Review
Engineering, Biomedical
Kenichi Arai, Takahiro Kitsuka, Koichi Nakayama
Summary: The safety and efficacy of new drugs are typically tested in animals, but differences in drug responses and potential cardiac side effects have led to many drug development projects being discontinued. Alternative methods to animal testing are needed. Tissue engineering techniques can create three-dimensional cardiac constructs from hiPSC-CMs, providing a new approach for drug screening.
Article
Engineering, Biomedical
Anna Gryadunova, Jesil Kasamkattil, Max Hans Peter Gay, Boris Dasen, Karoliina Pelttari, Vladimir Mironov, Ivan Martin, Stefan Schaeren, Andrea Barbero, Olga Krupkova, Arne Mehrkens
Summary: This study demonstrates the potential of scaffold-free spheroids derived from human nasal chondrocytes for nucleus pulposus regeneration, showing good injectability and biochemical properties under suitable culture conditions, making it a promising strategy for degenerative disc disease treatment.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Wei Chen, Yongsheng Li, Yuting Huang, Yao Dai, Tingfei Xi, Zheng Zhou, Hairong Liu
Summary: The study indicates that quercetin-modified PHBV fibrous scaffold has the potential to promote cartilage regeneration in tissue engineering. By regulating related genes, it can inhibit chondrocyte apoptosis and reduce oxidative stress.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Engineering, Manufacturing
Rigoberto Lopez Reyes, Min-Soo Ghim, Nae-Un Kang, Ji-Woo Park, So-Jung Gwak, Young-Sam Cho
Summary: Scaffolds for bone tissue engineering need to have sufficient mechanical properties and interconnectivity. This study proposes a modified honeycomb structure for 3D bone-tissue-engineering scaffolds, which improves the interconnectivity without decreasing the mechanical strength. Numerical analysis and experimental results show that the modified honeycomb structure scaffold has superior compressive stiffness and cell proliferation compared to other structure scaffolds.
ADDITIVE MANUFACTURING
(2022)
Review
Biotechnology & Applied Microbiology
Hamidreza Tolabi, Negar Bakhtiary, Shaghayegh Sayadi, Maryam Tamaddon, Farnaz Ghorbani, Aldo R. Boccaccini, Chaozong Liu
Summary: This review summarizes the recent discoveries and applications of polydopamine as a surface coating material for tackling musculoskeletal disorders. Polydopamine, with its adhesive properties to various substrates, has shown potential in creating pro-healing interfaces and personalized scaffolds. The review also highlights the potential applications of polydopamine in bioengineering, such as carriers and nanoparticles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Javad Esmaeili, Sorur Jadbabaee, Farnaz Mohebi Far, Mostafa Esmaeilpour Lukolayeh, Kevser Kubra Kirboga, Farnoush Sadat Rezaei, Aboulfazl Barati
Summary: Utilizing the stem of the Alstroemeria flower as a scaffold, this study fabricated a new scaffold material through decellularization and chitosan modification. The modified scaffold exhibited better porous structure, mechanical behavior, and biocompatibility compared to the unmodified scaffold. Modified tissue plants could be a promising candidate for tissue engineering of both soft and hard tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Ihn Han, Juie Nahushkumar Rana, Ji-Hye Kim, Eun Ha Choi, Youngsun Kim
Summary: This study evaluated the osteogenic potential of non-thermal biocompatible plasma (NBP)-treated chitosan scaffolds. The results showed that NBP-treated chitosan scaffolds demonstrated significant improvements in cell viability and differentiation.
Article
Polymer Science
Banafsheh Safari, Marziyeh Aghazadeh, Leila Roshangar, Ayuob Aghanejad, Soodabeh Davaran
Summary: This study reports the fabrication and evaluation of a bioactive hybrid scaffold collagen/P-PCL for bone tissue engineering. The scaffold showed biocompatibility, osteoconductivity, and osteoinductivity, supporting the proliferation and differentiation of AD-MSCs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Esmat Azizipour, Hossein Aghamollaei, Raheleh Halabian, Delaram Poormoghadam, Mostafa Saffari, Maliheh Entezari, Ali Salimi
Summary: Employing hydrogels with bioactive glass nanowhiskers for bone tissue repair showed successful induction of hMSCs differentiation into osteogenic lineage and biomineralization. Cell viability assays confirmed biocompatibility and increased proliferation with BGnW incorporation. Molecular investigations revealed elevated osteogenic markers level, suggesting Gel-Glu-Col/BGnW as a potential candidate for bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Elaheh Esmaeili, Zahra Malaie-Balasi, Mahboubeh Kabiri, Arash Khojasteh, Farzaneh Mohamadyar-Toupkanlou, Negar Sadeghzadeh, Zeinab Zarei-Behjani, Simzar Hosseinzadeh
Summary: Response surface methodology with D-optimal algorithm was utilized for electrospinning nanoclay/PAN composite scaffold to achieve lower fiber diameter and improved mechanical properties for bone regeneration. The optimized electrospinning parameters led to successful fabrication of composite scaffold with desired properties, which demonstrated enhanced bioactivity and bone regeneration potential.
Article
Materials Science, Multidisciplinary
Rui Luo, Fengji Li, Yanan Wang, Huiru Zou, Jianwei Shang, Yaru Fan, Han Liu, Zhaoyuan Xu, Ruixin Li, Hao Liu
Summary: In this study, a biomaterial that combines photothermal therapy and tissue engineering scaffold was developed, which can kill oral squamous cell carcinoma cells and promote the regeneration of mucosal defects. The research showed that the scaffold effectively inhibited cell growth and facilitated the repair of mucosal wounds.
MATERIALS & DESIGN
(2023)
Review
Biochemistry & Molecular Biology
Mithun Santra, Yu-Chi Liu, Vishal Jhanji, Gary Hin-Fai Yam
Summary: Corneal transparency is crucial for vision, but corneal opacity can cause blindness. Conventional corneal transplantation is limited by a lack of donor tissue, making bioengineered corneal tissues an emerging solution. Engineering with extracellular matrix (ECM) scaffolds, particularly using ultra-thin stromal laminar tissues obtained from refractive correction procedures, offers a promising approach for corneal regeneration and restoration of transparency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mohammad Foad Abazari, Sepehr Torabinejad, Shohreh Zare Karizi, Hadi Samadian, Sahar Jalili-ghelichi, Mehdi Norouzi, Hassan Askari, Vahdat Poortahmasebi, Seyedeh Elnaz Enderami, Fatemeh Soleimanifar
Summary: This study demonstrates the high osteo-supportive capacity of a modified nanofibrous scaffold using human placental extract. It provides a potential candidate for bone tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Oncology
Maria Donatella Mariniello, Matteo Ghilli, Benedetta Favati, Irini Gerges, Livio Colizzi, Margherita Tamplenizza, Alessandro Tocchio, Federico Martello, Maria Ghilardi, Maria Cristina Cossu, Serena Danti, Manuela Roncella
Summary: This study aimed to investigate the use of a biomimetic polyurethane-based scaffold for regenerating soft tissue in patients undergoing breast conserving surgery (BCS) for non-malignant breast lesions. The results showed positive outcomes in terms of safety and performance, suggesting that this innovative approach has the potential to significantly impact clinical application of tissue engineering.
Article
Cell & Tissue Engineering
Miranda Robbins, Venkat Pisupati, Roberta Azzarelli, Samer Nehme, Roger A. Barker, Ljiljana Fruk, Gabriele S. Kaminski Schierle
Summary: This study explores the use of bacterial cellulose as an in vitro scaffold to promote the growth and differentiation of different stem cell-derived cell types, focusing on dopaminergic neuronal progenitors. The results show that the covalent functionalisation of bacterial cellulose sheets with bioactive peptides can improve the growth and differentiation of human pluripotent stem cells into dopaminergic neuronal progenitors. This suggests that bacterial cellulose has potential applications in cell therapy and tissue engineering for repairing damage to the central nervous system, such as in Parkinson's disease.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Polymer Science
Ilnur Ishmukhametov, Svetlana Batasheva, Elvira Rozhina, Farida Akhatova, Rimma Mingaleeva, Artem Rozhin, Rawil Fakhrullin
Summary: This study demonstrates that substrates modified with magnetic nanoparticles and DNA can induce the differentiation of human adipose-derived MSCs into chondrocytes and osteoblasts. An increase in the concentration of magnetic nanoparticles leads to reduced cell adhesion and increased surface roughness.
Article
Chemistry, Multidisciplinary
Ilia A. Iakovlev, Alexander Y. Deviatov, Yuri Lvov, Golnur Fakhrullina, Rawil F. Fakhrullin, Vladimir V. Mazurenko
Summary: In this paper, the authors address the challenges of studying natural clays' diffusive motion and stochastic properties with limited experimental data. By utilizing dark-field microscopy and machine learning algorithms, they quantitatively characterize the rotational diffusive dynamics of nanotubes. The proposed method can be applied to explore diffusive dynamics of various biological systems in real time.
Review
Chemistry, Multidisciplinary
Katsuhiko Ariga, Rawil Fakhrullin
Summary: Nanoarchitectonics is an emerging methodology that explores various functional materials from atomic to cellular scales by regulating nanostructures. Significant progress has been made in this field, including atom and molecules nanoarchitectonics, supramolecular nanoarchitectonics, and nanoarchitectonics at cell-scale.
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
(2022)
Article
Chemistry, Physical
Yu. V. Cherednichenko, S. A. Konnova, R. F. Fakhrullin
Summary: This paper systematizes the data obtained in recent years on the application of interfacial self-assembly of halloysite nanoparticles into three-dimensional structures. It characterizes the mechanisms for the manifestation of the kinetic and physical properties of such structures and discusses possible methods of their employment in medicine, cosmetology, biology, and veterinary science.
Review
Toxicology
Jiayu Cao, Qing Yang, Jie Jiang, Tatenda Dalu, Aliaksei Kadushkin, Joginder Singh, Rawil Fakhrullin, Fangjun Wang, Xiaoming Cai, Ruibin Li
Summary: We are concerned about the environmental and health impacts of micro/nanoplastics (M/NPs) as emerging pollutants, as they have high surface area and strong binding affinity, allowing for extensive interactions with surrounding substances. In real exposure scenarios, formation of coronas on the surface of M/NPs is inevitable and often displays complex structures. Surface coronas have been found to impact the transportation, uptake, distribution, biotransformation and toxicity of particles.
PARTICLE AND FIBRE TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anna Stavitskaya, Eliza Sitmukhanova, Adeliya Sayfutdinova, Elnara Khusnetdenova, Kristina Mazurova, Kirill Cherednichenko, Ekaterina Naumenko, Rawil Fakhrullin
Summary: In this study, the researchers synthesized CdS nanoparticles on the surface of mesoporous aluminosilicates and silicates and tested their photocatalytic antibacterial efficiency. The CdS/MCM-41/HNTs showed the most prominent photocatalytic antibacterial effect and had less toxicity to eukaryotic cells.
Article
Chemistry, Multidisciplinary
Anna Vikulina, Alena Wulf, Guy Guday, Rawil Fakhrullin, Dmitry Volodkin
Summary: Cells recognize cues and exhibit molecular responses at their interfaces to implement specific functions. Researchers have developed an approach to mimic the cellular external microenvironment by assembling a lipid bilayer on top of a polyelectrolyte multilayer cushion, creating a 3D artificial extracellular matrix (ECM).
Article
Environmental Sciences
Svetlana Batasheva, Farida Akhatova, Nail Abubakirov, Rawil Fakhrullin
Summary: The high worldwide consumption of cheap plastic goods has led to a serious environmental plastic pollution, which has been exacerbated by the accumulation of disposed personal protective equipment during the COVID-19 outbreak. This study aimed to assess the feasibility of dark-field hyperspectral microscopy for detecting nanoplastics derived from weathered polypropylene masks in the 400-1000 wavelength range.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Anatomy & Morphology
Elizaveta K. Skalon, Viktor V. Starunov, Natalya I. Bondarenko, George S. Slyusarev
Summary: Orthonectids are parasitic bilaterians whose exact phylogenetic position is uncertain. The parasitic stage of orthonectids, known as plasmodium, remains underexplored. By studying the fine structure of Intoshia linei orthonectid plasmodium, this study found that it is an extracellular parasite with a possible mechanism of formation. Therefore, the term orthonectid plasmodium could be used temporarily instead.
JOURNAL OF MORPHOLOGY
(2023)
Review
Polymer Science
Kirill Cherednichenko, Dmitry Kopitsyn, Egor Smirnov, Nikita Nikolaev, Rawil Fakhrullin
Summary: Introduced in 1954, polyurethane foams gained popularity due to their light weight, high chemical stability, and excellent sound and thermal insulation properties. Despite their versatile applications, the high flammability of polyurethane foams limits their use. Nanoscale materials show potential as flame-retardant additives to improve the fireproof properties of polyurethane foams. This review focuses on the recent progress in modifying polyurethane foams with nanomaterials to enhance their flame retardance, including different types of nanomaterials and methods of incorporation, as well as the synergistic effects with other flame-retardant additives.
Article
Chemistry, Multidisciplinary
Nisha Lama, John Wilhite, Yuri Lvov, Svetlana Konnova, Rawil Fakhrullin
Summary: Cotton can be protected from fire by coating it with a layer-by-layer assembly of cationic polyethyleneimine (PEI) and anionic halloysite clay nanotubes (HNT). The treated cotton showed self-extinguishing properties when burned. The optimal flame retardancy was achieved with only two bilayers of PEI/HNT coating.
Article
Microbiology
Olga Karaseva, Georgii Ozhegov, Dilyara Khusnutdinova, Maria Siniagina, Elizaveta Anisimova, Farida Akhatova, Rawil Fakhrullin, Dina Yarullina
Summary: Lactiplantibacillus plantarum is a versatile bacterium widely used as a probiotic. In this study, the probiotic potential of a novel strain called L. plantarum FCa3L, isolated from fermented cabbage, was characterized through genome sequencing. The results showed that FCa3L had comparable properties to the reference strain, L. plantarum 8PA3, in terms of acid and bile tolerance, adhesiveness, H2O2 production, and acidification rate. FCa3L also exhibited superior antibacterial properties, although it had a higher antibiotic resistance gene content. The study provided genomic evidence supporting the adhesive and antibacterial properties, biosynthesis of bioactive metabolites, and safety of FCa3L, suggesting its potential as a probiotic.
Editorial Material
Chemistry, Physical
Katsuhiko Ariga, Rawil Fakhrullin
Article
Chemistry, Physical
Denis V. Voronin, Eliza Sitmukhanova, Rais I. Mendgaziev, Maria I. Rubtsova, Dmitry Kopitsyn, Kirill A. Cherednichenko, Anton P. Semenov, Rawil Fakhrullin, Dmitry G. Shchukin, Vladimir Vinokurov
Summary: Organic phase-change materials (PCMs) have the potential for developing advanced thermoregulation and responsive energy systems due to their high latent heat capacity and thermal reliability. In this study, organic PCM n-Octadecane was encapsulated into polyurethane capsules, and the effects of different n-Octadecane feedings on shell formation, capsule structure, and latent heat storage properties were investigated. The results showed that the shell thickness decreased and the latent heat storage capacity increased with increasing n-Octadecane feeding.
Article
Chemistry, Physical
Ivan Guryanov, Ekaterina Naumenko, Rawil Fakhrullin
Summary: This review article provides a brief overview of the recent approaches to nanoarchitectonics on hair. Different types of nanomodifications are used for cosmetic and medical applications, aiming to improve the aesthetics and treat hair and scalp diseases. The article discusses in detail the use of nanostructures to enhance the effect of daily care products and improve the penetration efficiency of active substances for hair regeneration. Nanocoatings show promise in improving hair structure and aesthetics, as well as protecting hair from environmental factors. The article also explores the potential of nanoarchitectonics and regenerative medicine for hair follicle regeneration.
APPLIED SURFACE SCIENCE ADVANCES
(2022)
