Article
Biochemistry & Molecular Biology
Diana Klein
Summary: Studies have shown the presence of mesenchymal stem cells (MSCs) in the lungs, which may play a role in regulating lung tissue repair and inflammation. However, the true function of tissue-resident MSCs in the lungs and the identification of their niche remain challenging. Future research directions include unraveling the localization of MSCs, controlling their signaling pathways, and exploring the therapeutic benefits of manipulating these cells directly within their endogenous niche.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Cell Biology
Sean Ashworth, Jodie Harrington, Greg M. Hammond, Kiranjit K. Bains, Elena Koudouna, Anthony J. Hayes, James R. Ralphs, Justyn W. Regini, Robert D. Young, Ryuhei Hayashi, Kohji Nishida, Clare E. Hughes, Andrew J. Quantock
Summary: Chondroitin sulfate plays crucial roles in controlling collagen fibrillogenesis and regulating signaling molecules in the cornea. Its precise expression helps define the local extracellular compartment that contributes to maintenance of the stem cell phenotype and corneal morphogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kiranjit K. Bains, Sean Ashworth, Elena Koudouna, Robert D. Young, Clare E. Hughes, Andrew J. Quantock
Summary: Chondroitin sulphate (CS) proteoglycans, which are closely associated with the stem cell niche of articular cartilage, were found to be present in the subepithelial corneal stroma and nearby ossicles in the adult chicken cornea. When cultivated on CS/dermatan sulphate (DS)-coated dishes, corneal stromal cells exhibited a less-differentiated phenotype and expressed stem cell markers. These findings suggest that CS/DS may play a role in maintaining a stem cell phenotype in corneal cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Developmental Biology
Jessica D. Manneken, Peter D. Currie
Summary: The cells of the innate immune system, particularly macrophages, play a vital role in tissue repair and stem cell activation. Recent studies have revealed the complex molecular processes involved in these mechanisms and the direct role of immune cells in coordinating these processes.
Review
Cell Biology
Nancy C. C. Allen, Nabora S. S. Reyes, Jin Young Lee, Tien Peng
Summary: Aging is the final stage of development that leads to stereotyped changes in tissue morphology and increases the risk of chronic lung diseases. Inflammation and cellular senescence, two hallmarks of aging, are mutually related and contribute to increased susceptibility to chronic diseases in aging tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Yangdan Liu, Chiakang Ho, Dongsheng Wen, Jiaming Sun, Lu Huang, Ya Gao, Qingfeng Li, Yifan Zhang
Summary: The self-renewal ability of stem cells is crucial for skin homeostasis, aging, and wound repair. COL17, as a component of the stem cell niche, plays a pivotal role in regulating stem cell maintenance and function.
Review
Cell Biology
Yan Man, Xiangmei Yao, Tonghua Yang, Yajie Wang
Summary: The self-renewal and differentiation of hematopoietic stem cells are tightly controlled by various cells and cytokines in the bone marrow microenvironment. Changes in the niche composition can lead to hematological malignancies, and processes like homing, proliferation, and differentiation of HSCs are crucial for the success of hematopoietic stem cell transplantation. Single-cell sequencing and in vivo imaging are powerful tools for studying the bone marrow microenvironment in diseases like leukemia and after transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kai Wang, Kun Man, Jiafeng Liu, Brian Meckes, Yong Yang
Summary: Regulating cell behavior using nanotopography is widely used, but the complex effects of physical and biochemical cues hinder our understanding, limiting its biomedical applications. To analyze the individual roles, substrates with different physical nanotopography but identical biochemical nanopatterns and vice versa were fabricated. The results showed physical topographies dominantly control cell spreading, YAP localization, proliferation, and differentiation, while biochemical nanopatterns affect hMSC elongation, YAP intracellular localization, and LAMAC expression. Physical nanogratings induce nanoscale curvature of nuclei, attenuating osteogenic differentiation of hMSCs. Fine-tuning cell behavior is possible by altering the presentation of biochemical cues on substrate surfaces.
Article
Cell Biology
Naresh Polisetti, Guenther Schlunck, Thomas Reinhard
Summary: The expression pattern of PAX6 in limbal niche cells, such as mesenchymal stromal cells and melanocytes, is not well understood. This study shows that PAX6 is mainly expressed in limbal epithelial cells and plays a crucial role in maintaining their identity and fate.
Review
Biochemistry & Molecular Biology
Thea L. Willis, Emily J. Lodge, Cynthia L. Andoniadou, Val Yianni
Summary: Stem cells in the anterior pituitary gland play a crucial role in organ development and maintenance through bi-directional signaling with neighboring cells. This review discusses core signaling pathways guiding pituitary progenitors towards specific endocrine fate decisions and highlights the importance of certain conserved signaling pathways in the postnatal stem cell niche. Additionally, the potential of single cell RNA sequencing studies to provide valuable insights into stem cell niche components is emphasized.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cell Biology
Raheleh Farahzadi, Behnaz Valipour, Soheila Montazersaheb, Ezzatollah Fathi
Summary: Adult stem cells (ASCs) throughout the body can support tissue growth and repair. The function of stem cells is influenced by signals derived from their specific microenvironment or niche. Studies have shown that aging of the niche can lead to a decline in stem cell function and is associated with aging and age-related disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Masaru Mizukoshi, Masaru Kaku, Lay Thant, Kohei Kitami, Moe Arai, Isao Saito, Katsumi Uoshima
Summary: The study revealed that periodontal ligament (PDL) cells exhibit dynamic proliferative characteristics during orthodontic tooth movement-induced tissue remodeling, with proliferative cells likely undergoing further division and contributing to tissue remodeling. Additionally, proliferating cells expressed various molecular markers, indicating the lineage plasticity of PDL cells in vivo.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Christopher M. Madl, Iris A. Flaig, Colin A. Holbrook, Yu Xin Wang, Helen M. Blau
Summary: MuSC responses are influenced by mechanical cues from the extracellular matrix, with soft hydrogels promoting activation and expansion, while stiff hydrogels impair proliferation and myogenic progression. Soluble factors like prostaglandin E2 and oncostatin M also play a role in influencing stem cell behavior on different substrates.
Article
Medicine, Research & Experimental
Yan Lin, Quan Gu, Shihong Lu, Zengkai Pan, Zining Yang, Yapu Li, Shangda Yang, Yanling Lv, Zhaofeng Zheng, Guohuan Sun, Fanglin Gou, Chang Xu, Xiangnan Zhao, Fengjiao Wang, Chenchen Wang, Shiru Yuan, Xiaobao Xie, Yang Cao, Yue Liu, Weiying Gu, Tao Cheng, Hui Cheng, Xiaoxia Hu
Summary: Severe acute graft-versus-host disease (aGVHD) is a complication of allogeneic hematopoietic stem cell transplantation. The bone marrow (BM) niche is damaged in aGVHD hosts, and the use of the JAK1/2 inhibitor ruxolitinib can restore BM mesenchymal stromal cell (BMSC) function and improve hematopoietic dysfunction caused by aGVHD.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Cell Biology
Fangyuan Shen, Yu Shi
Summary: The article reviews the research progress of single-cell RNA sequencing technology in the identification of osteogenic markers and differentiation pathways, as well as the application of single-cell technology combined with experimental techniques in MSC-related new insights. It also summarizes the latest findings regarding the interaction between stem cell fate and the microenvironment in homeostasis and pathological processes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Engineering, Biomedical
Muna M. Kareem, Tom Hodgkinson, Manuel Salmeron Sanchez, Matthew J. Dalby, K. Elizabeth Tanner
BIOMEDICAL MATERIALS
(2019)
Article
Cardiac & Cardiovascular Systems
Daniel A. Jones, Krishnaraj S. Rathod, Sudheer Koganti, Pitt Lim, Sam Firoozi, Richard Bogle, Ajay K. Jain, Philip A. MacCarthy, Miles C. Dalby, Iqbal S. Malik, Anthony Mathur, Ranil DeSilva, Roby Rakhit, Sundeep Singh Kalra, Simon Redwood, Peter Ludman, Andrew Wragg
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Vasileios F. Panoulas, Charles J. Ilsley, Konstantinos Kalogeras, Habib Khan, Maria Monteagudo Vela, Miles Dalby, Tito Kabir, Robert D. Smith, Mark Mason, Richard Grocott-Mason, Ian Cummings, Thomas F. Luscher, Shahzad G. Raja
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2019)
Article
Orthopedics
Kin R. Murray, Jorge Chahla, Marc R. Safran, Aaron J. Krych, Daniel B. F. Saris, Arnold Caplan, Robert F. LaPrade, Brian J. Cole, Farshid Guilak, Scott A. Rodeo, Christian Lattermann, Mark A. Birch, Bruno Peault, Leela C. Biant, Jorge Chahla, Constance R. Chu, Matthew J. Dalby, Allan B. Dietz, Jason L. Dragoo, Lars Engebretsen, Denis Evseenko, Alan Getgood, Andrew G. Geeslin, Anthony P. Hollander, Johnny Huard, Elizaveta Kon, Aaron J. Krych, Robert F. Laprade, Nicola Maffulli, Bert R. Mandelbaum, Rodrigo Mardones, Iain R. Murray, Frank A. Petrigliano, Marc R. Safran, Daniel B. F. Saris, A. Hamish R. W. Simpson, James H. C. Wang, Henning Madry, Chris H. Jo, Norimasa Nakamura
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2019)
Article
Genetics & Heredity
Zhao Peng, Ely Oliveira-Garcia, Guifang Lin, Ying Hu, Melinda Dalby, Pierre Migeon, Haibao Tang, Mark Farman, David Cook, Frank F. White, Barbara Valent, Sanzhen Liu
Article
Ophthalmology
Marius Dalby, Olav Kristianslund, Liv Drolsum
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Cameron Dowling, Sami Firoozi, Vasileios Panoulas, Miles Dalby, Mavin N. Kashyap, Tito Kabir, Konstantinos Kalogeras, Mamta H. Buch, Richard Levy, Saqib Chowdhary, Smriti Saraf, David Roberts, Ranjit More, Andrew Wiper, Hesham K. Abdelaziz, Antoinette Neylon, Darren Mylotte, Anthony D. Pisaniello, Douglas G. W. Fraser, Richard Anderson, Michael S. Cunnington, Christopher J. Malkin, Daniel J. Blackman, Paul F. Brennan, Colum G. Owens, Ganesh Manoharan, Mark S. Spence, Stephen J. Brecker
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2020)
Article
Cardiac & Cardiovascular Systems
Konstantinos Kalogeras, Richard J. Jabbour, Neil Ruparelia, Samuel Watson, Tito Kabir, Toru Naganuma, Manolis Vavuranakis, Sunao Nakamura, Iqbal S. Malik, Ghada Mikhail, Miles Dalby, Vasileios Panoulas
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2020)
Article
Engineering, Biomedical
Eline Huethorst, Marie F. A. Cutiongco, Fraser A. Campbell, Anwer Saeed, Rachel Love, Paul M. Reynolds, Matthew J. Dalby, Nikolaj Gadegaard
Article
Multidisciplinary Sciences
Paul Campsie, Peter G. Childs, Shaun N. Robertson, Kenny Cameron, James Hough, Manuel Salmeron-Sanchez, Penelope M. Tsimbouri, Parag Vichare, Matthew J. Dalby, Stuart Reid
SCIENTIFIC REPORTS
(2019)
News Item
Cardiac & Cardiovascular Systems
Miles Dalby
EUROPEAN HEART JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Anthony H. Gershlick, Amerjeet S. Banning, Emma Parker, Duolao Wang, Charley A. Budgeon, Damian J. Kelly, Peter O. Kane, Miles Dalby, Simon L. Hetherington, Gerry P. McCann, John P. Greenwood, Nick Curzen
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Review
Engineering, Biomedical
Marco Cantini, Hannah Donnelly, Matthew J. Dalby, Manuel Salmeron-Sanchez
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Cardiac & Cardiovascular Systems
Maria Monteagudo Vela, Andre Simon, Fernando Riesgo Gil, Alex Rosenberg, Miles Dalby, Tito Kabir, Diana Garcia Saez, Vasileios Panoulas
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Krishnaraj S. Rathod, Sudheer Koganti, Ajay K. Jain, Roby Rakhit, Miles C. Dalby, Tim Lockie, Sundeep Kalra, Iqbal S. Malik, Charles J. Knight, Mark Whitbread, Anthony Mathur, Sam Firoozi, Richard Bogle, Simon Redwood, Philip A. MacCarthy, Alexander Sirker, Constantinos O'Mahony, Andrew Wragg, Daniel A. Jones
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2020)