, or other organic molecules, further structural and functional properties can be achieved. In this study, we synthesized and investigated the aggregation behavior of peptide amphiphiles (PAs) containing cationic tetra- or hexa-peptides derivatized with an alkyl chain. These PAs were able to form highly ordered nanostructures and biocompatible hydrogels, showing potential for tissue engineering and diagnostic applications.
Article
Chemistry, Physical
Jinghua Liu, Jingqing Li, Binyuan Liu, Ian W. Hamley, Shichun Jiang
Summary: The Mpemba effect and its inverse can be explained by nonequilibrium thermodynamics. While changes of state in polymers are generally non-equilibrium processes, the Mpemba effect is rarely seen in their crystallization. Polybutene-1 (PB-1) has the lowest critical cooling rate among polyolefins and tends to maintain its original structure and properties in the melt. Experimental observations confirm the presence of the Mpemba effect in both the crystallization of PB-1 in form II and form I obtained at low melting temperatures.
Article
Chemistry, Physical
Biswanath Hansda, Biplab Mondal, Soumyajit Hazra, Krishna Sundar Das, Valeria Castelletto, Ian W. Hamley, Arindam Banerjee
Summary: Peptide-based multicomponent hydrogels offer tunable mechanical properties and physical characteristics, demonstrating good cell compatibility and sustained drug release capabilities, and have the potential to serve as scaffold materials for tissue engineering.
Article
Engineering, Mechanical
Anastassia Kostenko, Stephen Swioklo, Che J. Connon
Summary: The principle of three-dimensional (3D) bio-printing involves the integration of biomaterials, live cells, and controlled motor systems to create complex biomimetic structures. This study focuses on improving the printability of low concentration alginate bio-inks by utilizing pre-crosslinking with calcium sulfate (CaSO4). By adjusting the physiochemical parameters of alginate-based bio-inks, improvements in print resolution and cell viability can be achieved. The study found that pre-crosslinking significantly affects the viscosity of biomaterials, improving their suitability for the bio-printing process. The encapsulation of cells in pre-crosslinked alginate-based bio-inks did not have a detrimental effect on cell viability.
FRONTIERS IN MECHANICAL ENGINEERING-SWITZERLAND
(2022)
