期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 3, 期 12, 页码 1234-1260出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201402178
关键词
alpha-amino acids; alpha-aminophosphonates; asymmetric synthesis; Mannich reaction; quaternary stereocenters
资金
- DAE India
- CSIR, New Delhi
- IIT Bombay
Asymmetric synthesis of alpha-amino acids and their phosphonate analogues has received considerable attention due to their diverse biological activities. Quaternary alpha-amino acids and their phosphonate analogues are often more resistant to chemical and enzymatic degradation and therefore have been targets of various synthetic endeavors. This Focus Review provides a summary of recent approaches to catalytic asymmetric synthesis of quaternary alpha-amino acids and alpha-aminophosphonates.
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