Article
Oncology
Francesca Paolini, Carla Amici, Mariantonia Carosi, Claudia Bonomo, Paola Di Bonito, Aldo Venuti, Luisa Accardi
Summary: The study revealed that scFvs targeting HPV16 E6 and E7 proteins were effective in delaying tumor progression in experimental models, and their antitumor activity appeared to be based on driving tumor cells towards the apoptotic pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Microbiology
Om Basukala, Oscar Trejo-Cerro, Michael P. Myers, David Pim, Paola Massimi, Miranda Thomas, Corrado Guarnaccia, David Owen, Lawrence Banks
Summary: HPV-E7 plays a crucial role in HPV-induced malignancy by targeting AP2 complex and modulating clathrin-mediated endocytosis, which may contribute to cellular transformation.
Article
Virology
Oscar Trejo-Cerro, Paola Massimi, Justyna Broniarczyk, Michael Myers, Lawrence Banks
Summary: HPV-induced carcinogenesis is associated with unregulated expression of oncoproteins E6 and E7. In this study, we identified Memo1 as a novel binding partner of HPV16 E7 and found that HPV16 E7 targets Memo1 for proteasomal degradation. Overexpression of Memo1 decreases cell transformation and proliferation, while reduction of Memo1 levels correlate with activation of Akt and increased invasion of HPV-positive cervical cancer cell lines.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Carolina Olivera, Jessica P. Mosmann, Ailen N. Anna, Gloria N. Bettucci Ferrero, Daniela A. Paira, Fernando N. Ferreyra, Maria S. Martinez, Ruben D. Motrich, Cecilia G. Cuffini, Hector Alex Saka, Virginia E. Rivero
Summary: Coinfection of HPV and CT can lead to increased expression of immune inhibitory molecules and oncogenic proteins, as well as reduced severity and infectivity of CT infection. However, the specific effects of HPV infection on CT development are still not well understood.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Vuk Bortnik, Michelle Wu, Bryan Julcher, Ana Salinas, Iva Nikolic, Kaylene J. Simpson, Nigel Aj McMillan, Adi Idris
Summary: HPV-positive oropharyngeal squamous cell carcinomas are on the rise globally, surpassing cervical cancer in the USA. Targeting HPV oncogenes, particularly E6 and E7, may lead to tumor regression and favorable responses in HPV-driven OPSCCs.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Oncology
Jiang Zhu, Lingjing Chen, Qiaoli Zheng, Rui Han, Xianzhen Chen, Qiang Zhou, Hao Cheng
Summary: This study aimed to establish a reliable protocol for immunohistochemistry stains to detect HPV16 E7 protein and found a positive correlation between HPV16 E7 protein expression and malignancy grade.
Article
Virology
M. Elina Totaro, Juan A. Gili, D. Javier Liotta, Theodore G. Schurr, Maria A. Picconi, Ines Badano
Summary: The province of Misiones is considered a region with a high mortality rate due to cervical cancer. Genetic variation in the E6 350G gene of HPV16 is associated with an increased risk of CC in this region. Phylogenetic analysis shows the presence of Lineage A and D subtypes in the samples.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Cell Biology
Leslie Olmedo-Nieva, J. Omar Munoz-Bello, Imelda Martinez-Ramirez, Antonio Daniel Martinez-Gutierrez, Yunuen Ortiz-Pedraza, Claudia Gonzalez-Espinosa, Vicente Madrid-Marina, Kirvis Torres-Poveda, Margarita Bahena-Roman, Marcela Lizano
Summary: This study identified biomarkers affected by HPV-16 E6 and E7 oncoproteins that impact the prognosis of cervical cancer patients. The downregulated expression of RIPOR2 was found to be strongly associated with worse overall survival. Additionally, in a Mexican cohort, decreased RIPOR2 expression was associated with lesion progression and worse prognosis in cervical cancer patients.
Review
Biotechnology & Applied Microbiology
Shahin Amiri, Setare Adibzadeh, Samaneh Ghanbari, Behnaz Rahmani, Mohammad H. Kheirandish, Aref Farokhi-Fard, Mansoureh S. Dastjerdeh, Fatemeh Davami
Summary: Chinese hamster ovary (CHO) cells are the most commonly used host cell system for industrial production of recombinant protein biopharmaceuticals. The use of CRISPR-Cas technology along with donor design strategies has allowed scientists to efficiently modify CHO cell line genomes and achieve consistent and high-quality protein expression. This review summarizes the recent advancements in CHO cell line development, including different cell engineering approaches and targeted integration strategies, which can improve the product development process and yield.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Cell Biology
Saskia J. Santegoets, Anouk Stolk, Marij J. P. Welters, Sjoerd H. van der Burg
Summary: In patients with HPV16-positive OPSCC, the presence of HPV16-E2-specific CD4+ and CD8+ T cells in the tumor correlates with better survival.
CELL REPORTS MEDICINE
(2023)
Article
Biology
Joshua Hatterschide, Paola Castagnino, Hee Won Kim, Steven M. Sperry, Kathleen T. Montone, Devraj Basu, Elizabeth A. White
Summary: This study found that the HPV oncoprotein E7 activates YAP1 and promotes its nuclear localization in basal epithelial cells. E7 activates YAP1 through binding and degradation of PTPN14, which plays a critical role in HPV persistence and carcinogenesis.
Article
Chemistry, Analytical
Linlin Wang, Yixin Nie, Xin Zhang, Zihui Liang, Peilin Wang, Qiang Ma, Dahai Yu
Summary: The novel Eu3+ doped polydopamine nanoparticles (PDA:Eu NPs)-based electrochemiluminescence (ECL) sensor was developed for HPV 16 DNA detection. The optical performance of PDA NPs was improved by doping with Eu3+ and the sensitivity was further enhanced by incorporating Cu (I) particle-based hydrogel as a catalyst.
MICROCHEMICAL JOURNAL
(2022)
Article
Oncology
Lucia Oton-Gonzalez, John Charles Rotondo, Carmen Lanzillotti, Elisa Mazzoni, Ilaria Bononi, Maria Rosa Iaquinta, Luca Cerritelli, Nicola Malagutti, Andrea Ciorba, Chiara Bianchini, Stefano Pelucchi, Mauro Tognon, Fernanda Martini
Summary: Classical markers alone may not be enough to classify HPV-positive HNSCC patients, but when combined with serological markers, they are strong prognostic indicators in OPSCC patients. Detection of HPV16 E7 oncoprotein in serum at diagnosis is correlated with disease recurrence and patient overall survival, providing a useful tool for stratifying and monitoring HPV-positive HNSCC patients for worse prognosis.
Article
Microbiology
Shiwen Peng, Louise Ferrall, Stephanie Gaillard, Chenguang Wang, Wei-Yu Chi, Chuan-Hsiang Huang, Richard B. S. Roden, T-C Wu, Yung-Nien Chang, Chien-Fu Hung
Summary: Immunotherapy for cervical cancer targeting high-risk human papillomavirus types 16 and 18 shows promising results in preclinical studies, with pBI-11 DNA vaccine inducing strong immune responses and therapeutic effects in mouse models. Combination with TA-HPV boost and PD-1 antibody blockade improves tumor control and survival. Clinical translation of this strategy may provide a new approach for HPV16/18-associated tumors.
Article
Virology
Ting Li, Zhiping Yang, Chunlin Zhang, Sutong Wang, Bing Mei
Summary: In central China, HPV-16 E6 and E7 genes exhibit multiple variations, and a nucleotide variation (A647G, N29S) is significantly associated with a higher risk of cervical cancer. Variations in the E6 gene affect multiple B-cell epitopes, while variations in the E7 gene have minimal impact on B-cell epitopes. These variation data have important implications for HR-HPV prevention and vaccine development.
Article
Infectious Diseases
Zohreh Fattahi, Marzieh Mohseni, Khadijeh Jalalvand, Fatemeh Aghakhani Moghadam, Azam Ghaziasadi, Fatemeh Keshavarzi, Jila Yavarian, Ali Jafarpour, Seyedeh Elham Mortazavi, Fatemeh Ghodratpour, Hanieh Behravan, Mohammad Khazeni, Seyed Amir Momeni, Issa Jahanzad, Abdolvahab Moradi, Alijan Tabarraei, Sadegh Ali Azimi, Ebrahim Kord, Seyed Mohammad Hashemi-Shahri, Azarakhsh Azaran, Farid Yousefi, Zakiye Mokhames, Alireza Soleimani, Shokouh Ghafari, Masood Ziaee, Shahram Habibzadeh, Farhad Jeddi, Azar Hadadi, Alireza Abdollahi, Gholam Abbas Kaydani, Saber Soltani, Talat Mokhtari-Azad, Reza Najafipour, Reza Malekzadeh, Kimia Kahrizi, Seyed Mohammad Jazayeri, Hossein Najmabadi
Summary: This study provided 50 whole-genome sequences of SARS-CoV-2 viral isolates from different geographical locations in Iran during March-July 2020. Analysis revealed at least two introductions of the virus into the country, leading to the dominance of B.4 lineage in the early epidemic followed by an increase in frequency of D614G mutation and B.1* lineages from mid-May onwards, indicating a rapid viral transmission that could lead to drastic changes in the circulating viral lineages in the country.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Armina Shirangi, Fatemeh Mottaghitalab, Sajad Dinarvand, Fatemeh Atyabi
Summary: A nanoparticle system for targeted delivery of ROR1 siRNA in the treatment of triple-negative breast cancer was designed and tested. The nanoparticles showed good properties and effectively suppressed tumor cell growth both in vitro and in vivo. The accumulation of nanoparticles in breast tumors was increased by magnetic field guidance. This therapeutic strategy has potential in the treatment of triple-negative breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Correction
Pharmacology & Pharmacy
Hosniyeh Hosseinzadeh, Fatemeh Atyabi, Behrang Shiri Varnamkhasti, Reza Hosseinzadeh, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Rassoul Dinarvand
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Summary: The emerging pathological conditions and growing drug resistance call for the application of advanced technologies to discover therapeutic candidates and gain comprehensive understanding about their targets, action mechanisms, and interactions within the body. Physics- and chemistry-based techniques can be used for theranostic purposes, including preparing smart carriers, local drug or gene delivery, and enhancing pharmaceutical bioavailability. Crystal engineering and other techniques such as artificial intelligence and quantum-based methods can play a crucial role in manufacturing efficient pharmaceuticals and reducing adverse events.
JOURNAL OF CONTROLLED RELEASE
(2023)
Correction
Pharmacology & Pharmacy
Farhad Alvandifar, Baharnaz Ghaffari, Navid Goodarzi, Nazanin Shabani Ravari, Fahimeh Karami, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Mehdi Esfandyari-Manesh, Razieh Mohammad Jafari, Fatemeh Atyabi, Shiva Irani, Rassoul Dinarvand
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Retraction
Chemistry, Multidisciplinary
Armin Mahmoud Salehi, Farnaz Kheshti, Farnaz Hajizadeh, Asal Barshidi, Bentolhoda Rashidi, Farbod Ebrahimi, Simin Bahmanpour, Vahid Karpisheh, Fatemeh Karimian Noukabadi, Fariba Karoon Kiani, Hadi Hassannia, Fatemeh Atyabi, Seyed Hossein Kiaie, Fatah Kashanchi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Rafieh Bagherifar, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
PHARMACEUTICAL RESEARCH
(2023)
Article
Virology
Malihe Naderi, Seyed Masoud Hosseini, Naser Behnampour, Iraj Shahramian, Abdolvahab Moradi
Summary: The study evaluated the role of genetic polymorphisms in HLA-DQB1 in three generations of patients with chronic hepatitis B (CHB). The results showed that HLA-DQB1*03, HLA-DQB1*05, HLA-DQB1*04:01, and HLA-DQB1*03:01 were associated with HBV persistence and chronicity. HLA-DQB1*05:02 was found to be associated with risk to liver cirrhosis.
Article
Nanoscience & Nanotechnology
Gabriele Selvaggio, Niklas Herrmann, Bjoern Hill, Riza Dervisoglu, Sebastian Jung, Milan Weitzel, Meshkat Dinarvand, Dietmar Stalke, Loren Andreas, Sebastian Kruss
Summary: Egyptian Blue is an NIR fluorescent silicate that can be exfoliated into fluorescent nanosheets. By surface functionalization, the nanosheets can be modified for colloidal stability and targeted imaging. The experiments demonstrated the conjugation of visible fluorescent pyrene and carboxyl groups to the nanosheets, and the subsequent conjugation of folic acid for specific targeting of cancer cells.
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Seyed Reza Heydari, Mahnoush Samadi, Armina Shirangi, Mehdi Farokhi, Ayda Moradi, Reza Bafkary, Fatemeh Atyabi, Fatemeh Mottaghitalab, Rassoul Dinarvand
Summary: In this study, dual responsive mesoporous silica nanoparticles (MSNs) were designed to effectively deliver PB to osteosarcoma cancer cells. PB loaded MSNs showed higher drug release in the tumor microenvironment and enhanced cytotoxicity against cancer cells. This study provides a promising method for osteosarcoma treatment using PB loaded MSNs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Genetics & Heredity
Malihe Naderi, Seyed Masoud Hosseini, Naser Behnampour, Iraj Shahramian, Abdolvahab Moradi
Summary: This study examined the frequency of S gene mutations in three generations of HBV cases in northeastern Iran. The results showed that most CHB cases from the three-generation had HBV S gene mutations, particularly concentrated in the B cell epitope. These mutations may play a critical role in hepatitis pathogenesis and vaccine evasion.
Article
Pharmacology & Pharmacy
Nazanin Shabani Ravari, Maryam Ghareh Sheikhlou, Navid Goodarzi, Bahar Kharazian, Mohsen Amini, Fatemeh Atyabi, Saman A. A. Nasrollahi, Rassoul Dinarvand
Summary: Researchers used CPP as a carrier to create CPP-BoNT/A nanocomplexes by PEC method, aiming to increase toxin entrapment, reduce diffusion, and prolong the effect. The nanocomplexes showed higher cellular toxicity than the toxin and had a slower onset and longer duration of action on muscles.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Ophthalmology
Elham Delrish, Mahmoud Jabbarvand, Fariba Ghassemi, Fahimeh Asadi Amoli, Fatemeh Atyabi, Saeed Heidari Keshel, Alireza Lashay, Farnaz Sadat Mirzazadeh Tekie, Masoud Soleimani, Rassoul Dinarvand
Summary: This study aimed to evaluate the efficacy of thiolated chitosan-dextran nanoparticles (TPH-CMD-TCS-NPs) in improving intravitreal chemotherapy of retinoblastoma in a rabbit xenograft model. The results showed that the NPs had a mean diameter of 30 +/- 4 nm, a polydispersity index of 0.24 +/- 0.03, and a zeta potential of +10 +/- 3 mV. The TPH-CMD-TCS-NPs group showed a significant decrease in tumor volume compared to the control group (P = 0.039).
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2023)
Article
Pediatrics
Emad Behboudi, Alijan Tabarraei, Alireza Tahamtan, Mohammad Reza Kalani, Abdolvahab Moradi
Summary: This study assessed the mutations in SARS-CoV-2 NSP3 and NSP12, which are viral protease and viral polymerase (RdRp). The mutations identified may contribute to faster replication of the virus and evasion of pharmaceutical agents, playing a significant role in viral pathogenesis. This study emphasizes the importance of ongoing genomic variation studies on SARS-CoV-2 variants.
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD
(2022)
Article
Pediatrics
Bahman Iri, Masoud Khoshnia, Emad Behboudi, Abdolvahab Moradi
Summary: This study evaluated the immune response to HBV vaccine among children aged 8 to 18 months in Bandar-e Turkmen, Iran. The majority of children showed positive immune responses after three doses of vaccination, but a small number of children did not respond. Revaccination is recommended for those who are not protected.
INTERNATIONAL JOURNAL OF PEDIATRICS-MASHHAD
(2022)
